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The map label for this gene is manA [H]

Identifier: 17227786

GI number: 17227786

Start: 327539

End: 329509

Strand: Direct

Name: manA [H]

Synonym: alr0290

Alternate gene names: 17227786

Gene position: 327539-329509 (Clockwise)

Preceding gene: 17227785

Following gene: 17227791

Centisome position: 5.11

GC content: 37.09

Gene sequence:

>1971_bases
ATGGTAATTCATATTACTTTTATAAAAATGCAGCCTACTAACCCAAATTTTTCAAATGTCCAGATTATCAAAAATAAAAT
TTACGACCTTAATGGACAAGCATTTATTACTGAAGTAATCCATCCTTTTGCATGGGATGACATTTATGATATTTATTTAA
ATATTTGGGGATTAGACCATATTAGATATGCTGATTTTTTATTAGAAAATAATCATCAAGCTTACTCTGGGTATGACAAT
CATGAAATAGACAAAAAGACTGTAGATATCTATACTATTCAAGATGCGGTGGTCATGTTTGAAATTCATGACGGCATTGG
TGCATACAAGAATATTAGTAATCCCAGAAATCAATTTTATACTCATGGTATTAACATTAGTTTTGGGGATTACGGCTCTG
AGGATATAGGACTAGATGTTACATCGGCAGCCTCAAAATTCTCAAATTTTAAGATAATTGGCGATAAGATTTATGACCCC
AATGGGCAAGAATTTATTGCCAAAGGCATCAATACGTTCACATGGGATAAGGACTACAATATTTATTTAGATAATTGGGG
ATTTAACACTATTAGAGTTCCTAATTATTTATTAGGAAGTTATAATCAACCTCACCCTGCACAGGACAATTATCAAACAA
ACAAAAATATTGTCAATGTTTACACAAGTCAAAACGCAGTAGTTATTTTTGATGCTCACGATCGCATTGGTGGATATTAC
CAAGGAGATCAATGGGAAATCCTCAAAGACTATTGGCGCGAAATGGCGAAGCAGTTTAAAGATAATCCTTATGTTTGGTT
TAACTTACATAATGAACCTGGCAACAGTCAAGCACAACCTGAAAAATGGGTAAATTATCACCGTCAATTAATTGACATAA
TCCGAGCCGAAGGTGCTAACAATGTCATCGTGGTTGATGGAGAAGCGTGGGGACAAGACTATCTCACTCAGACAATTGCT
AGTCATGCTCACAATATTATGGCAGGTAACGAAAATATATTATTTTCGCTCCATGTTTACGACCAGTGGCTTAACAAGGA
TATTGGGGCTTATTTTGATCGCCTCCAAGCTCAGGATATTCCCATCATCGTCGGAGAATACGGCTCTGAAAATATAGGAC
TAGATGTTACGCAAGCGAGCGTCAATATGATGTTGGCAGCGCAGCCACGAGAGATTGGACGAATTGCTTGGGTGGGAAAA
GCTAACGATAACAATGATTTAACTTATGGAAAAGGAGGACACGCTTATTATTTCGATGGTAATAACACAGAGATTTTGAC
TGATTTGGGTCGTCTGACATGGCAAGATTTGCAGCGAAGCGAGAATTTAGGTTATGCAGATCACAATTTTTGGACACGCT
TTACTAGCCCTGATAAAGCTTCTGAAGCATCTGAGCAAGGAGTTTATGACATCGTAATTAGGGACATTTCTGGTAATAAA
AACTTCCCCAATAAACTTCAATCTAGCATCTTCATCTCAGGTGATAATGGCAACAATAAATTTGACGGTGGAGATCAAGA
TGATGTACTGATTGGTGGAGATGGTTCTGACAAACTATCAGGTCAGAATGGTAACGATTTACTAGTGGGCGGTAAAGGCA
ATGATGAACTAACAGGTGGTTCAGGTAATGATATTTTTTATATCGACGGCAGAGATGTCGGTAAGGATATAATCACAGAC
TTTAACCCACAAAATGATGCACTTTACATAAACAATATTATGGAAATTGCCCAAGCTTGGACTGATACCGGGCTTGATAA
GGCTAATCGTTATGGTCATCTAGGTGCGCTTCGAGTTACCAATCTAAAAGAGCTAGCTGATTTAACCGGAGTTCTTAACA
ATTTGGGAGGTAGTTTTGGAGCATACACTATTAAGAATCAAAATCAGCTAATTCTTGATCTTGGTGATACAGTCATTCAC
CTCAATGGTTTGTCTAATTATGTTCAACCCATCCAAGCACCATTAATCTGA

Upstream 100 bases:

>100_bases
TTATTTACATGAACACGTAAGCAAATATCATGAGTTTTATTGATAACTAGTAGTAAGTACATTTGACGTTGTTTCAAGTT
TTAAAAACTGCAAGTATTGA

Downstream 100 bases:

>100_bases
TAGGAAGTATGGCTGTTGACTGTTGACGGTTGACAGACTTGAAAGCCTTGTTTGTTTGGGGTTTGGTCTCAGCTTGATAT
CCTAACGGGACATCAACATT

Product: hypothetical protein

Products: NA

Alternate protein names: Mannan endo-1,4-beta-mannosidase A; Beta-mannanase; Endo-1,4-mannanase; Endo-1,4-beta-glucanase; Cellulase [H]

Number of amino acids: Translated: 656; Mature: 656

Protein sequence:

>656_residues
MVIHITFIKMQPTNPNFSNVQIIKNKIYDLNGQAFITEVIHPFAWDDIYDIYLNIWGLDHIRYADFLLENNHQAYSGYDN
HEIDKKTVDIYTIQDAVVMFEIHDGIGAYKNISNPRNQFYTHGINISFGDYGSEDIGLDVTSAASKFSNFKIIGDKIYDP
NGQEFIAKGINTFTWDKDYNIYLDNWGFNTIRVPNYLLGSYNQPHPAQDNYQTNKNIVNVYTSQNAVVIFDAHDRIGGYY
QGDQWEILKDYWREMAKQFKDNPYVWFNLHNEPGNSQAQPEKWVNYHRQLIDIIRAEGANNVIVVDGEAWGQDYLTQTIA
SHAHNIMAGNENILFSLHVYDQWLNKDIGAYFDRLQAQDIPIIVGEYGSENIGLDVTQASVNMMLAAQPREIGRIAWVGK
ANDNNDLTYGKGGHAYYFDGNNTEILTDLGRLTWQDLQRSENLGYADHNFWTRFTSPDKASEASEQGVYDIVIRDISGNK
NFPNKLQSSIFISGDNGNNKFDGGDQDDVLIGGDGSDKLSGQNGNDLLVGGKGNDELTGGSGNDIFYIDGRDVGKDIITD
FNPQNDALYINNIMEIAQAWTDTGLDKANRYGHLGALRVTNLKELADLTGVLNNLGGSFGAYTIKNQNQLILDLGDTVIH
LNGLSNYVQPIQAPLI

Sequences:

>Translated_656_residues
MVIHITFIKMQPTNPNFSNVQIIKNKIYDLNGQAFITEVIHPFAWDDIYDIYLNIWGLDHIRYADFLLENNHQAYSGYDN
HEIDKKTVDIYTIQDAVVMFEIHDGIGAYKNISNPRNQFYTHGINISFGDYGSEDIGLDVTSAASKFSNFKIIGDKIYDP
NGQEFIAKGINTFTWDKDYNIYLDNWGFNTIRVPNYLLGSYNQPHPAQDNYQTNKNIVNVYTSQNAVVIFDAHDRIGGYY
QGDQWEILKDYWREMAKQFKDNPYVWFNLHNEPGNSQAQPEKWVNYHRQLIDIIRAEGANNVIVVDGEAWGQDYLTQTIA
SHAHNIMAGNENILFSLHVYDQWLNKDIGAYFDRLQAQDIPIIVGEYGSENIGLDVTQASVNMMLAAQPREIGRIAWVGK
ANDNNDLTYGKGGHAYYFDGNNTEILTDLGRLTWQDLQRSENLGYADHNFWTRFTSPDKASEASEQGVYDIVIRDISGNK
NFPNKLQSSIFISGDNGNNKFDGGDQDDVLIGGDGSDKLSGQNGNDLLVGGKGNDELTGGSGNDIFYIDGRDVGKDIITD
FNPQNDALYINNIMEIAQAWTDTGLDKANRYGHLGALRVTNLKELADLTGVLNNLGGSFGAYTIKNQNQLILDLGDTVIH
LNGLSNYVQPIQAPLI
>Mature_656_residues
MVIHITFIKMQPTNPNFSNVQIIKNKIYDLNGQAFITEVIHPFAWDDIYDIYLNIWGLDHIRYADFLLENNHQAYSGYDN
HEIDKKTVDIYTIQDAVVMFEIHDGIGAYKNISNPRNQFYTHGINISFGDYGSEDIGLDVTSAASKFSNFKIIGDKIYDP
NGQEFIAKGINTFTWDKDYNIYLDNWGFNTIRVPNYLLGSYNQPHPAQDNYQTNKNIVNVYTSQNAVVIFDAHDRIGGYY
QGDQWEILKDYWREMAKQFKDNPYVWFNLHNEPGNSQAQPEKWVNYHRQLIDIIRAEGANNVIVVDGEAWGQDYLTQTIA
SHAHNIMAGNENILFSLHVYDQWLNKDIGAYFDRLQAQDIPIIVGEYGSENIGLDVTQASVNMMLAAQPREIGRIAWVGK
ANDNNDLTYGKGGHAYYFDGNNTEILTDLGRLTWQDLQRSENLGYADHNFWTRFTSPDKASEASEQGVYDIVIRDISGNK
NFPNKLQSSIFISGDNGNNKFDGGDQDDVLIGGDGSDKLSGQNGNDLLVGGKGNDELTGGSGNDIFYIDGRDVGKDIITD
FNPQNDALYINNIMEIAQAWTDTGLDKANRYGHLGALRVTNLKELADLTGVLNNLGGSFGAYTIKNQNQLILDLGDTVIH
LNGLSNYVQPIQAPLI

Specific function: Degradation of hemicelluloses, the second most abundant polysaccharides in nature. Contains two catalytic domains with mannanase and endoglucanase activities [H]

COG id: COG2730

COG function: function code G; Endoglucanase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBM3 (carbohydrate binding type-3) domains [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008965
- InterPro:   IPR001956
- InterPro:   IPR001547
- InterPro:   IPR018087
- InterPro:   IPR017853
- InterPro:   IPR013781 [H]

Pfam domain/function: PF00942 CBM_3; PF00150 Cellulase [H]

EC number: =3.2.1.78; =3.2.1.4 [H]

Molecular weight: Translated: 73903; Mature: 73903

Theoretical pI: Translated: 4.44; Mature: 4.44

Prosite motif: PS00330 HEMOLYSIN_CALCIUM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVIHITFIKMQPTNPNFSNVQIIKNKIYDLNGQAFITEVIHPFAWDDIYDIYLNIWGLDH
CEEEEEEEEEECCCCCCCCEEEEEEEHEECCCCCHHHHHHCCCCCCCCEEEEEEEECCCH
IRYADFLLENNHQAYSGYDNHEIDKKTVDIYTIQDAVVMFEIHDGIGAYKNISNPRNQFY
HHHHHHHEECCCCEECCCCCCCCCCEEEEEEEEEEEEEEEEEECCCCCHHCCCCCCHHHE
THGINISFGDYGSEDIGLDVTSAASKFSNFKIIGDKIYDPNGQEFIAKGINTFTWDKDYN
EECEEEEECCCCCCCCCEEHHHHHHHCCCEEEEECEEECCCCHHHHHCCCCEEEECCCCE
IYLDNWGFNTIRVPNYLLGSYNQPHPAQDNYQTNKNIVNVYTSQNAVVIFDAHDRIGGYY
EEEECCCCCEEECCCHHHCCCCCCCCCCCCCCCCCCEEEEEECCCEEEEEECCCCCCCEE
QGDQWEILKDYWREMAKQFKDNPYVWFNLHNEPGNSQAQPEKWVNYHRQLIDIIRAEGAN
ECCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCC
NVIVVDGEAWGQDYLTQTIASHAHNIMAGNENILFSLHVYDQWLNKDIGAYFDRLQAQDI
CEEEECCCCCCHHHHHHHHHHHHHHEEECCCCEEEEEEEEHHHHCCHHHHHHHHHCCCCC
PIIVGEYGSENIGLDVTQASVNMMLAAQPREIGRIAWVGKANDNNDLTYGKGGHAYYFDG
CEEEECCCCCCCCEEEEECCEEEEEEECCCCCCEEEEEECCCCCCCEEECCCCEEEEECC
NNTEILTDLGRLTWQDLQRSENLGYADHNFWTRFTSPDKASEASEQGVYDIVIRDISGNK
CCCEEEHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCCHHHHCCEEEEEEEECCCCC
NFPNKLQSSIFISGDNGNNKFDGGDQDDVLIGGDGSDKLSGQNGNDLLVGGKGNDELTGG
CCCCHHCCEEEEEECCCCCCCCCCCCCCEEECCCCCCCCCCCCCCEEEEECCCCCCCCCC
SGNDIFYIDGRDVGKDIITDFNPQNDALYINNIMEIAQAWTDTGLDKANRYGHLGALRVT
CCCEEEEECCCCCCHHHHCCCCCCCCEEEHHHHHHHHHHHHHCCCHHHCCCCCCEEEEEC
NLKELADLTGVLNNLGGSFGAYTIKNQNQLILDLGDTVIHLNGLSNYVQPIQAPLI
CHHHHHHHHHHHHHCCCCCCEEEECCCCEEEEEECCEEEEECCHHHHHHHHHCCCC
>Mature Secondary Structure
MVIHITFIKMQPTNPNFSNVQIIKNKIYDLNGQAFITEVIHPFAWDDIYDIYLNIWGLDH
CEEEEEEEEEECCCCCCCCEEEEEEEHEECCCCCHHHHHHCCCCCCCCEEEEEEEECCCH
IRYADFLLENNHQAYSGYDNHEIDKKTVDIYTIQDAVVMFEIHDGIGAYKNISNPRNQFY
HHHHHHHEECCCCEECCCCCCCCCCEEEEEEEEEEEEEEEEEECCCCCHHCCCCCCHHHE
THGINISFGDYGSEDIGLDVTSAASKFSNFKIIGDKIYDPNGQEFIAKGINTFTWDKDYN
EECEEEEECCCCCCCCCEEHHHHHHHCCCEEEEECEEECCCCHHHHHCCCCEEEECCCCE
IYLDNWGFNTIRVPNYLLGSYNQPHPAQDNYQTNKNIVNVYTSQNAVVIFDAHDRIGGYY
EEEECCCCCEEECCCHHHCCCCCCCCCCCCCCCCCCEEEEEECCCEEEEEECCCCCCCEE
QGDQWEILKDYWREMAKQFKDNPYVWFNLHNEPGNSQAQPEKWVNYHRQLIDIIRAEGAN
ECCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCC
NVIVVDGEAWGQDYLTQTIASHAHNIMAGNENILFSLHVYDQWLNKDIGAYFDRLQAQDI
CEEEECCCCCCHHHHHHHHHHHHHHEEECCCCEEEEEEEEHHHHCCHHHHHHHHHCCCCC
PIIVGEYGSENIGLDVTQASVNMMLAAQPREIGRIAWVGKANDNNDLTYGKGGHAYYFDG
CEEEECCCCCCCCEEEEECCEEEEEEECCCCCCEEEEEECCCCCCCEEECCCCEEEEECC
NNTEILTDLGRLTWQDLQRSENLGYADHNFWTRFTSPDKASEASEQGVYDIVIRDISGNK
CCCEEEHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCCHHHHCCEEEEEEEECCCCC
NFPNKLQSSIFISGDNGNNKFDGGDQDDVLIGGDGSDKLSGQNGNDLLVGGKGNDELTGG
CCCCHHCCEEEEEECCCCCCCCCCCCCCEEECCCCCCCCCCCCCCEEEEECCCCCCCCCC
SGNDIFYIDGRDVGKDIITDFNPQNDALYINNIMEIAQAWTDTGLDKANRYGHLGALRVT
CCCEEEEECCCCCCHHHHCCCCCCCCEEEHHHHHHHHHHHHHCCCHHHCCCCCCEEEEEC
NLKELADLTGVLNNLGGSFGAYTIKNQNQLILDLGDTVIHLNGLSNYVQPIQAPLI
CHHHHHHHHHHHHHCCCCCCEEEECCCCEEEEEECCEEEEECCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1476429; 2039230 [H]