Click here to switch to the map view.

The map label for this gene is rnc

Identifier: 17227776

GI number: 17227776

Start: 309610

End: 310296

Strand: Direct

Name: rnc

Synonym: alr0280

Alternate gene names: 17227776

Gene position: 309610-310296 (Clockwise)

Preceding gene: 17227775

Following gene: 17227782

Centisome position: 4.83

GC content: 38.57

Gene sequence:

>687_bases
ATGTACAAACTTTTAATGTTTCGTGATGATAAACTTTTACGCCGCGCCCTTACCCATCGTTCTTATGTAAATGAAAATCC
AGAAGAAGGCGAACATAATGAACGCTTAGAATTTCTTGGTGATGCGATATTGAATTTTTTAAGTGGTGAGTATCTCTATC
GCAGTCACCCTGACAGGGGAGAAGATGAATTAACGCGACGGCGTTCGGCGTTGGTAGACGAAAAGCAACTAGCAAAATTT
GCTATTGAGGTAGGTTTAGATTTTAAAATGCGCCTGGGGAAAGGTGCTATTCGAGATGGCGGTTATCAAAATCCTAATTT
ACTTAGCAGCACCTTTGAAGCGGTGATTGGTGCTTATTATCTAGATAATAATTCCAATATTGAAGCTGTACGCGCAATTA
TAGAACCTTTATTTGAATCTGTACCCGAACAAATTGTAGTTGTTCGCTCTAATGTAGACTCAAAAAATCGGTTTCAGGAA
TGGGTACAACGAAACATCGGCCCAACTCCTCCCAAATACTTAACAGAACAAATAGGTGGTTTTTCTCATGCCCCAGAGTT
TAAGGCTACGGTTTTAGTAGGAGAAAAAGAATATGGTGAAGGTATAGGTAAAAATAAAAAAGATGCTGAGAAAGCAGCAG
CCGAAAATGCTTTAGCTAATTTGAATAAGCAAGAATTATTACCATGA

Upstream 100 bases:

>100_bases
GTCTTACCTAATCAGGTGATATCCCTACCATGTTTCCCCGATTTGTCTCTGGATTTAAATAAAATATTTCCACCTTCTCG
GCAATAATATAAAGATAAAG

Downstream 100 bases:

>100_bases
ATATACTCGAACATACCTACAAGATATATTTATCATGATGCTGTCAAGAATACCTTAATCCGTATTTCGTTACTCTTGAT
AGCGGGTTTTGGAGGGCAAT

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III

Number of amino acids: Translated: 228; Mature: 228

Protein sequence:

>228_residues
MYKLLMFRDDKLLRRALTHRSYVNENPEEGEHNERLEFLGDAILNFLSGEYLYRSHPDRGEDELTRRRSALVDEKQLAKF
AIEVGLDFKMRLGKGAIRDGGYQNPNLLSSTFEAVIGAYYLDNNSNIEAVRAIIEPLFESVPEQIVVVRSNVDSKNRFQE
WVQRNIGPTPPKYLTEQIGGFSHAPEFKATVLVGEKEYGEGIGKNKKDAEKAAAENALANLNKQELLP

Sequences:

>Translated_228_residues
MYKLLMFRDDKLLRRALTHRSYVNENPEEGEHNERLEFLGDAILNFLSGEYLYRSHPDRGEDELTRRRSALVDEKQLAKF
AIEVGLDFKMRLGKGAIRDGGYQNPNLLSSTFEAVIGAYYLDNNSNIEAVRAIIEPLFESVPEQIVVVRSNVDSKNRFQE
WVQRNIGPTPPKYLTEQIGGFSHAPEFKATVLVGEKEYGEGIGKNKKDAEKAAAENALANLNKQELLP
>Mature_228_residues
MYKLLMFRDDKLLRRALTHRSYVNENPEEGEHNERLEFLGDAILNFLSGEYLYRSHPDRGEDELTRRRSALVDEKQLAKF
AIEVGLDFKMRLGKGAIRDGGYQNPNLLSSTFEAVIGAYYLDNNSNIEAVRAIIEPLFESVPEQIVVVRSNVDSKNRFQE
WVQRNIGPTPPKYLTEQIGGFSHAPEFKATVLVGEKEYGEGIGKNKKDAEKAAAENALANLNKQELLP

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain

Homologues:

Organism=Homo sapiens, GI155030236, Length=227, Percent_Identity=31.7180616740088, Blast_Score=87, Evalue=9e-18,
Organism=Homo sapiens, GI155030234, Length=227, Percent_Identity=31.7180616740088, Blast_Score=87, Evalue=9e-18,
Organism=Escherichia coli, GI1788920, Length=216, Percent_Identity=37.962962962963, Blast_Score=112, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17506883, Length=227, Percent_Identity=29.5154185022026, Blast_Score=81, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI193202651, Length=227, Percent_Identity=29.5154185022026, Blast_Score=81, Evalue=4e-16,
Organism=Drosophila melanogaster, GI17137682, Length=236, Percent_Identity=28.8135593220339, Blast_Score=67, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RNC_NOSS1 (Q8Z023)

Other databases:

- EMBL:   BA000019
- PIR:   AH1841
- RefSeq:   NP_484324.1
- ProteinModelPortal:   Q8Z023
- SMR:   Q8Z023
- STRING:   Q8Z023
- GeneID:   1103877
- GenomeReviews:   BA000019_GR
- KEGG:   ana:alr0280
- NMPDR:   fig|103690.1.peg.591
- eggNOG:   COG0571
- HOGENOM:   HBG744556
- OMA:   ALTHKSF
- ProtClustDB:   CLSK895247
- BioCyc:   NSP103690:ALR0280-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00104
- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907
- Gene3D:   G3DSA:3.30.160.20
- Gene3D:   G3DSA:1.10.1520.10
- SMART:   SM00358
- SMART:   SM00535
- TIGRFAMs:   TIGR02191

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3; SSF69065 RNase_III

EC number: =3.1.26.3

Molecular weight: Translated: 25873; Mature: 25873

Theoretical pI: Translated: 5.46; Mature: 5.46

Prosite motif: PS50137 DS_RBD; PS00517 RNASE_3_1; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYKLLMFRDDKLLRRALTHRSYVNENPEEGEHNERLEFLGDAILNFLSGEYLYRSHPDRG
CCEEEEECCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCHHCCCCCCCC
EDELTRRRSALVDEKQLAKFAIEVGLDFKMRLGKGAIRDGGYQNPNLLSSTFEAVIGAYY
HHHHHHHHHHHHCHHHHHHHHHHHCCCHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
LDNNSNIEAVRAIIEPLFESVPEQIVVVRSNVDSKNRFQEWVQRNIGPTPPKYLTEQIGG
CCCCCCHHHHHHHHHHHHHHCCHHEEEEECCCCHHHHHHHHHHHCCCCCCHHHHHHHHCC
FSHAPEFKATVLVGEKEYGEGIGKNKKDAEKAAAENALANLNKQELLP
CCCCCCCEEEEEECCHHHHCCCCCCHHHHHHHHHHHHHHCCCHHHCCC
>Mature Secondary Structure
MYKLLMFRDDKLLRRALTHRSYVNENPEEGEHNERLEFLGDAILNFLSGEYLYRSHPDRG
CCEEEEECCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCHHCCCCCCCC
EDELTRRRSALVDEKQLAKFAIEVGLDFKMRLGKGAIRDGGYQNPNLLSSTFEAVIGAYY
HHHHHHHHHHHHCHHHHHHHHHHHCCCHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
LDNNSNIEAVRAIIEPLFESVPEQIVVVRSNVDSKNRFQEWVQRNIGPTPPKYLTEQIGG
CCCCCCHHHHHHHHHHHHHHCCHHEEEEECCCCHHHHHHHHHHHCCCCCCHHHHHHHHCC
FSHAPEFKATVLVGEKEYGEGIGKNKKDAEKAAAENALANLNKQELLP
CCCCCCCEEEEEECCHHHHCCCCCCHHHHHHHHHHHHHHCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11759840