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The map label for this gene is proA [H]

Identifier: 17229658

GI number: 17229658

Start: 2601338

End: 2602654

Strand: Reverse

Name: proA [H]

Synonym: all2166

Alternate gene names: 17229658

Gene position: 2602654-2601338 (Counterclockwise)

Preceding gene: 17229659

Following gene: 17229657

Centisome position: 40.58

GC content: 44.65

Gene sequence:

>1317_bases
ATGACTAATAATATGACTACTCTCCAAGTTGCTTCTTCCTTGAATGACATCGCTCAACAAACTCGCCAAGCTGCAAGTTT
ATTGGCGATGCTGTCTACCGAGGCGAAAAATCAAGCGATCGCTGCTGTCGCTCAAGCCTTAGAATCTGCAAAGGAGGAAA
TTTTACAGGCAAATATTGATGATTGTGAAGCGGCTACGGCTGAAGGGATAGCCAAGCCATTATACAAGCGGTTGCAGTTG
GATGAACATAAATTAAGAGATGCGATCGCTGGGGTGCGGGATGTTGGTAAACTAGCAGATCCTATCGGACAAGTACAAAT
TCAGCGTGAACTAGATACAGGTTTAGTTCTCAAGCGGATAACTTGCCCGTTGGGAGTGTTGGGGATTATTTTTGAAGCCC
GTCCAGAAGCAGCCATTCAAATTATCTCCTTAGCTATCAAGTCGGGTAATGGCGTGATTCTCAAATGTGGGAAGGAAGCT
GTACGTTCTTGCGAAGCCATAGTAAAGGCTGTGAAACAGGGATTATCAACCACAGATGTCAATCCTGAGGTAGTACAGTT
ACTCACCACCAGAGAAGAAACCTTAGAACTTTTACGCCTAGATAAATATGTAGATTTAATTATTCCCAGAGGTTCTAACT
CTTTTGTGCGGTTTGTTCAGGAAAATACTCGTATTCCTGTACTTGGTCACGCCGATGGCATTTGCCATGTATATATAGAT
AAGTCCGCAGATATAGAGAAAGCAATTGCTGTGAGCGTCGATGCAAAGGTGCAGTATCCGGCTGCTTGTAACGCCATTGA
AACCTTACTTGTCCACCAATCAATTGCGGCGGAATTTTTACCAAAAGTAGCCCAAGCCTTAGCTGAACGTGAGGTGGAAT
TGAAAGGGGATGAACGGACTTTGCAGATATTACCTGAGATTGCGGCCGCCACAGCCATAGATTGGGAAACAGAATACAGC
GATTTTATCTTGTCCATTAAGATTGTAGACTCATTAACCGAGGCGATCGCTCATATCAATCAATATGGTTCTCGTCATAC
CGATGCCATTATTACCGAAGATGTGGCAGCCGTTAAAACCTTCTTTGGCTTAGTTAATTCAGCCGGAGTCTTTCACAACT
GTTCTACTCGCTTCGCCGACGGTTTCCGCTATGGCTTTGGCGCAGAAGTAGGTATTAGCACTCAACAAATGCCCCCCCGT
GGCCCCGTGGGTTTAGAAGGACTGGTGACATATAAATATCAGATGACAGGTGCAGGACATATTGTCGCCACTTACACAGG
GGAAAATGCCAAACCTTTTACTCACAAGGATTTCTAG

Upstream 100 bases:

>100_bases
GGAAATTGGCTCAACCAATGCAGCAGTTGCATATTATCTATAGTAGTTGGCTGTTGACTATGGACTAATGACTATGGACT
AATAACTAATAACTAATACT

Downstream 100 bases:

>100_bases
GATGAAAATCCCCCGCCTCCAAGGGGATGAGAAATTTGGTCATTGGTAATGGGTAATAGTCCAATTACCTATTACCCATT
AGCCATTACCAGATTCCTCA

Product: gamma-glutamyl phosphate reductase

Products: NA

Alternate protein names: GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GSA dehydrogenase [H]

Number of amino acids: Translated: 438; Mature: 437

Protein sequence:

>438_residues
MTNNMTTLQVASSLNDIAQQTRQAASLLAMLSTEAKNQAIAAVAQALESAKEEILQANIDDCEAATAEGIAKPLYKRLQL
DEHKLRDAIAGVRDVGKLADPIGQVQIQRELDTGLVLKRITCPLGVLGIIFEARPEAAIQIISLAIKSGNGVILKCGKEA
VRSCEAIVKAVKQGLSTTDVNPEVVQLLTTREETLELLRLDKYVDLIIPRGSNSFVRFVQENTRIPVLGHADGICHVYID
KSADIEKAIAVSVDAKVQYPAACNAIETLLVHQSIAAEFLPKVAQALAEREVELKGDERTLQILPEIAAATAIDWETEYS
DFILSIKIVDSLTEAIAHINQYGSRHTDAIITEDVAAVKTFFGLVNSAGVFHNCSTRFADGFRYGFGAEVGISTQQMPPR
GPVGLEGLVTYKYQMTGAGHIVATYTGENAKPFTHKDF

Sequences:

>Translated_438_residues
MTNNMTTLQVASSLNDIAQQTRQAASLLAMLSTEAKNQAIAAVAQALESAKEEILQANIDDCEAATAEGIAKPLYKRLQL
DEHKLRDAIAGVRDVGKLADPIGQVQIQRELDTGLVLKRITCPLGVLGIIFEARPEAAIQIISLAIKSGNGVILKCGKEA
VRSCEAIVKAVKQGLSTTDVNPEVVQLLTTREETLELLRLDKYVDLIIPRGSNSFVRFVQENTRIPVLGHADGICHVYID
KSADIEKAIAVSVDAKVQYPAACNAIETLLVHQSIAAEFLPKVAQALAEREVELKGDERTLQILPEIAAATAIDWETEYS
DFILSIKIVDSLTEAIAHINQYGSRHTDAIITEDVAAVKTFFGLVNSAGVFHNCSTRFADGFRYGFGAEVGISTQQMPPR
GPVGLEGLVTYKYQMTGAGHIVATYTGENAKPFTHKDF
>Mature_437_residues
TNNMTTLQVASSLNDIAQQTRQAASLLAMLSTEAKNQAIAAVAQALESAKEEILQANIDDCEAATAEGIAKPLYKRLQLD
EHKLRDAIAGVRDVGKLADPIGQVQIQRELDTGLVLKRITCPLGVLGIIFEARPEAAIQIISLAIKSGNGVILKCGKEAV
RSCEAIVKAVKQGLSTTDVNPEVVQLLTTREETLELLRLDKYVDLIIPRGSNSFVRFVQENTRIPVLGHADGICHVYIDK
SADIEKAIAVSVDAKVQYPAACNAIETLLVHQSIAAEFLPKVAQALAEREVELKGDERTLQILPEIAAATAIDWETEYSD
FILSIKIVDSLTEAIAHINQYGSRHTDAIITEDVAAVKTFFGLVNSAGVFHNCSTRFADGFRYGFGAEVGISTQQMPPRG
PVGLEGLVTYKYQMTGAGHIVATYTGENAKPFTHKDF

Specific function: Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate [H]

COG id: COG0014

COG function: function code E; Gamma-glutamyl phosphate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyl phosphate reductase family [H]

Homologues:

Organism=Homo sapiens, GI62912457, Length=424, Percent_Identity=41.0377358490566, Blast_Score=322, Evalue=4e-88,
Organism=Homo sapiens, GI21361368, Length=424, Percent_Identity=41.0377358490566, Blast_Score=322, Evalue=4e-88,
Organism=Escherichia coli, GI1786438, Length=398, Percent_Identity=41.4572864321608, Blast_Score=312, Evalue=2e-86,
Organism=Caenorhabditis elegans, GI17569967, Length=430, Percent_Identity=40.2325581395349, Blast_Score=310, Evalue=1e-84,
Organism=Caenorhabditis elegans, GI17569969, Length=430, Percent_Identity=40.2325581395349, Blast_Score=309, Evalue=1e-84,
Organism=Saccharomyces cerevisiae, GI6324899, Length=449, Percent_Identity=42.9844097995546, Blast_Score=355, Evalue=1e-98,
Organism=Drosophila melanogaster, GI21357643, Length=423, Percent_Identity=42.5531914893617, Blast_Score=334, Evalue=6e-92,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR000965
- InterPro:   IPR020593
- InterPro:   IPR012134 [H]

Pfam domain/function: PF00171 Aldedh [H]

EC number: =1.2.1.41 [H]

Molecular weight: Translated: 47425; Mature: 47294

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: PS01223 PROA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNNMTTLQVASSLNDIAQQTRQAASLLAMLSTEAKNQAIAAVAQALESAKEEILQANID
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
DCEAATAEGIAKPLYKRLQLDEHKLRDAIAGVRDVGKLADPIGQVQIQRELDTGLVLKRI
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCHHHEEEHHHHCCHHHHHHH
TCPLGVLGIIFEARPEAAIQIISLAIKSGNGVILKCGKEAVRSCEAIVKAVKQGLSTTDV
HCCHHHHHHHHHCCCHHHHHHHHHHEECCCCEEEECCHHHHHHHHHHHHHHHCCCCCCCC
NPEVVQLLTTREETLELLRLDKYVDLIIPRGSNSFVRFVQENTRIPVLGHADGICHVYID
CHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCHHHHHHHHCCCCEEEECCCCEEEEEEC
KSADIEKAIAVSVDAKVQYPAACNAIETLLVHQSIAAEFLPKVAQALAEREVELKGDERT
CCCCCCHHEEEEECCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHH
LQILPEIAAATAIDWETEYSDFILSIKIVDSLTEAIAHINQYGSRHTDAIITEDVAAVKT
HHHHHHHHHHHCCCCCCCCCHHEEEHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
FFGLVNSAGVFHNCSTRFADGFRYGFGAEVGISTQQMPPRGPVGLEGLVTYKYQMTGAGH
HHHHHHCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEECCCCE
IVATYTGENAKPFTHKDF
EEEEEECCCCCCCCCCCC
>Mature Secondary Structure 
TNNMTTLQVASSLNDIAQQTRQAASLLAMLSTEAKNQAIAAVAQALESAKEEILQANID
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
DCEAATAEGIAKPLYKRLQLDEHKLRDAIAGVRDVGKLADPIGQVQIQRELDTGLVLKRI
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCHHHEEEHHHHCCHHHHHHH
TCPLGVLGIIFEARPEAAIQIISLAIKSGNGVILKCGKEAVRSCEAIVKAVKQGLSTTDV
HCCHHHHHHHHHCCCHHHHHHHHHHEECCCCEEEECCHHHHHHHHHHHHHHHCCCCCCCC
NPEVVQLLTTREETLELLRLDKYVDLIIPRGSNSFVRFVQENTRIPVLGHADGICHVYID
CHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCHHHHHHHHCCCCEEEECCCCEEEEEEC
KSADIEKAIAVSVDAKVQYPAACNAIETLLVHQSIAAEFLPKVAQALAEREVELKGDERT
CCCCCCHHEEEEECCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHH
LQILPEIAAATAIDWETEYSDFILSIKIVDSLTEAIAHINQYGSRHTDAIITEDVAAVKT
HHHHHHHHHHHCCCCCCCCCHHEEEHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
FFGLVNSAGVFHNCSTRFADGFRYGFGAEVGISTQQMPPRGPVGLEGLVTYKYQMTGAGH
HHHHHHCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEECCCCE
IVATYTGENAKPFTHKDF
EEEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA