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The map label for this gene is dap [H]

Identifier: 17227649

GI number: 17227649

Start: 156575

End: 158188

Strand: Direct

Name: dap [H]

Synonym: alr0153

Alternate gene names: 17227649

Gene position: 156575-158188 (Clockwise)

Preceding gene: 17227646

Following gene: 17227655

Centisome position: 2.44

GC content: 41.08

Gene sequence:

>1614_bases
ATGACACTCCCATCACCAAATAAAGTCGATGAATTATTTTCCGAATGGGATAAACCAGGCTCTCCTGGTTTTGCTTTAGC
CATCACCAAAGATGGTGAGACTGTCTATAAGCGCGGCTATGGTATCGCTGACTTAGAACACAACATAAAGATTTTTCCAA
ATTCGGTCTTTGATATTGCCTCAACGTCCAAGCAGTTTACAGCGATGTGCATTGCTTTACTTGCAAGAAAGGGGAAACTT
TCTTTAGATGACGAGATCCAAATCTACATTTCAGAGATACCAAGATATGAGTATCCCATTACTGTGCGGCATCTGATTCA
CCACACAAGCGGCATTCGTGATTACTTAACCCTGATGGGATTGGCAGGAATGCGATGTGAGAATGAGTATCCTGATAACG
AAATCATTGGTTTAATAGCTCGTCAAAAAGAATTGAACTTCAAGCCAGGAGAGGAGCATTTGTACAGCAACTCAGGATAT
TTTCTTTTGGCAGAAATTGTCAAACGTGTCTCCGGAGAATCTCTTGCGGTTTTTGCTGATAAGCATATTTTCAGTCCCCT
TGGGATGAAGACAACTCACTTTCACGATGATTTCACAAGGATTGTCAGCAATAGAGCGATTGGCTACTCTCTGAAGGACG
AAGGTAGCTTTCGGATTGATATGTCTATTCTTGATGTAGTGGGTGACGGTGGTATCTACACTACGGTTGAGGATCTATGT
ATCTGGGATAAGAATTTTTACCAAAACAAATTAGGAGGATATGGGCAAGACCTGATCGAAGAAATCATTACACCTGGAAT
ATTGAATAGCGGCGAAGTGATAGATTATGCCTTTGGTTTAGTCAGAGGGCATTACCGAGGATTAGAAACCATCAGTCACA
GTGGCGGATGGATGGGTTACAGATCACAGATGCTTCGATTCCCCAAACAGAGATTCTCTGTAATTTGCTTGTCAAATTTG
GGCAGCGCTGAACCACCAGAGCTTGCCAGAAAAGTCGCAGATATCTACTTAGTTGATGACTTTACGGAGCAAAGCATAGA
ATCTGTAAGCCACCAAACCCAAATAATAGAAATTCCATCGGTTAATTTAGAGAGCAAGACTGGCTTTTATCAAAACCTAA
AAACAGGAACCGTTTGGGAGTTATTGGTAAAGGATAGAAAATTAATCGTGGAATTTGCCGGAATGAGCTTTACACTTGCT
CCTGTGAGTTCAAGTCATTTTGTCATAATGGATATTCCTTCTAATCCCGATGTTGAATTTGAAGAGTCAGGTTTAGATGA
ACCCTCTCATCTTTACGTTTGTGTGGATGGCAAACCACGGGACGTTTTCCAACGGCTGGACTTTGCTCCTCCTGATTCTG
AACAGTTGATGGATTTTACAGGAGAGTATTATTGCCAAGAGTTAGATATCACCTACAGAATCAGTATAGAAGGTGGAGAG
TTGCTGCTAAATCGAAGAAATTCTCTTCGAGAAACCCTCAAGCCAATTCATAAAGATTTACTGGAAGGTACGGACATCAC
TTTGCAGTTTGTCCGTGATGACTTTCATCAAGTTGCTGGATTCAATATGAGCGCAGGATATGGAAGTGTCAGAAACATTC
AATTTTTGAAATAA

Upstream 100 bases:

>100_bases
CCACTACAAGATCAGGCGATCGCACTAGCATCGGGTGAAGCGGGTCGTTGGGCGCTTCGTACAATAATAAGTAAATAAGT
CATCTTTTAAGCTTTCAATA

Downstream 100 bases:

>100_bases
AAAGATGCGCCCAACGATCTCGTTGCACACCGACCGTATAGAGTCTTTTCATTATGTCATTACAACTAAAAAGAGACTAT
CTAGAAACACTTCCTGATGC

Product: penicillin-binding protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 537; Mature: 536

Protein sequence:

>537_residues
MTLPSPNKVDELFSEWDKPGSPGFALAITKDGETVYKRGYGIADLEHNIKIFPNSVFDIASTSKQFTAMCIALLARKGKL
SLDDEIQIYISEIPRYEYPITVRHLIHHTSGIRDYLTLMGLAGMRCENEYPDNEIIGLIARQKELNFKPGEEHLYSNSGY
FLLAEIVKRVSGESLAVFADKHIFSPLGMKTTHFHDDFTRIVSNRAIGYSLKDEGSFRIDMSILDVVGDGGIYTTVEDLC
IWDKNFYQNKLGGYGQDLIEEIITPGILNSGEVIDYAFGLVRGHYRGLETISHSGGWMGYRSQMLRFPKQRFSVICLSNL
GSAEPPELARKVADIYLVDDFTEQSIESVSHQTQIIEIPSVNLESKTGFYQNLKTGTVWELLVKDRKLIVEFAGMSFTLA
PVSSSHFVIMDIPSNPDVEFEESGLDEPSHLYVCVDGKPRDVFQRLDFAPPDSEQLMDFTGEYYCQELDITYRISIEGGE
LLLNRRNSLRETLKPIHKDLLEGTDITLQFVRDDFHQVAGFNMSAGYGSVRNIQFLK

Sequences:

>Translated_537_residues
MTLPSPNKVDELFSEWDKPGSPGFALAITKDGETVYKRGYGIADLEHNIKIFPNSVFDIASTSKQFTAMCIALLARKGKL
SLDDEIQIYISEIPRYEYPITVRHLIHHTSGIRDYLTLMGLAGMRCENEYPDNEIIGLIARQKELNFKPGEEHLYSNSGY
FLLAEIVKRVSGESLAVFADKHIFSPLGMKTTHFHDDFTRIVSNRAIGYSLKDEGSFRIDMSILDVVGDGGIYTTVEDLC
IWDKNFYQNKLGGYGQDLIEEIITPGILNSGEVIDYAFGLVRGHYRGLETISHSGGWMGYRSQMLRFPKQRFSVICLSNL
GSAEPPELARKVADIYLVDDFTEQSIESVSHQTQIIEIPSVNLESKTGFYQNLKTGTVWELLVKDRKLIVEFAGMSFTLA
PVSSSHFVIMDIPSNPDVEFEESGLDEPSHLYVCVDGKPRDVFQRLDFAPPDSEQLMDFTGEYYCQELDITYRISIEGGE
LLLNRRNSLRETLKPIHKDLLEGTDITLQFVRDDFHQVAGFNMSAGYGSVRNIQFLK
>Mature_536_residues
TLPSPNKVDELFSEWDKPGSPGFALAITKDGETVYKRGYGIADLEHNIKIFPNSVFDIASTSKQFTAMCIALLARKGKLS
LDDEIQIYISEIPRYEYPITVRHLIHHTSGIRDYLTLMGLAGMRCENEYPDNEIIGLIARQKELNFKPGEEHLYSNSGYF
LLAEIVKRVSGESLAVFADKHIFSPLGMKTTHFHDDFTRIVSNRAIGYSLKDEGSFRIDMSILDVVGDGGIYTTVEDLCI
WDKNFYQNKLGGYGQDLIEEIITPGILNSGEVIDYAFGLVRGHYRGLETISHSGGWMGYRSQMLRFPKQRFSVICLSNLG
SAEPPELARKVADIYLVDDFTEQSIESVSHQTQIIEIPSVNLESKTGFYQNLKTGTVWELLVKDRKLIVEFAGMSFTLAP
VSSSHFVIMDIPSNPDVEFEESGLDEPSHLYVCVDGKPRDVFQRLDFAPPDSEQLMDFTGEYYCQELDITYRISIEGGEL
LLNRRNSLRETLKPIHKDLLEGTDITLQFVRDDFHQVAGFNMSAGYGSVRNIQFLK

Specific function: Hydrolyzes N-terminal residues in D-amino acid- containing peptides [H]

COG id: COG1680

COG function: function code V; Beta-lactamase class C and other penicillin binding proteins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S12 family [H]

Homologues:

Organism=Homo sapiens, GI26051231, Length=391, Percent_Identity=27.8772378516624, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI26051233, Length=255, Percent_Identity=31.3725490196078, Blast_Score=94, Evalue=2e-19,
Organism=Escherichia coli, GI87082101, Length=375, Percent_Identity=23.2, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1786574, Length=241, Percent_Identity=27.8008298755187, Blast_Score=79, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI115533026, Length=354, Percent_Identity=26.8361581920904, Blast_Score=102, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI17550934, Length=178, Percent_Identity=34.8314606741573, Blast_Score=100, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17565630, Length=328, Percent_Identity=26.5243902439024, Blast_Score=78, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001466
- InterPro:   IPR009090
- InterPro:   IPR012857 [H]

Pfam domain/function: PF00144 Beta-lactamase; PF07932 DAP_C [H]

EC number: =3.4.11.19 [H]

Molecular weight: Translated: 60685; Mature: 60553

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLPSPNKVDELFSEWDKPGSPGFALAITKDGETVYKRGYGIADLEHNIKIFPNSVFDIA
CCCCCCCHHHHHHHHHCCCCCCCEEEEEECCCCHHHHCCCCEEECCCCCEECCCCHHHHH
STSKQFTAMCIALLARKGKLSLDDEIQIYISEIPRYEYPITVRHLIHHTSGIRDYLTLMG
CCHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHCCHHHHHHHHH
LAGMRCENEYPDNEIIGLIARQKELNFKPGEEHLYSNSGYFLLAEIVKRVSGESLAVFAD
HCCCCCCCCCCCCHHEEEEEHHHCCCCCCCHHHEECCCCCEEHHHHHHHHCCCEEEEEEC
KHIFSPLGMKTTHFHDDFTRIVSNRAIGYSLKDEGSFRIDMSILDVVGDGGIYTTVEDLC
CHHCCCCCCCCCCCHHHHHHHHHCCCCCEEECCCCCEEEEEEEEEEECCCCCEEEHHHHH
IWDKNFYQNKLGGYGQDLIEEIITPGILNSGEVIDYAFGLVRGHYRGLETISHSGGWMGY
HHCCHHHHHHCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHH
RSQMLRFPKQRFSVICLSNLGSAEPPELARKVADIYLVDDFTEQSIESVSHQTQIIEIPS
HHHHHHCCHHHHEEEEECCCCCCCCHHHHHHHHHEEEECCHHHHHHHHHHHCEEEEEECC
VNLESKTGFYQNLKTGTVWELLVKDRKLIVEFAGMSFTLAPVSSSHFVIMDIPSNPDVEF
CCCCCCCCHHHCCCCCHHHHHHHHCCCEEEEECCCEEEEEECCCCCEEEEECCCCCCCCC
EESGLDEPSHLYVCVDGKPRDVFQRLDFAPPDSEQLMDFTGEYYCQELDITYRISIEGGE
HHCCCCCCCEEEEEECCCCHHHHHHCCCCCCCHHHHHHHHHHHEEEEECEEEEEEECCCC
LLLNRRNSLRETLKPIHKDLLEGTDITLQFVRDDFHQVAGFNMSAGYGSVRNIQFLK
EEECCHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHCCCCCCCCCCCCCEEECC
>Mature Secondary Structure 
TLPSPNKVDELFSEWDKPGSPGFALAITKDGETVYKRGYGIADLEHNIKIFPNSVFDIA
CCCCCCHHHHHHHHHCCCCCCCEEEEEECCCCHHHHCCCCEEECCCCCEECCCCHHHHH
STSKQFTAMCIALLARKGKLSLDDEIQIYISEIPRYEYPITVRHLIHHTSGIRDYLTLMG
CCHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHCCHHHHHHHHH
LAGMRCENEYPDNEIIGLIARQKELNFKPGEEHLYSNSGYFLLAEIVKRVSGESLAVFAD
HCCCCCCCCCCCCHHEEEEEHHHCCCCCCCHHHEECCCCCEEHHHHHHHHCCCEEEEEEC
KHIFSPLGMKTTHFHDDFTRIVSNRAIGYSLKDEGSFRIDMSILDVVGDGGIYTTVEDLC
CHHCCCCCCCCCCCHHHHHHHHHCCCCCEEECCCCCEEEEEEEEEEECCCCCEEEHHHHH
IWDKNFYQNKLGGYGQDLIEEIITPGILNSGEVIDYAFGLVRGHYRGLETISHSGGWMGY
HHCCHHHHHHCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHH
RSQMLRFPKQRFSVICLSNLGSAEPPELARKVADIYLVDDFTEQSIESVSHQTQIIEIPS
HHHHHHCCHHHHEEEEECCCCCCCCHHHHHHHHHEEEECCHHHHHHHHHHHCEEEEEECC
VNLESKTGFYQNLKTGTVWELLVKDRKLIVEFAGMSFTLAPVSSSHFVIMDIPSNPDVEF
CCCCCCCCHHHCCCCCHHHHHHHHCCCEEEEECCCEEEEEECCCCCEEEEECCCCCCCCC
EESGLDEPSHLYVCVDGKPRDVFQRLDFAPPDSEQLMDFTGEYYCQELDITYRISIEGGE
HHCCCCCCCEEEEEECCCCHHHHHHCCCCCCCHHHHHHHHHHHEEEEECEEEEEEECCCC
LLLNRRNSLRETLKPIHKDLLEGTDITLQFVRDDFHQVAGFNMSAGYGSVRNIQFLK
EEECCHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHCCCCCCCCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA