Click here to switch to the map view.

The map label for this gene is pgtB

Identifier: 16765723

GI number: 16765723

Start: 2508498

End: 2510504

Strand: Reverse

Name: pgtB

Synonym: STM2397

Alternate gene names: 16765723

Gene position: 2510504-2508498 (Counterclockwise)

Preceding gene: 16765724

Following gene: 16765722

Centisome position: 51.68

GC content: 53.86

Gene sequence:

>2007_bases
ATGAAGGGGAGATTATTGCAACGGCTTCGTCAGCTCAGTATCAGCAACAGTTTACGGGGCGCATTTTTAACGGGCGCATT
ACTGACGCTGATTGTCAGTATGGTCAGCCTTTATTCCTGGCATGAGCAAAGTTCGCAGGTTCGCTATTCGCTTGATGAAT
ATTTTCCTCGCATCCACTCCGCTTTTTTAATTGAGGGGAACCTGAATCTGGCCGTGGATCAACTCAATGAATTTTTGCTG
GCGCCGAACACGACGGTACGTTTGCAGTTACGTACGCAGATTATTCAGCATCTGGATAAGATTGAGCGTCTCAGTCAGGG
GCTTCAGCTTGCTGAGCGCCGGCAACTGGCCGTCATTTTACAGGATAGCCGGACCTTGCTGGCGGAGCTGGACAATGCCC
TCTACAACATGTTTTTGGTGCGGGAGAAAGTTAGCGAGCTTTCCGCTCGCATTGACTGGCTCCATGATGATTTCACCACG
GAGCTAAATTCGCTGGTACAGGATTTTACCTGGCAGCAGGGGACGCTGCTCGATCAAATTGAGGCGAATCAGGGCGATGC
AGCGCAGTATTTGCAACGTTCGCGCGAGGTGCAGAACGAGCAGCAGCAGGTATATACCCTGGCGCGAATTGAAAATCAGA
TTGTTGACGACCTGCGCGACAGATTGAATGAGCTCAAGTCCGGCAATAATGACGGGATGCTGGTGGAGACCCATATTCGC
TATCTGGAAAACCTAAAAAAAACGGCGGATGAGAATATTCGTGCGCTGGATGACTGGCCCAGTACGATCACGCTACGGCA
AACCATCGACGAACTATTGGAAATCGGGATGGTAAAAAATAAGATGCCCGATACCATGCGCGATTATGTTGCGGCGCAAA
AAGCCTTACTGGACGCCAGCCGCGCCAGAGAGGCTACGCTAGGGCGCTTTCGCACGCTGCTTGAGGCGCAGTTAGGTAGT
AGTCACCAGCAAATGCAGACGTTCAATCAACGCCTGGAACAGATTGTTCGCGTTAGCGGCGGGCTTATTTTAGTGGCGAC
GCTCCTGGCGTTGCTACTGGCCTGGGGACTCAACCACTATTTTATCCGTTCCCGACTGGTGAAGCGTTTTACCGCGCTTA
ATCAGGCTGTGGTACAGATAGGGCTGGGGAGAACCGACTCGACTATCCCGGTTTACGGGCGCGATGAGCTAGGACGGATA
GCCCGTTTGCTACGTCATACGCTGGGCCAGCTCAATATGCAACGCAGGCAGCTTGAACAAGAGGTCGCCGAGCGCAAAGA
GATAGAAGCCGACCTGCGCGCCATGCAGGATGAGTTGATTCAGACGGCGAAACTGGCGGTAGTCGGCCAGACCATGACCA
CGCTGGCGCATGAAATTAACCAGCCGCTGAATGCGCTTTCAATGTATTTATTTACGGCGGGACGCGCGATTGAACAAGGT
CAGAGCGGACAGGCGAGAAATACGCTCACCAAAGCGGAAGGGCTCATTAACCGGATTGACGCCATTATCCGTTCGCTGCG
GCAGTTTACCCGTCGGGCGGAGCTGGAAACGCCATTGTATCCCGTTGATCTGCGCCAAACCTTTGTGGCGGCATGGGAGT
TATTAGCCATGCGCCACCAATCCCGGCAGGGAGCGCTTTCACTGCCAACCGACACCGTATGGGTTAGCGGCGATGAAGTG
CGTATTCAGCAGGTTCTGGTGAATGTGCTGGCGAATGCGCTTGACGCCTGTTCGCATGATGCGGTGATCGCGGTGACGTG
GCAGACGCAGGGAGAGGCGCTGGAGGTTTATATTGCAGATAACGGCCCTGGCTGGCCTGTGGCGCTGTTGCCCTCTTTAC
TCAAGCCGTTTACCACCAGTAAAGCTGTCGGGTTGGGTATTGGGCTGTCGATTAGCGTGTCGCTGATGGCGCAAATGAAG
GGCGACCTGCGTCTGGCGTCGACGCTGACGCGTAACGCTTGCGTGGTGCTGCAATTCTCGGTAACGGATGTCGATGATGT
TGAATGA

Upstream 100 bases:

>100_bases
AGTTTGATAATAAAAGCTTTGCCGAACAAAAAATGATGGAGTGGCAGATCTGGTTTCTGAACAATCAGCGGCTGGCGATT
CACAAACTGGAAGAGCTGAA

Downstream 100 bases:

>100_bases
TGAATGTTCTATTTTGCTGATTGATGATGACGTTGATGTACTTGACGCCTATACCCAAATGCTTGAGCAGGCAGGCTACC
GCGTGCGTGGCTTTACCCAT

Product: phosphoglycerate transport system sensor protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 668; Mature: 668

Protein sequence:

>668_residues
MKGRLLQRLRQLSISNSLRGAFLTGALLTLIVSMVSLYSWHEQSSQVRYSLDEYFPRIHSAFLIEGNLNLAVDQLNEFLL
APNTTVRLQLRTQIIQHLDKIERLSQGLQLAERRQLAVILQDSRTLLAELDNALYNMFLVREKVSELSARIDWLHDDFTT
ELNSLVQDFTWQQGTLLDQIEANQGDAAQYLQRSREVQNEQQQVYTLARIENQIVDDLRDRLNELKSGNNDGMLVETHIR
YLENLKKTADENIRALDDWPSTITLRQTIDELLEIGMVKNKMPDTMRDYVAAQKALLDASRAREATLGRFRTLLEAQLGS
SHQQMQTFNQRLEQIVRVSGGLILVATLLALLLAWGLNHYFIRSRLVKRFTALNQAVVQIGLGRTDSTIPVYGRDELGRI
ARLLRHTLGQLNMQRRQLEQEVAERKEIEADLRAMQDELIQTAKLAVVGQTMTTLAHEINQPLNALSMYLFTAGRAIEQG
QSGQARNTLTKAEGLINRIDAIIRSLRQFTRRAELETPLYPVDLRQTFVAAWELLAMRHQSRQGALSLPTDTVWVSGDEV
RIQQVLVNVLANALDACSHDAVIAVTWQTQGEALEVYIADNGPGWPVALLPSLLKPFTTSKAVGLGIGLSISVSLMAQMK
GDLRLASTLTRNACVVLQFSVTDVDDVE

Sequences:

>Translated_668_residues
MKGRLLQRLRQLSISNSLRGAFLTGALLTLIVSMVSLYSWHEQSSQVRYSLDEYFPRIHSAFLIEGNLNLAVDQLNEFLL
APNTTVRLQLRTQIIQHLDKIERLSQGLQLAERRQLAVILQDSRTLLAELDNALYNMFLVREKVSELSARIDWLHDDFTT
ELNSLVQDFTWQQGTLLDQIEANQGDAAQYLQRSREVQNEQQQVYTLARIENQIVDDLRDRLNELKSGNNDGMLVETHIR
YLENLKKTADENIRALDDWPSTITLRQTIDELLEIGMVKNKMPDTMRDYVAAQKALLDASRAREATLGRFRTLLEAQLGS
SHQQMQTFNQRLEQIVRVSGGLILVATLLALLLAWGLNHYFIRSRLVKRFTALNQAVVQIGLGRTDSTIPVYGRDELGRI
ARLLRHTLGQLNMQRRQLEQEVAERKEIEADLRAMQDELIQTAKLAVVGQTMTTLAHEINQPLNALSMYLFTAGRAIEQG
QSGQARNTLTKAEGLINRIDAIIRSLRQFTRRAELETPLYPVDLRQTFVAAWELLAMRHQSRQGALSLPTDTVWVSGDEV
RIQQVLVNVLANALDACSHDAVIAVTWQTQGEALEVYIADNGPGWPVALLPSLLKPFTTSKAVGLGIGLSISVSLMAQMK
GDLRLASTLTRNACVVLQFSVTDVDDVE
>Mature_668_residues
MKGRLLQRLRQLSISNSLRGAFLTGALLTLIVSMVSLYSWHEQSSQVRYSLDEYFPRIHSAFLIEGNLNLAVDQLNEFLL
APNTTVRLQLRTQIIQHLDKIERLSQGLQLAERRQLAVILQDSRTLLAELDNALYNMFLVREKVSELSARIDWLHDDFTT
ELNSLVQDFTWQQGTLLDQIEANQGDAAQYLQRSREVQNEQQQVYTLARIENQIVDDLRDRLNELKSGNNDGMLVETHIR
YLENLKKTADENIRALDDWPSTITLRQTIDELLEIGMVKNKMPDTMRDYVAAQKALLDASRAREATLGRFRTLLEAQLGS
SHQQMQTFNQRLEQIVRVSGGLILVATLLALLLAWGLNHYFIRSRLVKRFTALNQAVVQIGLGRTDSTIPVYGRDELGRI
ARLLRHTLGQLNMQRRQLEQEVAERKEIEADLRAMQDELIQTAKLAVVGQTMTTLAHEINQPLNALSMYLFTAGRAIEQG
QSGQARNTLTKAEGLINRIDAIIRSLRQFTRRAELETPLYPVDLRQTFVAAWELLAMRHQSRQGALSLPTDTVWVSGDEV
RIQQVLVNVLANALDACSHDAVIAVTWQTQGEALEVYIADNGPGWPVALLPSLLKPFTTSKAVGLGIGLSISVSLMAQMK
GDLRLASTLTRNACVVLQFSVTDVDDVE

Specific function: Member of the two-component regulatory system pgtB/pgtA that regulates the inducible phosphoglycerate transport system. Activates pgtA by phosphorylation

COG id: COG4192

COG function: function code T; Signal transduction histidine kinase regulating phosphoglycerate transport system

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain

Homologues:

Organism=Escherichia coli, GI1790436, Length=230, Percent_Identity=28.2608695652174, Blast_Score=86, Evalue=7e-18,
Organism=Escherichia coli, GI1788549, Length=242, Percent_Identity=28.5123966942149, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI87081816, Length=293, Percent_Identity=26.2798634812287, Blast_Score=67, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PGTB_SALTY (P37433)

Other databases:

- EMBL:   M21279
- EMBL:   AE006468
- PIR:   T11778
- RefSeq:   NP_461338.1
- ProteinModelPortal:   P37433
- PRIDE:   P37433
- GeneID:   1253919
- GenomeReviews:   AE006468_GR
- KEGG:   stm:STM2397
- NMPDR:   fig|99287.1.peg.2319
- HOGENOM:   HBG416372
- OMA:   SHQQMQM
- ProtClustDB:   CLSK870493
- BioCyc:   STYP99287:STM2397-MONOMER
- BRENDA:   2.7.13.3
- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR017116
- Gene3D:   G3DSA:3.30.565.10
- PIRSF:   PIRSF037119
- SMART:   SM00304
- SMART:   SM00387
- SMART:   SM00388

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA; SSF55874 ATP_bd_ATPase; SSF47384 His_kin_homodim

EC number: =2.7.13.3

Molecular weight: Translated: 75405; Mature: 75405

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: PS50885 HAMP; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x10534d90)-; HASH(0xdb462d8)-;

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGRLLQRLRQLSISNSLRGAFLTGALLTLIVSMVSLYSWHEQSSQVRYSLDEYFPRIHS
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AFLIEGNLNLAVDQLNEFLLAPNTTVRLQLRTQIIQHLDKIERLSQGLQLAERRQLAVIL
EEEEECCCCHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEE
QDSRTLLAELDNALYNMFLVREKVSELSARIDWLHDDFTTELNSLVQDFTWQQGTLLDQI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
EANQGDAAQYLQRSREVQNEQQQVYTLARIENQIVDDLRDRLNELKSGNNDGMLVETHIR
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHH
YLENLKKTADENIRALDDWPSTITLRQTIDELLEIGMVKNKMPDTMRDYVAAQKALLDAS
HHHHHHHHHCCCCEECCCCCCCEEHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
RAREATLGRFRTLLEAQLGSSHQQMQTFNQRLEQIVRVSGGLILVATLLALLLAWGLNHY
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCHHH
FIRSRLVKRFTALNQAVVQIGLGRTDSTIPVYGRDELGRIARLLRHTLGQLNMQRRQLEQ
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
EVAERKEIEADLRAMQDELIQTAKLAVVGQTMTTLAHEINQPLNALSMYLFTAGRAIEQG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCC
QSGQARNTLTKAEGLINRIDAIIRSLRQFTRRAELETPLYPVDLRQTFVAAWELLAMRHQ
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHH
SRQGALSLPTDTVWVSGDEVRIQQVLVNVLANALDACSHDAVIAVTWQTQGEALEVYIAD
CCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEEEEEC
NGPGWPVALLPSLLKPFTTSKAVGLGIGLSISVSLMAQMKGDLRLASTLTRNACVVLQFS
CCCCCHHHHHHHHHCCCCCCCHHHCCCCHHHHHHHHHHHCCCHHHHHHHCCCCEEEEEEE
VTDVDDVE
CCCCCCCH
>Mature Secondary Structure
MKGRLLQRLRQLSISNSLRGAFLTGALLTLIVSMVSLYSWHEQSSQVRYSLDEYFPRIHS
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AFLIEGNLNLAVDQLNEFLLAPNTTVRLQLRTQIIQHLDKIERLSQGLQLAERRQLAVIL
EEEEECCCCHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEE
QDSRTLLAELDNALYNMFLVREKVSELSARIDWLHDDFTTELNSLVQDFTWQQGTLLDQI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
EANQGDAAQYLQRSREVQNEQQQVYTLARIENQIVDDLRDRLNELKSGNNDGMLVETHIR
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHH
YLENLKKTADENIRALDDWPSTITLRQTIDELLEIGMVKNKMPDTMRDYVAAQKALLDAS
HHHHHHHHHCCCCEECCCCCCCEEHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
RAREATLGRFRTLLEAQLGSSHQQMQTFNQRLEQIVRVSGGLILVATLLALLLAWGLNHY
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCHHH
FIRSRLVKRFTALNQAVVQIGLGRTDSTIPVYGRDELGRIARLLRHTLGQLNMQRRQLEQ
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
EVAERKEIEADLRAMQDELIQTAKLAVVGQTMTTLAHEINQPLNALSMYLFTAGRAIEQG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCC
QSGQARNTLTKAEGLINRIDAIIRSLRQFTRRAELETPLYPVDLRQTFVAAWELLAMRHQ
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHH
SRQGALSLPTDTVWVSGDEVRIQQVLVNVLANALDACSHDAVIAVTWQTQGEALEVYIAD
CCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEEEEEC
NGPGWPVALLPSLLKPFTTSKAVGLGIGLSISVSLMAQMKGDLRLASTLTRNACVVLQFS
CCCCCHHHHHHHHHCCCCCCCHHHCCCCHHHHHHHHHHHCCCHHHHHHHCCCCEEEEEEE
VTDVDDVE
CCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2842311; 11677609; 2842312