Click here to switch to the map view.

The map label for this gene is mscS [H]

Identifier: 16767368

GI number: 16767368

Start: 4313424

End: 4314281

Strand: Reverse

Name: mscS [H]

Synonym: STM4102

Alternate gene names: 16767368

Gene position: 4314281-4313424 (Counterclockwise)

Preceding gene: 16767369

Following gene: 16767365

Centisome position: 88.82

GC content: 46.97

Gene sequence:

>858_bases
ATGGAAGGTTTTGAGTTATTTCCAAAAATTAAAGGCGCGATCAAATGGATGGCCGAGCACAGTGACTCGGTAATTCATTT
TGGCTGGAATGTTGTTGCCGCCATCATTCTACTTTTCATCGGTAAGTTAATAGCTCGCTTACTATCGAGGGGGCTGGAAA
AATTACTTCTCAGGCGGCAAGTGGATGCCACTATTGTCCACTTTTTCTCCGCGCTGGTTCGCTACATCACGATAGCTTTC
ACGGCAGTAGCCGCTCTTGGCCGTGTCGGTATAGAAACCTCCTCAATTATTGCCGTTATCGGCGCGGCGGGTTTAGCCAT
TGGCCTGGCGCTGCAAGGGTCACTTTCCAACTTTGCCGCAGGCGTACTGCTTGTCTCCCTGCGTCCTTTCCGCGCCGGGG
AAATTGTACAAATTGGCCTGGTTATCGGCACAGTAGAAAAGGTCCATATTTTCTCCACCACTCTGCTCACTGCGGATAGC
AAAGAAGTTGTCATCCCGAATGGTAAAATTATTGCTGATAATATTATCAACTATTCACGACACCCCTATCGACGTATTGA
TCTGATTATTGGCGTGGATTACCAAAGCCGTATTGCTGACGTAAAAAACGTGATACATCGTATTATTGAGCAAGATCATC
GCATTGATAAAACCCGCGATATTACGGTCCGCTTGGGCGAACTTGCGCCCTCTAGCCTGAATTTCTATGTTCGCGTATGG
GTGCCCAACGCTCAGTACTGGAGTACTTACTACGATCTTCTGGAAAATATCAAGGAAGCAATGGATGAAAACGGCATCAA
TATTCCTTACCCCCGGATGGATGTCCGGGTTGAGAATGTAAAAAGCATCACGCCATAA

Upstream 100 bases:

>100_bases
GGGCGTTACTGCTGCCACCCGTCGGCGCGGCGATTATCCAGGCAAAAATGAACCGTTTTATTACCGCTAATACCGCGGAT
ACTGCTGACAGAGGATAAAC

Downstream 100 bases:

>100_bases
TGTTTCGTCAGCAATCGGATGGCGCTTCGTATATCAGTATCTACAGAATGACTGCATAACGTATTGATGAGGGAGCGAAG
CGCAACCCGGCGCTTCGCTC

Product: inner membrane protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 285; Mature: 285

Protein sequence:

>285_residues
MEGFELFPKIKGAIKWMAEHSDSVIHFGWNVVAAIILLFIGKLIARLLSRGLEKLLLRRQVDATIVHFFSALVRYITIAF
TAVAALGRVGIETSSIIAVIGAAGLAIGLALQGSLSNFAAGVLLVSLRPFRAGEIVQIGLVIGTVEKVHIFSTTLLTADS
KEVVIPNGKIIADNIINYSRHPYRRIDLIIGVDYQSRIADVKNVIHRIIEQDHRIDKTRDITVRLGELAPSSLNFYVRVW
VPNAQYWSTYYDLLENIKEAMDENGINIPYPRMDVRVENVKSITP

Sequences:

>Translated_285_residues
MEGFELFPKIKGAIKWMAEHSDSVIHFGWNVVAAIILLFIGKLIARLLSRGLEKLLLRRQVDATIVHFFSALVRYITIAF
TAVAALGRVGIETSSIIAVIGAAGLAIGLALQGSLSNFAAGVLLVSLRPFRAGEIVQIGLVIGTVEKVHIFSTTLLTADS
KEVVIPNGKIIADNIINYSRHPYRRIDLIIGVDYQSRIADVKNVIHRIIEQDHRIDKTRDITVRLGELAPSSLNFYVRVW
VPNAQYWSTYYDLLENIKEAMDENGINIPYPRMDVRVENVKSITP
>Mature_285_residues
MEGFELFPKIKGAIKWMAEHSDSVIHFGWNVVAAIILLFIGKLIARLLSRGLEKLLLRRQVDATIVHFFSALVRYITIAF
TAVAALGRVGIETSSIIAVIGAAGLAIGLALQGSLSNFAAGVLLVSLRPFRAGEIVQIGLVIGTVEKVHIFSTTLLTADS
KEVVIPNGKIIADNIINYSRHPYRRIDLIIGVDYQSRIADVKNVIHRIIEQDHRIDKTRDITVRLGELAPSSLNFYVRVW
VPNAQYWSTYYDLLENIKEAMDENGINIPYPRMDVRVENVKSITP

Specific function: Mechanosensitive channel that participates in the regulation of osmotic pressure changes within the cell. Forms an ion channel of 1.0 nanosiemens conductance with a slight preference for anions. The channel is sensitive to voltage [H]

COG id: COG0668

COG function: function code M; Small-conductance mechanosensitive channel

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mscS (TC 1.A.23) family [H]

Homologues:

Organism=Escherichia coli, GI1789291, Length=281, Percent_Identity=54.4483985765125, Blast_Score=305, Evalue=2e-84,
Organism=Escherichia coli, GI1786670, Length=251, Percent_Identity=29.0836653386454, Blast_Score=95, Evalue=5e-21,
Organism=Escherichia coli, GI1787591, Length=247, Percent_Identity=25.9109311740891, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI2367355, Length=254, Percent_Identity=23.2283464566929, Blast_Score=72, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010920
- InterPro:   IPR011066
- InterPro:   IPR006685
- InterPro:   IPR006686
- InterPro:   IPR011014
- InterPro:   IPR008910 [H]

Pfam domain/function: PF00924 MS_channel; PF05552 TM_helix [H]

EC number: NA

Molecular weight: Translated: 31744; Mature: 31744

Theoretical pI: Translated: 9.63; Mature: 9.63

Prosite motif: PS01246 UPF0003

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEGFELFPKIKGAIKWMAEHSDSVIHFGWNVVAAIILLFIGKLIARLLSRGLEKLLLRRQ
CCCHHHHHHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VDATIVHFFSALVRYITIAFTAVAALGRVGIETSSIIAVIGAAGLAIGLALQGSLSNFAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHH
GVLLVSLRPFRAGEIVQIGLVIGTVEKVHIFSTTLLTADSKEVVIPNGKIIADNIINYSR
HHHHEEECCCCCCCEEEEEEEHHCHHHEEEEEEEEEECCCCEEEECCCCEEEHHHHCCCC
HPYRRIDLIIGVDYQSRIADVKNVIHRIIEQDHRIDKTRDITVRLGELAPSSLNFYVRVW
CCCEEEEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCEEEEEEE
VPNAQYWSTYYDLLENIKEAMDENGINIPYPRMDVRVENVKSITP
ECCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCCCCCCC
>Mature Secondary Structure
MEGFELFPKIKGAIKWMAEHSDSVIHFGWNVVAAIILLFIGKLIARLLSRGLEKLLLRRQ
CCCHHHHHHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VDATIVHFFSALVRYITIAFTAVAALGRVGIETSSIIAVIGAAGLAIGLALQGSLSNFAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHH
GVLLVSLRPFRAGEIVQIGLVIGTVEKVHIFSTTLLTADSKEVVIPNGKIIADNIINYSR
HHHHEEECCCCCCCEEEEEEEHHCHHHEEEEEEEEEECCCCEEEECCCCEEEHHHHCCCC
HPYRRIDLIIGVDYQSRIADVKNVIHRIIEQDHRIDKTRDITVRLGELAPSSLNFYVRVW
CCCEEEEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCEEEEEEE
VPNAQYWSTYYDLLENIKEAMDENGINIPYPRMDVRVENVKSITP
ECCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12542086 [H]