Click here to switch to the map view.

The map label for this gene is glpK [H]

Identifier: 17229303

GI number: 17229303

Start: 2176667

End: 2178169

Strand: Reverse

Name: glpK [H]

Synonym: all1811

Alternate gene names: 17229303

Gene position: 2178169-2176667 (Counterclockwise)

Preceding gene: 17229304

Following gene: 17229299

Centisome position: 33.96

GC content: 45.58

Gene sequence:

>1503_bases
ATGCAGATATCATCTTCCGGCTATATCCTAGCGTTGGACTTGGGAACAACTGGAAACCGGGCATTTATCTTTAACAATGC
AGGTAAAATAGTTGCTCAAGCATATAAGGAACTAACACAACATTACCCCCAACCAGGATGGTTAGAGCATGACGCGGAAG
AAATCTGGCAAGATACCTGCTGGGTGATGAAGACAGCCATCGTCAATGCACAAATATCTCCTAGTGAAATTGCGGCTATA
GGTTTGACTGTACAACGGGAAACTTGCCTACTCTGGGACAAAACCACGGGGAGACCATTACATAAAGCCATTGTTTGGCA
AGACCGCCGCACGGCTCCCCTGTGTCATCAGTTACAGGAAAAAGGCTATGCTCAGGAAATTTACAGTCGTACTGGTTTAG
TAGTTGACGCTTATTTCTCCGCAACTAAACTCCGATGGTTATTAGACTACATCACAGGCGTTGATTTAAAAAATGTTTTG
GCAGGTACAATCGATACCTGGATATTGTGGAAATTAACAGGTGGGAAAGTCCACGCCACCGACCACAGCAATGCTAGCCG
CACCATGTTGATGAATTTGAAAACTGGTGAGTGGGATGAGCAACTACTAGAGATTTTGCAAATTCCTGCCCATATTCTGC
CGCAAATTCAACCCAGTTTGGGAAAATTTGGTGTTACAGATACCAGCTTATTAGATGCAGCTATCCCCATCACAGCCATT
TTAGGCGATCAACAGGCAGCTTTGTTTGGTCATGGCTGCGATCGCCCCGGTTTAATGAAATGTACTTATGGCACTGGTAG
CTTTTTAGTAGCTCATACTGGCTCTAATATTGTTCGTTCTCAACATCAATTAATTTCTACAATCGCCTGGACACAAGCCG
ATAAACAGGAAAATATCAATATTGGCTATGCTCTAGAAGGCAGTATGTTTACTAGTGGTGCTTGTATCCAATGGTTGCGT
GACGGCATCAAGCTAATTAAGACGGCTGCTGAAACTGAGACCATGGCAAATCAAGTAGCCGATAACGGTGGGGTGTACTT
TGTCCCCGCTTTTAGTGGACTAGGCGCACCCTACTGGGATATGAACGCTAGAGGAGCTTTTTTTGGCATTACAGCCAGCG
TCCAACCACAGCATTTAGTCCGGGCTGTATTAGAAGCGATCGCCTATCAAGTGTTAGAAGTAGTACAAGCCATCAATGCC
TCTTGTAGTAGCCCCATGCAGCGCCTAATTGTCGATGGTGGTGCTTGTGAGAACAATTTCCTCATGCAGTTCCAAGCAGA
TGTTTTAGGTATTCCCGTAGAACGTCCCACCATGCGCGACACAACAGTACAAGGTGCAGCCTTCGCCGCAGGTTTAGCCG
TGGGATTTTGGGATAGTTACACAGCATTAGTTAACCAACGCCAGATAGACCGCATTTTTGAACCAGGAGAAGGAAGCCAA
AACGCCACAGCCAATTTTGCGATATGGCAAAAGGCAGTTAAACGGAGTCTTGATTGGGTGTAG

Upstream 100 bases:

>100_bases
GGGGATGAAACAGAAAGACGATCGCCTAAACTATCCAAATATGTAGAGAGACACAAATATTTGTAGGATAGGTAGAGCGA
TCGCCTTTTAACTAAAGCCT

Downstream 100 bases:

>100_bases
GTATATAGGGGTGTAAAGGTTGAGAGTAGAGAAAGACTATTGATACTCCCCATTATCCATTATCCCGACTTAGCCGCCAA
CTTTAAATCCAAGGTATAAA

Product: glycerol kinase

Products: NA

Alternate protein names: ATP:glycerol 3-phosphotransferase; Glycerokinase; GK [H]

Number of amino acids: Translated: 500; Mature: 500

Protein sequence:

>500_residues
MQISSSGYILALDLGTTGNRAFIFNNAGKIVAQAYKELTQHYPQPGWLEHDAEEIWQDTCWVMKTAIVNAQISPSEIAAI
GLTVQRETCLLWDKTTGRPLHKAIVWQDRRTAPLCHQLQEKGYAQEIYSRTGLVVDAYFSATKLRWLLDYITGVDLKNVL
AGTIDTWILWKLTGGKVHATDHSNASRTMLMNLKTGEWDEQLLEILQIPAHILPQIQPSLGKFGVTDTSLLDAAIPITAI
LGDQQAALFGHGCDRPGLMKCTYGTGSFLVAHTGSNIVRSQHQLISTIAWTQADKQENINIGYALEGSMFTSGACIQWLR
DGIKLIKTAAETETMANQVADNGGVYFVPAFSGLGAPYWDMNARGAFFGITASVQPQHLVRAVLEAIAYQVLEVVQAINA
SCSSPMQRLIVDGGACENNFLMQFQADVLGIPVERPTMRDTTVQGAAFAAGLAVGFWDSYTALVNQRQIDRIFEPGEGSQ
NATANFAIWQKAVKRSLDWV

Sequences:

>Translated_500_residues
MQISSSGYILALDLGTTGNRAFIFNNAGKIVAQAYKELTQHYPQPGWLEHDAEEIWQDTCWVMKTAIVNAQISPSEIAAI
GLTVQRETCLLWDKTTGRPLHKAIVWQDRRTAPLCHQLQEKGYAQEIYSRTGLVVDAYFSATKLRWLLDYITGVDLKNVL
AGTIDTWILWKLTGGKVHATDHSNASRTMLMNLKTGEWDEQLLEILQIPAHILPQIQPSLGKFGVTDTSLLDAAIPITAI
LGDQQAALFGHGCDRPGLMKCTYGTGSFLVAHTGSNIVRSQHQLISTIAWTQADKQENINIGYALEGSMFTSGACIQWLR
DGIKLIKTAAETETMANQVADNGGVYFVPAFSGLGAPYWDMNARGAFFGITASVQPQHLVRAVLEAIAYQVLEVVQAINA
SCSSPMQRLIVDGGACENNFLMQFQADVLGIPVERPTMRDTTVQGAAFAAGLAVGFWDSYTALVNQRQIDRIFEPGEGSQ
NATANFAIWQKAVKRSLDWV
>Mature_500_residues
MQISSSGYILALDLGTTGNRAFIFNNAGKIVAQAYKELTQHYPQPGWLEHDAEEIWQDTCWVMKTAIVNAQISPSEIAAI
GLTVQRETCLLWDKTTGRPLHKAIVWQDRRTAPLCHQLQEKGYAQEIYSRTGLVVDAYFSATKLRWLLDYITGVDLKNVL
AGTIDTWILWKLTGGKVHATDHSNASRTMLMNLKTGEWDEQLLEILQIPAHILPQIQPSLGKFGVTDTSLLDAAIPITAI
LGDQQAALFGHGCDRPGLMKCTYGTGSFLVAHTGSNIVRSQHQLISTIAWTQADKQENINIGYALEGSMFTSGACIQWLR
DGIKLIKTAAETETMANQVADNGGVYFVPAFSGLGAPYWDMNARGAFFGITASVQPQHLVRAVLEAIAYQVLEVVQAINA
SCSSPMQRLIVDGGACENNFLMQFQADVLGIPVERPTMRDTTVQGAAFAAGLAVGFWDSYTALVNQRQIDRIFEPGEGSQ
NATANFAIWQKAVKRSLDWV

Specific function: Key enzyme in the regulation of glycerol uptake and metabolism [H]

COG id: COG0554

COG function: function code C; Glycerol kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGGY kinase family [H]

Homologues:

Organism=Homo sapiens, GI189409120, Length=509, Percent_Identity=41.8467583497053, Blast_Score=375, Evalue=1e-104,
Organism=Homo sapiens, GI4504007, Length=509, Percent_Identity=41.8467583497053, Blast_Score=374, Evalue=1e-104,
Organism=Homo sapiens, GI42794763, Length=514, Percent_Identity=41.6342412451362, Blast_Score=371, Evalue=1e-103,
Organism=Homo sapiens, GI41393575, Length=502, Percent_Identity=41.0358565737052, Blast_Score=370, Evalue=1e-102,
Organism=Homo sapiens, GI88196792, Length=513, Percent_Identity=33.9181286549708, Blast_Score=313, Evalue=2e-85,
Organism=Escherichia coli, GI1790361, Length=502, Percent_Identity=47.609561752988, Blast_Score=492, Evalue=1e-140,
Organism=Escherichia coli, GI1787789, Length=491, Percent_Identity=27.4949083503055, Blast_Score=124, Evalue=2e-29,
Organism=Escherichia coli, GI1790005, Length=497, Percent_Identity=24.5472837022133, Blast_Score=123, Evalue=3e-29,
Organism=Escherichia coli, GI1789987, Length=485, Percent_Identity=25.7731958762887, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1789138, Length=494, Percent_Identity=22.4696356275304, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1789168, Length=465, Percent_Identity=25.1612903225806, Blast_Score=85, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17535599, Length=505, Percent_Identity=37.029702970297, Blast_Score=317, Evalue=6e-87,
Organism=Caenorhabditis elegans, GI71986140, Length=531, Percent_Identity=27.1186440677966, Blast_Score=194, Evalue=8e-50,
Organism=Caenorhabditis elegans, GI71986147, Length=307, Percent_Identity=32.2475570032573, Blast_Score=141, Evalue=7e-34,
Organism=Saccharomyces cerevisiae, GI6321755, Length=555, Percent_Identity=31.5315315315315, Blast_Score=275, Evalue=1e-74,
Organism=Drosophila melanogaster, GI17864214, Length=513, Percent_Identity=39.5711500974659, Blast_Score=342, Evalue=4e-94,
Organism=Drosophila melanogaster, GI24654573, Length=436, Percent_Identity=41.9724770642202, Blast_Score=330, Evalue=1e-90,
Organism=Drosophila melanogaster, GI24655555, Length=512, Percent_Identity=36.1328125, Blast_Score=320, Evalue=1e-87,
Organism=Drosophila melanogaster, GI24655560, Length=512, Percent_Identity=36.1328125, Blast_Score=320, Evalue=1e-87,
Organism=Drosophila melanogaster, GI24655570, Length=512, Percent_Identity=36.1328125, Blast_Score=320, Evalue=1e-87,
Organism=Drosophila melanogaster, GI24655574, Length=512, Percent_Identity=36.1328125, Blast_Score=320, Evalue=1e-87,
Organism=Drosophila melanogaster, GI24655565, Length=512, Percent_Identity=36.1328125, Blast_Score=320, Evalue=1e-87,
Organism=Drosophila melanogaster, GI19922058, Length=530, Percent_Identity=31.6981132075472, Blast_Score=266, Evalue=2e-71,
Organism=Drosophila melanogaster, GI24652871, Length=495, Percent_Identity=32.1212121212121, Blast_Score=257, Evalue=2e-68,
Organism=Drosophila melanogaster, GI21357867, Length=528, Percent_Identity=30.3030303030303, Blast_Score=246, Evalue=3e-65,
Organism=Drosophila melanogaster, GI24656367, Length=514, Percent_Identity=30.7392996108949, Blast_Score=244, Evalue=1e-64,
Organism=Drosophila melanogaster, GI24656372, Length=374, Percent_Identity=30.7486631016043, Blast_Score=177, Evalue=1e-44,
Organism=Drosophila melanogaster, GI45552909, Length=312, Percent_Identity=28.525641025641, Blast_Score=125, Evalue=7e-29,

Paralogues:

None

Copy number: 2,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000577
- InterPro:   IPR018485
- InterPro:   IPR018483
- InterPro:   IPR018484
- InterPro:   IPR005999 [H]

Pfam domain/function: PF02782 FGGY_C; PF00370 FGGY_N [H]

EC number: =2.7.1.30 [H]

Molecular weight: Translated: 54911; Mature: 54911

Theoretical pI: Translated: 5.96; Mature: 5.96

Prosite motif: PS00445 FGGY_KINASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQISSSGYILALDLGTTGNRAFIFNNAGKIVAQAYKELTQHYPQPGWLEHDAEEIWQDTC
CEECCCCEEEEEEECCCCCEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHH
WVMKTAIVNAQISPSEIAAIGLTVQRETCLLWDKTTGRPLHKAIVWQDRRTAPLCHQLQE
HHHHHHHHCCCCCHHHEEEEEEEEECCEEEEEECCCCCCHHHHHEECCCCCCHHHHHHHH
KGYAQEIYSRTGLVVDAYFSATKLRWLLDYITGVDLKNVLAGTIDTWILWKLTGGKVHAT
CCHHHHHHHHCCEEEEEHHHHHHHHHHHHHHHCCCHHHHHHHCCCEEEEEEEECCEEEEC
DHSNASRTMLMNLKTGEWDEQLLEILQIPAHILPQIQPSLGKFGVTDTSLLDAAIPITAI
CCCCCCEEEEEEECCCCHHHHHHHHHHCCHHHHCCCCCCCCCCCCCCHHHHHHHCCCEEE
LGDQQAALFGHGCDRPGLMKCTYGTGSFLVAHTGSNIVRSQHQLISTIAWTQADKQENIN
ECCCCHHHCCCCCCCCCCEEEECCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCE
IGYALEGSMFTSGACIQWLRDGIKLIKTAAETETMANQVADNGGVYFVPAFSGLGAPYWD
EEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCC
MNARGAFFGITASVQPQHLVRAVLEAIAYQVLEVVQAINASCSSPMQRLIVDGGACENNF
CCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHCCHHHHHHCCCCCCCCCE
LMQFQADVLGIPVERPTMRDTTVQGAAFAAGLAVGFWDSYTALVNQRQIDRIFEPGEGSQ
EEEEECCEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
NATANFAIWQKAVKRSLDWV
CCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MQISSSGYILALDLGTTGNRAFIFNNAGKIVAQAYKELTQHYPQPGWLEHDAEEIWQDTC
CEECCCCEEEEEEECCCCCEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHH
WVMKTAIVNAQISPSEIAAIGLTVQRETCLLWDKTTGRPLHKAIVWQDRRTAPLCHQLQE
HHHHHHHHCCCCCHHHEEEEEEEEECCEEEEEECCCCCCHHHHHEECCCCCCHHHHHHHH
KGYAQEIYSRTGLVVDAYFSATKLRWLLDYITGVDLKNVLAGTIDTWILWKLTGGKVHAT
CCHHHHHHHHCCEEEEEHHHHHHHHHHHHHHHCCCHHHHHHHCCCEEEEEEEECCEEEEC
DHSNASRTMLMNLKTGEWDEQLLEILQIPAHILPQIQPSLGKFGVTDTSLLDAAIPITAI
CCCCCCEEEEEEECCCCHHHHHHHHHHCCHHHHCCCCCCCCCCCCCCHHHHHHHCCCEEE
LGDQQAALFGHGCDRPGLMKCTYGTGSFLVAHTGSNIVRSQHQLISTIAWTQADKQENIN
ECCCCHHHCCCCCCCCCCEEEECCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCE
IGYALEGSMFTSGACIQWLRDGIKLIKTAAETETMANQVADNGGVYFVPAFSGLGAPYWD
EEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCC
MNARGAFFGITASVQPQHLVRAVLEAIAYQVLEVVQAINASCSSPMQRLIVDGGACENNF
CCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHCCHHHHHHCCCCCCCCCE
LMQFQADVLGIPVERPTMRDTTVQGAAFAAGLAVGFWDSYTALVNQRQIDRIFEPGEGSQ
EEEEECCEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
NATANFAIWQKAVKRSLDWV
CCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA