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The map label for this gene is tdcA [H]

Identifier: 16766544

GI number: 16766544

Start: 3412473

End: 3413411

Strand: Reverse

Name: tdcA [H]

Synonym: STM3245

Alternate gene names: 16766544

Gene position: 3413411-3412473 (Counterclockwise)

Preceding gene: 16766545

Following gene: 16766543

Centisome position: 70.27

GC content: 44.73

Gene sequence:

>939_bases
ATGAATACTCTTGTTCTCCCTAAAACACAGCATTTGGTGGTCTTTCAGGAAGTCATTAGAAGTGGTTCTATCGGTTCTGC
CGCAAAATCGTTAGGGTTAACCCAACCCGCCGTCAGTAAAATCATTAGCGATGTTGAGGCCTATTTTGGCGTTGAGCTAA
TTGTACGTAAAAATACCGGCGTTACGTTGACCGAAGCGGGACAGGTACTGCTTTCCTGGTCTGAATCTATCACCCGCGAA
ATGAAAAACATGATCAACGAGATGAACAGTATGACGTGCAATACCGTTGTCGACGTCTCGTTTGGCTTTCCTTCGCTGAT
TGGCTTTACCTTCATGTCCGATATGATTCATAAGTTCAAAGAGGTCTTTCCAAAAGCGCAGGTATCCATGTACGAAGCCC
AGCTCTCTTCATTTCTGCCGGCCCTGCGCGACGGGCGGCTGGACTTTGCTATCGGTACGCTCAGTAATGAAATGCAGCTA
CAGGATCTGCATGTCGAGCCGCTGTTTGAATCAGAGTTTGTCCTGGTAGCCAGCAAGTCCCGAACATGCACCGGCACCAT
CACACTGGAATCGTTAAAAGACGAACAGTGGGTGTTGCCGCAAACGAATATGGGCTACTACAGCGAATTACTCACCACTC
TACAACGAAATGGCATCAGCATCGAAAACATTGTTAAAACAGATTCCGTCGTCACAATATATAATCTTGTTCTCAATGCT
GATTTCTTAACTGTTATTCCCTGCGATATGACCACGCCTTTTGGCTCTAATCAATTTATCACGATACCCATACAAGACAC
GTTACCCGTCGCACGTTATGCGGCGGTATGGTCTAAAAATTATCGTATCAAAAAAGCCGCTTCAGTATTAGTAGAATTGG
CTAAACAATATTCATCATATAATGGATGCAGACGCAGGCAGTTAATAGAAATTGAATGA

Upstream 100 bases:

>100_bases
AAAATTGTGGTAAGTTAATTTGTGAGTGGTCGCACATAACCTTTAAGATTTAATTTGCTACACTTCCTGCCGTTCACAAT
GTTATTTCAGAGCGGTAGAT

Downstream 100 bases:

>100_bases
TATGGAATAAACATATTTAGCGAAATTGACGTCACCTGTTTCTTTTGAACAGTGGGCAACGGTAACTTATTTTTAATACC
CAGGTTAAGAGGTTATAATG

Product: DNA-binding transcriptional activator TdcA

Products: NA

Alternate protein names: Tdc operon transcriptional activator [H]

Number of amino acids: Translated: 312; Mature: 312

Protein sequence:

>312_residues
MNTLVLPKTQHLVVFQEVIRSGSIGSAAKSLGLTQPAVSKIISDVEAYFGVELIVRKNTGVTLTEAGQVLLSWSESITRE
MKNMINEMNSMTCNTVVDVSFGFPSLIGFTFMSDMIHKFKEVFPKAQVSMYEAQLSSFLPALRDGRLDFAIGTLSNEMQL
QDLHVEPLFESEFVLVASKSRTCTGTITLESLKDEQWVLPQTNMGYYSELLTTLQRNGISIENIVKTDSVVTIYNLVLNA
DFLTVIPCDMTTPFGSNQFITIPIQDTLPVARYAAVWSKNYRIKKAASVLVELAKQYSSYNGCRRRQLIEIE

Sequences:

>Translated_312_residues
MNTLVLPKTQHLVVFQEVIRSGSIGSAAKSLGLTQPAVSKIISDVEAYFGVELIVRKNTGVTLTEAGQVLLSWSESITRE
MKNMINEMNSMTCNTVVDVSFGFPSLIGFTFMSDMIHKFKEVFPKAQVSMYEAQLSSFLPALRDGRLDFAIGTLSNEMQL
QDLHVEPLFESEFVLVASKSRTCTGTITLESLKDEQWVLPQTNMGYYSELLTTLQRNGISIENIVKTDSVVTIYNLVLNA
DFLTVIPCDMTTPFGSNQFITIPIQDTLPVARYAAVWSKNYRIKKAASVLVELAKQYSSYNGCRRRQLIEIE
>Mature_312_residues
MNTLVLPKTQHLVVFQEVIRSGSIGSAAKSLGLTQPAVSKIISDVEAYFGVELIVRKNTGVTLTEAGQVLLSWSESITRE
MKNMINEMNSMTCNTVVDVSFGFPSLIGFTFMSDMIHKFKEVFPKAQVSMYEAQLSSFLPALRDGRLDFAIGTLSNEMQL
QDLHVEPLFESEFVLVASKSRTCTGTITLESLKDEQWVLPQTNMGYYSELLTTLQRNGISIENIVKTDSVVTIYNLVLNA
DFLTVIPCDMTTPFGSNQFITIPIQDTLPVARYAAVWSKNYRIKKAASVLVELAKQYSSYNGCRRRQLIEIE

Specific function: Transcriptional activator for the tdcABCDE operon [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789506, Length=311, Percent_Identity=89.0675241157556, Blast_Score=581, Evalue=1e-167,
Organism=Escherichia coli, GI1787601, Length=276, Percent_Identity=27.1739130434783, Blast_Score=131, Evalue=5e-32,
Organism=Escherichia coli, GI1787879, Length=283, Percent_Identity=24.0282685512367, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1788481, Length=200, Percent_Identity=26.5, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1790399, Length=234, Percent_Identity=24.7863247863248, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI157672245, Length=260, Percent_Identity=21.5384615384615, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1790262, Length=190, Percent_Identity=25.7894736842105, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI1788748, Length=250, Percent_Identity=22.8, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1786401, Length=174, Percent_Identity=28.1609195402299, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 34871; Mature: 34871

Theoretical pI: Translated: 5.43; Mature: 5.43

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTLVLPKTQHLVVFQEVIRSGSIGSAAKSLGLTQPAVSKIISDVEAYFGVELIVRKNTG
CCCEECCCCHHHHHHHHHHHCCCCCHHHHHCCCCHHHHHHHHHHHHHHCCEEEEEECCCC
VTLTEAGQVLLSWSESITREMKNMINEMNSMTCNTVVDVSFGFPSLIGFTFMSDMIHKFK
EEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHH
EVFPKAQVSMYEAQLSSFLPALRDGRLDFAIGTLSNEMQLQDLHVEPLFESEFVLVASKS
HHCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCEEEEECCCCCCCCCCEEEEEECC
RTCTGTITLESLKDEQWVLPQTNMGYYSELLTTLQRNGISIENIVKTDSVVTIYNLVLNA
CEEEEEEEEECCCCCCEECCCCCCHHHHHHHHHHHHCCCCHHHHHCCCCHHHHHHHHHCC
DFLTVIPCDMTTPFGSNQFITIPIQDTLPVARYAAVWSKNYRIKKAASVLVELAKQYSSY
CEEEEEECCCCCCCCCCCEEEEECCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCC
NGCRRRQLIEIE
CCCCCCEEEECC
>Mature Secondary Structure
MNTLVLPKTQHLVVFQEVIRSGSIGSAAKSLGLTQPAVSKIISDVEAYFGVELIVRKNTG
CCCEECCCCHHHHHHHHHHHCCCCCHHHHHCCCCHHHHHHHHHHHHHHCCEEEEEECCCC
VTLTEAGQVLLSWSESITREMKNMINEMNSMTCNTVVDVSFGFPSLIGFTFMSDMIHKFK
EEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHH
EVFPKAQVSMYEAQLSSFLPALRDGRLDFAIGTLSNEMQLQDLHVEPLFESEFVLVASKS
HHCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCEEEEECCCCCCCCCCEEEEEECC
RTCTGTITLESLKDEQWVLPQTNMGYYSELLTTLQRNGISIENIVKTDSVVTIYNLVLNA
CEEEEEEEEECCCCCCEECCCCCCHHHHHHHHHHHHCCCCHHHHHCCCCHHHHHHHHHCC
DFLTVIPCDMTTPFGSNQFITIPIQDTLPVARYAAVWSKNYRIKKAASVLVELAKQYSSY
CEEEEEECCCCCCCCCCCEEEEECCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCC
NGCRRRQLIEIE
CCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]