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The map label for this gene is tdcC [H]

Identifier: 16766542

GI number: 16766542

Start: 3410034

End: 3411365

Strand: Reverse

Name: tdcC [H]

Synonym: STM3243

Alternate gene names: 16766542

Gene position: 3411365-3410034 (Counterclockwise)

Preceding gene: 16766543

Following gene: 16766541

Centisome position: 70.23

GC content: 50.9

Gene sequence:

>1332_bases
ATGAGTACTACTGATAGCATTGTATCCAGCCAGGCAAAACAGTCGTCATGGCGTAAATCGGACACGACGTGGACGCTGGG
TTTATTTGGTACCGCCATCGGCGCCGGGGTGCTGTTTTTCCCTATCCGCGCCGGGTTTGGCGGGCTTATCCCCATTCTTC
TGATGCTGGTTTTAGCTTACCCCATTGCGTTCTATTGTCACCGGGCGCTGGCGCGTCTGTGTTTATCCGGATCTAATCCG
TCCGGCAATATTACGGAAACGGTCGAAGAGCACTTTGGTAAAACGGGCGGGGTAGTTATCACGTTCCTTTACTTCTTTGC
GATTTGTCCGCTGCTGTGGATTTATGGCGTCACCATTACTAACACGTTCATGACGTTTTGGGAAAACCAGCTGCAGATGC
CAGCGTTGAATCGCGGTTTCGTGGCGCTGTTCTTGCTGCTGCTGATGGCCTTTGTGATCTGGTTTGGTAAAGATCTGATG
GTTAAGGTGATGAGTTACCTGGTATGGCCGTTTATCGCCAGTCTGGTACTAATCTCATTATCGCTGATTCCTTACTGGAA
CTCGGCGGTTATCGATCAGGTTGATCTCAGTAATATCGCGCTGACCGGGCACGATGGCATACTGGTTACGGTGTGGCTGG
GCATCTCTATCATGGTGTTCTCCTTTAACTTTTCGCCCATCGTCTCTTCCTTCGTGGTGTCTAAGCGTGAAGAGTATGAG
AAAGAGTTTGGCCGCGAATTTACCGAGCGTAAATGTTCACAGATCATCTCGCGCGCCAGTATGCTGATGGTCGCCGTGGT
GATGTTCTTCGCCTTTAGCTGCCTGTTTACGCTCTCCCCGCAGAACATGGCGGATGCGAAAGCGCAGAACATTCCGGTAC
TTTCCTACCTGGCCAACCATTTCGCCTCTTTGTCGGGGACAAAATCTACTTTTGCAACGGTGCTGGAGTATGGCGCGTCT
ATCATCGCGCTGGTTGCTATTTTCAAATCTTTCTTCGGCCACTACCTGGGGACGCTGGAAGGGCTGAACGGCCTGGTGCT
GAAATTTGGTTATAAAGGCGATAAAACCAAAGTCTCTATGGGCAAGCTTAACACCATCAGCATGATCTTCATTATGGGGT
CTACCTGGGTCGTAGCTTACGCAAACCCGAACATTCTGGACCTGATTGAAGCGATGGGCGCGCCGATTATCGCCTCGCTG
TTATGCCTGCTGCCGATGTACGCCATTCGTAAAGCGCCGTCGCTGGCGAAGTACCGTGGTCGTCTGGATAACGTGTTCGT
CACCCTGATTGGTCTGCTGACCATCCTGAATATTGTCTACAAATTGTTCTAA

Upstream 100 bases:

>100_bases
GAAAAACGGTCAGTATTATTTCTGGCGGCAATATCGATCTTTCTCGGGTATCACAAATTACGGGTTTAGTTGACGCTTAA
TCTTTTCGTGAGGATAGGAT

Downstream 100 bases:

>100_bases
TCCTCACGTTTAGCCTGCGTCCGCCCCAGGGCGCGGACGCAGGCTGACATCGACGGAGGCACTACATGAATGAATTTCCG
GTCGTTCTGGTCATTAATTG

Product: threonine/serine transporter TdcC

Products: Proton [Cytoplasm]; D-serine [Cytoplasm]; L-threonine [Cytoplasm] [C]

Alternate protein names: H(+)/threonine-serine symporter [H]

Number of amino acids: Translated: 443; Mature: 442

Protein sequence:

>443_residues
MSTTDSIVSSQAKQSSWRKSDTTWTLGLFGTAIGAGVLFFPIRAGFGGLIPILLMLVLAYPIAFYCHRALARLCLSGSNP
SGNITETVEEHFGKTGGVVITFLYFFAICPLLWIYGVTITNTFMTFWENQLQMPALNRGFVALFLLLLMAFVIWFGKDLM
VKVMSYLVWPFIASLVLISLSLIPYWNSAVIDQVDLSNIALTGHDGILVTVWLGISIMVFSFNFSPIVSSFVVSKREEYE
KEFGREFTERKCSQIISRASMLMVAVVMFFAFSCLFTLSPQNMADAKAQNIPVLSYLANHFASLSGTKSTFATVLEYGAS
IIALVAIFKSFFGHYLGTLEGLNGLVLKFGYKGDKTKVSMGKLNTISMIFIMGSTWVVAYANPNILDLIEAMGAPIIASL
LCLLPMYAIRKAPSLAKYRGRLDNVFVTLIGLLTILNIVYKLF

Sequences:

>Translated_443_residues
MSTTDSIVSSQAKQSSWRKSDTTWTLGLFGTAIGAGVLFFPIRAGFGGLIPILLMLVLAYPIAFYCHRALARLCLSGSNP
SGNITETVEEHFGKTGGVVITFLYFFAICPLLWIYGVTITNTFMTFWENQLQMPALNRGFVALFLLLLMAFVIWFGKDLM
VKVMSYLVWPFIASLVLISLSLIPYWNSAVIDQVDLSNIALTGHDGILVTVWLGISIMVFSFNFSPIVSSFVVSKREEYE
KEFGREFTERKCSQIISRASMLMVAVVMFFAFSCLFTLSPQNMADAKAQNIPVLSYLANHFASLSGTKSTFATVLEYGAS
IIALVAIFKSFFGHYLGTLEGLNGLVLKFGYKGDKTKVSMGKLNTISMIFIMGSTWVVAYANPNILDLIEAMGAPIIASL
LCLLPMYAIRKAPSLAKYRGRLDNVFVTLIGLLTILNIVYKLF
>Mature_442_residues
STTDSIVSSQAKQSSWRKSDTTWTLGLFGTAIGAGVLFFPIRAGFGGLIPILLMLVLAYPIAFYCHRALARLCLSGSNPS
GNITETVEEHFGKTGGVVITFLYFFAICPLLWIYGVTITNTFMTFWENQLQMPALNRGFVALFLLLLMAFVIWFGKDLMV
KVMSYLVWPFIASLVLISLSLIPYWNSAVIDQVDLSNIALTGHDGILVTVWLGISIMVFSFNFSPIVSSFVVSKREEYEK
EFGREFTERKCSQIISRASMLMVAVVMFFAFSCLFTLSPQNMADAKAQNIPVLSYLANHFASLSGTKSTFATVLEYGASI
IALVAIFKSFFGHYLGTLEGLNGLVLKFGYKGDKTKVSMGKLNTISMIFIMGSTWVVAYANPNILDLIEAMGAPIIASLL
CLLPMYAIRKAPSLAKYRGRLDNVFVTLIGLLTILNIVYKLF

Specific function: Involved in the import of threonine and serine into the cell, with the concomitant import of a proton (symport system) [H]

COG id: COG0814

COG function: function code E; Amino acid permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid/polyamine transporter 2 family. SdaC/TdcC subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789504, Length=443, Percent_Identity=94.8081264108352, Blast_Score=830, Evalue=0.0,
Organism=Escherichia coli, GI1789160, Length=442, Percent_Identity=50, Blast_Score=431, Evalue=1e-122,
Organism=Escherichia coli, GI1789211, Length=425, Percent_Identity=31.0588235294118, Blast_Score=211, Evalue=5e-56,
Organism=Escherichia coli, GI145693183, Length=417, Percent_Identity=24.9400479616307, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1789961, Length=422, Percent_Identity=23.9336492890995, Blast_Score=100, Evalue=3e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004694
- InterPro:   IPR018227 [H]

Pfam domain/function: PF03222 Trp_Tyr_perm [H]

EC number: NA

Molecular weight: Translated: 48975; Mature: 48844

Theoretical pI: Translated: 9.21; Mature: 9.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTTDSIVSSQAKQSSWRKSDTTWTLGLFGTAIGAGVLFFPIRAGFGGLIPILLMLVLAY
CCCHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
PIAFYCHRALARLCLSGSNPSGNITETVEEHFGKTGGVVITFLYFFAICPLLWIYGVTIT
HHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
NTFMTFWENQLQMPALNRGFVALFLLLLMAFVIWFGKDLMVKVMSYLVWPFIASLVLISL
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHH
SLIPYWNSAVIDQVDLSNIALTGHDGILVTVWLGISIMVFSFNFSPIVSSFVVSKREEYE
HHHCCCCCHHHCCCCCCCEEEECCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
KEFGREFTERKCSQIISRASMLMVAVVMFFAFSCLFTLSPQNMADAKAQNIPVLSYLANH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHH
FASLSGTKSTFATVLEYGASIIALVAIFKSFFGHYLGTLEGLNGLVLKFGYKGDKTKVSM
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCEEEC
GKLNTISMIFIMGSTWVVAYANPNILDLIEAMGAPIIASLLCLLPMYAIRKAPSLAKYRG
CCCCHHHEEEEECCCEEEEECCCCHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHH
RLDNVFVTLIGLLTILNIVYKLF
HHHHHHHHHHHHHHHHHHHHHHC
>Mature Secondary Structure 
STTDSIVSSQAKQSSWRKSDTTWTLGLFGTAIGAGVLFFPIRAGFGGLIPILLMLVLAY
CCHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
PIAFYCHRALARLCLSGSNPSGNITETVEEHFGKTGGVVITFLYFFAICPLLWIYGVTIT
HHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
NTFMTFWENQLQMPALNRGFVALFLLLLMAFVIWFGKDLMVKVMSYLVWPFIASLVLISL
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHH
SLIPYWNSAVIDQVDLSNIALTGHDGILVTVWLGISIMVFSFNFSPIVSSFVVSKREEYE
HHHCCCCCHHHCCCCCCCEEEECCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
KEFGREFTERKCSQIISRASMLMVAVVMFFAFSCLFTLSPQNMADAKAQNIPVLSYLANH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHH
FASLSGTKSTFATVLEYGASIIALVAIFKSFFGHYLGTLEGLNGLVLKFGYKGDKTKVSM
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCEEEC
GKLNTISMIFIMGSTWVVAYANPNILDLIEAMGAPIIASLLCLLPMYAIRKAPSLAKYRG
CCCCHHHEEEEECCCEEEEECCCCHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHH
RLDNVFVTLIGLLTILNIVYKLF
HHHHHHHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; D-serine [Periplasm]; L-threonine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + D-serine [Periplasm] = Proton [Cytoplasm] + D-serine [Cytoplasm] Proton [Periplasm] + L-threonine [Periplasm] = Proton [Cytoplasm] + L-threonine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA