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The map label for this gene is hemC [H]

Identifier: 17229370

GI number: 17229370

Start: 2240586

End: 2241596

Strand: Direct

Name: hemC [H]

Synonym: alr1878

Alternate gene names: 17229370

Gene position: 2240586-2241596 (Clockwise)

Preceding gene: 17229369

Following gene: 17229371

Centisome position: 34.93

GC content: 44.61

Gene sequence:

>1011_bases
ATGAGAGTGAAATTATCGCCTGGTTTGACATATTGTTTTATGACTTCAGTTGTTTCCAGTGCTAGACGCACAATCCGTAT
AGGTTCTCGTAAAAGTCAACTCGCTCTAGTTCAGACATACTGGGTTAGAGAGCAATTACAAAACAGTTTCCCTGATATCA
ATTTTGAAGTCCACACCATGTCTACCCAAGGCGACAAAATCCTTGATGTAGCATTAGCCAAAATCGGCGATAAAGGACTA
TTCACCAAAGAACTGGAAGTGGGAATGATCAATGAGGAGATTGATTTTGCTGTCCATTCCCTGAAAGATTTGCCGACTAA
CTTACCGGAAGGGTTAGCACTAGCCGCGATTACAGAACGGGAAAACCCGGCAGATGCGCTAGTAGTGCATGAAAATTTTA
AGGATAAGCAAATTGATACCTTACCAGCCGGCGCGGTAATTGGGACATCTTCTTTACGACGCTTGGCGCAGTTACGCAAC
CAATTTCCCCACTTGACATTTAAAGATGTACGGGGAAATTTGAATACACGGTTAGCTAAACTAGATGCAGGTGAGTATGA
CGGTCTAATTTTAGCGGCTGCTGGGTTACAGCGCTTAGGTATGGGCGATCGCGTCCACCAAATCCTCCCCAAAGAAATCT
CTCTCCACGCTGTCGGACAAGGCGCTTTAGGGATTGAATGCCGTGCCGATGATGCGGAATTAATCACCGTACTCAAAGCC
ATTGAACACCCCGAAACACGCGATCGCTGTCTGGCTGAACGCTCTTTTTTACGCAGTTTAGAAGGCGGTTGTCAAGTACC
CATCGGTGTAAATACAGAAATCAATGGTAATGAATTAATCCTCACAGGTGTAGTTGCTAGTGTAGACGGTCAAAACTTGG
TGAAAGACACTGTTTCTGGTAATGCTAGTGATGCCGAAGCGATCGGTATAAGATTAGCAGAACTCCTCCGTGAACAAGGA
GCGCAAGAGATTTTAAATACAATCTTTGCAGAGATCCAACGTGGTTCTTAA

Upstream 100 bases:

>100_bases
GTAATTCTAAATAATGTAAAAGAGTGTAAAGAAAGGCCAAAATAAACTTAATTTGCATCAGGGGAAACCAATCAGGGAGT
CACCCACTGCGGTAGTCTAG

Downstream 100 bases:

>100_bases
TCGATTGGTCAACTATATATGTTTAGATAAGTAATCAGTAGTCAGTGAACAGTGAACAATTAAGAACTGATAACTGATAC
TGATAACTGTATAGGCAGAA

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase [H]

Number of amino acids: Translated: 336; Mature: 336

Protein sequence:

>336_residues
MRVKLSPGLTYCFMTSVVSSARRTIRIGSRKSQLALVQTYWVREQLQNSFPDINFEVHTMSTQGDKILDVALAKIGDKGL
FTKELEVGMINEEIDFAVHSLKDLPTNLPEGLALAAITERENPADALVVHENFKDKQIDTLPAGAVIGTSSLRRLAQLRN
QFPHLTFKDVRGNLNTRLAKLDAGEYDGLILAAAGLQRLGMGDRVHQILPKEISLHAVGQGALGIECRADDAELITVLKA
IEHPETRDRCLAERSFLRSLEGGCQVPIGVNTEINGNELILTGVVASVDGQNLVKDTVSGNASDAEAIGIRLAELLREQG
AQEILNTIFAEIQRGS

Sequences:

>Translated_336_residues
MRVKLSPGLTYCFMTSVVSSARRTIRIGSRKSQLALVQTYWVREQLQNSFPDINFEVHTMSTQGDKILDVALAKIGDKGL
FTKELEVGMINEEIDFAVHSLKDLPTNLPEGLALAAITERENPADALVVHENFKDKQIDTLPAGAVIGTSSLRRLAQLRN
QFPHLTFKDVRGNLNTRLAKLDAGEYDGLILAAAGLQRLGMGDRVHQILPKEISLHAVGQGALGIECRADDAELITVLKA
IEHPETRDRCLAERSFLRSLEGGCQVPIGVNTEINGNELILTGVVASVDGQNLVKDTVSGNASDAEAIGIRLAELLREQG
AQEILNTIFAEIQRGS
>Mature_336_residues
MRVKLSPGLTYCFMTSVVSSARRTIRIGSRKSQLALVQTYWVREQLQNSFPDINFEVHTMSTQGDKILDVALAKIGDKGL
FTKELEVGMINEEIDFAVHSLKDLPTNLPEGLALAAITERENPADALVVHENFKDKQIDTLPAGAVIGTSSLRRLAQLRN
QFPHLTFKDVRGNLNTRLAKLDAGEYDGLILAAAGLQRLGMGDRVHQILPKEISLHAVGQGALGIECRADDAELITVLKA
IEHPETRDRCLAERSFLRSLEGGCQVPIGVNTEINGNELILTGVVASVDGQNLVKDTVSGNASDAEAIGIRLAELLREQG
AQEILNTIFAEIQRGS

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps [H]

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family [H]

Homologues:

Organism=Homo sapiens, GI20149500, Length=338, Percent_Identity=49.112426035503, Blast_Score=311, Evalue=4e-85,
Organism=Homo sapiens, GI66933009, Length=334, Percent_Identity=49.4011976047904, Blast_Score=311, Evalue=6e-85,
Organism=Escherichia coli, GI48994974, Length=306, Percent_Identity=49.6732026143791, Blast_Score=290, Evalue=7e-80,
Organism=Saccharomyces cerevisiae, GI6319996, Length=317, Percent_Identity=42.9022082018927, Blast_Score=246, Evalue=4e-66,
Organism=Drosophila melanogaster, GI20130425, Length=325, Percent_Identity=48.9230769230769, Blast_Score=292, Evalue=2e-79,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000860
- InterPro:   IPR022419
- InterPro:   IPR022417
- InterPro:   IPR022418 [H]

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC [H]

EC number: =2.5.1.61 [H]

Molecular weight: Translated: 36610; Mature: 36610

Theoretical pI: Translated: 5.46; Mature: 5.46

Prosite motif: PS00533 PORPHOBILINOGEN_DEAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVKLSPGLTYCFMTSVVSSARRTIRIGSRKSQLALVQTYWVREQLQNSFPDINFEVHTM
CEEEECCCCHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEE
STQGDKILDVALAKIGDKGLFTKELEVGMINEEIDFAVHSLKDLPTNLPEGLALAAITER
CCCCCHHHHHHHHHHCCCCCEEEHHEEEECCHHHHHHHHHHHHCCCCCCCCEEEEEEECC
ENPADALVVHENFKDKQIDTLPAGAVIGTSSLRRLAQLRNQFPHLTFKDVRGNLNTRLAK
CCCCCEEEEECCCCCCCCCCCCCCCEECHHHHHHHHHHHHHCCCCCHHHHCCCCHHEEEE
LDAGEYDGLILAAAGLQRLGMGDRVHQILPKEISLHAVGQGALGIECRADDAELITVLKA
CCCCCCCCEEEEEHHHHHCCCCHHHHHHCCCCCEEEEECCCCEEEEECCCCHHHHHHHHH
IEHPETRDRCLAERSFLRSLEGGCQVPIGVNTEINGNELILTGVVASVDGQNLVKDTVSG
HCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEEEEECCCCHHHHHHHCC
NASDAEAIGIRLAELLREQGAQEILNTIFAEIQRGS
CCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MRVKLSPGLTYCFMTSVVSSARRTIRIGSRKSQLALVQTYWVREQLQNSFPDINFEVHTM
CEEEECCCCHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEE
STQGDKILDVALAKIGDKGLFTKELEVGMINEEIDFAVHSLKDLPTNLPEGLALAAITER
CCCCCHHHHHHHHHHCCCCCEEEHHEEEECCHHHHHHHHHHHHCCCCCCCCEEEEEEECC
ENPADALVVHENFKDKQIDTLPAGAVIGTSSLRRLAQLRNQFPHLTFKDVRGNLNTRLAK
CCCCCEEEEECCCCCCCCCCCCCCCEECHHHHHHHHHHHHHCCCCCHHHHCCCCHHEEEE
LDAGEYDGLILAAAGLQRLGMGDRVHQILPKEISLHAVGQGALGIECRADDAELITVLKA
CCCCCCCCEEEEEHHHHHCCCCHHHHHHCCCCCEEEEECCCCEEEEECCCCHHHHHHHHH
IEHPETRDRCLAERSFLRSLEGGCQVPIGVNTEINGNELILTGVVASVDGQNLVKDTVSG
HCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEEEEECCCCHHHHHHHCC
NASDAEAIGIRLAELLREQGAQEILNTIFAEIQRGS
CCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11759840 [H]