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The map label for this gene is pgi [H]

Identifier: 16767471

GI number: 16767471

Start: 4440162

End: 4441811

Strand: Direct

Name: pgi [H]

Synonym: STM4221

Alternate gene names: 16767471

Gene position: 4440162-4441811 (Clockwise)

Preceding gene: 39546392

Following gene: 39546393

Centisome position: 91.41

GC content: 52.85

Gene sequence:

>1650_bases
ATGAAAAACATCAATCCAACGCAGACTTCTGCCTGGCAGGCGCTCCAGAAACACTACGATGAAATGAAAGACGTTACGAT
CGCTGAGCTTTTCGCGAACGATAGCGACCGTTTCGCTAAATTTTCCGCGACGTTTGACGATCTGATGCTGGTGGATTTCT
CCAAAAACCGCATCACCGAAGAGACGCTGGCAAAATTACAGGATCTGGCGAAAGAGACCGATCTGGCCGGCGCGATTAAA
TCCATGTTCTCCGGCGAGAAGATCAACCGCACCGAAGACCGCGCCGTGCTGCACGTGGCGCTGCGTAACCGTAGCAATAC
GCCGATCATTGTGGACGGCAAAGATGTGATGCCGGAAGTGAACGCCGTACTTGAGAAGATGAAAACTTTCTCGCAAGCGA
TTATCTCCGGTCAGTGGAAAGGCTACACCGGTAAGGCCATCACCGACGTGGTGAACATCGGTATCGGCGGTTCCGACCTC
GGCCCGTTCATGGTGACCGAAGCGCTGCGTCCGTATAAAAATCATCTGACTATGCACTTCGTCTCTAACGTCGATGGTAC
CCACATCGCTGAAGTGCTGAAGAAAGTGAACCCTGAAACCACGCTGTTCCTGGTCGCGTCGAAAACTTTCACCACCCAGG
AAACCATGACCAACGCCCACAGCGCGCGCGACTGGTTCCTGAAAACTGCAGGCGATGAAAAACACGTGGCGAAACACTTT
GCTGCGCTCTCCACCAACGCCAAAGCGGTCGGCGAATTTGGTATCGACACGGCCAATATGTTCGAGTTCTGGGACTGGGT
CGGTGGTCGTTACTCGCTGTGGTCTGCCATCGGGCTGTCCATTATTCTGTCCGTCGGTTTCGACAACTTTGTCGAGCTGC
TTTCCGGCGCGCACGCGATGGACAAGCATTTCTCCACCACTCCGGCGGAGAAAAACCTACCCATTCTGCTGGCGTTGATT
GGCATCTGGTACAACAATTTCTTCGGCGCGGAAACCGAAGCCATTCTGCCGTATGACCAGTATATGCACCGTTTCGCCGC
CTACTTCCAGCAGGGTAACATGGAATCCAACGGTAAATACGTTGACCGTAACGGCAACGCCGTGGATTACCAGACAGGCC
CAATTATCTGGGGCGAACCAGGCACCAACGGTCAGCACGCGTTTTATCAATTGATTCACCAGGGTACTAAAATGGTGCCG
TGTGATTTTATCGCCCCGGCTATCACCCATAACCCGCTATCCGATCATCATCAGAAGCTGCTGTCTAACTTCTTCGCGCA
GACCGAAGCGCTGGCGTTTGGTAAATCCCGCGAGGTGGTTGAGCAGGAATATCGCGATCAGGGTAAAGATCCGGCGCAGC
TTGAACACGTTGTGCCATTCAAAGTGTTTGAAGGCAACCGCCCGACCAACTCTATCCTGCTGCGCGAAATTACGCCGTTC
AGCCTGGGCGCACTGATTGCGTTGTATGAGCATAAAATCTTTACGCAGGGCGTCATCCTGAACATCTTTACTTTCGACCA
GTGGGGCGTTGAGTTGGGTAAACAGTTGGCTAACCGTATTCTGCCGGAGTTGGGCGATGATAAAGCTATTTCGTCCCATG
ATAGCTCTACTAACGGTCTGATTAACCGTTATAAAGCCTGGCGCGCCTGA

Upstream 100 bases:

>100_bases
GACAGTGCCTGGGGCAACGGCACTAAAACAATCACACTTTTCTGTGACTGGCGTTACAATCGATCCCAGTCACAATTCTC
AAATCAGAAGAGTATTGCTA

Downstream 100 bases:

>100_bases
TGGCACTGCGCTTATCCGGTCTACGTAATGCATAGCGTCTGTAGGCCGGGTAAGGCGTTTCGCCGCCATCCGGCAAAAAG
AGAATAAGATAATAAAAAGG

Product: glucose-6-phosphate isomerase

Products: NA

Alternate protein names: GPI; Phosphoglucose isomerase; PGI; Phosphohexose isomerase; PHI [H]

Number of amino acids: Translated: 549; Mature: 549

Protein sequence:

>549_residues
MKNINPTQTSAWQALQKHYDEMKDVTIAELFANDSDRFAKFSATFDDLMLVDFSKNRITEETLAKLQDLAKETDLAGAIK
SMFSGEKINRTEDRAVLHVALRNRSNTPIIVDGKDVMPEVNAVLEKMKTFSQAIISGQWKGYTGKAITDVVNIGIGGSDL
GPFMVTEALRPYKNHLTMHFVSNVDGTHIAEVLKKVNPETTLFLVASKTFTTQETMTNAHSARDWFLKTAGDEKHVAKHF
AALSTNAKAVGEFGIDTANMFEFWDWVGGRYSLWSAIGLSIILSVGFDNFVELLSGAHAMDKHFSTTPAEKNLPILLALI
GIWYNNFFGAETEAILPYDQYMHRFAAYFQQGNMESNGKYVDRNGNAVDYQTGPIIWGEPGTNGQHAFYQLIHQGTKMVP
CDFIAPAITHNPLSDHHQKLLSNFFAQTEALAFGKSREVVEQEYRDQGKDPAQLEHVVPFKVFEGNRPTNSILLREITPF
SLGALIALYEHKIFTQGVILNIFTFDQWGVELGKQLANRILPELGDDKAISSHDSSTNGLINRYKAWRA

Sequences:

>Translated_549_residues
MKNINPTQTSAWQALQKHYDEMKDVTIAELFANDSDRFAKFSATFDDLMLVDFSKNRITEETLAKLQDLAKETDLAGAIK
SMFSGEKINRTEDRAVLHVALRNRSNTPIIVDGKDVMPEVNAVLEKMKTFSQAIISGQWKGYTGKAITDVVNIGIGGSDL
GPFMVTEALRPYKNHLTMHFVSNVDGTHIAEVLKKVNPETTLFLVASKTFTTQETMTNAHSARDWFLKTAGDEKHVAKHF
AALSTNAKAVGEFGIDTANMFEFWDWVGGRYSLWSAIGLSIILSVGFDNFVELLSGAHAMDKHFSTTPAEKNLPILLALI
GIWYNNFFGAETEAILPYDQYMHRFAAYFQQGNMESNGKYVDRNGNAVDYQTGPIIWGEPGTNGQHAFYQLIHQGTKMVP
CDFIAPAITHNPLSDHHQKLLSNFFAQTEALAFGKSREVVEQEYRDQGKDPAQLEHVVPFKVFEGNRPTNSILLREITPF
SLGALIALYEHKIFTQGVILNIFTFDQWGVELGKQLANRILPELGDDKAISSHDSSTNGLINRYKAWRA
>Mature_549_residues
MKNINPTQTSAWQALQKHYDEMKDVTIAELFANDSDRFAKFSATFDDLMLVDFSKNRITEETLAKLQDLAKETDLAGAIK
SMFSGEKINRTEDRAVLHVALRNRSNTPIIVDGKDVMPEVNAVLEKMKTFSQAIISGQWKGYTGKAITDVVNIGIGGSDL
GPFMVTEALRPYKNHLTMHFVSNVDGTHIAEVLKKVNPETTLFLVASKTFTTQETMTNAHSARDWFLKTAGDEKHVAKHF
AALSTNAKAVGEFGIDTANMFEFWDWVGGRYSLWSAIGLSIILSVGFDNFVELLSGAHAMDKHFSTTPAEKNLPILLALI
GIWYNNFFGAETEAILPYDQYMHRFAAYFQQGNMESNGKYVDRNGNAVDYQTGPIIWGEPGTNGQHAFYQLIHQGTKMVP
CDFIAPAITHNPLSDHHQKLLSNFFAQTEALAFGKSREVVEQEYRDQGKDPAQLEHVVPFKVFEGNRPTNSILLREITPF
SLGALIALYEHKIFTQGVILNIFTFDQWGVELGKQLANRILPELGDDKAISSHDSSTNGLINRYKAWRA

Specific function: Involved in glycolysis and in gluconeogenesis. [C]

COG id: COG0166

COG function: function code G; Glucose-6-phosphate isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GPI family [H]

Homologues:

Organism=Homo sapiens, GI18201905, Length=549, Percent_Identity=64.8451730418944, Blast_Score=739, Evalue=0.0,
Organism=Homo sapiens, GI296080693, Length=549, Percent_Identity=60.8378870673953, Blast_Score=678, Evalue=0.0,
Organism=Escherichia coli, GI1790457, Length=549, Percent_Identity=95.264116575592, Blast_Score=1100, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71996708, Length=546, Percent_Identity=63.5531135531135, Blast_Score=718, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71996703, Length=541, Percent_Identity=63.9556377079482, Blast_Score=716, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6319673, Length=549, Percent_Identity=59.0163934426229, Blast_Score=652, Evalue=0.0,
Organism=Drosophila melanogaster, GI24651916, Length=549, Percent_Identity=64.1165755919854, Blast_Score=723, Evalue=0.0,
Organism=Drosophila melanogaster, GI24651914, Length=549, Percent_Identity=64.1165755919854, Blast_Score=723, Evalue=0.0,
Organism=Drosophila melanogaster, GI17737445, Length=549, Percent_Identity=64.1165755919854, Blast_Score=723, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001672
- InterPro:   IPR023096
- InterPro:   IPR018189 [H]

Pfam domain/function: PF00342 PGI [H]

EC number: =5.3.1.9 [H]

Molecular weight: Translated: 61429; Mature: 61429

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: PS00765 P_GLUCOSE_ISOMERASE_1 ; PS00174 P_GLUCOSE_ISOMERASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNINPTQTSAWQALQKHYDEMKDVTIAELFANDSDRFAKFSATFDDLMLVDFSKNRITE
CCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHCCCCHHHEEHHCCCCCEEEEECCCCCCCH
ETLAKLQDLAKETDLAGAIKSMFSGEKINRTEDRAVLHVALRNRSNTPIIVDGKDVMPEV
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHEEEEEECCCCCCCEEECCHHHHHHH
NAVLEKMKTFSQAIISGQWKGYTGKAITDVVNIGIGGSDLGPFMVTEALRPYKNHLTMHF
HHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCEEEEE
VSNVDGTHIAEVLKKVNPETTLFLVASKTFTTQETMTNAHSARDWFLKTAGDEKHVAKHF
ECCCCHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
AALSTNAKAVGEFGIDTANMFEFWDWVGGRYSLWSAIGLSIILSVGFDNFVELLSGAHAM
HHHCCCCHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCHHHHHHHHHCCHHH
DKHFSTTPAEKNLPILLALIGIWYNNFFGAETEAILPYDQYMHRFAAYFQQGNMESNGKY
HHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEECCHHHHHHHHHHHHHCCCCCCCCEE
VDRNGNAVDYQTGPIIWGEPGTNGQHAFYQLIHQGTKMVPCDFIAPAITHNPLSDHHQKL
ECCCCCEEEECCCCEEECCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHCCCCCHHHHHHH
LSNFFAQTEALAFGKSREVVEQEYRDQGKDPAQLEHVVPFKVFEGNRPTNSILLREITPF
HHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHCCCEEEECCCCCCCCEEEECCCCH
SLGALIALYEHKIFTQGVILNIFTFDQWGVELGKQLANRILPELGDDKAISSHDSSTNGL
HHHHHHHHHHHHHHHCCEEEEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHH
INRYKAWRA
HHHHHHCCC
>Mature Secondary Structure
MKNINPTQTSAWQALQKHYDEMKDVTIAELFANDSDRFAKFSATFDDLMLVDFSKNRITE
CCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHCCCCHHHEEHHCCCCCEEEEECCCCCCCH
ETLAKLQDLAKETDLAGAIKSMFSGEKINRTEDRAVLHVALRNRSNTPIIVDGKDVMPEV
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHEEEEEECCCCCCCEEECCHHHHHHH
NAVLEKMKTFSQAIISGQWKGYTGKAITDVVNIGIGGSDLGPFMVTEALRPYKNHLTMHF
HHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCEEEEE
VSNVDGTHIAEVLKKVNPETTLFLVASKTFTTQETMTNAHSARDWFLKTAGDEKHVAKHF
ECCCCHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
AALSTNAKAVGEFGIDTANMFEFWDWVGGRYSLWSAIGLSIILSVGFDNFVELLSGAHAM
HHHCCCCHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCHHHHHHHHHCCHHH
DKHFSTTPAEKNLPILLALIGIWYNNFFGAETEAILPYDQYMHRFAAYFQQGNMESNGKY
HHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEECCHHHHHHHHHHHHHCCCCCCCCEE
VDRNGNAVDYQTGPIIWGEPGTNGQHAFYQLIHQGTKMVPCDFIAPAITHNPLSDHHQKL
ECCCCCEEEECCCCEEECCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHCCCCCHHHHHHH
LSNFFAQTEALAFGKSREVVEQEYRDQGKDPAQLEHVVPFKVFEGNRPTNSILLREITPF
HHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHCCCEEEECCCCCCCCEEEECCCCH
SLGALIALYEHKIFTQGVILNIFTFDQWGVELGKQLANRILPELGDDKAISSHDSSTNGL
HHHHHHHHHHHHHHHCCEEEEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHH
INRYKAWRA
HHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA