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The map label for this gene is ilvG [H]

Identifier: 16767177

GI number: 16767177

Start: 4108973

End: 4110619

Strand: Direct

Name: ilvG [H]

Synonym: STM3901

Alternate gene names: 16767177

Gene position: 4108973-4110619 (Clockwise)

Preceding gene: 16767176

Following gene: 308065950

Centisome position: 84.59

GC content: 56.34

Gene sequence:

>1647_bases
ATGAACGGGGCACAGTGGGTGGTACATGCTTTGCGAGCGCAGGGGGTGAAAACCGTATTTGGTTATCCTGGCGGCGCAAT
TATGCCGGTTTACGACGCGTTGTATGACGGTGGTGTGGAGCATTTGTTGTGCCGACACGAGCAGGGTGCGGCAATGGCGG
CAATCGGTTATGCCCGTTCTACCGGCAAAACCGGTGTTTGTATCGCCACTTCCGGCCCTGGCGCCACTAACCTGATCACT
GGCCTGGCGGATGCGTTGTTAGATTCGGTCCCCGTCGTCGCGATCACGGGTCAGGTTTCCGCCCCGTTCATCGGCACCGA
TGCGTTCCAGGAGGTGGATGTGTTAGGGCTGTCGCTGGCCTGTACCAAACACAGCTTCCTGGTGCAGTCGCTGGAAGAGT
TGCCGCGCATCATGGCGGAGGCTTTTGAAGTCGCCAACGCTGGCCGTCCTGGCCCGGTTCTGGTGGATATCCCGAAAGAT
ATCCAGTTGGCCAGCGGTGAGCTGGAACCCTGGTTTACTACCGTTGCTAACGAAGCGACTTTCCCGCAGGCTGATGTGGA
ACAGGCGCGCCAGATGCTGGAACAGGCGAAAAAACCCATGCTGTACGTCGGCGGTGGTGTTGGTATGGCGCAGGCAGTTC
CGGCGCTGCGTAAATTTATCGCGGTAACGCAAATGCCAGTTACCTGCACGCTGAAAGGGCTGGGGGCTGTTGAAGCTGAT
TATCCGTACTATCTGGGCATGCTGGGAATGCACGGTACTAAAGCGGCTAATTTCGCGGTGCAAGAGTGTGATTTACTGAT
CGCAGTGGGTGCACGTTTTGATGACCGGGTGACCGGTAAGCTGAATACGTTTGCGCCGAACGCCAGCGTAATCCATATGG
ATATCGACCCGGCGGAAATGAACAAACTGCGTCAGGCACACGTCGCGTTGCAGGGCGATTTAAATTCGCTGTTGCCGGCA
TTACAGCAACCGCTGAAGATCGACGCATGGCGTCAGTCCTGTGCAGAGCTGCGCGCAGAACACGCCTGGCGCTATGACCA
TCCTGGCGAGACTATCTATGCGCCGTTGTTGTTGAAGCAATTGTCGGAACGCAAACCCGCAGACAGCGTGGTGACGACGG
ATGTGGGGCAGCATCAGATGTGGTCAGCCCAGCATATGACTTACACCCGCCCGGAGAACTTCATCACCTCCAGCGGTCTG
GGGACGATGGGATTCGGCTTACCGGCGGCCGTTGGCGCGCAGGTAGCGCGACCGAATGATACCGTTATCTGTATCTCCGG
TGACGGCTCCTTCATGATGAATGTTCAGGAGTTGGGCACCGTAAAACGCAAGCAGTTACCGTTGAAGATAGTCTTACTCG
ACAACCAGCGGTTAGGGATGGTTCGACAATGGCAGCAACTGTTTTTCCAGGAGCGATATAGCGAAACCACCCTGACCGAT
AACCCCGATTTCCTCATGCTGGCCAGCGCCTTCGGCATTCCAGGCCAGCACATTACTCGTAAAGACCAGGTTGAAGCGGC
ACTCGACACGATGTTGGCAAGCGAAGGGCCGTACCTGCTTCACGTCTCAATCGACGAACTTGAAAATGTCTGGCCGTTGG
TGCCGCCTGGCGCCAGTAACTCTGAAATGCTGGAGAAATTATCATGA

Upstream 100 bases:

>100_bases
GTCCGGGGGTTTTTTTTGGCCTGAAAAACTTAAGCGAGGAGCAGAGCGTGAATAACAGCATAAAATTCTGTTTCTCAAGA
TTTACGACGGGGATGTAACT

Downstream 100 bases:

>100_bases
TGCAACATCAGGTCAATGTATCGGCACGCTTTAATCCAGAAACCTTAGAACGTGTTTTACGCGTGGTGCGCCATCGTGGT
TTTCAGGTGTGCTCCATGAA

Product: acetolactate synthase 2 catalytic subunit

Products: NA

Alternate protein names: AHAS-II; ALS-II; Acetohydroxy-acid synthase II large subunit [H]

Number of amino acids: Translated: 548; Mature: 548

Protein sequence:

>548_residues
MNGAQWVVHALRAQGVKTVFGYPGGAIMPVYDALYDGGVEHLLCRHEQGAAMAAIGYARSTGKTGVCIATSGPGATNLIT
GLADALLDSVPVVAITGQVSAPFIGTDAFQEVDVLGLSLACTKHSFLVQSLEELPRIMAEAFEVANAGRPGPVLVDIPKD
IQLASGELEPWFTTVANEATFPQADVEQARQMLEQAKKPMLYVGGGVGMAQAVPALRKFIAVTQMPVTCTLKGLGAVEAD
YPYYLGMLGMHGTKAANFAVQECDLLIAVGARFDDRVTGKLNTFAPNASVIHMDIDPAEMNKLRQAHVALQGDLNSLLPA
LQQPLKIDAWRQSCAELRAEHAWRYDHPGETIYAPLLLKQLSERKPADSVVTTDVGQHQMWSAQHMTYTRPENFITSSGL
GTMGFGLPAAVGAQVARPNDTVICISGDGSFMMNVQELGTVKRKQLPLKIVLLDNQRLGMVRQWQQLFFQERYSETTLTD
NPDFLMLASAFGIPGQHITRKDQVEAALDTMLASEGPYLLHVSIDELENVWPLVPPGASNSEMLEKLS

Sequences:

>Translated_548_residues
MNGAQWVVHALRAQGVKTVFGYPGGAIMPVYDALYDGGVEHLLCRHEQGAAMAAIGYARSTGKTGVCIATSGPGATNLIT
GLADALLDSVPVVAITGQVSAPFIGTDAFQEVDVLGLSLACTKHSFLVQSLEELPRIMAEAFEVANAGRPGPVLVDIPKD
IQLASGELEPWFTTVANEATFPQADVEQARQMLEQAKKPMLYVGGGVGMAQAVPALRKFIAVTQMPVTCTLKGLGAVEAD
YPYYLGMLGMHGTKAANFAVQECDLLIAVGARFDDRVTGKLNTFAPNASVIHMDIDPAEMNKLRQAHVALQGDLNSLLPA
LQQPLKIDAWRQSCAELRAEHAWRYDHPGETIYAPLLLKQLSERKPADSVVTTDVGQHQMWSAQHMTYTRPENFITSSGL
GTMGFGLPAAVGAQVARPNDTVICISGDGSFMMNVQELGTVKRKQLPLKIVLLDNQRLGMVRQWQQLFFQERYSETTLTD
NPDFLMLASAFGIPGQHITRKDQVEAALDTMLASEGPYLLHVSIDELENVWPLVPPGASNSEMLEKLS
>Mature_548_residues
MNGAQWVVHALRAQGVKTVFGYPGGAIMPVYDALYDGGVEHLLCRHEQGAAMAAIGYARSTGKTGVCIATSGPGATNLIT
GLADALLDSVPVVAITGQVSAPFIGTDAFQEVDVLGLSLACTKHSFLVQSLEELPRIMAEAFEVANAGRPGPVLVDIPKD
IQLASGELEPWFTTVANEATFPQADVEQARQMLEQAKKPMLYVGGGVGMAQAVPALRKFIAVTQMPVTCTLKGLGAVEAD
YPYYLGMLGMHGTKAANFAVQECDLLIAVGARFDDRVTGKLNTFAPNASVIHMDIDPAEMNKLRQAHVALQGDLNSLLPA
LQQPLKIDAWRQSCAELRAEHAWRYDHPGETIYAPLLLKQLSERKPADSVVTTDVGQHQMWSAQHMTYTRPENFITSSGL
GTMGFGLPAAVGAQVARPNDTVICISGDGSFMMNVQELGTVKRKQLPLKIVLLDNQRLGMVRQWQQLFFQERYSETTLTD
NPDFLMLASAFGIPGQHITRKDQVEAALDTMLASEGPYLLHVSIDELENVWPLVPPGASNSEMLEKLS

Specific function: Catalyzes the first step in the biosynthesis of branched-chain amino acids [H]

COG id: COG0028

COG function: function code EH; Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Homo sapiens, GI93004078, Length=554, Percent_Identity=24.0072202166065, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI21361361, Length=498, Percent_Identity=25.1004016064257, Blast_Score=141, Evalue=2e-33,
Organism=Escherichia coli, GI1790104, Length=552, Percent_Identity=46.9202898550725, Blast_Score=514, Evalue=1e-147,
Organism=Escherichia coli, GI87081685, Length=563, Percent_Identity=43.1616341030195, Blast_Score=467, Evalue=1e-133,
Organism=Escherichia coli, GI1786717, Length=560, Percent_Identity=29.1071428571429, Blast_Score=259, Evalue=4e-70,
Organism=Escherichia coli, GI1787096, Length=541, Percent_Identity=29.0203327171904, Blast_Score=201, Evalue=1e-52,
Organism=Escherichia coli, GI1788716, Length=548, Percent_Identity=26.6423357664234, Blast_Score=157, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI17531299, Length=551, Percent_Identity=27.7676950998185, Blast_Score=164, Evalue=9e-41,
Organism=Caenorhabditis elegans, GI17531301, Length=551, Percent_Identity=27.7676950998185, Blast_Score=164, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI17542570, Length=572, Percent_Identity=24.1258741258741, Blast_Score=123, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6323755, Length=577, Percent_Identity=44.5407279029463, Blast_Score=465, Evalue=1e-131,
Organism=Saccharomyces cerevisiae, GI6320816, Length=489, Percent_Identity=22.2903885480573, Blast_Score=91, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6323163, Length=485, Percent_Identity=23.0927835051546, Blast_Score=87, Evalue=6e-18,
Organism=Saccharomyces cerevisiae, GI6321524, Length=494, Percent_Identity=21.8623481781377, Blast_Score=83, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6323073, Length=480, Percent_Identity=23.5416666666667, Blast_Score=77, Evalue=8e-15,
Organism=Drosophila melanogaster, GI19922626, Length=565, Percent_Identity=26.9026548672566, Blast_Score=179, Evalue=3e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012846
- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR000399
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]

EC number: =2.2.1.6 [H]

Molecular weight: Translated: 59225; Mature: 59225

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: PS00187 TPP_ENZYMES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNGAQWVVHALRAQGVKTVFGYPGGAIMPVYDALYDGGVEHLLCRHEQGAAMAAIGYARS
CCHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHCCHHHHHHHCCCCCEEEEEHHHCC
TGKTGVCIATSGPGATNLITGLADALLDSVPVVAITGQVSAPFIGTDAFQEVDVLGLSLA
CCCCCEEEEECCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHCEEEH
CTKHSFLVQSLEELPRIMAEAFEVANAGRPGPVLVDIPKDIQLASGELEPWFTTVANEAT
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCEECCCCCCHHHHHHCCCCC
FPQADVEQARQMLEQAKKPMLYVGGGVGMAQAVPALRKFIAVTQMPVTCTLKGLGAVEAD
CCHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCC
YPYYLGMLGMHGTKAANFAVQECDLLIAVGARFDDRVTGKLNTFAPNASVIHMDIDPAEM
CCHHHHHHCCCCCCHHHHHHHHCCEEEEECCCCCCCCCCCEEEECCCCEEEEEECCHHHH
NKLRQAHVALQGDLNSLLPALQQPLKIDAWRQSCAELRAEHAWRYDHPGETIYAPLLLKQ
HHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHH
LSERKPADSVVTTDVGQHQMWSAQHMTYTRPENFITSSGLGTMGFGLPAAVGAQVARPND
HHCCCCCCCEEECCCCCHHHCCCCCCEEECCCCCEECCCCCCCCCCCHHHHCCEECCCCC
TVICISGDGSFMMNVQELGTVKRKQLPLKIVLLDNQRLGMVRQWQQLFFQERYSETTLTD
EEEEEECCCCEEEEHHHHCCHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCC
NPDFLMLASAFGIPGQHITRKDQVEAALDTMLASEGPYLLHVSIDELENVWPLVPPGASN
CCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEHHHHHCCCCCCCCCCCC
SEMLEKLS
HHHHHHCC
>Mature Secondary Structure
MNGAQWVVHALRAQGVKTVFGYPGGAIMPVYDALYDGGVEHLLCRHEQGAAMAAIGYARS
CCHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHCCHHHHHHHCCCCCEEEEEHHHCC
TGKTGVCIATSGPGATNLITGLADALLDSVPVVAITGQVSAPFIGTDAFQEVDVLGLSLA
CCCCCEEEEECCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHCEEEH
CTKHSFLVQSLEELPRIMAEAFEVANAGRPGPVLVDIPKDIQLASGELEPWFTTVANEAT
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCEECCCCCCHHHHHHCCCCC
FPQADVEQARQMLEQAKKPMLYVGGGVGMAQAVPALRKFIAVTQMPVTCTLKGLGAVEAD
CCHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCC
YPYYLGMLGMHGTKAANFAVQECDLLIAVGARFDDRVTGKLNTFAPNASVIHMDIDPAEM
CCHHHHHHCCCCCCHHHHHHHHCCEEEEECCCCCCCCCCCEEEECCCCEEEEEECCHHHH
NKLRQAHVALQGDLNSLLPALQQPLKIDAWRQSCAELRAEHAWRYDHPGETIYAPLLLKQ
HHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHH
LSERKPADSVVTTDVGQHQMWSAQHMTYTRPENFITSSGLGTMGFGLPAAVGAQVARPND
HHCCCCCCCEEECCCCCHHHCCCCCCEEECCCCCEECCCCCCCCCCCHHHHCCEECCCCC
TVICISGDGSFMMNVQELGTVKRKQLPLKIVLLDNQRLGMVRQWQQLFFQERYSETTLTD
EEEEEECCCCEEEEHHHHCCHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCC
NPDFLMLASAFGIPGQHITRKDQVEAALDTMLASEGPYLLHVSIDELENVWPLVPPGASN
CCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEHHHHHCCCCCCCCCCCC
SEMLEKLS
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3550695; 1379743; 9278503; 1995430; 6154938; 7015336; 3897211 [H]