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The map label for this gene is manC [H]

Identifier: 17227684

GI number: 17227684

Start: 202511

End: 203587

Strand: Direct

Name: manC [H]

Synonym: alr0188

Alternate gene names: 17227684

Gene position: 202511-203587 (Clockwise)

Preceding gene: 17227679

Following gene: 17227685

Centisome position: 3.16

GC content: 44.29

Gene sequence:

>1077_bases
GTGTATGACAACATGAGTAGCCCATTGTTCCCAGTAATCCTGGCTGGTGGTAAAGGCGAACGTTTTTGGCCTCTTAGCCG
CCAAGATCGACCCAAACAATTTTTAAGTCTTGATGGTAGCTCCAGAAGTCTATTGCAATCAACCGCCGAGCGACTGGTTA
AGTTCGCAGGCGAGTGGAATGACCTATGGGTAATCACCTCTAGTCAGTTAGGACAAGGGGTGCAACAACAACTACCCGAA
TTACCATCGCAAAATTTGTTGACTGAGCCGCAGGGTAGAGACACGGCTGCGGCCGTTGCTTGGGCCAGTTTGGAAATTCA
AAAGCGTTATGGTGATGACGCGATTATAGGCTTTTTTCCCTCCGATCACTGGATAGCTGATCCGGAGGCGTTTAAACGCA
CTTTAGATGCTGCTAGCCAATTAGCGACAAGCACAGAGGCAATTGTCACTTTGGGGATCAAACCGACTTTCCCATCAACT
GGTTACGGCTACATTGAACAAGGAGAAAAAATTGGTACCTTTAATGAGTTGCCAGCTTATCATGTCAATCGCTTTACTGA
AAAGCCTATCCGGGAAAAAGCCGAAAGTTTTCTGTCTACGGGACGATATAGCTGGAATAGCGGTATGTTTGTTTTCCGAG
CCGGAGTTGTTCTTAAGGAACTCTATACCTATGCGCCAGAAATCATTGAACCACTTGTAAAACATGGGGTTGATGTTTAT
CCCCAGTTACCTAAACAGAGTATAGACTACGCACTCATGGAAAAGACAAATCTAGTATATGTCTTACCAGCAGATTTTGG
GTGGGATGATTTAGGAGATTGGAATGCGATCGAGCGTTTACTAAAAAAACCTGATAATCCTAATGTAGAACTAGCTACTC
ATGTGGGTCTAGATACTCAGGGGGCGATTGTTTATGCGACTAATCCAGAGGATGTAATTGTTACTATTGGTTTAGAGGAT
GTAGTGATTGTGCGCGATCGCAATGTTACTCTCATAGTCAATAAGGAACGTACCCAGGAAATCAAACAAATCCTCAAAAC
CTTACAAAGCGATCCCCGATTTACTGACCTACTCTAA

Upstream 100 bases:

>100_bases
ATCTCCCCACTCAACCACTCCCTAAAATTTATGTTAAAGCAAGCTACCAATCTTGCCAGTGTAAGACCGCACTGTACACT
TGAAATGTTCTACCGTTTGT

Downstream 100 bases:

>100_bases
TTATACTAAGTTGTAAAAGTTAAAACCCTTGGCAGAGGTTGAACTGCGGGGTTTTTATTATAACTAGCTATGAAGAGGCA
GAGGGGTGTAGGGAGGAGGA

Product: GDP-mannose pyrophosphorylase

Products: NA

Alternate protein names: GDP-mannose pyrophosphorylase; GMP; GMPP [H]

Number of amino acids: Translated: 358; Mature: 358

Protein sequence:

>358_residues
MYDNMSSPLFPVILAGGKGERFWPLSRQDRPKQFLSLDGSSRSLLQSTAERLVKFAGEWNDLWVITSSQLGQGVQQQLPE
LPSQNLLTEPQGRDTAAAVAWASLEIQKRYGDDAIIGFFPSDHWIADPEAFKRTLDAASQLATSTEAIVTLGIKPTFPST
GYGYIEQGEKIGTFNELPAYHVNRFTEKPIREKAESFLSTGRYSWNSGMFVFRAGVVLKELYTYAPEIIEPLVKHGVDVY
PQLPKQSIDYALMEKTNLVYVLPADFGWDDLGDWNAIERLLKKPDNPNVELATHVGLDTQGAIVYATNPEDVIVTIGLED
VVIVRDRNVTLIVNKERTQEIKQILKTLQSDPRFTDLL

Sequences:

>Translated_358_residues
MYDNMSSPLFPVILAGGKGERFWPLSRQDRPKQFLSLDGSSRSLLQSTAERLVKFAGEWNDLWVITSSQLGQGVQQQLPE
LPSQNLLTEPQGRDTAAAVAWASLEIQKRYGDDAIIGFFPSDHWIADPEAFKRTLDAASQLATSTEAIVTLGIKPTFPST
GYGYIEQGEKIGTFNELPAYHVNRFTEKPIREKAESFLSTGRYSWNSGMFVFRAGVVLKELYTYAPEIIEPLVKHGVDVY
PQLPKQSIDYALMEKTNLVYVLPADFGWDDLGDWNAIERLLKKPDNPNVELATHVGLDTQGAIVYATNPEDVIVTIGLED
VVIVRDRNVTLIVNKERTQEIKQILKTLQSDPRFTDLL
>Mature_358_residues
MYDNMSSPLFPVILAGGKGERFWPLSRQDRPKQFLSLDGSSRSLLQSTAERLVKFAGEWNDLWVITSSQLGQGVQQQLPE
LPSQNLLTEPQGRDTAAAVAWASLEIQKRYGDDAIIGFFPSDHWIADPEAFKRTLDAASQLATSTEAIVTLGIKPTFPST
GYGYIEQGEKIGTFNELPAYHVNRFTEKPIREKAESFLSTGRYSWNSGMFVFRAGVVLKELYTYAPEIIEPLVKHGVDVY
PQLPKQSIDYALMEKTNLVYVLPADFGWDDLGDWNAIERLLKKPDNPNVELATHVGLDTQGAIVYATNPEDVIVTIGLED
VVIVRDRNVTLIVNKERTQEIKQILKTLQSDPRFTDLL

Specific function: Involved in GDP-mannose biosynthesis which serves as the activated sugar nucleotide precursor for mannose residues in cell surface polysaccharides. This enzyme participates in synthesis of the LPS O9 antigen [H]

COG id: COG0836

COG function: function code M; Mannose-1-phosphate guanylyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannose-6-phosphate isomerase type 2 family [H]

Homologues:

Organism=Escherichia coli, GI1788362, Length=364, Percent_Identity=36.2637362637363, Blast_Score=218, Evalue=3e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR006375
- InterPro:   IPR001538
- InterPro:   IPR005835
- InterPro:   IPR014710 [H]

Pfam domain/function: PF01050 MannoseP_isomer; PF00483 NTP_transferase [H]

EC number: =2.7.7.13 [H]

Molecular weight: Translated: 40165; Mature: 40165

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: PS00180 GLNA_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYDNMSSPLFPVILAGGKGERFWPLSRQDRPKQFLSLDGSSRSLLQSTAERLVKFAGEWN
CCCCCCCCCEEEEEECCCCCEECCCCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHCCCC
DLWVITSSQLGQGVQQQLPELPSQNLLTEPQGRDTAAAVAWASLEIQKRYGDDAIIGFFP
EEEEEECHHHCCHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHEEEHHHCCCCEEEEECC
SDHWIADPEAFKRTLDAASQLATSTEAIVTLGIKPTFPSTGYGYIEQGEKIGTFNELPAY
CCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCHHHCCCCCCCHHCCCCH
HVNRFTEKPIREKAESFLSTGRYSWNSGMFVFRAGVVLKELYTYAPEIIEPLVKHGVDVY
HHHHHHCCHHHHHHHHHHHCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCC
PQLPKQSIDYALMEKTNLVYVLPADFGWDDLGDWNAIERLLKKPDNPNVELATHVGLDTQ
CCCCHHHCCCCEECCCCEEEEEECCCCCCCCCCHHHHHHHHHCCCCCCEEEEEEECCCCC
GAIVYATNPEDVIVTIGLEDVVIVRDRNVTLIVNKERTQEIKQILKTLQSDPRFTDLL
CEEEEEECCCCEEEEECCCEEEEEECCCEEEEEECHHHHHHHHHHHHHHCCCCHHCCC
>Mature Secondary Structure
MYDNMSSPLFPVILAGGKGERFWPLSRQDRPKQFLSLDGSSRSLLQSTAERLVKFAGEWN
CCCCCCCCCEEEEEECCCCCEECCCCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHCCCC
DLWVITSSQLGQGVQQQLPELPSQNLLTEPQGRDTAAAVAWASLEIQKRYGDDAIIGFFP
EEEEEECHHHCCHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHEEEHHHCCCCEEEEECC
SDHWIADPEAFKRTLDAASQLATSTEAIVTLGIKPTFPSTGYGYIEQGEKIGTFNELPAY
CCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCHHHCCCCCCCHHCCCCH
HVNRFTEKPIREKAESFLSTGRYSWNSGMFVFRAGVVLKELYTYAPEIIEPLVKHGVDVY
HHHHHHCCHHHHHHHHHHHCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCC
PQLPKQSIDYALMEKTNLVYVLPADFGWDDLGDWNAIERLLKKPDNPNVELATHVGLDTQ
CCCCHHHCCCCEECCCCEEEEEECCCCCCCCCCHHHHHHHHHCCCCCCEEEEEEECCCCC
GAIVYATNPEDVIVTIGLEDVVIVRDRNVTLIVNKERTQEIKQILKTLQSDPRFTDLL
CEEEEEECCCCEEEEECCCEEEEEECCCEEEEEECHHHHHHHHHHHHHHCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7515042; 9004408 [H]