Click here to switch to the map view.

The map label for this gene is fabG [C]

Identifier: 17229214

GI number: 17229214

Start: 2071069

End: 2072004

Strand: Direct

Name: fabG [C]

Synonym: alr1722

Alternate gene names: 17229214

Gene position: 2071069-2072004 (Clockwise)

Preceding gene: 17229213

Following gene: 17229218

Centisome position: 32.29

GC content: 42.95

Gene sequence:

>936_bases
ATGAAAAATGAAAAATGGAACGCTGAAAATATTCCTCCTCAAAAAGGAAGACTAGCAATTGTAACGGGTTCAAGCAGTGG
CATCGGTTACGAAACGGCGCGGGTTTTAGCTAATAAACAAGCGTCTGTAATCATTGCGGTTCGCAATTTGGACAAAGGAA
ACAAGGCACTGGCAAAAATCCTTCAACAGAATAAAGATGCCGACGTAAAGTTGATGGAACTTGATTTGGCGAATTTAGCA
TCAGTTAAAAATTTCGCTGAAAACTTTCGGAAAAATTATTTGCGTCTGGATTTACTGATTAATAATGCGGGTGTGATGAT
TCCGCCGTATTCAAAAACGACGGATGGTTTTGAATTGCAGTTCGGCACTAATCATCTCGGACATTTTGCTTTGACGGGAC
AACTTTTAGAATTTTTGATTAGCACCGAAGGCTCTCGAATCGTTAATGTTTCGAGCGGCGCACATAATATGGGCAAGATA
GATTTCGATGATTTGAATTGGGAGCAGAGAAGTTATGCTAAATGGAAAGCTTACGGCGACAGCAAACTTGCCAACCTCTA
CTTTACCTACGAACTCGACCGAAAACTAAAAGATAACGGTATCGACACACTTGTAACCGCCTCGCATCCGGGCTGGACTG
CAACCGAATTGCAGAGAACTGCGGGTGGCATTGTGAAATATCTCAACGGCATCGTTGCTCAAGACATCACAATGGGTGCG
TTACCGACTCTGCGGGCGGCAATCGAAGCAGGCTTAAAAGGCGCAGAATATTTCGGCCCCAATGGGTTTATGGAAATGCG
CGGCTATCCAATAAAAGTCGAATCAAACGAGTTATCCAAAGACCAAGCACTCGCCAAAAAACTATGGGTTGTATCGGAAA
AACTAACCGATGTGAAATTTGAATTTAATAAAAAGGCGCAAAGCGCGGGCAAATAA

Upstream 100 bases:

>100_bases
ACCACCTATAAAATTGCATGGGATGCAGTAACGAATTAATTCTTTTTTCGAGTACATTAAACGAATATTCGATTAATTAA
TTAGGAGAAGAGTAAATCAA

Downstream 100 bases:

>100_bases
GAAACCCCTGATAGTGGTGAGCTAGGGTTTTTCTGTCCACTGTCTACTTTGTGTCTAGATGTCTGCCTCTGTCCCTTGCT
GTATAAAGGTTATGTCTACT

Product: short chain dehydrogenase

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 311; Mature: 311

Protein sequence:

>311_residues
MKNEKWNAENIPPQKGRLAIVTGSSSGIGYETARVLANKQASVIIAVRNLDKGNKALAKILQQNKDADVKLMELDLANLA
SVKNFAENFRKNYLRLDLLINNAGVMIPPYSKTTDGFELQFGTNHLGHFALTGQLLEFLISTEGSRIVNVSSGAHNMGKI
DFDDLNWEQRSYAKWKAYGDSKLANLYFTYELDRKLKDNGIDTLVTASHPGWTATELQRTAGGIVKYLNGIVAQDITMGA
LPTLRAAIEAGLKGAEYFGPNGFMEMRGYPIKVESNELSKDQALAKKLWVVSEKLTDVKFEFNKKAQSAGK

Sequences:

>Translated_311_residues
MKNEKWNAENIPPQKGRLAIVTGSSSGIGYETARVLANKQASVIIAVRNLDKGNKALAKILQQNKDADVKLMELDLANLA
SVKNFAENFRKNYLRLDLLINNAGVMIPPYSKTTDGFELQFGTNHLGHFALTGQLLEFLISTEGSRIVNVSSGAHNMGKI
DFDDLNWEQRSYAKWKAYGDSKLANLYFTYELDRKLKDNGIDTLVTASHPGWTATELQRTAGGIVKYLNGIVAQDITMGA
LPTLRAAIEAGLKGAEYFGPNGFMEMRGYPIKVESNELSKDQALAKKLWVVSEKLTDVKFEFNKKAQSAGK
>Mature_311_residues
MKNEKWNAENIPPQKGRLAIVTGSSSGIGYETARVLANKQASVIIAVRNLDKGNKALAKILQQNKDADVKLMELDLANLA
SVKNFAENFRKNYLRLDLLINNAGVMIPPYSKTTDGFELQFGTNHLGHFALTGQLLEFLISTEGSRIVNVSSGAHNMGKI
DFDDLNWEQRSYAKWKAYGDSKLANLYFTYELDRKLKDNGIDTLVTASHPGWTATELQRTAGGIVKYLNGIVAQDITMGA
LPTLRAAIEAGLKGAEYFGPNGFMEMRGYPIKVESNELSKDQALAKKLWVVSEKLTDVKFEFNKKAQSAGK

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI225579078, Length=291, Percent_Identity=40.2061855670103, Blast_Score=183, Evalue=2e-46,
Organism=Homo sapiens, GI186928839, Length=290, Percent_Identity=40, Blast_Score=182, Evalue=5e-46,
Organism=Homo sapiens, GI166795268, Length=282, Percent_Identity=39.7163120567376, Blast_Score=174, Evalue=8e-44,
Organism=Homo sapiens, GI7706523, Length=298, Percent_Identity=35.5704697986577, Blast_Score=159, Evalue=4e-39,
Organism=Homo sapiens, GI10190746, Length=305, Percent_Identity=37.7049180327869, Blast_Score=155, Evalue=5e-38,
Organism=Homo sapiens, GI19923931, Length=257, Percent_Identity=39.6887159533074, Blast_Score=153, Evalue=1e-37,
Organism=Homo sapiens, GI193804850, Length=296, Percent_Identity=35.1351351351351, Blast_Score=147, Evalue=1e-35,
Organism=Homo sapiens, GI146231950, Length=293, Percent_Identity=35.8361774744027, Blast_Score=145, Evalue=6e-35,
Organism=Homo sapiens, GI13375997, Length=167, Percent_Identity=30.5389221556886, Blast_Score=72, Evalue=7e-13,
Organism=Homo sapiens, GI72534732, Length=174, Percent_Identity=29.8850574712644, Blast_Score=72, Evalue=9e-13,
Organism=Escherichia coli, GI1787335, Length=214, Percent_Identity=27.5700934579439, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17532791, Length=305, Percent_Identity=33.1147540983607, Blast_Score=128, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI17532805, Length=291, Percent_Identity=33.3333333333333, Blast_Score=124, Evalue=9e-29,
Organism=Caenorhabditis elegans, GI17558006, Length=214, Percent_Identity=35.981308411215, Blast_Score=121, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI193207620, Length=298, Percent_Identity=31.2080536912752, Blast_Score=116, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17505416, Length=314, Percent_Identity=30.2547770700637, Blast_Score=115, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI71992402, Length=243, Percent_Identity=31.6872427983539, Blast_Score=105, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17535059, Length=243, Percent_Identity=32.9218106995885, Blast_Score=104, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI32565532, Length=205, Percent_Identity=34.1463414634146, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI72001364, Length=311, Percent_Identity=29.903536977492, Blast_Score=92, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI71994604, Length=208, Percent_Identity=30.7692307692308, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI115533174, Length=302, Percent_Identity=25.4966887417219, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI115533172, Length=302, Percent_Identity=25.4966887417219, Blast_Score=69, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6324820, Length=225, Percent_Identity=31.5555555555556, Blast_Score=90, Evalue=6e-19,
Organism=Saccharomyces cerevisiae, GI6322067, Length=138, Percent_Identity=32.6086956521739, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24586328, Length=293, Percent_Identity=39.2491467576792, Blast_Score=171, Evalue=7e-43,
Organism=Drosophila melanogaster, GI19921754, Length=297, Percent_Identity=39.3939393939394, Blast_Score=168, Evalue=4e-42,
Organism=Drosophila melanogaster, GI28573296, Length=255, Percent_Identity=40.7843137254902, Blast_Score=164, Evalue=1e-40,
Organism=Drosophila melanogaster, GI22024069, Length=294, Percent_Identity=39.1156462585034, Blast_Score=163, Evalue=2e-40,
Organism=Drosophila melanogaster, GI45554248, Length=208, Percent_Identity=45.6730769230769, Blast_Score=160, Evalue=1e-39,
Organism=Drosophila melanogaster, GI24640117, Length=208, Percent_Identity=45.6730769230769, Blast_Score=160, Evalue=1e-39,
Organism=Drosophila melanogaster, GI161076371, Length=291, Percent_Identity=37.4570446735395, Blast_Score=155, Evalue=2e-38,
Organism=Drosophila melanogaster, GI20129347, Length=293, Percent_Identity=34.8122866894198, Blast_Score=143, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24656154, Length=247, Percent_Identity=35.6275303643725, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI19922628, Length=247, Percent_Identity=35.6275303643725, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI45553409, Length=207, Percent_Identity=35.2657004830918, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI24647948, Length=207, Percent_Identity=35.2657004830918, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI24647946, Length=199, Percent_Identity=36.1809045226131, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24647931, Length=218, Percent_Identity=38.0733944954128, Blast_Score=108, Evalue=4e-24,
Organism=Drosophila melanogaster, GI21357041, Length=214, Percent_Identity=31.7757009345794, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI23397609, Length=231, Percent_Identity=29.004329004329, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 34368; Mature: 34368

Theoretical pI: Translated: 9.71; Mature: 9.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNEKWNAENIPPQKGRLAIVTGSSSGIGYETARVLANKQASVIIAVRNLDKGNKALAKI
CCCCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHCCCCEEEEEEECCCCCHHHHHHH
LQQNKDADVKLMELDLANLASVKNFAENFRKNYLRLDLLINNAGVMIPPYSKTTDGFELQ
HHCCCCCCEEEEEECHHHHHHHHHHHHHHHHCEEEEEEEEECCCEEECCCCCCCCCEEEE
FGTNHLGHFALTGQLLEFLISTEGSRIVNVSSGAHNMGKIDFDDLNWEQRSYAKWKAYGD
ECCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCEECCCCCCCHHHHHHHHCCCC
SKLANLYFTYELDRKLKDNGIDTLVTASHPGWTATELQRTAGGIVKYLNGIVAQDITMGA
CEEEEEEEEEEECCHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
LPTLRAAIEAGLKGAEYFGPNGFMEMRGYPIKVESNELSKDQALAKKLWVVSEKLTDVKF
HHHHHHHHHHCCCCCEEECCCCCEECCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCEEE
EFNKKAQSAGK
EECCCHHCCCC
>Mature Secondary Structure
MKNEKWNAENIPPQKGRLAIVTGSSSGIGYETARVLANKQASVIIAVRNLDKGNKALAKI
CCCCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHCCCCEEEEEEECCCCCHHHHHHH
LQQNKDADVKLMELDLANLASVKNFAENFRKNYLRLDLLINNAGVMIPPYSKTTDGFELQ
HHCCCCCCEEEEEECHHHHHHHHHHHHHHHHCEEEEEEEEECCCEEECCCCCCCCCEEEE
FGTNHLGHFALTGQLLEFLISTEGSRIVNVSSGAHNMGKIDFDDLNWEQRSYAKWKAYGD
ECCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCEECCCCCCCHHHHHHHHCCCC
SKLANLYFTYELDRKLKDNGIDTLVTASHPGWTATELQRTAGGIVKYLNGIVAQDITMGA
CEEEEEEEEEEECCHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
LPTLRAAIEAGLKGAEYFGPNGFMEMRGYPIKVESNELSKDQALAKKLWVVSEKLTDVKF
HHHHHHHHHHCCCCCEEECCCCCEECCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCEEE
EFNKKAQSAGK
EECCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8383668 [H]