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The map label for this gene is upp

Identifier: 17229555

GI number: 17229555

Start: 2469353

End: 2470003

Strand: Reverse

Name: upp

Synonym: all2063

Alternate gene names: 17229555

Gene position: 2470003-2469353 (Counterclockwise)

Preceding gene: 17229557

Following gene: 17229554

Centisome position: 38.51

GC content: 47.47

Gene sequence:

>651_bases
ATGACGGTACAACTGCGTGTTTACGTTCCTCCCCATCCTTTAATTAAGCACTGGCTGGCAGTTGCCCGTGATGCTGCCAC
ACCTTCAGTCTTATTTCGTAGTGCCATCACCGAGTTGGGTAGATGGCTAACTTATGAAGCAGCGCGGGAATGGTTGCCTA
CAGAGGAGACGACGGTACAAACTCCCTTAGAGATATGCCCAGCGACTGTAATCAATCCCCAAGTGCCTGTGGCAGTGGTG
CCGATTTTGCGGGCAGGATTAGGCTTATTAGAGGGGGCGCAAACTGTCTTACCTTTGGCTTCAATTTACCACCTGGGTTT
GGTGCGTAATGAGGAGACATTGGAAGCTTCATGTTACCTCAACAAATTGCCAGAAAAATTTGACCCCCAAACTAGAGTGT
TAATTACCGATCCGATGTTAGCTACAGGCGGGTCTATCATGAAGGCAATGTCAGAATTAACAGAACGTGGCGTTGACCCG
TCTTTAGTGAGAATTGTCTCTGTAGTGGCAGCACCACCAGCTTTACAAAAATTGAATGCGGCTTATTCTGGTTTGATAGT
TTACACCGCAACAATTGATGAAACGGTGAATGATCAAGGGTTTATTGTCCCAGGATTAGGCGACGCAGGCGATCGCATTT
TTGGGACATGA

Upstream 100 bases:

>100_bases
ACATAAGTCATAATTAATTACGAATTACGAATTACAAATTACGAGACAGAGTATGATGATGTTTCAGTTCTCATAGAATT
AAAATTGGCAATTTCCGGCT

Downstream 100 bases:

>100_bases
GCTACTATGCAGCTAGGGAAGGAAAAAAATAGCTTAACTAATGTAAAAGTTGCTTCAAGGCGGTATTATGAGTCAGCGTG
ATGGTTTTGCTAGCGGTTTT

Product: uracil phosphoribosyltransferase

Products: NA

Alternate protein names: UMP pyrophosphorylase; UPRTase

Number of amino acids: Translated: 216; Mature: 215

Protein sequence:

>216_residues
MTVQLRVYVPPHPLIKHWLAVARDAATPSVLFRSAITELGRWLTYEAAREWLPTEETTVQTPLEICPATVINPQVPVAVV
PILRAGLGLLEGAQTVLPLASIYHLGLVRNEETLEASCYLNKLPEKFDPQTRVLITDPMLATGGSIMKAMSELTERGVDP
SLVRIVSVVAAPPALQKLNAAYSGLIVYTATIDETVNDQGFIVPGLGDAGDRIFGT

Sequences:

>Translated_216_residues
MTVQLRVYVPPHPLIKHWLAVARDAATPSVLFRSAITELGRWLTYEAAREWLPTEETTVQTPLEICPATVINPQVPVAVV
PILRAGLGLLEGAQTVLPLASIYHLGLVRNEETLEASCYLNKLPEKFDPQTRVLITDPMLATGGSIMKAMSELTERGVDP
SLVRIVSVVAAPPALQKLNAAYSGLIVYTATIDETVNDQGFIVPGLGDAGDRIFGT
>Mature_215_residues
TVQLRVYVPPHPLIKHWLAVARDAATPSVLFRSAITELGRWLTYEAAREWLPTEETTVQTPLEICPATVINPQVPVAVVP
ILRAGLGLLEGAQTVLPLASIYHLGLVRNEETLEASCYLNKLPEKFDPQTRVLITDPMLATGGSIMKAMSELTERGVDPS
LVRIVSVVAAPPALQKLNAAYSGLIVYTATIDETVNDQGFIVPGLGDAGDRIFGT

Specific function: Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate

COG id: COG0035

COG function: function code F; Uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPRTase family

Homologues:

Organism=Homo sapiens, GI301129207, Length=204, Percent_Identity=27.4509803921569, Blast_Score=68, Evalue=7e-12,
Organism=Homo sapiens, GI57863312, Length=204, Percent_Identity=27.4509803921569, Blast_Score=67, Evalue=1e-11,
Organism=Escherichia coli, GI87082118, Length=215, Percent_Identity=41.3953488372093, Blast_Score=155, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6321920, Length=138, Percent_Identity=32.6086956521739, Blast_Score=86, Evalue=5e-18,
Organism=Drosophila melanogaster, GI45550449, Length=208, Percent_Identity=27.4038461538462, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI28573516, Length=208, Percent_Identity=27.4038461538462, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI28573514, Length=208, Percent_Identity=27.4038461538462, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI28573512, Length=208, Percent_Identity=27.4038461538462, Blast_Score=72, Evalue=4e-13,

Paralogues:

None

Copy number: 2580 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): UPP_NOSS1 (Q8YVB5)

Other databases:

- EMBL:   BA000019
- PIR:   AI2063
- RefSeq:   NP_486103.1
- ProteinModelPortal:   Q8YVB5
- SMR:   Q8YVB5
- STRING:   Q8YVB5
- GeneID:   1105658
- GenomeReviews:   BA000019_GR
- KEGG:   ana:all2063
- NMPDR:   fig|103690.1.peg.2370
- eggNOG:   COG0035
- HOGENOM:   HBG326432
- OMA:   VYVLDPM
- PhylomeDB:   Q8YVB5
- ProtClustDB:   PRK00129
- BioCyc:   NSP103690:ALL2063-MONOMER
- HAMAP:   MF_01218_B
- InterPro:   IPR000836
- InterPro:   IPR005765
- TIGRFAMs:   TIGR01091

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.9

Molecular weight: Translated: 23364; Mature: 23233

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: NA

Important sites: BINDING 84-84 BINDING 109-109 BINDING 202-202 BINDING 208-208

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVQLRVYVPPHPLIKHWLAVARDAATPSVLFRSAITELGRWLTYEAAREWLPTEETTVQ
CEEEEEEEECCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
TPLEICPATVINPQVPVAVVPILRAGLGLLEGAQTVLPLASIYHLGLVRNEETLEASCYL
CHHHHCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
NKLPEKFDPQTRVLITDPMLATGGSIMKAMSELTERGVDPSLVRIVSVVAAPPALQKLNA
HHCCHHCCCCCEEEEECCHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHH
AYSGLIVYTATIDETVNDQGFIVPGLGDAGDRIFGT
HHCCEEEEEEEECCCCCCCCEEECCCCCCCCCCCCC
>Mature Secondary Structure 
TVQLRVYVPPHPLIKHWLAVARDAATPSVLFRSAITELGRWLTYEAAREWLPTEETTVQ
EEEEEEEECCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
TPLEICPATVINPQVPVAVVPILRAGLGLLEGAQTVLPLASIYHLGLVRNEETLEASCYL
CHHHHCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
NKLPEKFDPQTRVLITDPMLATGGSIMKAMSELTERGVDPSLVRIVSVVAAPPALQKLNA
HHCCHHCCCCCEEEEECCHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHH
AYSGLIVYTATIDETVNDQGFIVPGLGDAGDRIFGT
HHCCEEEEEEEECCCCCCCCEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11759840