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The map label for this gene is dctB [H]

Identifier: 17228138

GI number: 17228138

Start: 744780

End: 746987

Strand: Direct

Name: dctB [H]

Synonym: alr0642

Alternate gene names: 17228138

Gene position: 744780-746987 (Clockwise)

Preceding gene: 17228132

Following gene: 17228139

Centisome position: 11.61

GC content: 40.99

Gene sequence:

>2208_bases
ATGAATATGAAAAGGCGTAACTTTAGCAAAGTGCAAGCTTTCCCATTACAGATGGTTTTAATTGTTCCATTTGTTCTGCA
AATTTTTGGGGCTGTGGGTTTGGTTGGCTACTTGTCCTTTAAAAATGGACAGAAAACAGTGCAAGAGTTGGCAGAGCGAT
TAATGGATCAAACTAACAATAAAGTAGAGCAACATCTGGATGCTTATCTATCTATTCCTCACAGGGTGAACCAAATTAAT
GCTGGTGCAATTGAGATGGGATTATTGGATGTGCGCGATCGCCAAGCCATCAGCAAGTATTTTTGGCACCTCATGCAGGC
TTATGACGTTAGTTACATCGGCATTGGGCTGACAACAGGCGAAGGCGCGGGCGCGGCTCGCTACGATGGGAAAACGGTAA
CAATTGAAGATTGGGGAGCTAAGTTACCAAACAACGGCAAAAATTACGCCACTGATAACCAAGGTAATCGTATCCGTGTA
AAGAATACATTTAATTACAATAACTTTAATCAAAGTTGGTATACAGAACCAATCAAAGCAGGCAAACCCATCTGGTCGCG
CATCTACAGTTGGAATAAGGATAATGATTTATATATCACAGCTGCTACTGGTCGTCCTATCTATGATGCTCAAAAGCGAT
TGCTAGGGATGGTGGGTGCAGATATTCATCTTTTAAAACTCAGCCAATTTTTACGACGATTGGAAGTTAGTCGTTCGGGA
CAGGTCTTTATTGTAGAACGCAACGGAATGTTAATTGCTAACTCCAGTACTCAGACACCTTTCTCTGTAATTAATCATCA
AATTCATCGCCTGAAAGCAACCCACAGCCCAGATCCGGTAATTCAAGAAATCGCCAAACAGATTCAGCAAAATTCACAAG
GGTTTGAGTCGATTACTGAAGCGAAAAAATTACAACTCGAATGGCAAGGAGAACGTAATTATGTTTATGTCAACCCTTGG
CGTGATCAATATGGACTAGATTGGCTAGTAGTGGTGAGTGTGCCAGAAAAAGTTTTCATGTCCAAAATTAAGGCTCACAC
CCAAATTACTATAGCTCTGTGTTTAGGAGCATTAGCAATAGCAGTTTTAATCGGTTATTTCACATCAGTCTGGATTACTC
GCCCGATTTTGCGAATGAATTTAGCCAGTCAGGCGATCGCTTCAGGTAAACTAGACCAAAAAATAAATTTTAGTCATATT
CAGGAACTCAACATCCTGACTCAATCGTTTAATTATATGGCGGGAAAATTAAGTGAATTTTTTACCGCTTTAGAAACTAG
TAAAGCAGAATTGGAAGACCGGGTAGAACAACGTACTGCTGACCTCAAAACCGCTTTAACTGAGTTGCAACGTACCCAAG
CCCAGGTCATTCAAGGTGAAAAAATGTCGAGTTTGGGTCAACTAGTTGCAGGTGTTGCCCATGAAATAAATAATCCTGTA
AATTTCATTTACGGCAATATTACCCATCTCAACGCATATACTCAAGATTTGCTGAGAATGATTCATCTCTACCAAGAACG
TCATCCCAGCGATGACCCTGAGGTGCAAGCCCTAGCAACAGAAATTGATTTAGACTTTTTGGTCGAAGATTTGCAGAAGA
TGTTATCCTCGATGAACATGGGGACTGAACGTATTCGCAGCATTGTGTTATCGCTGCGGAACTTTTCCCGGATAGACGAA
GCGGAATTTAAAGCAGTGGACATTCATGAAGGAATCGAAAGTACGCTGTTAATTTTGCAACATCGCCTCAAAGATCAGCC
CGACAAACCAGCTATTGAAGTCATCCGCGACTATGGCAACCTACCACTTATAGAGTGCTATGCTGGACAACTAAATCAAG
TTTTGATGAATATTCTAGTCAACGCTATTGATGCCTTAGATGAACTCAACATCAAGCGTACTTATGAGGAAATCAAGGCA
AATCCTAGTCAAATTACTATCCGTACTTCGGTTAACGATGCTCAATGGATGGAAATTGCGATCGCTGATAATGGCCCAGG
AATACCAGAACAATTGAAAAACCGCATCTTTGACCCCTTCTTTACCACCAAACCCGTAGGCAAAGGCACAGGTATGGGTA
TGGCCATCAGCTATCAAATCATTACAGAAAAGCATAGTGGCAAATTAGAATGCTTCTCAACTGTTGGCCAGGGATCTGAA
TTTAGAATTCAAGTACCTATTCGACAAAAAAATTCTCTATTAGTTTAG

Upstream 100 bases:

>100_bases
GTGATTTCTGACGTGGGAATACTAGCCATGTAAGACCAAGCTTTGCTCATGGTTGTTAATTACCTGTACTTACAAAGGCA
GACATTGATGCAGGATAAAA

Downstream 100 bases:

>100_bases
GTAGGTTTCCCAAGCAGAAAGTTTTTTCGTCATACTCCCGCGTTAAGCTAATTCTCAAGTTGTAAAATTCGAGTGTTCAA
TTCAAGAACCCTAACTTTAC

Product: two-component sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 735; Mature: 735

Protein sequence:

>735_residues
MNMKRRNFSKVQAFPLQMVLIVPFVLQIFGAVGLVGYLSFKNGQKTVQELAERLMDQTNNKVEQHLDAYLSIPHRVNQIN
AGAIEMGLLDVRDRQAISKYFWHLMQAYDVSYIGIGLTTGEGAGAARYDGKTVTIEDWGAKLPNNGKNYATDNQGNRIRV
KNTFNYNNFNQSWYTEPIKAGKPIWSRIYSWNKDNDLYITAATGRPIYDAQKRLLGMVGADIHLLKLSQFLRRLEVSRSG
QVFIVERNGMLIANSSTQTPFSVINHQIHRLKATHSPDPVIQEIAKQIQQNSQGFESITEAKKLQLEWQGERNYVYVNPW
RDQYGLDWLVVVSVPEKVFMSKIKAHTQITIALCLGALAIAVLIGYFTSVWITRPILRMNLASQAIASGKLDQKINFSHI
QELNILTQSFNYMAGKLSEFFTALETSKAELEDRVEQRTADLKTALTELQRTQAQVIQGEKMSSLGQLVAGVAHEINNPV
NFIYGNITHLNAYTQDLLRMIHLYQERHPSDDPEVQALATEIDLDFLVEDLQKMLSSMNMGTERIRSIVLSLRNFSRIDE
AEFKAVDIHEGIESTLLILQHRLKDQPDKPAIEVIRDYGNLPLIECYAGQLNQVLMNILVNAIDALDELNIKRTYEEIKA
NPSQITIRTSVNDAQWMEIAIADNGPGIPEQLKNRIFDPFFTTKPVGKGTGMGMAISYQIITEKHSGKLECFSTVGQGSE
FRIQVPIRQKNSLLV

Sequences:

>Translated_735_residues
MNMKRRNFSKVQAFPLQMVLIVPFVLQIFGAVGLVGYLSFKNGQKTVQELAERLMDQTNNKVEQHLDAYLSIPHRVNQIN
AGAIEMGLLDVRDRQAISKYFWHLMQAYDVSYIGIGLTTGEGAGAARYDGKTVTIEDWGAKLPNNGKNYATDNQGNRIRV
KNTFNYNNFNQSWYTEPIKAGKPIWSRIYSWNKDNDLYITAATGRPIYDAQKRLLGMVGADIHLLKLSQFLRRLEVSRSG
QVFIVERNGMLIANSSTQTPFSVINHQIHRLKATHSPDPVIQEIAKQIQQNSQGFESITEAKKLQLEWQGERNYVYVNPW
RDQYGLDWLVVVSVPEKVFMSKIKAHTQITIALCLGALAIAVLIGYFTSVWITRPILRMNLASQAIASGKLDQKINFSHI
QELNILTQSFNYMAGKLSEFFTALETSKAELEDRVEQRTADLKTALTELQRTQAQVIQGEKMSSLGQLVAGVAHEINNPV
NFIYGNITHLNAYTQDLLRMIHLYQERHPSDDPEVQALATEIDLDFLVEDLQKMLSSMNMGTERIRSIVLSLRNFSRIDE
AEFKAVDIHEGIESTLLILQHRLKDQPDKPAIEVIRDYGNLPLIECYAGQLNQVLMNILVNAIDALDELNIKRTYEEIKA
NPSQITIRTSVNDAQWMEIAIADNGPGIPEQLKNRIFDPFFTTKPVGKGTGMGMAISYQIITEKHSGKLECFSTVGQGSE
FRIQVPIRQKNSLLV
>Mature_735_residues
MNMKRRNFSKVQAFPLQMVLIVPFVLQIFGAVGLVGYLSFKNGQKTVQELAERLMDQTNNKVEQHLDAYLSIPHRVNQIN
AGAIEMGLLDVRDRQAISKYFWHLMQAYDVSYIGIGLTTGEGAGAARYDGKTVTIEDWGAKLPNNGKNYATDNQGNRIRV
KNTFNYNNFNQSWYTEPIKAGKPIWSRIYSWNKDNDLYITAATGRPIYDAQKRLLGMVGADIHLLKLSQFLRRLEVSRSG
QVFIVERNGMLIANSSTQTPFSVINHQIHRLKATHSPDPVIQEIAKQIQQNSQGFESITEAKKLQLEWQGERNYVYVNPW
RDQYGLDWLVVVSVPEKVFMSKIKAHTQITIALCLGALAIAVLIGYFTSVWITRPILRMNLASQAIASGKLDQKINFSHI
QELNILTQSFNYMAGKLSEFFTALETSKAELEDRVEQRTADLKTALTELQRTQAQVIQGEKMSSLGQLVAGVAHEINNPV
NFIYGNITHLNAYTQDLLRMIHLYQERHPSDDPEVQALATEIDLDFLVEDLQKMLSSMNMGTERIRSIVLSLRNFSRIDE
AEFKAVDIHEGIESTLLILQHRLKDQPDKPAIEVIRDYGNLPLIECYAGQLNQVLMNILVNAIDALDELNIKRTYEEIKA
NPSQITIRTSVNDAQWMEIAIADNGPGIPEQLKNRIFDPFFTTKPVGKGTGMGMAISYQIITEKHSGKLECFSTVGQGSE
FRIQVPIRQKNSLLV

Specific function: Member of the two-component regulatory system dctB/dctD involved in the transport of C4-dicarboxylates. DctB functions as a membrane-associated protein kinase that phosphorylates dctD in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788549, Length=284, Percent_Identity=31.3380281690141, Blast_Score=107, Evalue=3e-24,
Organism=Escherichia coli, GI1790436, Length=285, Percent_Identity=27.0175438596491, Blast_Score=92, Evalue=8e-20,
Organism=Escherichia coli, GI87081816, Length=427, Percent_Identity=24.3559718969555, Blast_Score=80, Evalue=6e-16,
Organism=Escherichia coli, GI1789149, Length=538, Percent_Identity=24.5353159851301, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1790300, Length=270, Percent_Identity=28.1481481481481, Blast_Score=71, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR017055
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 83196; Mature: 83196

Theoretical pI: Translated: 7.79; Mature: 7.79

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNMKRRNFSKVQAFPLQMVLIVPFVLQIFGAVGLVGYLSFKNGQKTVQELAERLMDQTNN
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCH
KVEQHLDAYLSIPHRVNQINAGAIEMGLLDVRDRQAISKYFWHLMQAYDVSYIGIGLTTG
HHHHHHHHHHCCCHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHCCEEEEEEEECC
EGAGAARYDGKTVTIEDWGAKLPNNGKNYATDNQGNRIRVKNTFNYNNFNQSWYTEPIKA
CCCCCEECCCCEEEEECCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCHHC
GKPIWSRIYSWNKDNDLYITAATGRPIYDAQKRLLGMVGADIHLLKLSQFLRRLEVSRSG
CCHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCC
QVFIVERNGMLIANSSTQTPFSVINHQIHRLKATHSPDPVIQEIAKQIQQNSQGFESITE
CEEEEECCCEEEECCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCHHHHHHH
AKKLQLEWQGERNYVYVNPWRDQYGLDWLVVVSVPEKVFMSKIKAHTQITIALCLGALAI
HHHEEEEEECCCCEEEECCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHH
AVLIGYFTSVWITRPILRMNLASQAIASGKLDQKINFSHIQELNILTQSFNYMAGKLSEF
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
FTALETSKAELEDRVEQRTADLKTALTELQRTQAQVIQGEKMSSLGQLVAGVAHEINNPV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCC
NFIYGNITHLNAYTQDLLRMIHLYQERHPSDDPEVQALATEIDLDFLVEDLQKMLSSMNM
EEEECCEEEHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
GTERIRSIVLSLRNFSRIDEAEFKAVDIHEGIESTLLILQHRLKDQPDKPAIEVIRDYGN
CHHHHHHHHHHHHHHCCCCCCCCEEEEHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCC
LPLIECYAGQLNQVLMNILVNAIDALDELNIKRTYEEIKANPSQITIRTSVNDAQWMEIA
CCEEHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCEEEEEECCCCCEEEEEE
IADNGPGIPEQLKNRIFDPFFTTKPVGKGTGMGMAISYQIITEKHSGKLECFSTVGQGSE
EECCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEEEEECCCCCEEEHHHCCCCCE
FRIQVPIRQKNSLLV
EEEEEECCCCCCCCC
>Mature Secondary Structure
MNMKRRNFSKVQAFPLQMVLIVPFVLQIFGAVGLVGYLSFKNGQKTVQELAERLMDQTNN
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCH
KVEQHLDAYLSIPHRVNQINAGAIEMGLLDVRDRQAISKYFWHLMQAYDVSYIGIGLTTG
HHHHHHHHHHCCCHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHCCEEEEEEEECC
EGAGAARYDGKTVTIEDWGAKLPNNGKNYATDNQGNRIRVKNTFNYNNFNQSWYTEPIKA
CCCCCEECCCCEEEEECCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCHHC
GKPIWSRIYSWNKDNDLYITAATGRPIYDAQKRLLGMVGADIHLLKLSQFLRRLEVSRSG
CCHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCC
QVFIVERNGMLIANSSTQTPFSVINHQIHRLKATHSPDPVIQEIAKQIQQNSQGFESITE
CEEEEECCCEEEECCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCHHHHHHH
AKKLQLEWQGERNYVYVNPWRDQYGLDWLVVVSVPEKVFMSKIKAHTQITIALCLGALAI
HHHEEEEEECCCCEEEECCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHH
AVLIGYFTSVWITRPILRMNLASQAIASGKLDQKINFSHIQELNILTQSFNYMAGKLSEF
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
FTALETSKAELEDRVEQRTADLKTALTELQRTQAQVIQGEKMSSLGQLVAGVAHEINNPV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCC
NFIYGNITHLNAYTQDLLRMIHLYQERHPSDDPEVQALATEIDLDFLVEDLQKMLSSMNM
EEEECCEEEHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
GTERIRSIVLSLRNFSRIDEAEFKAVDIHEGIESTLLILQHRLKDQPDKPAIEVIRDYGN
CHHHHHHHHHHHHHHCCCCCCCCEEEEHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCC
LPLIECYAGQLNQVLMNILVNAIDALDELNIKRTYEEIKANPSQITIRTSVNDAQWMEIA
CCEEHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCEEEEEECCCCCEEEEEE
IADNGPGIPEQLKNRIFDPFFTTKPVGKGTGMGMAISYQIITEKHSGKLECFSTVGQGSE
EECCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEEEEECCCCCEEEHHHCCCCCE
FRIQVPIRQKNSLLV
EEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3671068 [H]