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The map label for this gene is degU [H]

Identifier: 17229196

GI number: 17229196

Start: 2044111

End: 2044830

Strand: Reverse

Name: degU [H]

Synonym: all1704

Alternate gene names: 17229196

Gene position: 2044830-2044111 (Counterclockwise)

Preceding gene: 17229199

Following gene: 17229195

Centisome position: 31.88

GC content: 42.64

Gene sequence:

>720_bases
ATGAATAAAATTCGGATTGCGCTGATTGAGGATCATGATCTCACCCGTGTGGGTATTCGGACAGCACTGCTACAAAAAGA
AGAAATTGAAGTGGTGGGAGAAGCTGCCAATGCGACAGAAGGACTAAATATGTTAAAAAAGGTACAACCAGATATTGCGA
TCGTCGATATCGGTTTGCCAGATAAAGACGGAATTGAGCTAACAAAGGAATTAAAATCAATCAGTAACGGCGCAGACTTA
CCAACAAAAGTATTGATTTTAACCTTGCGTGATAATAAAGAAGCAGTTTTGGCAGCTTTCGCAGCTGGGGCTGATTCTTA
CTGTATGAAAGATATTAGGTTTGATAATCTACTGGAAGCAGTTAGAGTAACTTATAATGGCAACGCTTGGATTGATCCAG
CGATCGCCAGAATTGTACTACAACAAGCACAACAACAGTCTCCAAAACCAGTAACCACCATAACAGAAGCGAAAAATTCC
TTCGCAAACTCAGAAACCGAAGATAACTTAGAGACTATCGACTCCTATACCCTGACGGAAAGAGAGTTAGAAGTATTACA
GCTAATTGTCGAAGGCTGTAGTAACGCGGTCATCGCTGAACGCCTTTACATTACAGTCGGCACTGTAAAAACCCACGTTC
GCAATATTCTCAATAAACTCTGCGCCGATGACCGCACCCAAGCTGCTGTCCGCGCCTTACGCTCTGGATTAGTGGGTTAA

Upstream 100 bases:

>100_bases
CTATATTTATTGTTGGGTAACTGCTGAAAACTGTATCTATGAAAAATTTCCGATAAATACGATTTTGAAGTTAAGCTAGC
GTGACGGGTAGAAATTGACT

Downstream 100 bases:

>100_bases
ATTTACTAGCGATTTAAAGATTTACCAATAACTCAAAGAGTAAAGTTATACTTGTCAGACAAGTAAGCTTTTCATCAAAG
ATTACTTTTGAGAACGCCTT

Product: two-component response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 239; Mature: 239

Protein sequence:

>239_residues
MNKIRIALIEDHDLTRVGIRTALLQKEEIEVVGEAANATEGLNMLKKVQPDIAIVDIGLPDKDGIELTKELKSISNGADL
PTKVLILTLRDNKEAVLAAFAAGADSYCMKDIRFDNLLEAVRVTYNGNAWIDPAIARIVLQQAQQQSPKPVTTITEAKNS
FANSETEDNLETIDSYTLTERELEVLQLIVEGCSNAVIAERLYITVGTVKTHVRNILNKLCADDRTQAAVRALRSGLVG

Sequences:

>Translated_239_residues
MNKIRIALIEDHDLTRVGIRTALLQKEEIEVVGEAANATEGLNMLKKVQPDIAIVDIGLPDKDGIELTKELKSISNGADL
PTKVLILTLRDNKEAVLAAFAAGADSYCMKDIRFDNLLEAVRVTYNGNAWIDPAIARIVLQQAQQQSPKPVTTITEAKNS
FANSETEDNLETIDSYTLTERELEVLQLIVEGCSNAVIAERLYITVGTVKTHVRNILNKLCADDRTQAAVRALRSGLVG
>Mature_239_residues
MNKIRIALIEDHDLTRVGIRTALLQKEEIEVVGEAANATEGLNMLKKVQPDIAIVDIGLPDKDGIELTKELKSISNGADL
PTKVLILTLRDNKEAVLAAFAAGADSYCMKDIRFDNLLEAVRVTYNGNAWIDPAIARIVLQQAQQQSPKPVTTITEAKNS
FANSETEDNLETIDSYTLTERELEVLQLIVEGCSNAVIAERLYITVGTVKTHVRNILNKLCADDRTQAAVRALRSGLVG

Specific function: Regulating factor for the production of extracellular proteases. The N-terminal region acts as an inhibitor, whereas the C-terminal region carries enhancing activity [H]

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1787473, Length=225, Percent_Identity=30.6666666666667, Blast_Score=91, Evalue=5e-20,
Organism=Escherichia coli, GI1788521, Length=231, Percent_Identity=28.5714285714286, Blast_Score=90, Evalue=1e-19,
Organism=Escherichia coli, GI1788222, Length=234, Percent_Identity=26.9230769230769, Blast_Score=78, Evalue=5e-16,
Organism=Escherichia coli, GI1788712, Length=220, Percent_Identity=25.4545454545455, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1786747, Length=220, Percent_Identity=24.0909090909091, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1787375, Length=126, Percent_Identity=30.952380952381, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1788546, Length=227, Percent_Identity=25.5506607929515, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI87082052, Length=109, Percent_Identity=31.1926605504587, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 26180; Mature: 26180

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00622 HTH_LUXR_1 ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKIRIALIEDHDLTRVGIRTALLQKEEIEVVGEAANATEGLNMLKKVQPDIAIVDIGLP
CCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEECCCC
DKDGIELTKELKSISNGADLPTKVLILTLRDNKEAVLAAFAAGADSYCMKDIRFDNLLEA
CCCHHHHHHHHHHHCCCCCCCEEEEEEEEECCCHHHHHHHHCCCHHHHHHHCCHHHHHHH
VRVTYNGNAWIDPAIARIVLQQAQQQSPKPVTTITEAKNSFANSETEDNLETIDSYTLTE
HEEEECCCCEECHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
RELEVLQLIVEGCSNAVIAERLYITVGTVKTHVRNILNKLCADDRTQAAVRALRSGLVG
HHHHHHHHHHHHCCCHHHHHHHEEEEHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNKIRIALIEDHDLTRVGIRTALLQKEEIEVVGEAANATEGLNMLKKVQPDIAIVDIGLP
CCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEECCCC
DKDGIELTKELKSISNGADLPTKVLILTLRDNKEAVLAAFAAGADSYCMKDIRFDNLLEA
CCCHHHHHHHHHHHCCCCCCCEEEEEEEEECCCHHHHHHHHCCCHHHHHHHCCHHHHHHH
VRVTYNGNAWIDPAIARIVLQQAQQQSPKPVTTITEAKNSFANSETEDNLETIDSYTLTE
HEEEECCCCEECHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
RELEVLQLIVEGCSNAVIAERLYITVGTVKTHVRNILNKLCADDRTQAAVRALRSGLVG
HHHHHHHHHHHHCCCHHHHHHHEEEEHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7765823 [H]