Click here to switch to the map view.

The map label for this gene is trxC [H]

Identifier: 16765969

GI number: 16765969

Start: 2788654

End: 2789073

Strand: Direct

Name: trxC [H]

Synonym: STM2649

Alternate gene names: 16765969

Gene position: 2788654-2789073 (Clockwise)

Preceding gene: 16765967

Following gene: 16765970

Centisome position: 57.41

GC content: 53.57

Gene sequence:

>420_bases
ATGAACACCGTTTGTACCCATTGTCAGGCCATTAACCGCATCCCCGACGATCGGCTTCAGGATGCGGCAAAATGTGGACG
CTGCGGTCATGAGTTGTTTGACGGAGAAGTCATTAATGCGACCGGCGAAACGCTGGACAAACTGTTGAAGGACGATCTTC
CAGTGGTGATCGACTTTTGGGCCCCCTGGTGCGGCCCTTGCCGTAACTTTGCGCCAATCTTCGAGGATGTCGCAGAAGAG
CGCAGCGGTAAAGTCCGTTTCGTCAAAGTGAATACCGAGGCGGAACGGGAACTCAGCGCCCGTTTCGGTATCCGCAGCAT
CCCGACGATTATGATTTTTAAACATGGACAGGTGGTCGATATGCTTAATGGCGCAGTGCCTAAAGCGCCTTTCGACAGCT
GGCTGAACGAAGCGCTGTAA

Upstream 100 bases:

>100_bases
AAACACATTGTTGTTTAGCACAGACTCCTCGATAATATGTAACATTATAGAAACATCCCGCGCGTAGCGGGACGTCTTCC
GACGTATTCAGAGGTTAGCT

Downstream 100 bases:

>100_bases
ACGCCACGGGGCGCATCTTGTGCCCCGTTTTCACCTCTGCCACAATAGCGTTTTTCTCCGCAAACGCTTTCTATGACCAA
TAACGCTGTCCTTCAGTTAC

Product: thioredoxin 2

Products: NA

Alternate protein names: Trx-2; Protein-disulfide reductase [H]

Number of amino acids: Translated: 139; Mature: 139

Protein sequence:

>139_residues
MNTVCTHCQAINRIPDDRLQDAAKCGRCGHELFDGEVINATGETLDKLLKDDLPVVIDFWAPWCGPCRNFAPIFEDVAEE
RSGKVRFVKVNTEAERELSARFGIRSIPTIMIFKHGQVVDMLNGAVPKAPFDSWLNEAL

Sequences:

>Translated_139_residues
MNTVCTHCQAINRIPDDRLQDAAKCGRCGHELFDGEVINATGETLDKLLKDDLPVVIDFWAPWCGPCRNFAPIFEDVAEE
RSGKVRFVKVNTEAERELSARFGIRSIPTIMIFKHGQVVDMLNGAVPKAPFDSWLNEAL
>Mature_139_residues
MNTVCTHCQAINRIPDDRLQDAAKCGRCGHELFDGEVINATGETLDKLLKDDLPVVIDFWAPWCGPCRNFAPIFEDVAEE
RSGKVRFVKVNTEAERELSARFGIRSIPTIMIFKHGQVVDMLNGAVPKAPFDSWLNEAL

Specific function: Efficient electron donor for the essential enzyme ribonucleotide reductase. Is also able to reduce the interchain disulfide bridges of insulin [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI4758304, Length=83, Percent_Identity=37.3493975903614, Blast_Score=70, Evalue=8e-13,
Organism=Homo sapiens, GI21361403, Length=94, Percent_Identity=30.8510638297872, Blast_Score=69, Evalue=9e-13,
Organism=Homo sapiens, GI24308127, Length=68, Percent_Identity=45.5882352941176, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI5031973, Length=87, Percent_Identity=37.9310344827586, Blast_Score=68, Evalue=3e-12,
Organism=Escherichia coli, GI1788936, Length=139, Percent_Identity=94.9640287769784, Blast_Score=280, Evalue=3e-77,
Organism=Escherichia coli, GI87082331, Length=105, Percent_Identity=37.1428571428571, Blast_Score=89, Evalue=9e-20,
Organism=Escherichia coli, GI87081747, Length=105, Percent_Identity=30.4761904761905, Blast_Score=72, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI212646193, Length=111, Percent_Identity=30.6306306306306, Blast_Score=79, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17507705, Length=75, Percent_Identity=44, Blast_Score=73, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI25144092, Length=88, Percent_Identity=32.9545454545455, Blast_Score=70, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17510299, Length=75, Percent_Identity=42.6666666666667, Blast_Score=69, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17556044, Length=81, Percent_Identity=38.2716049382716, Blast_Score=68, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71998175, Length=71, Percent_Identity=42.2535211267606, Blast_Score=65, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI115532380, Length=99, Percent_Identity=29.2929292929293, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17544108, Length=102, Percent_Identity=29.4117647058824, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI115532378, Length=99, Percent_Identity=29.2929292929293, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71980565, Length=72, Percent_Identity=31.9444444444444, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71980562, Length=72, Percent_Identity=31.9444444444444, Blast_Score=64, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6323072, Length=89, Percent_Identity=32.5842696629214, Blast_Score=64, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6321648, Length=92, Percent_Identity=33.695652173913, Blast_Score=63, Evalue=2e-11,
Organism=Drosophila melanogaster, GI28573567, Length=93, Percent_Identity=33.3333333333333, Blast_Score=76, Evalue=7e-15,
Organism=Drosophila melanogaster, GI19921434, Length=100, Percent_Identity=39, Blast_Score=71, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24639826, Length=77, Percent_Identity=36.3636363636364, Blast_Score=71, Evalue=2e-13,
Organism=Drosophila melanogaster, GI17647799, Length=104, Percent_Identity=29.8076923076923, Blast_Score=66, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: =1.8.1.8 [H]

Molecular weight: Translated: 15560; Mature: 15560

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
4.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
6.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTVCTHCQAINRIPDDRLQDAAKCGRCGHELFDGEVINATGETLDKLLKDDLPVVIDFW
CCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCEEECCCHHHHHHHHHCCCCEEEECC
APWCGPCRNFAPIFEDVAEERSGKVRFVKVNTEAERELSARFGIRSIPTIMIFKHGQVVD
CCCCCCCCCHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHCCCCCCCEEEEECCCCHHH
MLNGAVPKAPFDSWLNEAL
HHCCCCCCCCHHHHHHHCC
>Mature Secondary Structure
MNTVCTHCQAINRIPDDRLQDAAKCGRCGHELFDGEVINATGETLDKLLKDDLPVVIDFW
CCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCEEECCCHHHHHHHHHCCCCEEEECC
APWCGPCRNFAPIFEDVAEERSGKVRFVKVNTEAERELSARFGIRSIPTIMIFKHGQVVD
CCCCCCCCCHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHCCCCCCCEEEEECCCCHHH
MLNGAVPKAPFDSWLNEAL
HHCCCCCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]