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The map label for this gene is trxA [H]

Identifier: 17229697

GI number: 17229697

Start: 2644877

End: 2645218

Strand: Direct

Name: trxA [H]

Synonym: alr2205

Alternate gene names: 17229697

Gene position: 2644877-2645218 (Clockwise)

Preceding gene: 17229696

Following gene: 17229698

Centisome position: 41.24

GC content: 39.77

Gene sequence:

>342_bases
ATGCAGAAAACTTTTACTATTGATCAAACTTTCTTCACAGGAAAAGAAGCTTTTGACTGGTTGATGCAGGAATCCGATCA
GCTAATCATTGTCAAATTTGTAGCTCCCTACTGTCCTTCCTGCGAAACGCTTAAACCTGTCCTACATCAAATAGCTGAGG
AAAACACAGGTAAATTGCATTTGGTTGAACTTGACATGAGCGAAGAACCTGAATTAGCGATTAACTTTGGTGTCAGAAGC
GCACCAACAGTAGTATTACTTAAACACCAGCAAACATTGGCACAAATTGCAGGCTTGAAACCTAAGAAACAGTACACCGA
AATGATTCAATCTGCGCTCTAA

Upstream 100 bases:

>100_bases
GGTTGTCAGAAAGGCAATTGTCTCCGGCGGACGGAACACCAACCCTTGTTTCTTTCGCTGCGTAAATAGTATTTTTTATC
ACAATTACAAGGAGATAAAT

Downstream 100 bases:

>100_bases
GACAGGTGGATAAATGTCTATAGCCTTATCCCGTCTAGATTCTTAATTTTGTAGCTTTAGCTTCCCGTAGGGTATTTTGA
GTTTTGAATTGACAATGAGT

Product: thioredoxin

Products: thioredoxin disulfide; NADPH; H+

Alternate protein names: Trx [H]

Number of amino acids: Translated: 113; Mature: 113

Protein sequence:

>113_residues
MQKTFTIDQTFFTGKEAFDWLMQESDQLIIVKFVAPYCPSCETLKPVLHQIAEENTGKLHLVELDMSEEPELAINFGVRS
APTVVLLKHQQTLAQIAGLKPKKQYTEMIQSAL

Sequences:

>Translated_113_residues
MQKTFTIDQTFFTGKEAFDWLMQESDQLIIVKFVAPYCPSCETLKPVLHQIAEENTGKLHLVELDMSEEPELAINFGVRS
APTVVLLKHQQTLAQIAGLKPKKQYTEMIQSAL
>Mature_113_residues
MQKTFTIDQTFFTGKEAFDWLMQESDQLIIVKFVAPYCPSCETLKPVLHQIAEENTGKLHLVELDMSEEPELAINFGVRS
APTVVLLKHQQTLAQIAGLKPKKQYTEMIQSAL

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Escherichia coli, GI1788936, Length=98, Percent_Identity=30.6122448979592, Blast_Score=72, Evalue=7e-15,
Organism=Escherichia coli, GI87082331, Length=106, Percent_Identity=31.1320754716981, Blast_Score=69, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: 1.8.1.9

Molecular weight: Translated: 12809; Mature: 12809

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKTFTIDQTFFTGKEAFDWLMQESDQLIIVKFVAPYCPSCETLKPVLHQIAEENTGKLH
CCCEEECCHHHHCCHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHHHHHHCCCCCCEE
LVELDMSEEPELAINFGVRSAPTVVLLKHQQTLAQIAGLKPKKQYTEMIQSAL
EEEECCCCCCCEEEECCCCCCCEEEEEECHHHHHHHHCCCCHHHHHHHHHHCC
>Mature Secondary Structure
MQKTFTIDQTFFTGKEAFDWLMQESDQLIIVKFVAPYCPSCETLKPVLHQIAEENTGKLH
CCCEEECCHHHHCCHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHHHHHHCCCCCCEE
LVELDMSEEPELAINFGVRSAPTVVLLKHQQTLAQIAGLKPKKQYTEMIQSAL
EEEECCCCCCCEEEECCCCCCCEEEEEECHHHHHHHHCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: thioredoxin; NADP+

Specific reaction: thioredoxin + NADP+ = thioredoxin disulfide + NADPH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8125314 [H]