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The map label for this gene is vraS [H]

Identifier: 17229629

GI number: 17229629

Start: 2564524

End: 2567358

Strand: Direct

Name: vraS [H]

Synonym: alr2137

Alternate gene names: 17229629

Gene position: 2564524-2567358 (Clockwise)

Preceding gene: 17229628

Following gene: 17229630

Centisome position: 39.98

GC content: 47.41

Gene sequence:

>2835_bases
ATGCAGCCAATCTCCTCTCTGGCGCTTTTGAGCCTACCGCTCGATGCTTCAAACTCCCAAAAAGTAGCTTGGCTCAATTG
TGTTAACATTAACCAAGAAAAGATGCAGAAATGGGCAGAAAATGCTCCCATGAATGATCTACATAAATTTCATCTAGTCG
AGGCAGAAAAAGCACGAGTCTTAGGGCAATTTTTTGAGGCTGAAGAGTTTTACGAGCGAGCGATCGCAGGTGCTGCTGAA
AATGAGTTTATCCAGGAAGAAGCATTAGCCTATGAATTAGCGGCTAAACATTATTTGGCGCGAGGTCGGTCAAAAATTGC
CCAAACCTACATGAAAGAGGCGCACTATTGCTACGATCGCTGGGGCGCAACCGCTAAAGTTAAAGATTTAGAAAAACGCT
ATCCACAACTCCTCAACACCAACCTAGTTCGGCAATCACATTCAATCGTGACCGATGAAACGATCCGTCATCCGACTGCG
GCGATAGATTTGGCTGCGGCGATGAAAGCGGCTCAAGCCATCTCAGAAATGATCCATCTCGATCAATTAACTGCAACGTT
GATGCAGGTGGTGATAGAAAATGCAGGAGCCGAAACTGGCGCTCTGGTTCTCCTGGAAGATGATCGGCTCACTGTTGTGG
CTCAGTGCAGTGGGAGTAGACAGTGTAACCTGGAAAAGATCGCTGTTGCTGGCTGTGCAACAATTCCTGTTTCCGTCATT
CACTCGGTAGAACGCACTCAAGAAACTCTGGTGTTTGATGATGCAGTCAGCAAATTGTCTTTTTCAACTGATCCTTATAT
TCAACATCAACAAACGCGATCGCTCCTGTGTATGCCCATTCTCAAGCAAAATCAGCTGATTGGCATACTTTACCTGGAGA
ACAATCTTAGTACCGGAGTGTTTACTAGCGATCGCGTGCAAGTCCTTAAACTGTTGATTGCTCAGGCAGCAATTTCACTG
GAGAATACTCGGTTATATGAACGGTTATCGGATTATTCCGAAACACTGGAAAGGAAGGTAGAAGAGCAAACTCAAGCCTT
GCAGCAGGAGATCGCGGAACGCCGACAAACTGAAGCCGCATTGAGACAAAGTGAAGCAAATTATCGCAACCTGCTACAAA
CCGCAAATTCCGTTATCATTCGCTATGATCCGCAAGGACGGATTCACTACATTAACGATTATGGGGTAAAGCTTCTTGGC
TATGAAGAACATCAGATTTTAGGGCGAACCTTATTTGAAACAATCATTCCAGACATCGAAATCTCTGGACGCGATGTCAA
ACCCTTTGTCCATGATTTACTTCGTAATCCTCAATCGTACCCGCAAGGCGAGGGTGAAAACCTGTGTCGAGACGGTCGGC
GAGTTTGGGTTGCTTGGTCAAATCAAGCTATCTTCAATGAACAGGGAGATGTCGTTGAAATCTTATCGGTTGGCAATGAC
ACCACCCAGCGTAGACAAGCAGAAGAGGCATTACAACGCAGTGAAGCCAAGTTCCGAGCTATCTTTGAAAACTCGCAGGT
TGGCATCTACCGAACCCGCACCTGTGATGGATTAATTCTCAATGCCAATCAACGCTTTGCCGATCTGTTTGGCTTTGATT
CACCCCAAGAAATTATTGGGATTGAACACACTATAGGCTATTGGGTCAATCCCAGCGATCGCCAACAAGGCATTGAGGTG
ATGAAGCGGGATGGGGAAGTGCGAAGCTATGAAGCACAGATGCGAAAACGAGATGGGACAGTGTTTTGGGGACTTTTCTC
TTCTTATCTGAATGCAGGCGATGACTACATCGAAGGGGTGATTGCAGATATTAGCGATGTCTACGACGAGCTCCGCTTAC
GCAAACAGGCAGAAGTAGCATTGCAAGCCTCTGAAGCAGAGCTACGGTCGCTCTTTTCAGCCATTCCCGATCCGCTATGT
GTTGTTACTGCCCAAGGGCGAGTGATCGAAACAGTCGCAGGGAATCCGAGGCAGTTGTATAGTTCAGTTGAGGAGAAGGT
TGGTAAAACACTGCATCAGATTTTTGAAGAAGAACAAGCCGATAAATTTATGGGTTATATTCAGCAGGTGCTGAGAACCC
AACAAGTACTTACCGTTGAATACAGCCTACAGATAGATGGGCGAGAAACTTGGTTTTCGGCGCGTATTGCACCGATTCGG
CACGAACAGGTGATTTGGATAGCGCGAGATATTACGCTGCAAAAGCGAGCAGAAGCAGCCTCAATTCTGGAAGAGCGTAA
CCGTATGGCACGCGAAATTCACGACACACTCGCTCAGGCGTTTACAGGCATTCTGGCTCAGGTGGGAGCGGCAAAACAGG
TGCTAACGGATGATTTAGAAGCAACTGAGTCACACCTAGACCTGATCAAAGAATTGGCGCGAACTGGACTGGTTGAAGCG
CGGAGATCGGTAGTAGCACTCCGTCCTCAGCTTTTGGAGGAAGGCAGTCTACAGAGCGCTCTACATCGTCTCGTCGCTCA
ACTTAGAACTGCCGCAATAGATACGACTTTATATTATGAGATTGAGGGTGCAGTATATTCTCTGCCGACTGAAATCGAGA
GTAACCTACTGCGGATGGGGCAGGAAGCCTTAACCAATGCGATTAGACACGCCAATGCTGACGAAATCCGAGTAGAACTA
GTCTACGATCGCGATCGATTCTGCTTGCGCGTGAGAGACAATGGACAGGGCTTTGGAGTTGGCAGTATTCCAGCCTCTGA
GGGTTTTGGCTTATTAGGCATGAGCGAACGGGCAGAGCGCATCGGCGCACAACTCACGATTAGGAGTCAACCTGGACAAG
GAACAGAGATTGTTGTTACCGTCAATTGGGAGTAG

Upstream 100 bases:

>100_bases
TATTATCACTATCATTAGCGTCTAGATATACTCTGCCCCATGCCTTTATCCACTTTTCTTGGTCTTGCGATTGCTATTTG
GGACATTCTGGGCAGAATCC

Downstream 100 bases:

>100_bases
CATCACGATGAGCCAAGCCATAACCATTCGGGTTCTGATTGCAGACGATCATGCTATTTTTCGGCAAGGATTAGCCACGA
TTATTAACCGTGACCCAGAG

Product: two-component sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 944; Mature: 944

Protein sequence:

>944_residues
MQPISSLALLSLPLDASNSQKVAWLNCVNINQEKMQKWAENAPMNDLHKFHLVEAEKARVLGQFFEAEEFYERAIAGAAE
NEFIQEEALAYELAAKHYLARGRSKIAQTYMKEAHYCYDRWGATAKVKDLEKRYPQLLNTNLVRQSHSIVTDETIRHPTA
AIDLAAAMKAAQAISEMIHLDQLTATLMQVVIENAGAETGALVLLEDDRLTVVAQCSGSRQCNLEKIAVAGCATIPVSVI
HSVERTQETLVFDDAVSKLSFSTDPYIQHQQTRSLLCMPILKQNQLIGILYLENNLSTGVFTSDRVQVLKLLIAQAAISL
ENTRLYERLSDYSETLERKVEEQTQALQQEIAERRQTEAALRQSEANYRNLLQTANSVIIRYDPQGRIHYINDYGVKLLG
YEEHQILGRTLFETIIPDIEISGRDVKPFVHDLLRNPQSYPQGEGENLCRDGRRVWVAWSNQAIFNEQGDVVEILSVGND
TTQRRQAEEALQRSEAKFRAIFENSQVGIYRTRTCDGLILNANQRFADLFGFDSPQEIIGIEHTIGYWVNPSDRQQGIEV
MKRDGEVRSYEAQMRKRDGTVFWGLFSSYLNAGDDYIEGVIADISDVYDELRLRKQAEVALQASEAELRSLFSAIPDPLC
VVTAQGRVIETVAGNPRQLYSSVEEKVGKTLHQIFEEEQADKFMGYIQQVLRTQQVLTVEYSLQIDGRETWFSARIAPIR
HEQVIWIARDITLQKRAEAASILEERNRMAREIHDTLAQAFTGILAQVGAAKQVLTDDLEATESHLDLIKELARTGLVEA
RRSVVALRPQLLEEGSLQSALHRLVAQLRTAAIDTTLYYEIEGAVYSLPTEIESNLLRMGQEALTNAIRHANADEIRVEL
VYDRDRFCLRVRDNGQGFGVGSIPASEGFGLLGMSERAERIGAQLTIRSQPGQGTEIVVTVNWE

Sequences:

>Translated_944_residues
MQPISSLALLSLPLDASNSQKVAWLNCVNINQEKMQKWAENAPMNDLHKFHLVEAEKARVLGQFFEAEEFYERAIAGAAE
NEFIQEEALAYELAAKHYLARGRSKIAQTYMKEAHYCYDRWGATAKVKDLEKRYPQLLNTNLVRQSHSIVTDETIRHPTA
AIDLAAAMKAAQAISEMIHLDQLTATLMQVVIENAGAETGALVLLEDDRLTVVAQCSGSRQCNLEKIAVAGCATIPVSVI
HSVERTQETLVFDDAVSKLSFSTDPYIQHQQTRSLLCMPILKQNQLIGILYLENNLSTGVFTSDRVQVLKLLIAQAAISL
ENTRLYERLSDYSETLERKVEEQTQALQQEIAERRQTEAALRQSEANYRNLLQTANSVIIRYDPQGRIHYINDYGVKLLG
YEEHQILGRTLFETIIPDIEISGRDVKPFVHDLLRNPQSYPQGEGENLCRDGRRVWVAWSNQAIFNEQGDVVEILSVGND
TTQRRQAEEALQRSEAKFRAIFENSQVGIYRTRTCDGLILNANQRFADLFGFDSPQEIIGIEHTIGYWVNPSDRQQGIEV
MKRDGEVRSYEAQMRKRDGTVFWGLFSSYLNAGDDYIEGVIADISDVYDELRLRKQAEVALQASEAELRSLFSAIPDPLC
VVTAQGRVIETVAGNPRQLYSSVEEKVGKTLHQIFEEEQADKFMGYIQQVLRTQQVLTVEYSLQIDGRETWFSARIAPIR
HEQVIWIARDITLQKRAEAASILEERNRMAREIHDTLAQAFTGILAQVGAAKQVLTDDLEATESHLDLIKELARTGLVEA
RRSVVALRPQLLEEGSLQSALHRLVAQLRTAAIDTTLYYEIEGAVYSLPTEIESNLLRMGQEALTNAIRHANADEIRVEL
VYDRDRFCLRVRDNGQGFGVGSIPASEGFGLLGMSERAERIGAQLTIRSQPGQGTEIVVTVNWE
>Mature_944_residues
MQPISSLALLSLPLDASNSQKVAWLNCVNINQEKMQKWAENAPMNDLHKFHLVEAEKARVLGQFFEAEEFYERAIAGAAE
NEFIQEEALAYELAAKHYLARGRSKIAQTYMKEAHYCYDRWGATAKVKDLEKRYPQLLNTNLVRQSHSIVTDETIRHPTA
AIDLAAAMKAAQAISEMIHLDQLTATLMQVVIENAGAETGALVLLEDDRLTVVAQCSGSRQCNLEKIAVAGCATIPVSVI
HSVERTQETLVFDDAVSKLSFSTDPYIQHQQTRSLLCMPILKQNQLIGILYLENNLSTGVFTSDRVQVLKLLIAQAAISL
ENTRLYERLSDYSETLERKVEEQTQALQQEIAERRQTEAALRQSEANYRNLLQTANSVIIRYDPQGRIHYINDYGVKLLG
YEEHQILGRTLFETIIPDIEISGRDVKPFVHDLLRNPQSYPQGEGENLCRDGRRVWVAWSNQAIFNEQGDVVEILSVGND
TTQRRQAEEALQRSEAKFRAIFENSQVGIYRTRTCDGLILNANQRFADLFGFDSPQEIIGIEHTIGYWVNPSDRQQGIEV
MKRDGEVRSYEAQMRKRDGTVFWGLFSSYLNAGDDYIEGVIADISDVYDELRLRKQAEVALQASEAELRSLFSAIPDPLC
VVTAQGRVIETVAGNPRQLYSSVEEKVGKTLHQIFEEEQADKFMGYIQQVLRTQQVLTVEYSLQIDGRETWFSARIAPIR
HEQVIWIARDITLQKRAEAASILEERNRMAREIHDTLAQAFTGILAQVGAAKQVLTDDLEATESHLDLIKELARTGLVEA
RRSVVALRPQLLEEGSLQSALHRLVAQLRTAAIDTTLYYEIEGAVYSLPTEIESNLLRMGQEALTNAIRHANADEIRVEL
VYDRDRFCLRVRDNGQGFGVGSIPASEGFGLLGMSERAERIGAQLTIRSQPGQGTEIVVTVNWE

Specific function: Member of the two-component regulatory system vraS/vraR involved in the control of the cell wall peptidoglycan biosynthesis. Probably activates vraR by phosphorylation [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788812, Length=254, Percent_Identity=27.9527559055118, Blast_Score=86, Evalue=1e-17,
Organism=Escherichia coli, GI1787474, Length=211, Percent_Identity=28.9099526066351, Blast_Score=79, Evalue=9e-16,
Organism=Escherichia coli, GI87082311, Length=198, Percent_Identity=30.3030303030303, Blast_Score=66, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011712
- InterPro:   IPR017202 [H]

Pfam domain/function: PF02518 HATPase_c; PF07730 HisKA_3 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 106405; Mature: 106405

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: PS50112 PAS ; PS50113 PAC ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQPISSLALLSLPLDASNSQKVAWLNCVNINQEKMQKWAENAPMNDLHKFHLVEAEKARV
CCCHHHHHHEEECCCCCCCCEEEEEEEECCCHHHHHHHHHCCCHHHHHHHHEECHHHHHH
LGQFFEAEEFYERAIAGAAENEFIQEEALAYELAAKHYLARGRSKIAQTYMKEAHYCYDR
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WGATAKVKDLEKRYPQLLNTNLVRQSHSIVTDETIRHPTAAIDLAAAMKAAQAISEMIHL
HCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHH
DQLTATLMQVVIENAGAETGALVLLEDDRLTVVAQCSGSRQCNLEKIAVAGCATIPVSVI
HHHHHHHHHHHHHHCCCCCCEEEEEECCCEEEEEECCCCCCCCHHHHHHHCCHHHHHHHH
HSVERTQETLVFDDAVSKLSFSTDPYIQHQQTRSLLCMPILKQNQLIGILYLENNLSTGV
HHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCC
FTSDRVQVLKLLIAQAAISLENTRLYERLSDYSETLERKVEEQTQALQQEIAERRQTEAA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LRQSEANYRNLLQTANSVIIRYDPQGRIHYINDYGVKLLGYEEHQILGRTLFETIIPDIE
HHHHCHHHHHHHHHCCCEEEEECCCCCEEEEECCCEEEECCHHHHHHHHHHHHHHCCCCE
ISGRDVKPFVHDLLRNPQSYPQGEGENLCRDGRRVWVAWSNQAIFNEQGDVVEILSVGND
ECCCCCCHHHHHHHCCCCCCCCCCCCHHHHCCCEEEEEECCCEEECCCCCEEEEEECCCC
TTQRRQAEEALQRSEAKFRAIFENSQVGIYRTRTCDGLILNANQRFADLFGFDSPQEIIG
HHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCEEEEECCCHHHHHHCCCCCHHHCC
IEHTIGYWVNPSDRQQGIEVMKRDGEVRSYEAQMRKRDGTVFWGLFSSYLNAGDDYIEGV
CCHHCCEECCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCCEEHHHHHHHHCCCHHHHHHH
IADISDVYDELRLRKQAEVALQASEAELRSLFSAIPDPLCVVTAQGRVIETVAGNPRQLY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEEECCCCHHHHH
SSVEEKVGKTLHQIFEEEQADKFMGYIQQVLRTQQVLTVEYSLQIDGRETWFSARIAPIR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEEEECCCHHHHHHCCCCCC
HEQVIWIARDITLQKRAEAASILEERNRMAREIHDTLAQAFTGILAQVGAAKQVLTDDLE
CCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ATESHLDLIKELARTGLVEARRSVVALRPQLLEEGSLQSALHRLVAQLRTAAIDTTLYYE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCEEEEEE
IEGAVYSLPTEIESNLLRMGQEALTNAIRHANADEIRVELVYDRDRFCLRVRDNGQGFGV
ECCCEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEEEECCCCCCCC
GSIPASEGFGLLGMSERAERIGAQLTIRSQPGQGTEIVVTVNWE
CCCCCCCCCCCCCCHHHHHHCCCEEEEECCCCCCCEEEEEEECC
>Mature Secondary Structure
MQPISSLALLSLPLDASNSQKVAWLNCVNINQEKMQKWAENAPMNDLHKFHLVEAEKARV
CCCHHHHHHEEECCCCCCCCEEEEEEEECCCHHHHHHHHHCCCHHHHHHHHEECHHHHHH
LGQFFEAEEFYERAIAGAAENEFIQEEALAYELAAKHYLARGRSKIAQTYMKEAHYCYDR
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WGATAKVKDLEKRYPQLLNTNLVRQSHSIVTDETIRHPTAAIDLAAAMKAAQAISEMIHL
HCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHH
DQLTATLMQVVIENAGAETGALVLLEDDRLTVVAQCSGSRQCNLEKIAVAGCATIPVSVI
HHHHHHHHHHHHHHCCCCCCEEEEEECCCEEEEEECCCCCCCCHHHHHHHCCHHHHHHHH
HSVERTQETLVFDDAVSKLSFSTDPYIQHQQTRSLLCMPILKQNQLIGILYLENNLSTGV
HHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCC
FTSDRVQVLKLLIAQAAISLENTRLYERLSDYSETLERKVEEQTQALQQEIAERRQTEAA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LRQSEANYRNLLQTANSVIIRYDPQGRIHYINDYGVKLLGYEEHQILGRTLFETIIPDIE
HHHHCHHHHHHHHHCCCEEEEECCCCCEEEEECCCEEEECCHHHHHHHHHHHHHHCCCCE
ISGRDVKPFVHDLLRNPQSYPQGEGENLCRDGRRVWVAWSNQAIFNEQGDVVEILSVGND
ECCCCCCHHHHHHHCCCCCCCCCCCCHHHHCCCEEEEEECCCEEECCCCCEEEEEECCCC
TTQRRQAEEALQRSEAKFRAIFENSQVGIYRTRTCDGLILNANQRFADLFGFDSPQEIIG
HHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCEEEEECCCHHHHHHCCCCCHHHCC
IEHTIGYWVNPSDRQQGIEVMKRDGEVRSYEAQMRKRDGTVFWGLFSSYLNAGDDYIEGV
CCHHCCEECCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCCEEHHHHHHHHCCCHHHHHHH
IADISDVYDELRLRKQAEVALQASEAELRSLFSAIPDPLCVVTAQGRVIETVAGNPRQLY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEEECCCCHHHHH
SSVEEKVGKTLHQIFEEEQADKFMGYIQQVLRTQQVLTVEYSLQIDGRETWFSARIAPIR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEEEECCCHHHHHHCCCCCC
HEQVIWIARDITLQKRAEAASILEERNRMAREIHDTLAQAFTGILAQVGAAKQVLTDDLE
CCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ATESHLDLIKELARTGLVEARRSVVALRPQLLEEGSLQSALHRLVAQLRTAAIDTTLYYE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCEEEEEE
IEGAVYSLPTEIESNLLRMGQEALTNAIRHANADEIRVELVYDRDRFCLRVRDNGQGFGV
ECCCEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEEEECCCCCCCC
GSIPASEGFGLLGMSERAERIGAQLTIRSQPGQGTEIVVTVNWE
CCCCCCCCCCCCCCHHHHHHCCCEEEEECCCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA