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The map label for this gene is msrA [H]

Identifier: 16767654

GI number: 16767654

Start: 4645202

End: 4645840

Strand: Reverse

Name: msrA [H]

Synonym: STM4408

Alternate gene names: 16767654

Gene position: 4645840-4645202 (Counterclockwise)

Preceding gene: 16767658

Following gene: 16767653

Centisome position: 95.64

GC content: 54.3

Gene sequence:

>639_bases
ATGAGTTTATTTGATAAAAAACATCTGGTTACTCAAGCAGATGCGTTACCAGGACGCAACACCCCGATGCCGATCGCCAC
TCTGCATGCGGTAAATGAACACTCTATGACCAATGTCCCTGCCGGGATGGAGATCGCCTACTTCGCTATGGGCTGTTTCT
GGGGCGTAGAACGTTTATTCTGGCAATTGCCCGGCGTATATAGCACCGCGGCAGGGTATGCAGGCGGTTACACGCCTAAT
CCAACCTACCGGGAAGTCTGCTCCGGGCAGACCGGTCATGCCGAAGCGGTACGGATAGTGTACGATCCTGCCGTTATCAG
TTATGAGCAGCTTTTACAGACCTTCTGGGAAAATCACGATCCGACGCAGGGGATGCAACAAGGTAACGATCACGGTACGC
AATACCGTTCTGCGATTTATCCCTTAACGCCGGAACAGAATGCCGCCGCTCACGCCAGTCGCGAGCGCTTTCAGTCGGCA
ATGACCGCCGCCGGAGACCATCGCCCTATTACCACGGAAATCGCCCATGCGACGCCGTTTTACTACGCCGAAGATGAACA
CCAACAGTATCTGCACAAAAATCCATATGGTTACTGCGGGATTGGCGGGATCGGCGTTTGCCTGCCGCCTGACGCGTGA

Upstream 100 bases:

>100_bases
TTCTTATGGTTAAATCCAGATACATTAATGTTGTTATTGTGTGCAAAGATGCGTCTCGTTACAACCTTAACGCCAATTAA
CGCTTTCGGGAGAATAGCTC

Downstream 100 bases:

>100_bases
CGACGCTGGCGTAGGGGGAACTTGTCGGAGTTGAAAATGAACCCTCTGGCGACTTTACAGTAGCTTACGCTATACTAGCC
CTGAACTTATCGGCTCACTG

Product: methionine sulfoxide reductase A

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase [H]

Number of amino acids: Translated: 212; Mature: 211

Protein sequence:

>212_residues
MSLFDKKHLVTQADALPGRNTPMPIATLHAVNEHSMTNVPAGMEIAYFAMGCFWGVERLFWQLPGVYSTAAGYAGGYTPN
PTYREVCSGQTGHAEAVRIVYDPAVISYEQLLQTFWENHDPTQGMQQGNDHGTQYRSAIYPLTPEQNAAAHASRERFQSA
MTAAGDHRPITTEIAHATPFYYAEDEHQQYLHKNPYGYCGIGGIGVCLPPDA

Sequences:

>Translated_212_residues
MSLFDKKHLVTQADALPGRNTPMPIATLHAVNEHSMTNVPAGMEIAYFAMGCFWGVERLFWQLPGVYSTAAGYAGGYTPN
PTYREVCSGQTGHAEAVRIVYDPAVISYEQLLQTFWENHDPTQGMQQGNDHGTQYRSAIYPLTPEQNAAAHASRERFQSA
MTAAGDHRPITTEIAHATPFYYAEDEHQQYLHKNPYGYCGIGGIGVCLPPDA
>Mature_211_residues
SLFDKKHLVTQADALPGRNTPMPIATLHAVNEHSMTNVPAGMEIAYFAMGCFWGVERLFWQLPGVYSTAAGYAGGYTPNP
TYREVCSGQTGHAEAVRIVYDPAVISYEQLLQTFWENHDPTQGMQQGNDHGTQYRSAIYPLTPEQNAAAHASRERFQSAM
TAAGDHRPITTEIAHATPFYYAEDEHQQYLHKNPYGYCGIGGIGVCLPPDA

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=203, Percent_Identity=59.1133004926108, Blast_Score=254, Evalue=5e-68,
Organism=Homo sapiens, GI208609995, Length=181, Percent_Identity=60.7734806629834, Blast_Score=236, Evalue=8e-63,
Organism=Homo sapiens, GI208609993, Length=203, Percent_Identity=44.3349753694581, Blast_Score=166, Evalue=1e-41,
Organism=Escherichia coli, GI1790665, Length=212, Percent_Identity=89.1509433962264, Blast_Score=373, Evalue=1e-105,
Organism=Caenorhabditis elegans, GI17533973, Length=150, Percent_Identity=38, Blast_Score=99, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6320881, Length=167, Percent_Identity=34.1317365269461, Blast_Score=97, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24664627, Length=170, Percent_Identity=39.4117647058824, Blast_Score=98, Evalue=3e-21,
Organism=Drosophila melanogaster, GI45553131, Length=143, Percent_Identity=41.958041958042, Blast_Score=94, Evalue=9e-20,
Organism=Drosophila melanogaster, GI24664631, Length=170, Percent_Identity=38.2352941176471, Blast_Score=91, Evalue=5e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 23397; Mature: 23266

Theoretical pI: Translated: 5.91; Mature: 5.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLFDKKHLVTQADALPGRNTPMPIATLHAVNEHSMTNVPAGMEIAYFAMGCFWGVERLF
CCCCCHHHHHHHHHCCCCCCCCCCCHHEEHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
WQLPGVYSTAAGYAGGYTPNPTYREVCSGQTGHAEAVRIVYDPAVISYEQLLQTFWENHD
HHCCCHHHHHCCCCCCCCCCCHHHHHHCCCCCCCEEEEEEECCHHHHHHHHHHHHHCCCC
PTQGMQQGNDHGTQYRSAIYPLTPEQNAAAHASRERFQSAMTAAGDHRPITTEIAHATPF
CCHHHHCCCCCCHHHHHEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCC
YYAEDEHQQYLHKNPYGYCGIGGIGVCLPPDA
EEECHHHHHHHHCCCCCEECCCCCEEECCCCC
>Mature Secondary Structure 
SLFDKKHLVTQADALPGRNTPMPIATLHAVNEHSMTNVPAGMEIAYFAMGCFWGVERLF
CCCCHHHHHHHHHCCCCCCCCCCCHHEEHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
WQLPGVYSTAAGYAGGYTPNPTYREVCSGQTGHAEAVRIVYDPAVISYEQLLQTFWENHD
HHCCCHHHHHCCCCCCCCCCCHHHHHHCCCCCCCEEEEEEECCHHHHHHHHHHHHHCCCC
PTQGMQQGNDHGTQYRSAIYPLTPEQNAAAHASRERFQSAMTAAGDHRPITTEIAHATPF
CCHHHHCCCCCCHHHHHEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCC
YYAEDEHQQYLHKNPYGYCGIGGIGVCLPPDA
EEECHHHHHHHHCCCCCEECCCCCEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA