Click here to switch to the map view.

The map label for this gene is sdaC [H]

Identifier: 16766275

GI number: 16766275

Start: 3120771

End: 3122060

Strand: Direct

Name: sdaC [H]

Synonym: STM2970

Alternate gene names: 16766275

Gene position: 3120771-3122060 (Clockwise)

Preceding gene: 16766274

Following gene: 16766276

Centisome position: 64.25

GC content: 53.26

Gene sequence:

>1290_bases
ATGGAAACCACTCAGACCAGCACTATTGCTTCGATTGACTCTCGAAGCGCATGGCGCAAAACGGATACCATGTGGATGCT
GGGCCTTTACGGCACGGCTATCGGCGCGGGCGTTCTGTTCCTGCCGATCAACGCAGGCGTCGGCGGCATGATTCCGCTCA
TCATCATGGCGATTCTCGCTTTCCCGATGACCTTTTTCGCACACCGTGGTTTAACCCGCTTCGTGCTGTCCGGTAAAAAT
CCGGGTGAAGACATCACTGAAGTCGTTGAGGAACACTTCGGTATCGGCGCAGGTAAACTGATTACCCTGCTTTACTTCTT
CGCGATTTACCCCATCCTGCTGGTTTACAGCGTGGCGATTACTAATACCGTGGAAAGCTTCCTGACCCACCAGTTAGCGA
TTAATCCGCCGCCGCGGGCGATTCTTTCCCTGATCCTGATTGTTGGCATGATGACCATCGTGCGCTTCGGCGAGCAAATG
ATCGTTAAGGCGATGAGTATCCTGGTATTCCCGTTCGTCGCTGCGCTGATGCTGCTGGCCTTGTACCTGATCCCGCAGTG
GAACGGCGCGGCGCTGGAAACTCTGTCCTTTGATTCCGCCGCGTCTACCGGTAACGGTCTGTGGATGACGCTGTGGCTGG
CGATTCCGGTGATGGTTTTCTCTTTCAACCACTCCCCGATCATCTCCTCCTTCGCGGTTGCGAAGCGTGAAGAGTACGGT
GAAGGCGCTGAGAAGAAATGTTCTAAAATTCTGGCCTTCGCCCACATCATGATGGTGCTGACCGTGATGTTCTTCGTCTT
CAGCTGCGTGCTGAGCCTGACGCCGGCAGATCTGGCAGCGGCAAAAGAGCAGAACATCTCTATTCTGTCTTACCTGGCGA
ACCATTTTAACGCGCCGATCATCGCCTGGATGGCGCCGATCATTGCGATGATTGCTATCACCAAATCCTTCCTCGGCCAC
TACCTTGGCGCGCGTGAAGGCTTTAACGGGATGGTGATTAAATCGCTGCGTGGTAAAGGTAAATCCATCGAAATCAACAA
ACTGAATAAAATTACCGCGCTGTTCATGCTGGTCACCACCTGGATTGTGGCGACGCTGAACCCCAGCATCCTGGGCATGA
TTGAAACCCTGGGCGGCCCGATCATCGCGATGATTCTGTTCCTGATGCCGATGTATGCCATCCAGAAAGTACCGGCAATG
CGTAAGTACAGCGGTCATATCAGCAACGTATTCGTTGTGATTATGGGCCTGATTGCCATCTCCGCTATTTTCTACTCACT
GTTCAGCTAA

Upstream 100 bases:

>100_bases
ATATAAAAAGCGTCCCTAAGCAGATTTCATTTTACGATCAGGTCTTTTTTCATTGGATTAGACCAGCAACCTGATTTTTA
GCATCCTCCAGGAGAAATAG

Downstream 100 bases:

>100_bases
GTCCTTTAGCGCCGCTTACCGCGGCGCTTCTCTATGATACAACCGCAATGGATGCCCTATGATTAGCGTATTCGATATTT
TTAAAATCGGCATTGGCCCT

Product: serine transport protein

Products: Proton [Cytoplasm]; D-serine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 429; Mature: 429

Protein sequence:

>429_residues
METTQTSTIASIDSRSAWRKTDTMWMLGLYGTAIGAGVLFLPINAGVGGMIPLIIMAILAFPMTFFAHRGLTRFVLSGKN
PGEDITEVVEEHFGIGAGKLITLLYFFAIYPILLVYSVAITNTVESFLTHQLAINPPPRAILSLILIVGMMTIVRFGEQM
IVKAMSILVFPFVAALMLLALYLIPQWNGAALETLSFDSAASTGNGLWMTLWLAIPVMVFSFNHSPIISSFAVAKREEYG
EGAEKKCSKILAFAHIMMVLTVMFFVFSCVLSLTPADLAAAKEQNISILSYLANHFNAPIIAWMAPIIAMIAITKSFLGH
YLGAREGFNGMVIKSLRGKGKSIEINKLNKITALFMLVTTWIVATLNPSILGMIETLGGPIIAMILFLMPMYAIQKVPAM
RKYSGHISNVFVVIMGLIAISAIFYSLFS

Sequences:

>Translated_429_residues
METTQTSTIASIDSRSAWRKTDTMWMLGLYGTAIGAGVLFLPINAGVGGMIPLIIMAILAFPMTFFAHRGLTRFVLSGKN
PGEDITEVVEEHFGIGAGKLITLLYFFAIYPILLVYSVAITNTVESFLTHQLAINPPPRAILSLILIVGMMTIVRFGEQM
IVKAMSILVFPFVAALMLLALYLIPQWNGAALETLSFDSAASTGNGLWMTLWLAIPVMVFSFNHSPIISSFAVAKREEYG
EGAEKKCSKILAFAHIMMVLTVMFFVFSCVLSLTPADLAAAKEQNISILSYLANHFNAPIIAWMAPIIAMIAITKSFLGH
YLGAREGFNGMVIKSLRGKGKSIEINKLNKITALFMLVTTWIVATLNPSILGMIETLGGPIIAMILFLMPMYAIQKVPAM
RKYSGHISNVFVVIMGLIAISAIFYSLFS
>Mature_429_residues
METTQTSTIASIDSRSAWRKTDTMWMLGLYGTAIGAGVLFLPINAGVGGMIPLIIMAILAFPMTFFAHRGLTRFVLSGKN
PGEDITEVVEEHFGIGAGKLITLLYFFAIYPILLVYSVAITNTVESFLTHQLAINPPPRAILSLILIVGMMTIVRFGEQM
IVKAMSILVFPFVAALMLLALYLIPQWNGAALETLSFDSAASTGNGLWMTLWLAIPVMVFSFNHSPIISSFAVAKREEYG
EGAEKKCSKILAFAHIMMVLTVMFFVFSCVLSLTPADLAAAKEQNISILSYLANHFNAPIIAWMAPIIAMIAITKSFLGH
YLGAREGFNGMVIKSLRGKGKSIEINKLNKITALFMLVTTWIVATLNPSILGMIETLGGPIIAMILFLMPMYAIQKVPAM
RKYSGHISNVFVVIMGLIAISAIFYSLFS

Specific function: Involved in the import of serine into the cell. May be required for phage C1 adsorption by interacting with DrcB. May also be involved in ampicillin sensitivity [H]

COG id: COG0814

COG function: function code E; Amino acid permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid/polyamine transporter 2 family. SdaC/TdcC subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789160, Length=429, Percent_Identity=95.5710955710956, Blast_Score=803, Evalue=0.0,
Organism=Escherichia coli, GI1789504, Length=442, Percent_Identity=50.2262443438914, Blast_Score=440, Evalue=1e-124,
Organism=Escherichia coli, GI1789211, Length=416, Percent_Identity=40.1442307692308, Blast_Score=304, Evalue=7e-84,
Organism=Escherichia coli, GI145693183, Length=424, Percent_Identity=27.8301886792453, Blast_Score=134, Evalue=8e-33,
Organism=Escherichia coli, GI1789961, Length=410, Percent_Identity=24.6341463414634, Blast_Score=117, Evalue=2e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004694
- InterPro:   IPR018227 [H]

Pfam domain/function: PF03222 Trp_Tyr_perm [H]

EC number: NA

Molecular weight: Translated: 46861; Mature: 46861

Theoretical pI: Translated: 9.54; Mature: 9.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
6.1 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
6.1 %Met     (Mature Protein)
6.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METTQTSTIASIDSRSAWRKTDTMWMLGLYGTAIGAGVLFLPINAGVGGMIPLIIMAILA
CCCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHH
FPMTFFAHRGLTRFVLSGKNPGEDITEVVEEHFGIGAGKLITLLYFFAIYPILLVYSVAI
HHHHHHHHCCHHHHHCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
TNTVESFLTHQLAINPPPRAILSLILIVGMMTIVRFGEQMIVKAMSILVFPFVAALMLLA
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LYLIPQWNGAALETLSFDSAASTGNGLWMTLWLAIPVMVFSFNHSPIISSFAVAKREEYG
HHHHCCCCCCHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHC
EGAEKKCSKILAFAHIMMVLTVMFFVFSCVLSLTPADLAAAKEQNISILSYLANHFNAPI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHCCCH
IAWMAPIIAMIAITKSFLGHYLGAREGFNGMVIKSLRGKGKSIEINKLNKITALFMLVTT
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCEEEHHHHHHHHHHHHHHHH
WIVATLNPSILGMIETLGGPIIAMILFLMPMYAIQKVPAMRKYSGHISNVFVVIMGLIAI
HHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHHHH
SAIFYSLFS
HHHHHHHHC
>Mature Secondary Structure
METTQTSTIASIDSRSAWRKTDTMWMLGLYGTAIGAGVLFLPINAGVGGMIPLIIMAILA
CCCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHH
FPMTFFAHRGLTRFVLSGKNPGEDITEVVEEHFGIGAGKLITLLYFFAIYPILLVYSVAI
HHHHHHHHCCHHHHHCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
TNTVESFLTHQLAINPPPRAILSLILIVGMMTIVRFGEQMIVKAMSILVFPFVAALMLLA
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LYLIPQWNGAALETLSFDSAASTGNGLWMTLWLAIPVMVFSFNHSPIISSFAVAKREEYG
HHHHCCCCCCHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHC
EGAEKKCSKILAFAHIMMVLTVMFFVFSCVLSLTPADLAAAKEQNISILSYLANHFNAPI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHCCCH
IAWMAPIIAMIAITKSFLGHYLGAREGFNGMVIKSLRGKGKSIEINKLNKITALFMLVTT
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCEEEHHHHHHHHHHHHHHHH
WIVATLNPSILGMIETLGGPIIAMILFLMPMYAIQKVPAMRKYSGHISNVFVVIMGLIAI
HHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHHHH
SAIFYSLFS
HHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; D-serine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + D-serine [Periplasm] = Proton [Cytoplasm] + D-serine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]