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The map label for this gene is gabT [C]

Identifier: 17229890

GI number: 17229890

Start: 2881109

End: 2882404

Strand: Direct

Name: gabT [C]

Synonym: alr2398

Alternate gene names: 17229890

Gene position: 2881109-2882404 (Clockwise)

Preceding gene: 17229886

Following gene: 17229896

Centisome position: 44.92

GC content: 47.15

Gene sequence:

>1296_bases
ATGTTAAGTATCCCTATTAATCAACATTTACCTTATACACCTCGTTTGGTGACATCCTTACCGGGGCCTAGAGCTAAAGC
AATTGTAGAACGCGATCGCGCTGTTACTTCTCCTTCTTATACCCGCGACTATCCCTTGGTGGTGAATCGTGGTGAAGGCT
GCATGGTGGAAGATGTAGACGGCAATGTATTTTTAGACATGACAGCAGGTATCGCCGTTACCTCCACCGGACACGCCCAC
CCAGAAGTAGTTAGGGCCATTCAAGAACAGTCGGCGCGTCTCATACATATGTCGGGGACGGATTTCTATTATGAGCCGAT
GGTGGAACTAGCCGAAAACCTAGCCAGCCAAGCCCCTTTTGTTCACGATACAAAGGTATTCTTCACCAATTCCGGTGCTG
AGTCCAACGAAGGAGCCATTAAACTAGCTCGATATTACACCAAGCGATCGCTCATCATTGCTTTTTTAGGCGCATTCCAC
GGGCGCACCTATGGGGCTATGTCTTTGACTGGTTCTAAAACTGTACAGCGTGCCAATTTCGGGCCGTTAGTACCAGGAGT
GACTCACATTCCCTACGGCACTCACGCCAGCCTAGATTACCTAGAAAATAATTTATTGACTACAATTATCCCTGCCCATG
AAGTAGCAGCCATTGTCGTTGAACCAATCCAGGGAGAAGGCGGTTATATCGTGCCAGAGGATGGATTTTTGCAGAGAATC
CGTAATATCTGCGATCGCTATGGCATATTAATGGTAGTTGATGAAGTGCAATCAGGCATGGGGCGCACCGGACGCTTATT
TGCCATTGAGCATTGGAATGTCACACCTGATATTATTACCACCGCCAAAGGTATCGCTAGCGGTATGCCTTTAGGCGCAA
TTTTAGCCCGTGCTGAATTGATGACTTGGCCTCCCGGTTCCCACGCCACCACATTCGGCGGCAATCCAGTAGCTTGTGCG
GCTGGTATTGTCACCCTCAAACTACTAGAAAGTGGCTTGATGGATAACGCCACCCAAATGGGCGAATTATTACAAACTGG
TTTAACCCAACTGCATGAACAATTCCCCAGAATGTCCTTACCCAGAGGTAAAGGATTAATGGTGGCGGTGGATTTATTAG
ATGAAGACGGTAATTTTGATTCTACATTGCGCGATCGCATTATCCAAGAAGCCTTCTATCACGGACTGTTATTACTAGGT
TGTGGTAAAGCCGCAATTCGTTTTTGTCCACCGCTAGTTATCAACCGCGAACAAATCCAAACCAGCCTGGATATCCTCGC
AGGAATTTTAAGATAA

Upstream 100 bases:

>100_bases
TTGTCAATTACTAAGTTATACACATAGAGAATCACACACTACTGTTAAGAATTACACTTGGCAGTTTAATTATCCGGATA
CAGAAATACCTGAAAACAAA

Downstream 100 bases:

>100_bases
GTAGATACATCCTATGTAGCTTCTCTACTATTGACGAAAAACTCACATTTTAGAGATTATCAGGGTCAATATTCAATTCT
CGCAACTTAGCGGCTAGGCG

Product: 4-aminobutyrate aminotransferase

Products: succinate semialdehyde; L-glutamate

Alternate protein names: ORF B [H]

Number of amino acids: Translated: 431; Mature: 431

Protein sequence:

>431_residues
MLSIPINQHLPYTPRLVTSLPGPRAKAIVERDRAVTSPSYTRDYPLVVNRGEGCMVEDVDGNVFLDMTAGIAVTSTGHAH
PEVVRAIQEQSARLIHMSGTDFYYEPMVELAENLASQAPFVHDTKVFFTNSGAESNEGAIKLARYYTKRSLIIAFLGAFH
GRTYGAMSLTGSKTVQRANFGPLVPGVTHIPYGTHASLDYLENNLLTTIIPAHEVAAIVVEPIQGEGGYIVPEDGFLQRI
RNICDRYGILMVVDEVQSGMGRTGRLFAIEHWNVTPDIITTAKGIASGMPLGAILARAELMTWPPGSHATTFGGNPVACA
AGIVTLKLLESGLMDNATQMGELLQTGLTQLHEQFPRMSLPRGKGLMVAVDLLDEDGNFDSTLRDRIIQEAFYHGLLLLG
CGKAAIRFCPPLVINREQIQTSLDILAGILR

Sequences:

>Translated_431_residues
MLSIPINQHLPYTPRLVTSLPGPRAKAIVERDRAVTSPSYTRDYPLVVNRGEGCMVEDVDGNVFLDMTAGIAVTSTGHAH
PEVVRAIQEQSARLIHMSGTDFYYEPMVELAENLASQAPFVHDTKVFFTNSGAESNEGAIKLARYYTKRSLIIAFLGAFH
GRTYGAMSLTGSKTVQRANFGPLVPGVTHIPYGTHASLDYLENNLLTTIIPAHEVAAIVVEPIQGEGGYIVPEDGFLQRI
RNICDRYGILMVVDEVQSGMGRTGRLFAIEHWNVTPDIITTAKGIASGMPLGAILARAELMTWPPGSHATTFGGNPVACA
AGIVTLKLLESGLMDNATQMGELLQTGLTQLHEQFPRMSLPRGKGLMVAVDLLDEDGNFDSTLRDRIIQEAFYHGLLLLG
CGKAAIRFCPPLVINREQIQTSLDILAGILR
>Mature_431_residues
MLSIPINQHLPYTPRLVTSLPGPRAKAIVERDRAVTSPSYTRDYPLVVNRGEGCMVEDVDGNVFLDMTAGIAVTSTGHAH
PEVVRAIQEQSARLIHMSGTDFYYEPMVELAENLASQAPFVHDTKVFFTNSGAESNEGAIKLARYYTKRSLIIAFLGAFH
GRTYGAMSLTGSKTVQRANFGPLVPGVTHIPYGTHASLDYLENNLLTTIIPAHEVAAIVVEPIQGEGGYIVPEDGFLQRI
RNICDRYGILMVVDEVQSGMGRTGRLFAIEHWNVTPDIITTAKGIASGMPLGAILARAELMTWPPGSHATTFGGNPVACA
AGIVTLKLLESGLMDNATQMGELLQTGLTQLHEQFPRMSLPRGKGLMVAVDLLDEDGNFDSTLRDRIIQEAFYHGLLLLG
CGKAAIRFCPPLVINREQIQTSLDILAGILR

Specific function: 4-aminobutyrate (GABA) degradation. [C]

COG id: COG0160

COG function: function code E; 4-aminobutyrate aminotransferase and related aminotransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=420, Percent_Identity=33.5714285714286, Blast_Score=216, Evalue=3e-56,
Organism=Homo sapiens, GI13994255, Length=443, Percent_Identity=30.4740406320542, Blast_Score=185, Evalue=7e-47,
Organism=Homo sapiens, GI284507298, Length=308, Percent_Identity=35.0649350649351, Blast_Score=177, Evalue=2e-44,
Organism=Homo sapiens, GI188536080, Length=473, Percent_Identity=27.061310782241, Blast_Score=155, Evalue=5e-38,
Organism=Homo sapiens, GI38679950, Length=473, Percent_Identity=27.061310782241, Blast_Score=155, Evalue=5e-38,
Organism=Homo sapiens, GI38679946, Length=473, Percent_Identity=27.061310782241, Blast_Score=155, Evalue=5e-38,
Organism=Homo sapiens, GI24119277, Length=440, Percent_Identity=28.6363636363636, Blast_Score=152, Evalue=4e-37,
Organism=Homo sapiens, GI37574042, Length=413, Percent_Identity=26.8765133171913, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI226442709, Length=381, Percent_Identity=27.2965879265092, Blast_Score=127, Evalue=3e-29,
Organism=Homo sapiens, GI226442705, Length=413, Percent_Identity=25.90799031477, Blast_Score=120, Evalue=2e-27,
Organism=Escherichia coli, GI1789016, Length=419, Percent_Identity=38.6634844868735, Blast_Score=278, Evalue=5e-76,
Organism=Escherichia coli, GI1787560, Length=391, Percent_Identity=40.920716112532, Blast_Score=277, Evalue=1e-75,
Organism=Escherichia coli, GI145693181, Length=376, Percent_Identity=39.8936170212766, Blast_Score=245, Evalue=4e-66,
Organism=Escherichia coli, GI1788044, Length=393, Percent_Identity=37.4045801526718, Blast_Score=243, Evalue=2e-65,
Organism=Escherichia coli, GI1789759, Length=387, Percent_Identity=35.9173126614987, Blast_Score=226, Evalue=3e-60,
Organism=Escherichia coli, GI1786991, Length=399, Percent_Identity=31.5789473684211, Blast_Score=142, Evalue=6e-35,
Organism=Escherichia coli, GI1786349, Length=320, Percent_Identity=29.6875, Blast_Score=129, Evalue=4e-31,
Organism=Caenorhabditis elegans, GI25144271, Length=429, Percent_Identity=34.7319347319347, Blast_Score=242, Evalue=3e-64,
Organism=Caenorhabditis elegans, GI32564660, Length=435, Percent_Identity=30.3448275862069, Blast_Score=186, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI25144274, Length=333, Percent_Identity=34.8348348348348, Blast_Score=178, Evalue=5e-45,
Organism=Caenorhabditis elegans, GI71992977, Length=425, Percent_Identity=29.8823529411765, Blast_Score=154, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17541228, Length=473, Percent_Identity=27.2727272727273, Blast_Score=149, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI71981843, Length=192, Percent_Identity=31.25, Blast_Score=93, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6324432, Length=409, Percent_Identity=32.518337408313, Blast_Score=219, Evalue=6e-58,
Organism=Saccharomyces cerevisiae, GI6323470, Length=423, Percent_Identity=30.7328605200946, Blast_Score=205, Evalue=1e-53,
Organism=Saccharomyces cerevisiae, GI6321456, Length=482, Percent_Identity=25.9336099585062, Blast_Score=132, Evalue=7e-32,
Organism=Saccharomyces cerevisiae, GI6324386, Length=378, Percent_Identity=24.8677248677249, Blast_Score=99, Evalue=1e-21,
Organism=Drosophila melanogaster, GI21357415, Length=420, Percent_Identity=33.5714285714286, Blast_Score=228, Evalue=6e-60,
Organism=Drosophila melanogaster, GI28574759, Length=452, Percent_Identity=33.1858407079646, Blast_Score=184, Evalue=1e-46,
Organism=Drosophila melanogaster, GI161085790, Length=451, Percent_Identity=33.0376940133038, Blast_Score=181, Evalue=6e-46,
Organism=Drosophila melanogaster, GI21356575, Length=412, Percent_Identity=30.8252427184466, Blast_Score=164, Evalue=1e-40,
Organism=Drosophila melanogaster, GI281366494, Length=475, Percent_Identity=28.4210526315789, Blast_Score=151, Evalue=8e-37,
Organism=Drosophila melanogaster, GI24667139, Length=475, Percent_Identity=28.4210526315789, Blast_Score=151, Evalue=8e-37,
Organism=Drosophila melanogaster, GI24667143, Length=475, Percent_Identity=28.4210526315789, Blast_Score=151, Evalue=8e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: 2.6.1.19

Molecular weight: Translated: 46838; Mature: 46838

Theoretical pI: Translated: 6.19; Mature: 6.19

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSIPINQHLPYTPRLVTSLPGPRAKAIVERDRAVTSPSYTRDYPLVVNRGEGCMVEDVD
CCCCCCCCCCCCCCHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCEEEECC
GNVFLDMTAGIAVTSTGHAHPEVVRAIQEQSARLIHMSGTDFYYEPMVELAENLASQAPF
CCEEEEEECCEEEECCCCCCHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHCCC
VHDTKVFFTNSGAESNEGAIKLARYYTKRSLIIAFLGAFHGRTYGAMSLTGSKTVQRANF
EECCEEEEECCCCCCCCCCEEHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHCCC
GPLVPGVTHIPYGTHASLDYLENNLLTTIIPAHEVAAIVVEPIQGEGGYIVPEDGFLQRI
CCCCCCCCCCCCCCCCHHHHHHCCCEEEEECHHHEEEEEEEEEECCCCEECCCCHHHHHH
RNICDRYGILMVVDEVQSGMGRTGRLFAIEHWNVTPDIITTAKGIASGMPLGAILARAEL
HHHHHHCCEEEEEEHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHH
MTWPPGSHATTFGGNPVACAAGIVTLKLLESGLMDNATQMGELLQTGLTQLHEQFPRMSL
EECCCCCCCEECCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCC
PRGKGLMVAVDLLDEDGNFDSTLRDRIIQEAFYHGLLLLGCGKAAIRFCPPLVINREQIQ
CCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHCEEEEECCHHHHHHCCCCEECHHHHH
TSLDILAGILR
HHHHHHHHHHC
>Mature Secondary Structure
MLSIPINQHLPYTPRLVTSLPGPRAKAIVERDRAVTSPSYTRDYPLVVNRGEGCMVEDVD
CCCCCCCCCCCCCCHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCEEEECC
GNVFLDMTAGIAVTSTGHAHPEVVRAIQEQSARLIHMSGTDFYYEPMVELAENLASQAPF
CCEEEEEECCEEEECCCCCCHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHCCC
VHDTKVFFTNSGAESNEGAIKLARYYTKRSLIIAFLGAFHGRTYGAMSLTGSKTVQRANF
EECCEEEEECCCCCCCCCCEEHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHCCC
GPLVPGVTHIPYGTHASLDYLENNLLTTIIPAHEVAAIVVEPIQGEGGYIVPEDGFLQRI
CCCCCCCCCCCCCCCCHHHHHHCCCEEEEECHHHEEEEEEEEEECCCCEECCCCHHHHHH
RNICDRYGILMVVDEVQSGMGRTGRLFAIEHWNVTPDIITTAKGIASGMPLGAILARAEL
HHHHHHCCEEEEEEHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHH
MTWPPGSHATTFGGNPVACAAGIVTLKLLESGLMDNATQMGELLQTGLTQLHEQFPRMSL
EECCCCCCCEECCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCC
PRGKGLMVAVDLLDEDGNFDSTLRDRIIQEAFYHGLLLLGCGKAAIRFCPPLVINREQIQ
CCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHCEEEEECCHHHHHHCCCCEECHHHHH
TSLDILAGILR
HHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: Pyridoxal 5'-phosphate lysine-residue [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 3.3 {4-aminobutanoate}} 1.1 {4-aminobutanoate}} 1.3 {2-oxoglutarate}} 0.7 {2-oxoglutarate}} [C]

Substrates: 4-aminobutanoate; 2-oxoglutarate

Specific reaction: 4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate

General reaction: Amino group transfer [C]

Inhibitor: 2-Oxoglutarate; Lysyl reagents; SH-group reagents [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA