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The map label for this gene is nuoN [H]

Identifier: 17229334

GI number: 17229334

Start: 2204149

End: 2205576

Strand: Reverse

Name: nuoN [H]

Synonym: all1842

Alternate gene names: 17229334

Gene position: 2205576-2204149 (Counterclockwise)

Preceding gene: 17229335

Following gene: 17229333

Centisome position: 34.39

GC content: 45.03

Gene sequence:

>1428_bases
ATGACTACTATTACCCTCACCTGGATTACACTACCGTTTTTACTAGGGTTCATCATTTATCTTGTTCCCAAACTTGACAA
ATACCTCGCTCTGGGTGCGGCTCTTGCCTCGGCCGGATACGCAGCCCAGTTATTTGTGGCTCAGTCACCCCTAGAACTGA
GATTACTGGATAACTTCGGTGTCACCCTCACACTGGACGAATTAACGGGCTACTTTATCCTCACAAACGCCCTGGTAACG
ATCGCCGTTATCCTCTACTGTTGGCAAAGTGATAAGACGGCTTTTTTTTACGTCCAAACCATGATGTTACATGGTAGCGT
TAATGCCGCTTTTGCCTGCACGGATTTTATCAGTTTATACGTAGCGCTAGAGGTAAGTGGGATTGCGGCGTTTCTCTTGA
TTGCCTATCCTCGAACGGACAGATCAATTTGGGTAGGCTTGCGCTATCTGTTTATCAGCAACGTAGCCATGTTGTTTTAT
TTGGTAGGTGCGGTGCTGGCCTATCAAACCAATCACTCGTTTGCTTTTTCTTCCTTACGCGGCGCACCACCGGAAGCGCT
AGCCCTGATATTTTTAGGGCTACTGGTAAAAGGTGGGGTATTTGTATCAGGATTGTGGCTACCCTTAACCCACTCCGAAT
CAGACACGCCAGTTTCCGCATTGCTTTCGGGGGTTGTAGTCAAAACTGGCGTCTATCCCCTGGTACGTTGTGCGCTGATT
TTAGACGAGGTTGACCCCGTAATTAGAATCTTGGGAGCAGGAACAGCTCTTCTGGGAGTAAGCTATGCAATCTTTGAGAA
AGATACCAAGCGTATGCTGGCATGGAGTACGATTTCGCAATTAGGCTGGATTATGTCCGCGCCAGAGGTTGCTGGTTTTT
ACGCACTAACACACGGCTTAGTAAAATCAGTGCTGTTCTTAATAGCAGGCTCCTTACCAAGCCGAAACTTTAAGGAGTTA
AAAAATAAGCCCATAAATACCTCTGTCTGGATTGCTTTAGTTATAGGCAGCTTATCCATATCCGGCTTTCCATTGTTTTC
CGGCTTTGGGGCAAAGTTGTTGACAATGAAGAATCTGTTACCTTGGCAAGTTATCGTTATGAACGTTGCGGCTTTGGGAA
CAGCTATAACGTTTGCCAAGTTCATATTTTTGCCACATGGGGGAAAACGTGAGGTAAAACAAGGTTTATGGCCTGGAGTG
ATACTCCTGATCAGTGCGTTGATCGTCGCTAATATCGTTTATTATGACGCTTATACAGTTGACAACATCATCAAAGCACT
AGCAATTATCGGCATTGGCTGGCTAGTGTATTTGTTTATTGTTCAAAGATTGACTATTAAACTCCCCCGTGTACTAGAAC
AATTTGAGCATCTTGTCGGTTTCATGAGTCTGATGTTAGTTCTACTCTTCTGGATGGTATTAGCATGA

Upstream 100 bases:

>100_bases
TCGGTTTTTCGATTCAAGCCTTAATGCTGGTTGGTGTCATGAAGTTGGCACGGGATAATCCCACATTGGAAAGCAACGAA
ATCGAGAAGAACAATACCCC

Downstream 100 bases:

>100_bases
CCGGATATCTAAATGTTTTATTGCGATTGGCTATCTGGTTCCTGCTCACTGCCAATCTGAGTGTGGCAAATATCATCATC
GGTGTGAGTATTGCGCTCTT

Product: putative monovalent cation/H+ antiporter subunit D

Products: NA

Alternate protein names: NADH dehydrogenase I subunit N; NDH-1 subunit N [H]

Number of amino acids: Translated: 475; Mature: 474

Protein sequence:

>475_residues
MTTITLTWITLPFLLGFIIYLVPKLDKYLALGAALASAGYAAQLFVAQSPLELRLLDNFGVTLTLDELTGYFILTNALVT
IAVILYCWQSDKTAFFYVQTMMLHGSVNAAFACTDFISLYVALEVSGIAAFLLIAYPRTDRSIWVGLRYLFISNVAMLFY
LVGAVLAYQTNHSFAFSSLRGAPPEALALIFLGLLVKGGVFVSGLWLPLTHSESDTPVSALLSGVVVKTGVYPLVRCALI
LDEVDPVIRILGAGTALLGVSYAIFEKDTKRMLAWSTISQLGWIMSAPEVAGFYALTHGLVKSVLFLIAGSLPSRNFKEL
KNKPINTSVWIALVIGSLSISGFPLFSGFGAKLLTMKNLLPWQVIVMNVAALGTAITFAKFIFLPHGGKREVKQGLWPGV
ILLISALIVANIVYYDAYTVDNIIKALAIIGIGWLVYLFIVQRLTIKLPRVLEQFEHLVGFMSLMLVLLFWMVLA

Sequences:

>Translated_475_residues
MTTITLTWITLPFLLGFIIYLVPKLDKYLALGAALASAGYAAQLFVAQSPLELRLLDNFGVTLTLDELTGYFILTNALVT
IAVILYCWQSDKTAFFYVQTMMLHGSVNAAFACTDFISLYVALEVSGIAAFLLIAYPRTDRSIWVGLRYLFISNVAMLFY
LVGAVLAYQTNHSFAFSSLRGAPPEALALIFLGLLVKGGVFVSGLWLPLTHSESDTPVSALLSGVVVKTGVYPLVRCALI
LDEVDPVIRILGAGTALLGVSYAIFEKDTKRMLAWSTISQLGWIMSAPEVAGFYALTHGLVKSVLFLIAGSLPSRNFKEL
KNKPINTSVWIALVIGSLSISGFPLFSGFGAKLLTMKNLLPWQVIVMNVAALGTAITFAKFIFLPHGGKREVKQGLWPGV
ILLISALIVANIVYYDAYTVDNIIKALAIIGIGWLVYLFIVQRLTIKLPRVLEQFEHLVGFMSLMLVLLFWMVLA
>Mature_474_residues
TTITLTWITLPFLLGFIIYLVPKLDKYLALGAALASAGYAAQLFVAQSPLELRLLDNFGVTLTLDELTGYFILTNALVTI
AVILYCWQSDKTAFFYVQTMMLHGSVNAAFACTDFISLYVALEVSGIAAFLLIAYPRTDRSIWVGLRYLFISNVAMLFYL
VGAVLAYQTNHSFAFSSLRGAPPEALALIFLGLLVKGGVFVSGLWLPLTHSESDTPVSALLSGVVVKTGVYPLVRCALIL
DEVDPVIRILGAGTALLGVSYAIFEKDTKRMLAWSTISQLGWIMSAPEVAGFYALTHGLVKSVLFLIAGSLPSRNFKELK
NKPINTSVWIALVIGSLSISGFPLFSGFGAKLLTMKNLLPWQVIVMNVAALGTAITFAKFIFLPHGGKREVKQGLWPGVI
LLISALIVANIVYYDAYTVDNIIKALAIIGIGWLVYLFIVQRLTIKLPRVLEQFEHLVGFMSLMLVLLFWMVLA

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translo

COG id: COG0651

COG function: function code CP; Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 2 family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=263, Percent_Identity=30.0380228136882, Blast_Score=77, Evalue=5e-14,
Organism=Escherichia coli, GI1788827, Length=352, Percent_Identity=27.8409090909091, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI1788829, Length=258, Percent_Identity=30.6201550387597, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI1788614, Length=381, Percent_Identity=25.9842519685039, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI1788831, Length=281, Percent_Identity=25.6227758007117, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1788613, Length=364, Percent_Identity=25, Blast_Score=69, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010096
- InterPro:   IPR001750
- InterPro:   IPR003918 [H]

Pfam domain/function: PF00361 Oxidored_q1 [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 52001; Mature: 51870

Theoretical pI: Translated: 9.24; Mature: 9.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTITLTWITLPFLLGFIIYLVPKLDKYLALGAALASAGYAAQLFVAQSPLELRLLDNFG
CCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEEEECCCC
VTLTLDELTGYFILTNALVTIAVILYCWQSDKTAFFYVQTMMLHGSVNAAFACTDFISLY
CEEEEHHHCCHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHCCCCHHHHHHHHHHHH
VALEVSGIAAFLLIAYPRTDRSIWVGLRYLFISNVAMLFYLVGAVLAYQTNHSFAFSSLR
HHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCC
GAPPEALALIFLGLLVKGGVFVSGLWLPLTHSESDTPVSALLSGVVVKTGVYPLVRCALI
CCCHHHHHHHHHHHHHHCCCEEEEEEEEEECCCCCCCHHHHHHHHHHHHCHHHHHHHHHH
LDEVDPVIRILGAGTALLGVSYAIFEKDTKRMLAWSTISQLGWIMSAPEVAGFYALTHGL
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
VKSVLFLIAGSLPSRNFKELKNKPINTSVWIALVIGSLSISGFPLFSGFGAKLLTMKNLL
HHHHHHHHHCCCCCCCHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCC
PWQVIVMNVAALGTAITFAKFIFLPHGGKREVKQGLWPGVILLISALIVANIVYYDAYTV
CHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
DNIIKALAIIGIGWLVYLFIVQRLTIKLPRVLEQFEHLVGFMSLMLVLLFWMVLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
>Mature Secondary Structure 
TTITLTWITLPFLLGFIIYLVPKLDKYLALGAALASAGYAAQLFVAQSPLELRLLDNFG
CEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEEEECCCC
VTLTLDELTGYFILTNALVTIAVILYCWQSDKTAFFYVQTMMLHGSVNAAFACTDFISLY
CEEEEHHHCCHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHCCCCHHHHHHHHHHHH
VALEVSGIAAFLLIAYPRTDRSIWVGLRYLFISNVAMLFYLVGAVLAYQTNHSFAFSSLR
HHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCC
GAPPEALALIFLGLLVKGGVFVSGLWLPLTHSESDTPVSALLSGVVVKTGVYPLVRCALI
CCCHHHHHHHHHHHHHHCCCEEEEEEEEEECCCCCCCHHHHHHHHHHHHCHHHHHHHHHH
LDEVDPVIRILGAGTALLGVSYAIFEKDTKRMLAWSTISQLGWIMSAPEVAGFYALTHGL
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
VKSVLFLIAGSLPSRNFKELKNKPINTSVWIALVIGSLSISGFPLFSGFGAKLLTMKNLL
HHHHHHHHHCCCCCCCHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCC
PWQVIVMNVAALGTAITFAKFIFLPHGGKREVKQGLWPGVILLISALIVANIVYYDAYTV
CHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
DNIIKALAIIGIGWLVYLFIVQRLTIKLPRVLEQFEHLVGFMSLMLVLLFWMVLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA