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The map label for this gene is ilvC [H]

Identifier: 17229807

GI number: 17229807

Start: 2789748

End: 2790743

Strand: Reverse

Name: ilvC [H]

Synonym: all2315

Alternate gene names: 17229807

Gene position: 2790743-2789748 (Counterclockwise)

Preceding gene: 17229808

Following gene: 17229806

Centisome position: 43.51

GC content: 43.37

Gene sequence:

>996_bases
ATGGCCCGGATGTACTATGACGAAGATGCCAATTTAGACCTTTTGGCTGGAAAAACCATTGCAATTATCGGCTATGGTTC
TCAAGGTCATGCCCACGCTTTAAATTTAAAAGATAGTGGTTTGAATGTGATTGTGGGGCTATATCCGGGTAGTAAGTCAG
CAGAAAAAGCCCAAGCAGCTGGGTTAACAGTGAAAAATGTGGCGGATGCTGCTAACATTGCTGACTTCATCATGATTTTG
TTACCCGATGAAGTGCAGAAAACAGTTTACAAAAACGAAATCGAACCAAATCTGCAAGAAGGAAACACTTTAGCTTTTGC
TCACGGGTTTAATATTCACTTTGGGCAAGTCGTACCACCTGCGAACGTAGACGTAGTTATGGTAGCACCCAAAGGCCCTG
GGCATTTGGTACGACGCACTTACGAACAAGGTCAAGGTGTACCAGCGCTGTTTGCCGTTTATCAAGATGCTAGTGGAAAA
GCACGCGATCGCGCCCTATCTTATGCTAAAGGTATCGGTGGCACTCGTGGCGGTGTTTTGGAAACAACTTTCCGTGAAGA
AACTGAAACCGATTTATTCGGTGAACAAGCCGTATTATGCGGTGGTTTGAGTGCTTTAATTAAAGCTGGTTTTGAAACCT
TGGTAGAAGCAGGTTATCAACCAGAACTAGCTTATTTTGAATGTCTACACGAAGTTAAATTAATTGTTGACTTGGTAGTA
GAAGGCGGTTTAGCCAAAATGCGCGACAGCATTTCTAACACTGCTGAATATGGTGATTACACTCGCGGGCCTCGGATTGT
CAACGAACAAACCAAAGCCGAAATGCGGAAGGTTCTCAGCGAAATTCAATCAGGACAATTTGCACGGGAATTTGTGTTAG
AAAACCAATCTGGTAAACCCGGATTTACTGCAATGCGTCGTCAAGAAGCTGAACACCCAATTGAAGAAGTTGGTAAAGAT
TTACGGGCAATGTTTAGCTGGTTGAAGAAAGTTTAA

Upstream 100 bases:

>100_bases
TTAACTGTTAACTCATGACTACTTGTACCCGTGGTAACACAATTTGGGGTAAAATCAAAGACTTGCCAATAAATGATGCT
TGCTGACAGGAGATGCTTGT

Downstream 100 bases:

>100_bases
AACATTCTTTTAAATCACTAAAAAAGACGCAACAGCAAACAAAACTGCTTTGCGTCTTTATTTTTTGGTGTTAAATTGTC
AGCAAAACACTAAATTTAAA

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase [H]

Number of amino acids: Translated: 331; Mature: 330

Protein sequence:

>331_residues
MARMYYDEDANLDLLAGKTIAIIGYGSQGHAHALNLKDSGLNVIVGLYPGSKSAEKAQAAGLTVKNVADAANIADFIMIL
LPDEVQKTVYKNEIEPNLQEGNTLAFAHGFNIHFGQVVPPANVDVVMVAPKGPGHLVRRTYEQGQGVPALFAVYQDASGK
ARDRALSYAKGIGGTRGGVLETTFREETETDLFGEQAVLCGGLSALIKAGFETLVEAGYQPELAYFECLHEVKLIVDLVV
EGGLAKMRDSISNTAEYGDYTRGPRIVNEQTKAEMRKVLSEIQSGQFAREFVLENQSGKPGFTAMRRQEAEHPIEEVGKD
LRAMFSWLKKV

Sequences:

>Translated_331_residues
MARMYYDEDANLDLLAGKTIAIIGYGSQGHAHALNLKDSGLNVIVGLYPGSKSAEKAQAAGLTVKNVADAANIADFIMIL
LPDEVQKTVYKNEIEPNLQEGNTLAFAHGFNIHFGQVVPPANVDVVMVAPKGPGHLVRRTYEQGQGVPALFAVYQDASGK
ARDRALSYAKGIGGTRGGVLETTFREETETDLFGEQAVLCGGLSALIKAGFETLVEAGYQPELAYFECLHEVKLIVDLVV
EGGLAKMRDSISNTAEYGDYTRGPRIVNEQTKAEMRKVLSEIQSGQFAREFVLENQSGKPGFTAMRRQEAEHPIEEVGKD
LRAMFSWLKKV
>Mature_330_residues
ARMYYDEDANLDLLAGKTIAIIGYGSQGHAHALNLKDSGLNVIVGLYPGSKSAEKAQAAGLTVKNVADAANIADFIMILL
PDEVQKTVYKNEIEPNLQEGNTLAFAHGFNIHFGQVVPPANVDVVMVAPKGPGHLVRRTYEQGQGVPALFAVYQDASGKA
RDRALSYAKGIGGTRGGVLETTFREETETDLFGEQAVLCGGLSALIKAGFETLVEAGYQPELAYFECLHEVKLIVDLVVE
GGLAKMRDSISNTAEYGDYTRGPRIVNEQTKAEMRKVLSEIQSGQFAREFVLENQSGKPGFTAMRRQEAEHPIEEVGKDL
RAMFSWLKKV

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family [H]

Homologues:

Organism=Escherichia coli, GI1790210, Length=288, Percent_Identity=36.4583333333333, Blast_Score=146, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6323387, Length=255, Percent_Identity=38.0392156862745, Blast_Score=151, Evalue=1e-37,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116 [H]

Pfam domain/function: PF01450 IlvC; PF07991 IlvN [H]

EC number: =1.1.1.86 [H]

Molecular weight: Translated: 36011; Mature: 35880

Theoretical pI: Translated: 5.27; Mature: 5.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARMYYDEDANLDLLAGKTIAIIGYGSQGHAHALNLKDSGLNVIVGLYPGSKSAEKAQAA
CCCEEECCCCCEEEEECCEEEEEEECCCCCEEEEEECCCCCEEEEEECCCCCCHHHHHHC
GLTVKNVADAANIADFIMILLPDEVQKTVYKNEIEPNLQEGNTLAFAHGFNIHFGQVVPP
CCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCEEEEEECCCEEECCCCCC
ANVDVVMVAPKGPGHLVRRTYEQGQGVPALFAVYQDASGKARDRALSYAKGIGGTRGGVL
CCCCEEEECCCCCHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHCCCCCCCCEE
ETTFREETETDLFGEQAVLCGGLSALIKAGFETLVEAGYQPELAYFECLHEVKLIVDLVV
EHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
EGGLAKMRDSISNTAEYGDYTRGPRIVNEQTKAEMRKVLSEIQSGQFAREFVLENQSGKP
CCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCC
GFTAMRRQEAEHPIEEVGKDLRAMFSWLKKV
CHHHHHHHHHCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
ARMYYDEDANLDLLAGKTIAIIGYGSQGHAHALNLKDSGLNVIVGLYPGSKSAEKAQAA
CCEEECCCCCEEEEECCEEEEEEECCCCCEEEEEECCCCCEEEEEECCCCCCHHHHHHC
GLTVKNVADAANIADFIMILLPDEVQKTVYKNEIEPNLQEGNTLAFAHGFNIHFGQVVPP
CCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCEEEEEECCCEEECCCCCC
ANVDVVMVAPKGPGHLVRRTYEQGQGVPALFAVYQDASGKARDRALSYAKGIGGTRGGVL
CCCCEEEECCCCCHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHCCCCCCCCEE
ETTFREETETDLFGEQAVLCGGLSALIKAGFETLVEAGYQPELAYFECLHEVKLIVDLVV
EHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
EGGLAKMRDSISNTAEYGDYTRGPRIVNEQTKAEMRKVLSEIQSGQFAREFVLENQSGKP
CCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCC
GFTAMRRQEAEHPIEEVGKDLRAMFSWLKKV
CHHHHHHHHHCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA