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The map label for this gene is adrB [H]

Identifier: 39546327

GI number: 39546327

Start: 1924881

End: 1926482

Strand: Direct

Name: adrB [H]

Synonym: STM1827.S

Alternate gene names: 39546327

Gene position: 1924881-1926482 (Clockwise)

Preceding gene: 16765167

Following gene: 16765171

Centisome position: 39.63

GC content: 53.25

Gene sequence:

>1602_bases
ATGCAAACAGCACAACGGATCATCAATCATTATCGCCGTAATCGTTTCATTGTTTGCACGATTTGTGCACTGGTCACGCT
CATTCTTACGCTGAGCATCCGATTTATTTCGGAGCGGAACTTAAATCACCATCGCACGGTTGCATTCGCGAATCATGCCG
TTGATGCGCTGGATAATGTGCTGCATCCTCTCCTGGTCGGACGAAACATACTGCTCCCCTTGCTTGAGCTTCCGTGCGCG
ACCGCGCATTTGCCGTTGCGTAAGCAAGCCGCCCGCCTACAAACCATTCGTTCTATCGGGCTGGTAAAAGAGGGAATTCT
CTATTGCTCAAGCATTTTTGGCGCCCGTAATACTCCCATACGCCAGCTTCAGCCCGATCTTCCCGCAGTCGGCGATCTGC
TGCTACTTTCCACAGACCAATCGTTACTCAAGGGAAGCCCGATCCTCATTCAGTGGTATCCCGCCTCTGCCGATGGCCAG
GATGGCGTGATGGAAATTGTGAATATTGACTTGCTGACGACTATGCTACTTGAGCCGCAGCAGCCGCAAATTACCAGCGC
CAGCCTGACGGTCGGCAAACGACACCTGTTATATGGTCGGGGCGTGGTCGATACTCTTCCGGAATTAAAAAAAGATGAAG
AGCGTTACCAGCTTTCATCGCGACATTTCCCTTTTACTATCAGCGTCAGCGGGCCGTCGGCAGGCGTACTGGCGTTCAAA
CATCTCCCGACGCAGTTACCGCTGGCCGTATTGCTTAGCCTGTTGATCGGTTATATCGCCTGGCTGGCAACGGCCAGCAG
AATGAGCTTTTCCTGGGAAATTAATCTGGCCCTTGCCGAACGGGAGTTTGAGCTATTTTGTCAGCCGTTGCTTAATGCCC
GCACGCAGCAGTGTACCGGCGTTGAGATCCTGTTACGCTGGAACAACCCGCGCCAGGGCTGGATCTCACCGGATGTTTTT
ATTCCTATCGCCGAGGAACATAACCTGATAGCGCCGCTGACCCGCTATGTGATTGCGGAAACCATTCGGCAGCGGCACTA
CTTCCCCATCAACCATCAGTTTCATATCGGCATCAATGTAGCGGCAAGCCATTTCCGACACGGCGTGCTTCTCAAAGATC
TTAATCAGTACTGGTTTAGTGCGGAACCTGTTCAGCAACTGGTGCTGGAGCTCACGGAACGCGACGCGTTGCTTGACGTT
GATTACCGCCTGATGCGCGAGCTGCATCGTAAAGGCGTGAAGTTAGCCATCGATGATTTTGGCACAGGAAACAGCTCGCT
CTCCTGGCTGGAAAAACTGCGGCCGGATATTTTGAAAATCGATAAATCCTTCACCGCCGCCATCGGTACCGATGCGGTCA
ATTCAACGGTGACCGATATTATTATCGCGCTGGGGCAAAGACTGAATATTGAACTGGTGGCGGAAGGGGTCGAAAACCAG
ACGCAGGCACAGCATTTGCGCCAGCATGGCGTGCAAATGTTACAGGGCTATCTCTATGCGAAGCCGATGCCCATTAGCGA
ATTTCCACAGTGGCTGGCGGGCAGCGCGCCGCCGCCCGCCCGGCATAACGGACAGATTATGTCCGCGATGCCGCATCTAT
AG

Upstream 100 bases:

>100_bases
GGGCGAAATTTTTATCTCTTCCTCGTCGACTCCACGTTTCCCCACTACACTTGCTGTGTCGCGGTTGGCTTTTGTCGCCA
ACGCTTATTGGGCGGCCCGC

Downstream 100 bases:

>100_bases
ACTTGATTCCTGCGTGTGACGTTATTCCTCTTCGTCGTGGGCAGGCTGTTCTTTAACAATTCGAACCAGATCGACACGAT
AGTCGTTGGCCTCGACAATG

Product: diguanylate cyclase/phosphodiesterase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 533; Mature: 533

Protein sequence:

>533_residues
MQTAQRIINHYRRNRFIVCTICALVTLILTLSIRFISERNLNHHRTVAFANHAVDALDNVLHPLLVGRNILLPLLELPCA
TAHLPLRKQAARLQTIRSIGLVKEGILYCSSIFGARNTPIRQLQPDLPAVGDLLLLSTDQSLLKGSPILIQWYPASADGQ
DGVMEIVNIDLLTTMLLEPQQPQITSASLTVGKRHLLYGRGVVDTLPELKKDEERYQLSSRHFPFTISVSGPSAGVLAFK
HLPTQLPLAVLLSLLIGYIAWLATASRMSFSWEINLALAEREFELFCQPLLNARTQQCTGVEILLRWNNPRQGWISPDVF
IPIAEEHNLIAPLTRYVIAETIRQRHYFPINHQFHIGINVAASHFRHGVLLKDLNQYWFSAEPVQQLVLELTERDALLDV
DYRLMRELHRKGVKLAIDDFGTGNSSLSWLEKLRPDILKIDKSFTAAIGTDAVNSTVTDIIIALGQRLNIELVAEGVENQ
TQAQHLRQHGVQMLQGYLYAKPMPISEFPQWLAGSAPPPARHNGQIMSAMPHL

Sequences:

>Translated_533_residues
MQTAQRIINHYRRNRFIVCTICALVTLILTLSIRFISERNLNHHRTVAFANHAVDALDNVLHPLLVGRNILLPLLELPCA
TAHLPLRKQAARLQTIRSIGLVKEGILYCSSIFGARNTPIRQLQPDLPAVGDLLLLSTDQSLLKGSPILIQWYPASADGQ
DGVMEIVNIDLLTTMLLEPQQPQITSASLTVGKRHLLYGRGVVDTLPELKKDEERYQLSSRHFPFTISVSGPSAGVLAFK
HLPTQLPLAVLLSLLIGYIAWLATASRMSFSWEINLALAEREFELFCQPLLNARTQQCTGVEILLRWNNPRQGWISPDVF
IPIAEEHNLIAPLTRYVIAETIRQRHYFPINHQFHIGINVAASHFRHGVLLKDLNQYWFSAEPVQQLVLELTERDALLDV
DYRLMRELHRKGVKLAIDDFGTGNSSLSWLEKLRPDILKIDKSFTAAIGTDAVNSTVTDIIIALGQRLNIELVAEGVENQ
TQAQHLRQHGVQMLQGYLYAKPMPISEFPQWLAGSAPPPARHNGQIMSAMPHL
>Mature_533_residues
MQTAQRIINHYRRNRFIVCTICALVTLILTLSIRFISERNLNHHRTVAFANHAVDALDNVLHPLLVGRNILLPLLELPCA
TAHLPLRKQAARLQTIRSIGLVKEGILYCSSIFGARNTPIRQLQPDLPAVGDLLLLSTDQSLLKGSPILIQWYPASADGQ
DGVMEIVNIDLLTTMLLEPQQPQITSASLTVGKRHLLYGRGVVDTLPELKKDEERYQLSSRHFPFTISVSGPSAGVLAFK
HLPTQLPLAVLLSLLIGYIAWLATASRMSFSWEINLALAEREFELFCQPLLNARTQQCTGVEILLRWNNPRQGWISPDVF
IPIAEEHNLIAPLTRYVIAETIRQRHYFPINHQFHIGINVAASHFRHGVLLKDLNQYWFSAEPVQQLVLELTERDALLDV
DYRLMRELHRKGVKLAIDDFGTGNSSLSWLEKLRPDILKIDKSFTAAIGTDAVNSTVTDIIIALGQRLNIELVAEGVENQ
TQAQHLRQHGVQMLQGYLYAKPMPISEFPQWLAGSAPPPARHNGQIMSAMPHL

Specific function: May serve as a negative regulator of cellulose synthesis (as has been suggested for S.typhimurium); over-expression inhibits cell aggregation in strains able to produce adhesive curli fimbriae. Cyclic-di-GMP is a second messenger which controls cell surfa

COG id: COG2200

COG function: function code T; FOG: EAL domain

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 EAL domain [H]

Homologues:

Organism=Escherichia coli, GI87081980, Length=531, Percent_Identity=75.7062146892655, Blast_Score=817, Evalue=0.0,
Organism=Escherichia coli, GI1788502, Length=522, Percent_Identity=29.1187739463602, Blast_Score=219, Evalue=5e-58,
Organism=Escherichia coli, GI87081845, Length=519, Percent_Identity=28.7090558766859, Blast_Score=164, Evalue=1e-41,
Organism=Escherichia coli, GI1786507, Length=247, Percent_Identity=39.2712550607287, Blast_Score=162, Evalue=5e-41,
Organism=Escherichia coli, GI1790496, Length=241, Percent_Identity=37.344398340249, Blast_Score=155, Evalue=5e-39,
Organism=Escherichia coli, GI87081921, Length=261, Percent_Identity=34.4827586206897, Blast_Score=140, Evalue=2e-34,
Organism=Escherichia coli, GI87081743, Length=271, Percent_Identity=34.6863468634686, Blast_Score=138, Evalue=8e-34,
Organism=Escherichia coli, GI1787541, Length=243, Percent_Identity=32.5102880658436, Blast_Score=124, Evalue=2e-29,
Organism=Escherichia coli, GI226510982, Length=256, Percent_Identity=30.078125, Blast_Score=112, Evalue=6e-26,
Organism=Escherichia coli, GI1787055, Length=242, Percent_Identity=32.2314049586777, Blast_Score=109, Evalue=4e-25,
Organism=Escherichia coli, GI1788849, Length=237, Percent_Identity=32.9113924050633, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI87082096, Length=247, Percent_Identity=28.7449392712551, Blast_Score=103, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001633 [H]

Pfam domain/function: PF00563 EAL [H]

EC number: =3.1.4.52 [H]

Molecular weight: Translated: 59879; Mature: 59879

Theoretical pI: Translated: 8.18; Mature: 8.18

Prosite motif: PS50883 EAL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTAQRIINHYRRNRFIVCTICALVTLILTLSIRFISERNLNHHRTVAFANHAVDALDNV
CCHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHH
LHPLLVGRNILLPLLELPCATAHLPLRKQAARLQTIRSIGLVKEGILYCSSIFGARNTPI
HHHHHHCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
RQLQPDLPAVGDLLLLSTDQSLLKGSPILIQWYPASADGQDGVMEIVNIDLLTTMLLEPQ
HHCCCCCCCCCCEEEEECCHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCC
QPQITSASLTVGKRHLLYGRGVVDTLPELKKDEERYQLSSRHFPFTISVSGPSAGVLAFK
CCCCCCHHHHHCCHHEEECCCHHHHHHHHHCCHHHHHHHCCCCCEEEEECCCCCCCHHHH
HLPTQLPLAVLLSLLIGYIAWLATASRMSFSWEINLALAEREFELFCQPLLNARTQQCTG
HCCCCCCHHHHHHHHHHHHHHHHHHHHCEEEEEEEEEEEHHHHHHHHHHHHCCCCCCCCC
VEILLRWNNPRQGWISPDVFIPIAEEHNLIAPLTRYVIAETIRQRHYFPINHQFHIGINV
EEEEEEECCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEH
AASHFRHGVLLKDLNQYWFSAEPVQQLVLELTERDALLDVDYRLMRELHRKGVKLAIDDF
HHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHCCCEECCCHHHHHHHHHCCCEEEEECC
GTGNSSLSWLEKLRPDILKIDKSFTAAIGTDAVNSTVTDIIIALGQRLNIELVAEGVENQ
CCCCCHHHHHHHHCHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCH
TQAQHLRQHGVQMLQGYLYAKPMPISEFPQWLAGSAPPPARHNGQIMSAMPHL
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCCCHHHCCCCC
>Mature Secondary Structure
MQTAQRIINHYRRNRFIVCTICALVTLILTLSIRFISERNLNHHRTVAFANHAVDALDNV
CCHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHH
LHPLLVGRNILLPLLELPCATAHLPLRKQAARLQTIRSIGLVKEGILYCSSIFGARNTPI
HHHHHHCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
RQLQPDLPAVGDLLLLSTDQSLLKGSPILIQWYPASADGQDGVMEIVNIDLLTTMLLEPQ
HHCCCCCCCCCCEEEEECCHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCC
QPQITSASLTVGKRHLLYGRGVVDTLPELKKDEERYQLSSRHFPFTISVSGPSAGVLAFK
CCCCCCHHHHHCCHHEEECCCHHHHHHHHHCCHHHHHHHCCCCCEEEEECCCCCCCHHHH
HLPTQLPLAVLLSLLIGYIAWLATASRMSFSWEINLALAEREFELFCQPLLNARTQQCTG
HCCCCCCHHHHHHHHHHHHHHHHHHHHCEEEEEEEEEEEHHHHHHHHHHHHCCCCCCCCC
VEILLRWNNPRQGWISPDVFIPIAEEHNLIAPLTRYVIAETIRQRHYFPINHQFHIGINV
EEEEEEECCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEH
AASHFRHGVLLKDLNQYWFSAEPVQQLVLELTERDALLDVDYRLMRELHRKGVKLAIDDF
HHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHCCCEECCCHHHHHHHHHCCCEEEEECC
GTGNSSLSWLEKLRPDILKIDKSFTAAIGTDAVNSTVTDIIIALGQRLNIELVAEGVENQ
CCCCCHHHHHHHHCHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCH
TQAQHLRQHGVQMLQGYLYAKPMPISEFPQWLAGSAPPPARHNGQIMSAMPHL
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCCCHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503 [H]