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The map label for this gene is glcK [H]

Identifier: 17229474

GI number: 17229474

Start: 2370491

End: 2371444

Strand: Direct

Name: glcK [H]

Synonym: alr1982

Alternate gene names: 17229474

Gene position: 2370491-2371444 (Clockwise)

Preceding gene: 17229471

Following gene: 17229489

Centisome position: 36.96

GC content: 46.54

Gene sequence:

>954_bases
ATGATGAAATTAACTTTAGCGCTGGATTTTGGGGGAACGAAGCTAGCAGCAGGGTTAGTAAATGCTGATTCTAGAGAATG
GTTGCGTTATGAACGTCGCTTTTCCCCAATTAATGGCGATGCTAACACAGACTTGGCAATTATGCGATCGCTCATTCACT
CCTTACTCCAAGGTGCAACTCCCGTCGCCATTGGTGTTAGCTTCGGCGGCCCCGTAGACGCAACCACTGGGACTGTCAGA
CTATCTCATCACGTCCCTGGCTGGGAAAATATTCCCCTCAAAAGCTTGCTAGAGAAAGAGTTTGGTGTAACTACCAGTGT
AGACAACGATGCCAACGTTGCGGCTTTAGGCGAACAGCACTTTGGCGCAGGCCAAGGATACGATAGCCTGTTTTACATTA
CCATCAGCACTGGTGTGGGTGGCGGGTGGATACTCAACGGTAAACCTTGGCGGGGTGCAGTTGGGATGGCTGGTGAAATT
GGCCATATAGTTGTAGAACCTGCTGGGCCTATGTGTTTATGTGGTAAGCGTGGATGCGTAGAACGTTTAGCATCAGGGCC
TTATATGGCGCAAAATGCCAAAGATATTTTAGAAAATCAACCAGAACGGGAAGACGGACAAATACTCAGAAATTTGGTAG
GGAATAACTTAAATTTACTCACAGGTCAACTAATCAGCGAAGCGGCTATAAAAGGAGATCATCTAGCTCAAGCTGTTTTG
CAAAAATCTGCTTGGGCTTTAGGTGTAGGTATCGGTAACGTAGCTAATCTCATTAACCCCCAACGTTTTATTTTAGGTGG
TAGCGTCACCAAAGCAGGGGAAACTTGGTGGACTGTATTACAAGAAACAGCCAGATTCACAGCATTACCAGAAGTACCAT
TGGAAATCGTGCCGGCAGCATTAGCCGACGATGCACCATTATGGGGTGCTGTAGCTTTAGCCCAAAATCTTTAA

Upstream 100 bases:

>100_bases
AAGATTAAATGACATAACATCATAGATTTAACCAATGCACAGGTAAACTTTTTGCTGTGATGTCCTAGACTTAACCTGAA
TATTGGTTTTTGACGAAAAA

Downstream 100 bases:

>100_bases
TCAACTTTCCTTGTTTCGGTGTGAAATAAAACCAAATATTACAAAACGGAAGACTTACTCTCAGACACCTGAGTAAACGA
TTCAAACTCACCATTGGGCA

Product: hypothetical protein

Products: NA

Alternate protein names: Glucose kinase [H]

Number of amino acids: Translated: 317; Mature: 317

Protein sequence:

>317_residues
MMKLTLALDFGGTKLAAGLVNADSREWLRYERRFSPINGDANTDLAIMRSLIHSLLQGATPVAIGVSFGGPVDATTGTVR
LSHHVPGWENIPLKSLLEKEFGVTTSVDNDANVAALGEQHFGAGQGYDSLFYITISTGVGGGWILNGKPWRGAVGMAGEI
GHIVVEPAGPMCLCGKRGCVERLASGPYMAQNAKDILENQPEREDGQILRNLVGNNLNLLTGQLISEAAIKGDHLAQAVL
QKSAWALGVGIGNVANLINPQRFILGGSVTKAGETWWTVLQETARFTALPEVPLEIVPAALADDAPLWGAVALAQNL

Sequences:

>Translated_317_residues
MMKLTLALDFGGTKLAAGLVNADSREWLRYERRFSPINGDANTDLAIMRSLIHSLLQGATPVAIGVSFGGPVDATTGTVR
LSHHVPGWENIPLKSLLEKEFGVTTSVDNDANVAALGEQHFGAGQGYDSLFYITISTGVGGGWILNGKPWRGAVGMAGEI
GHIVVEPAGPMCLCGKRGCVERLASGPYMAQNAKDILENQPEREDGQILRNLVGNNLNLLTGQLISEAAIKGDHLAQAVL
QKSAWALGVGIGNVANLINPQRFILGGSVTKAGETWWTVLQETARFTALPEVPLEIVPAALADDAPLWGAVALAQNL
>Mature_317_residues
MMKLTLALDFGGTKLAAGLVNADSREWLRYERRFSPINGDANTDLAIMRSLIHSLLQGATPVAIGVSFGGPVDATTGTVR
LSHHVPGWENIPLKSLLEKEFGVTTSVDNDANVAALGEQHFGAGQGYDSLFYITISTGVGGGWILNGKPWRGAVGMAGEI
GHIVVEPAGPMCLCGKRGCVERLASGPYMAQNAKDILENQPEREDGQILRNLVGNNLNLLTGQLISEAAIKGDHLAQAVL
QKSAWALGVGIGNVANLINPQRFILGGSVTKAGETWWTVLQETARFTALPEVPLEIVPAALADDAPLWGAVALAQNL

Specific function: Acts As A Repressor Of The Nagebacd Operon And Acts Both As An Activator And A Repressor For The Transcription Of The Glmsu Operon. [C]

COG id: COG1940

COG function: function code KG; Transcriptional regulator/sugar kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ROK (nagC/xylR) family [H]

Homologues:

Organism=Homo sapiens, GI298566325, Length=288, Percent_Identity=28.8194444444444, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI298566315, Length=288, Percent_Identity=28.8194444444444, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI190014632, Length=288, Percent_Identity=28.8194444444444, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI4885285, Length=288, Percent_Identity=28.8194444444444, Blast_Score=102, Evalue=6e-22,
Organism=Escherichia coli, GI1786891, Length=256, Percent_Identity=32.8125, Blast_Score=118, Evalue=4e-28,
Organism=Escherichia coli, GI1787878, Length=231, Percent_Identity=29.8701298701299, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI87082127, Length=288, Percent_Identity=28.4722222222222, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI87082230, Length=273, Percent_Identity=33.6996336996337, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI87081733, Length=322, Percent_Identity=25.776397515528, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1787363, Length=280, Percent_Identity=27.1428571428571, Blast_Score=80, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000600
- InterPro:   IPR004654 [H]

Pfam domain/function: PF00480 ROK [H]

EC number: =2.7.1.2 [H]

Molecular weight: Translated: 33534; Mature: 33534

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMKLTLALDFGGTKLAAGLVNADSREWLRYERRFSPINGDANTDLAIMRSLIHSLLQGAT
CEEEEEEEECCCHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCC
PVAIGVSFGGPVDATTGTVRLSHHVPGWENIPLKSLLEKEFGVTTSVDNDANVAALGEQH
CEEEEEECCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHCCCEECCCCCCCEEEECHHH
FGAGQGYDSLFYITISTGVGGGWILNGKPWRGAVGMAGEIGHIVVEPAGPMCLCGKRGCV
CCCCCCCCEEEEEEEECCCCCEEEECCCCCCCCCCCCCCCCEEEECCCCCEEECCCHHHH
ERLASGPYMAQNAKDILENQPEREDGQILRNLVGNNLNLLTGQLISEAAIKGDHLAQAVL
HHHHCCCCCCCCHHHHHHCCCCCHHHHHHHHHHCCCCEEHHHHHHHHHHHCHHHHHHHHH
QKSAWALGVGIGNVANLINPQRFILGGSVTKAGETWWTVLQETARFTALPEVPLEIVPAA
HHCCCEEECCHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHH
LADDAPLWGAVALAQNL
HCCCCCHHHHHHHHHCC
>Mature Secondary Structure
MMKLTLALDFGGTKLAAGLVNADSREWLRYERRFSPINGDANTDLAIMRSLIHSLLQGAT
CEEEEEEEECCCHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCC
PVAIGVSFGGPVDATTGTVRLSHHVPGWENIPLKSLLEKEFGVTTSVDNDANVAALGEQH
CEEEEEECCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHCCCEECCCCCCCEEEECHHH
FGAGQGYDSLFYITISTGVGGGWILNGKPWRGAVGMAGEIGHIVVEPAGPMCLCGKRGCV
CCCCCCCCEEEEEEEECCCCCEEEECCCCCCCCCCCCCCCCEEEECCCCCEEECCCHHHH
ERLASGPYMAQNAKDILENQPEREDGQILRNLVGNNLNLLTGQLISEAAIKGDHLAQAVL
HHHHCCCCCCCCHHHHHHCCCCCHHHHHHHHHHCCCCEEHHHHHHHHHHHCHHHHHHHHH
QKSAWALGVGIGNVANLINPQRFILGGSVTKAGETWWTVLQETARFTALPEVPLEIVPAA
HHCCCEEECCHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHH
LADDAPLWGAVALAQNL
HCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]