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The map label for this gene is ubiB [C]

Identifier: 17227685

GI number: 17227685

Start: 203773

End: 205416

Strand: Direct

Name: ubiB [C]

Synonym: alr0189

Alternate gene names: 17227685

Gene position: 203773-205416 (Clockwise)

Preceding gene: 17227684

Following gene: 17227686

Centisome position: 3.18

GC content: 43.07

Gene sequence:

>1644_bases
ATGTTCCTCACCCAAACTGTCCCCCGTCAACGAGAAATTATTGAAGTTGTCCTCCGCAATGGCTGGGATTATATGCGGCG
GCTACTTACAGGTGGTAAGGCTGATGAACCCCAACTACCGACACCTGCGGTTTTAAAGAATATTTTGGTGGACTTAGGGC
CGGTTTATGTGAAACTCGGTCAGCTGATGTCTACCCGTCCAGATTTACTCAGTGCGGCTTACATTGAGGAACTTTCTACA
CTTCAAGATGAAGTACCACCTGTTCCTTGGATAGATATTGAAATTCTCATCCGCAAACAATTAAAACGCCCTCTGGAAGA
AACTTTCAGTAAAGTTAACCCTATACCTGTGGCGGCGGGATCAATTGCTCAGACTCACCGCGCTACATTGATAGATGGTC
GGGAAGTGGCGCTGAAGGTGCAACGACCGGGGATCGATCTGACTATTGCCCAAGATATTGCTTTAATTCAAGGAATTGCT
GATTTGGTGGCGCGTACCGATTTTGGGCAGAACTACGAAATTAAATCAATTGCAGAAGAATTTACCAAAGCTTTAGAAGC
AGAGTTAGATTTTACACGGGAAGCAGGACATACAGACCTATTGCGCCGTAATTTATCTCGTAGTCGCTGGTTTGATCCCA
CACAGCTAGTAGTAGCTGAGATTTACTGGTCTTTAACTACAGAAAAATTAATGGTGATGGAATGGCTAGATGGTGTACCA
ATACTGTCAGCAAGCTTGAACAATAATAACGGTAAAGACCCGGTAGCCGAACGTAAAGCAGTGACGACTCTGTTATTTCG
GGCTTTCTTTCAGCAGTTATATGTTGATGGCTTTTTCCATGCTGATCCCCATCCGGGGAATATCTTTTATCTCAGTGATG
GTCGTGTTGCTCTGTTAGATTGTGGCATGGTGGGCAGACTTGATCCCCGTACTCAGCAGATATTAACAGAAATGTTGTTG
GCGATCGTCGATTTAGATGCGGGGCGATGCGCTCAATTAACATTGCAATTGTCAGATTCCGCCCAACCAGTGATTTTGTC
TCGCTTAGAAAGCGATTATGACCGGATGTTGCGGAAGTATTATAACGTTAGTTTGACTGAGATGAATTTTAGTCAAATTT
TTTATGAAATTTTGCAAATTGCTAGAAATAACAAAATTCGTTTACCCAGCAATATGGGTTTGTATGCCAAGACTATAGCG
AATTTGGAAGGGGTGGCACAGACCTTTAATCCAGAGGTAAATTTATTTGATGAAATTCAACCATTAATTACAGATTTGTT
TCGGCGGCAGTTATTGGGGGATAATCCAGTGCGATCGCTCCTGAGAACAGCCTTAGATTTAAAAAGTCTCTCTCTACAAT
CTCCCCGACAAATCGAACTATTATTAGACCGGGTAACATCAGAAACTCTGCGGTGGAATCTTTCCCTACATGGTTTAGAT
GGTGTGCGCCGCACAATGGACGATGCTGCCAATCGCTTGTCATTCAGTATACTAGTGGGTTCACTGATTATGGGTGCAGC
AGTTATATCTAATAATGCTCAGACAAGTGAGTTGTCATTTTTGAGTAGTGTCTTGTTTGCAGTGGCGAGTTTGTTGGGAT
TGTGGCTAATTGTGAGTATATTGCGATCGGGTCGTTTAAAATAA

Upstream 100 bases:

>100_bases
GTGTAGGGAGGAGGAGAAGGGGAAATCATACTGAAATATTCTCCTCCTTGCTCCCTGCTCCCTGCGCCAATTCCCATTCC
CCACTCCCAACTCCCCAACA

Downstream 100 bases:

>100_bases
TTTTTTTTAACGCAGCGAAAAGTTCTGTTCGTGTAGCGTCTCCGTCAGGAGAAGGAGGGTTTCCCTTCGTAGGAACGCCA
CTTGCTACAAGCCGGGGAAC

Product: hypothetical protein

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 547; Mature: 547

Protein sequence:

>547_residues
MFLTQTVPRQREIIEVVLRNGWDYMRRLLTGGKADEPQLPTPAVLKNILVDLGPVYVKLGQLMSTRPDLLSAAYIEELST
LQDEVPPVPWIDIEILIRKQLKRPLEETFSKVNPIPVAAGSIAQTHRATLIDGREVALKVQRPGIDLTIAQDIALIQGIA
DLVARTDFGQNYEIKSIAEEFTKALEAELDFTREAGHTDLLRRNLSRSRWFDPTQLVVAEIYWSLTTEKLMVMEWLDGVP
ILSASLNNNNGKDPVAERKAVTTLLFRAFFQQLYVDGFFHADPHPGNIFYLSDGRVALLDCGMVGRLDPRTQQILTEMLL
AIVDLDAGRCAQLTLQLSDSAQPVILSRLESDYDRMLRKYYNVSLTEMNFSQIFYEILQIARNNKIRLPSNMGLYAKTIA
NLEGVAQTFNPEVNLFDEIQPLITDLFRRQLLGDNPVRSLLRTALDLKSLSLQSPRQIELLLDRVTSETLRWNLSLHGLD
GVRRTMDDAANRLSFSILVGSLIMGAAVISNNAQTSELSFLSSVLFAVASLLGLWLIVSILRSGRLK

Sequences:

>Translated_547_residues
MFLTQTVPRQREIIEVVLRNGWDYMRRLLTGGKADEPQLPTPAVLKNILVDLGPVYVKLGQLMSTRPDLLSAAYIEELST
LQDEVPPVPWIDIEILIRKQLKRPLEETFSKVNPIPVAAGSIAQTHRATLIDGREVALKVQRPGIDLTIAQDIALIQGIA
DLVARTDFGQNYEIKSIAEEFTKALEAELDFTREAGHTDLLRRNLSRSRWFDPTQLVVAEIYWSLTTEKLMVMEWLDGVP
ILSASLNNNNGKDPVAERKAVTTLLFRAFFQQLYVDGFFHADPHPGNIFYLSDGRVALLDCGMVGRLDPRTQQILTEMLL
AIVDLDAGRCAQLTLQLSDSAQPVILSRLESDYDRMLRKYYNVSLTEMNFSQIFYEILQIARNNKIRLPSNMGLYAKTIA
NLEGVAQTFNPEVNLFDEIQPLITDLFRRQLLGDNPVRSLLRTALDLKSLSLQSPRQIELLLDRVTSETLRWNLSLHGLD
GVRRTMDDAANRLSFSILVGSLIMGAAVISNNAQTSELSFLSSVLFAVASLLGLWLIVSILRSGRLK
>Mature_547_residues
MFLTQTVPRQREIIEVVLRNGWDYMRRLLTGGKADEPQLPTPAVLKNILVDLGPVYVKLGQLMSTRPDLLSAAYIEELST
LQDEVPPVPWIDIEILIRKQLKRPLEETFSKVNPIPVAAGSIAQTHRATLIDGREVALKVQRPGIDLTIAQDIALIQGIA
DLVARTDFGQNYEIKSIAEEFTKALEAELDFTREAGHTDLLRRNLSRSRWFDPTQLVVAEIYWSLTTEKLMVMEWLDGVP
ILSASLNNNNGKDPVAERKAVTTLLFRAFFQQLYVDGFFHADPHPGNIFYLSDGRVALLDCGMVGRLDPRTQQILTEMLL
AIVDLDAGRCAQLTLQLSDSAQPVILSRLESDYDRMLRKYYNVSLTEMNFSQIFYEILQIARNNKIRLPSNMGLYAKTIA
NLEGVAQTFNPEVNLFDEIQPLITDLFRRQLLGDNPVRSLLRTALDLKSLSLQSPRQIELLLDRVTSETLRWNLSLHGLD
GVRRTMDDAANRLSFSILVGSLIMGAAVISNNAQTSELSFLSSVLFAVASLLGLWLIVSILRSGRLK

Specific function: Required, Probably Indirectly, For The Hydroxylation Of 2-Octaprenylphenol To 2-Octaprenyl-6-Hydroxy-Phenol, The Fourth Step In Ubiquinone Biosynthesis. Specific For Aerobically Grown Log-Phase Cells. [C]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the protein kinase superfamily. ADCK protein kinase family [H]

Homologues:

Organism=Homo sapiens, GI40254938, Length=271, Percent_Identity=29.520295202952, Blast_Score=119, Evalue=7e-27,
Organism=Homo sapiens, GI217035081, Length=276, Percent_Identity=29.3478260869565, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI41393593, Length=277, Percent_Identity=27.4368231046931, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI27363457, Length=281, Percent_Identity=25.2669039145907, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI217416386, Length=241, Percent_Identity=27.3858921161826, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI2367309, Length=400, Percent_Identity=30.25, Blast_Score=173, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI17559152, Length=279, Percent_Identity=26.8817204301075, Blast_Score=108, Evalue=9e-24,
Organism=Saccharomyces cerevisiae, GI6323282, Length=286, Percent_Identity=24.4755244755245, Blast_Score=94, Evalue=7e-20,
Organism=Saccharomyces cerevisiae, GI6325148, Length=433, Percent_Identity=20.7852193995381, Blast_Score=88, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6321319, Length=267, Percent_Identity=26.5917602996255, Blast_Score=77, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24662575, Length=279, Percent_Identity=31.1827956989247, Blast_Score=130, Evalue=3e-30,
Organism=Drosophila melanogaster, GI22024280, Length=321, Percent_Identity=26.791277258567, Blast_Score=123, Evalue=3e-28,
Organism=Drosophila melanogaster, GI18859849, Length=279, Percent_Identity=25.089605734767, Blast_Score=76, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009
- InterPro:   IPR000719 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 61499; Mature: 61499

Theoretical pI: Translated: 5.42; Mature: 5.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFLTQTVPRQREIIEVVLRNGWDYMRRLLTGGKADEPQLPTPAVLKNILVDLGPVYVKLG
CCCCCCCCHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
QLMSTRPDLLSAAYIEELSTLQDEVPPVPWIDIEILIRKQLKRPLEETFSKVNPIPVAAG
HHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
SIAQTHRATLIDGREVALKVQRPGIDLTIAQDIALIQGIADLVARTDFGQNYEIKSIAEE
CHHHHHHHHEECCCEEEEEEECCCCCEEHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
FTKALEAELDFTREAGHTDLLRRNLSRSRWFDPTQLVVAEIYWSLTTEKLMVMEWLDGVP
HHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
ILSASLNNNNGKDPVAERKAVTTLLFRAFFQQLYVDGFFHADPHPGNIFYLSDGRVALLD
EEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCEEEEE
CGMVGRLDPRTQQILTEMLLAIVDLDAGRCAQLTLQLSDSAQPVILSRLESDYDRMLRKY
CCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHH
YNVSLTEMNFSQIFYEILQIARNNKIRLPSNMGLYAKTIANLEGVAQTFNPEVNLFDEIQ
HCCEEEECCHHHHHHHHHHHHCCCCEECCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHH
PLITDLFRRQLLGDNPVRSLLRTALDLKSLSLQSPRQIELLLDRVTSETLRWNLSLHGLD
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHEEEEEEECCH
GVRRTMDDAANRLSFSILVGSLIMGAAVISNNAQTSELSFLSSVLFAVASLLGLWLIVSI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LRSGRLK
HHHCCCC
>Mature Secondary Structure
MFLTQTVPRQREIIEVVLRNGWDYMRRLLTGGKADEPQLPTPAVLKNILVDLGPVYVKLG
CCCCCCCCHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
QLMSTRPDLLSAAYIEELSTLQDEVPPVPWIDIEILIRKQLKRPLEETFSKVNPIPVAAG
HHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
SIAQTHRATLIDGREVALKVQRPGIDLTIAQDIALIQGIADLVARTDFGQNYEIKSIAEE
CHHHHHHHHEECCCEEEEEEECCCCCEEHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
FTKALEAELDFTREAGHTDLLRRNLSRSRWFDPTQLVVAEIYWSLTTEKLMVMEWLDGVP
HHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
ILSASLNNNNGKDPVAERKAVTTLLFRAFFQQLYVDGFFHADPHPGNIFYLSDGRVALLD
EEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCEEEEE
CGMVGRLDPRTQQILTEMLLAIVDLDAGRCAQLTLQLSDSAQPVILSRLESDYDRMLRKY
CCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHH
YNVSLTEMNFSQIFYEILQIARNNKIRLPSNMGLYAKTIANLEGVAQTFNPEVNLFDEIQ
HCCEEEECCHHHHHHHHHHHHCCCCEECCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHH
PLITDLFRRQLLGDNPVRSLLRTALDLKSLSLQSPRQIELLLDRVTSETLRWNLSLHGLD
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHEEEEEEECCH
GVRRTMDDAANRLSFSILVGSLIMGAAVISNNAQTSELSFLSSVLFAVASLLGLWLIVSI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LRSGRLK
HHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]