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The map label for this gene is livM [H]

Identifier: 17229441

GI number: 17229441

Start: 2331387

End: 2332505

Strand: Reverse

Name: livM [H]

Synonym: all1949

Alternate gene names: 17229441

Gene position: 2332505-2331387 (Counterclockwise)

Preceding gene: 17229442

Following gene: 17229440

Centisome position: 36.37

GC content: 42.63

Gene sequence:

>1119_bases
ATGAAAAAGGGAGGACGGTTAATATTAATTGAGGTTGGGGTGGTGGTAGCGATCGCTCTCATCCTCATTTTAATTATGCC
ACTGGTGCTGTCAGAGTTTCGCTTGAATCTGTTGGGGCGATTTTTGTCTTTGGCAATTGTGGCTTTAGGTATTGATTTAA
TTTGGGGTTACACTGGTTTGCTCAGTTTGGGACATGGTATCTTTTTTGGGTTGGGTGGATATGCGATCGCAATGTACCTA
AAACTGCAAATCCCAGAGGGTGAGTTACCTGATTTCATGGAATTGTATGGTGTCACGGAACTTCCTTGGTTTTGGCGACC
TTTTTATTCGTTCCCCATAGCAGTGGCGGCTGTGGTGATAATTCCAGGGTTGCTGGCGGGGTTATTAGGATATTTGGTAT
TCCGCAATCGGATTAAGGGCGTTTATTTTTCGATTTTGACCCAAGCGGCGATTATTGTATTCTTCAACTTTTTTAACGGT
CAACAGCAATTTTTTAATGGTACTAACGGGCTAATAGATTTTACAACTTTGTTTGGTGCAACTGTCAGCGATCCAAAAAC
AAAATTTATCTTCTACACTCTCACAGTCCTGTTTCTCGCTGCTACCTACGGGATTTGTCGCTGGTTGACTAGCGGACGCT
TTGGACGACTGTTAATTGCAATTCGAGACGATGAAAGCCGGGTGAGATTTTCTGGTTATGACCCTACAGATTTTAAAACA
TTAGTCTTTGCAGTTTCTGGTGCGATCGCTGGTATCGCAGGAGCATTTTACACCCTGCAAAGTGGTTCTGTCTCACCTAG
AGCTATGGATATTGCTTTTTCCATTGAAATGGTGATTTGGGTAGCTGTGGGGGGACGCGCTACATTAATCGGGGCAGTTT
TGGGAACTTTATTAGTTAATTATGCCCGTGCTTTTTTGAGTGAACAATTTGCCGAAATCTGGCTATTTTTCCAAGGCGCA
TTATTTTTAATTGTCGTGACCGTCCTTCCTGATGGCTTAGTAGGATGGTTACGTAGTCAAAACATTCCTTTTCTCAAACG
CCCTCAACAAATTTCTACATATCCCAGTTTGGAAGAAGACCCAGAAGTACAACATGAACGCCAAAATCTTGGAAACTGA

Upstream 100 bases:

>100_bases
TTTTTGCAGTGGAAGCCTGGGGGGATGTTTCCGCAAAAGGGTCGTAGTGTTGATGTTTAATTTTTTTTAATCTCACGCAG
AGACGCGGAGGGCGCAGAGA

Downstream 100 bases:

>100_bases
AAATGTTACTGTTAGCTTTGATGGTTTTAAAGCTCTAAACCAACTAAATTTTAGTATGGATGTGGGGGAATTGCGAGTAG
TAATTGGCCCTAATGGTGCG

Product: permease protein of ABC transporter

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein M [H]

Number of amino acids: Translated: 372; Mature: 372

Protein sequence:

>372_residues
MKKGGRLILIEVGVVVAIALILILIMPLVLSEFRLNLLGRFLSLAIVALGIDLIWGYTGLLSLGHGIFFGLGGYAIAMYL
KLQIPEGELPDFMELYGVTELPWFWRPFYSFPIAVAAVVIIPGLLAGLLGYLVFRNRIKGVYFSILTQAAIIVFFNFFNG
QQQFFNGTNGLIDFTTLFGATVSDPKTKFIFYTLTVLFLAATYGICRWLTSGRFGRLLIAIRDDESRVRFSGYDPTDFKT
LVFAVSGAIAGIAGAFYTLQSGSVSPRAMDIAFSIEMVIWVAVGGRATLIGAVLGTLLVNYARAFLSEQFAEIWLFFQGA
LFLIVVTVLPDGLVGWLRSQNIPFLKRPQQISTYPSLEEDPEVQHERQNLGN

Sequences:

>Translated_372_residues
MKKGGRLILIEVGVVVAIALILILIMPLVLSEFRLNLLGRFLSLAIVALGIDLIWGYTGLLSLGHGIFFGLGGYAIAMYL
KLQIPEGELPDFMELYGVTELPWFWRPFYSFPIAVAAVVIIPGLLAGLLGYLVFRNRIKGVYFSILTQAAIIVFFNFFNG
QQQFFNGTNGLIDFTTLFGATVSDPKTKFIFYTLTVLFLAATYGICRWLTSGRFGRLLIAIRDDESRVRFSGYDPTDFKT
LVFAVSGAIAGIAGAFYTLQSGSVSPRAMDIAFSIEMVIWVAVGGRATLIGAVLGTLLVNYARAFLSEQFAEIWLFFQGA
LFLIVVTVLPDGLVGWLRSQNIPFLKRPQQISTYPSLEEDPEVQHERQNLGN
>Mature_372_residues
MKKGGRLILIEVGVVVAIALILILIMPLVLSEFRLNLLGRFLSLAIVALGIDLIWGYTGLLSLGHGIFFGLGGYAIAMYL
KLQIPEGELPDFMELYGVTELPWFWRPFYSFPIAVAAVVIIPGLLAGLLGYLVFRNRIKGVYFSILTQAAIIVFFNFFNG
QQQFFNGTNGLIDFTTLFGATVSDPKTKFIFYTLTVLFLAATYGICRWLTSGRFGRLLIAIRDDESRVRFSGYDPTDFKT
LVFAVSGAIAGIAGAFYTLQSGSVSPRAMDIAFSIEMVIWVAVGGRATLIGAVLGTLLVNYARAFLSEQFAEIWLFFQGA
LFLIVVTVLPDGLVGWLRSQNIPFLKRPQQISTYPSLEEDPEVQHERQNLGN

Specific function: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane [H]

COG id: COG4177

COG function: function code E; ABC-type branched-chain amino acid transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789865, Length=326, Percent_Identity=28.2208588957055, Blast_Score=72, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851
- InterPro:   IPR021807 [H]

Pfam domain/function: PF02653 BPD_transp_2; PF11862 DUF3382 [H]

EC number: NA

Molecular weight: Translated: 41147; Mature: 41147

Theoretical pI: Translated: 8.35; Mature: 8.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKGGRLILIEVGVVVAIALILILIMPLVLSEFRLNLLGRFLSLAIVALGIDLIWGYTGL
CCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSLGHGIFFGLGGYAIAMYLKLQIPEGELPDFMELYGVTELPWFWRPFYSFPIAVAAVVI
HHHCCHHHHHHHHHHEEHEEEEECCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
IPGLLAGLLGYLVFRNRIKGVYFSILTQAAIIVFFNFFNGQQQFFNGTNGLIDFTTLFGA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCEEHHHHHCC
TVSDPKTKFIFYTLTVLFLAATYGICRWLTSGRFGRLLIAIRDDESRVRFSGYDPTDFKT
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCEEECCCCCCHHHH
LVFAVSGAIAGIAGAFYTLQSGSVSPRAMDIAFSIEMVIWVAVGGRATLIGAVLGTLLVN
HHHHHHHHHHHHHHHHHEECCCCCCCCCEEHHEEEEEEEEEEECCHHHHHHHHHHHHHHH
YARAFLSEQFAEIWLFFQGALFLIVVTVLPDGLVGWLRSQNIPFLKRPQQISTYPSLEED
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCHHCCCCCCCCC
PEVQHERQNLGN
CCHHHHHHCCCC
>Mature Secondary Structure
MKKGGRLILIEVGVVVAIALILILIMPLVLSEFRLNLLGRFLSLAIVALGIDLIWGYTGL
CCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSLGHGIFFGLGGYAIAMYLKLQIPEGELPDFMELYGVTELPWFWRPFYSFPIAVAAVVI
HHHCCHHHHHHHHHHEEHEEEEECCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
IPGLLAGLLGYLVFRNRIKGVYFSILTQAAIIVFFNFFNGQQQFFNGTNGLIDFTTLFGA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCEEHHHHHCC
TVSDPKTKFIFYTLTVLFLAATYGICRWLTSGRFGRLLIAIRDDESRVRFSGYDPTDFKT
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCEEECCCCCCHHHH
LVFAVSGAIAGIAGAFYTLQSGSVSPRAMDIAFSIEMVIWVAVGGRATLIGAVLGTLLVN
HHHHHHHHHHHHHHHHHEECCCCCCCCCEEHHEEEEEEEEEEECCHHHHHHHHHHHHHHH
YARAFLSEQFAEIWLFFQGALFLIVVTVLPDGLVGWLRSQNIPFLKRPQQISTYPSLEED
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCHHCCCCCCCCC
PEVQHERQNLGN
CCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2195019; 8041620; 9278503 [H]