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The map label for this gene is cirA [H]

Identifier: 16765529

GI number: 16765529

Start: 2296551

End: 2298542

Strand: Reverse

Name: cirA [H]

Synonym: STM2199

Alternate gene names: 16765529

Gene position: 2298542-2296551 (Counterclockwise)

Preceding gene: 16765530

Following gene: 16765526

Centisome position: 47.32

GC content: 54.52

Gene sequence:

>1992_bases
ATGTTTAGGTTTAACCCTTTCGTTCGGGTAGGGCTTTGTATGTCCGCAGTTACGTTGGCCTGGCCGGTTGCCGCGGCAAC
GGATGATGGTGAAACCATGGTCGTTACCGCGTCCGCCATCGAACAAAATCTGAAAGATGCGCCAGCAAGTATCAGCGTCA
TTACCCAGCAAGATTTACAGCGCAGGCCCGTGCAAAACCTGAAAGATGTCCTGAAAGAGGTGCCGGGCGTACAGCTCACT
AACGAAGGGGATAACCGTAAAGGCGTGAGTATTCGTGGTCTGGACAGCAGTTATACGCTGATCCTGATCGACGGTAAGCG
CGTTAACTCCCGTAACGCGGTCTTCCGCCATAATGATTTTGATCTGAACTGGATACCGGTTGACGCTATCGAACGTATTG
AAGTGGTGCGTGGCCCCATGTCCTCGCTGTATGGCTCCGATGCGCTGGGCGGCGTGGTCAACATTATCACCAAAAAAATT
GGTCAGAAATGGCACGGCAGCGTCACGGTTGACTCCACTATTCAGGAACATCGCGACCGTGGCGATACTTATAACGGTCA
GTTCTTTACCAGCGGTCCGCTGATCGACGGCGTGCTGGGAATGAAAGCCTACGGTAGCCTGGCGAAACGCGAAAAAGACG
AGCAGCAGAGTTCCGCCACCACCGCTACGGGTGAAACGCCGCGCATTGAAGGATTTACCAGCCGGGATGGAAACGTCGAG
TTTGCCTGGACACCAAACGAAAATCATGACGTTACCGCAGGCTACGGTTTTGATCGCCAGGACCGGGACTCAGACTCGCT
GGATAAAAACCGTCTGGAACGGCAAAACTATGCGTTGAGCCATAACGGACGTTGGGATCTCGGCAATAGTGAGCTCAAAT
TCTACGGCGAAAAAGTGGAAAACAAAAACCCCGGCAACAGTAGCCCTATCACGTCAGAAAGCAATTCGATTGACGGGAAA
TACGTTCTGCCGTTAGCGTCTGTCAACCAGTTCCTCACCTTCGGCGGCGAATGGCGTCACGATAAACTGAGCGATGCGGT
GAACCTGACCGGCGGTTCCAGTACTAAAACCTCCGCCAGCCAGTACGCTCTGTTCCTTGAAGATGAGTGGCGCATCTTCG
AACCGCTGGCGCTGACCACCGGTATTCGTATGGATGACCATGAAACCTATGGCGATCACTGGAGCCCGCGTGCTTATCTG
GTCTATAACGCAACGGATACCCTGACGGTGAAAGGTGGGTGGGCCACGGCCTTTAAAGCGCCGTCGCTATTGCAATTAAG
CCCGGACTGGGCGACCAACTCCTGCCGTGGCGGATGCCGCATTGTCGGTAGCCCGGATCTGAAACCTGAAACCAGTGAAA
GCTGGGAGCTCGGCCTTTATTACCGGGGCGAAGAAGGCATACTGGAGGGCGTGGAAGCGAGCGTTACCACGTTCCGTAAC
GATGTGGACAATCGCATCAGCATTAGCCGTACCCCTGACGTTAACGCCGCGCCCGGCTATTCCAACTTTGTCGGTTTCGA
AACCAACAGTCGGGGACAGCGCGTTCCGGTCTTCCGTTATTACAACGTGAATAAAGCGCGTATTCAGGGCGTGGAAACCG
AGTTGAAAGTTCCGTTTAACGAGGCGTGGAAACTGTCGTTGAATTACACCTATAACGACGGGCGCGACGTCAGTAATGGC
GGGAACAAGCCGCTTTCCGATCTGCCGTTCCACACCGCGAACGGTACGCTGGACTGGAAACCGGTGCAGCTCGAAGACTG
GTCATTCTACGTATCAGGGAATTATACCGGGCGTAAGCGGGCCGACAGCGCAACAGCGAAAACGCCGGGCGGGTACGTGG
TCTGGGATACCGGCGCGGCATGGCAGGCGACGAAAAACGTTAAACTGCGTGCGGGCGTTCTGAACGTGGGCGATAAAGAT
CTCAAACGCGACGACTACGGTTATACCGAAGACGGACGTCGTTACTTTATGGCGGTGGATTACCGTTTCTGA

Upstream 100 bases:

>100_bases
AAAAAGAGTTCGCCGTGATAACCGTTATCGCAGGCGAAACGTAATGCGTTGTGAGCGATAACCGATTTTTTTTGTCGTAT
TTACCTCATGGAGAAATGGA

Downstream 100 bases:

>100_bases
CAGAGACTGGCGACAGCCGCGTTTTGCCGCTGTCGCCAGAATGTTATAACCGATGCAGCCTGGAGAGCAGCGCCAGCGAC
AGAGTCGTTAGCAGAATGGC

Product: colicin I receptor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 663; Mature: 663

Protein sequence:

>663_residues
MFRFNPFVRVGLCMSAVTLAWPVAAATDDGETMVVTASAIEQNLKDAPASISVITQQDLQRRPVQNLKDVLKEVPGVQLT
NEGDNRKGVSIRGLDSSYTLILIDGKRVNSRNAVFRHNDFDLNWIPVDAIERIEVVRGPMSSLYGSDALGGVVNIITKKI
GQKWHGSVTVDSTIQEHRDRGDTYNGQFFTSGPLIDGVLGMKAYGSLAKREKDEQQSSATTATGETPRIEGFTSRDGNVE
FAWTPNENHDVTAGYGFDRQDRDSDSLDKNRLERQNYALSHNGRWDLGNSELKFYGEKVENKNPGNSSPITSESNSIDGK
YVLPLASVNQFLTFGGEWRHDKLSDAVNLTGGSSTKTSASQYALFLEDEWRIFEPLALTTGIRMDDHETYGDHWSPRAYL
VYNATDTLTVKGGWATAFKAPSLLQLSPDWATNSCRGGCRIVGSPDLKPETSESWELGLYYRGEEGILEGVEASVTTFRN
DVDNRISISRTPDVNAAPGYSNFVGFETNSRGQRVPVFRYYNVNKARIQGVETELKVPFNEAWKLSLNYTYNDGRDVSNG
GNKPLSDLPFHTANGTLDWKPVQLEDWSFYVSGNYTGRKRADSATAKTPGGYVVWDTGAAWQATKNVKLRAGVLNVGDKD
LKRDDYGYTEDGRRYFMAVDYRF

Sequences:

>Translated_663_residues
MFRFNPFVRVGLCMSAVTLAWPVAAATDDGETMVVTASAIEQNLKDAPASISVITQQDLQRRPVQNLKDVLKEVPGVQLT
NEGDNRKGVSIRGLDSSYTLILIDGKRVNSRNAVFRHNDFDLNWIPVDAIERIEVVRGPMSSLYGSDALGGVVNIITKKI
GQKWHGSVTVDSTIQEHRDRGDTYNGQFFTSGPLIDGVLGMKAYGSLAKREKDEQQSSATTATGETPRIEGFTSRDGNVE
FAWTPNENHDVTAGYGFDRQDRDSDSLDKNRLERQNYALSHNGRWDLGNSELKFYGEKVENKNPGNSSPITSESNSIDGK
YVLPLASVNQFLTFGGEWRHDKLSDAVNLTGGSSTKTSASQYALFLEDEWRIFEPLALTTGIRMDDHETYGDHWSPRAYL
VYNATDTLTVKGGWATAFKAPSLLQLSPDWATNSCRGGCRIVGSPDLKPETSESWELGLYYRGEEGILEGVEASVTTFRN
DVDNRISISRTPDVNAAPGYSNFVGFETNSRGQRVPVFRYYNVNKARIQGVETELKVPFNEAWKLSLNYTYNDGRDVSNG
GNKPLSDLPFHTANGTLDWKPVQLEDWSFYVSGNYTGRKRADSATAKTPGGYVVWDTGAAWQATKNVKLRAGVLNVGDKD
LKRDDYGYTEDGRRYFMAVDYRF
>Mature_663_residues
MFRFNPFVRVGLCMSAVTLAWPVAAATDDGETMVVTASAIEQNLKDAPASISVITQQDLQRRPVQNLKDVLKEVPGVQLT
NEGDNRKGVSIRGLDSSYTLILIDGKRVNSRNAVFRHNDFDLNWIPVDAIERIEVVRGPMSSLYGSDALGGVVNIITKKI
GQKWHGSVTVDSTIQEHRDRGDTYNGQFFTSGPLIDGVLGMKAYGSLAKREKDEQQSSATTATGETPRIEGFTSRDGNVE
FAWTPNENHDVTAGYGFDRQDRDSDSLDKNRLERQNYALSHNGRWDLGNSELKFYGEKVENKNPGNSSPITSESNSIDGK
YVLPLASVNQFLTFGGEWRHDKLSDAVNLTGGSSTKTSASQYALFLEDEWRIFEPLALTTGIRMDDHETYGDHWSPRAYL
VYNATDTLTVKGGWATAFKAPSLLQLSPDWATNSCRGGCRIVGSPDLKPETSESWELGLYYRGEEGILEGVEASVTTFRN
DVDNRISISRTPDVNAAPGYSNFVGFETNSRGQRVPVFRYYNVNKARIQGVETELKVPFNEAWKLSLNYTYNDGRDVSNG
GNKPLSDLPFHTANGTLDWKPVQLEDWSFYVSGNYTGRKRADSATAKTPGGYVVWDTGAAWQATKNVKLRAGVLNVGDKD
LKRDDYGYTEDGRRYFMAVDYRF

Specific function: Not yet known. Postulated to participate in iron transport. Outer membrane receptor for colicins IA and IB [H]

COG id: COG4771

COG function: function code P; Outer membrane receptor for ferrienterochelin and colicins

Gene ontology:

Cell location: Cell outer membrane [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tonB-dependent receptor family [H]

Homologues:

Organism=Escherichia coli, GI1788478, Length=663, Percent_Identity=88.0844645550528, Blast_Score=1238, Evalue=0.0,
Organism=Escherichia coli, GI1786798, Length=755, Percent_Identity=32.1854304635762, Blast_Score=271, Evalue=1e-73,
Organism=Escherichia coli, GI1790405, Length=704, Percent_Identity=25.8522727272727, Blast_Score=163, Evalue=3e-41,
Organism=Escherichia coli, GI1787723, Length=155, Percent_Identity=30.9677419354839, Blast_Score=67, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012910
- InterPro:   IPR000531
- InterPro:   IPR010916
- InterPro:   IPR010917 [H]

Pfam domain/function: PF07715 Plug; PF00593 TonB_dep_Rec [H]

EC number: NA

Molecular weight: Translated: 73712; Mature: 73712

Theoretical pI: Translated: 5.36; Mature: 5.36

Prosite motif: PS00430 TONB_DEPENDENT_REC_1 ; PS01156 TONB_DEPENDENT_REC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFRFNPFVRVGLCMSAVTLAWPVAAATDDGETMVVTASAIEQNLKDAPASISVITQQDLQ
CCCCCCHHHHHHHHHHHHHHHEEEEECCCCCEEEEEHHHHHHHHHCCCCEEEEEEHHHHH
RRPVQNLKDVLKEVPGVQLTNEGDNRKGVSIRGLDSSYTLILIDGKRVNSRNAVFRHNDF
HCCHHHHHHHHHHCCCEEEECCCCCCCCCEEEECCCCEEEEEEECCEECCCCCEEEECCC
DLNWIPVDAIERIEVVRGPMSSLYGSDALGGVVNIITKKIGQKWHGSVTVDSTIQEHRDR
CCEEEEHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHHHHHCHHHCCCEEEHHHHHHHHHC
GDTYNGQFFTSGPLIDGVLGMKAYGSLAKREKDEQQSSATTATGETPRIEGFTSRDGNVE
CCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEECCCCCEE
FAWTPNENHDVTAGYGFDRQDRDSDSLDKNRLERQNYALSHNGRWDLGNSELKFYGEKVE
EEECCCCCCCEEECCCCCCCCCCCCCHHHHHHHHHCEEECCCCEECCCCCCEEEEEHHHC
NKNPGNSSPITSESNSIDGKYVLPLASVNQFLTFGGEWRHDKLSDAVNLTGGSSTKTSAS
CCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHCCCCCCCCHHCCEEEECCCCCCCCCCC
QYALFLEDEWRIFEPLALTTGIRMDDHETYGDHWSPRAYLVYNATDTLTVKGGWATAFKA
EEEEEEECCCEEECCEEHHCCCEECCCCCCCCCCCCCEEEEEECCEEEEEECCEEEEECC
PSLLQLSPDWATNSCRGGCRIVGSPDLKPETSESWELGLYYRGEEGILEGVEASVTTFRN
CCEEEECCCCCCCCCCCCEEEECCCCCCCCCCCCEEEEEEEECCCCHHHCCHHHHHHHHC
DVDNRISISRTPDVNAAPGYSNFVGFETNSRGQRVPVFRYYNVNKARIQGVETELKVPFN
CCCCEEEEECCCCCCCCCCCCCEEEEECCCCCCCCCEEEEECCCHHHEECCCEEEECCCC
EAWKLSLNYTYNDGRDVSNGGNKPLSDLPFHTANGTLDWKPVQLEDWSFYVSGNYTGRKR
CEEEEEEEEEECCCCCCCCCCCCCCCCCCEECCCCEECCEEEEEECEEEEEECCCCCCCC
ADSATAKTPGGYVVWDTGAAWQATKNVKLRAGVLNVGDKDLKRDDYGYTEDGRRYFMAVD
CCCCCCCCCCCEEEECCCCCEEECCCEEEEEEEECCCCHHCCCCCCCCCCCCCEEEEEEE
YRF
ECC
>Mature Secondary Structure
MFRFNPFVRVGLCMSAVTLAWPVAAATDDGETMVVTASAIEQNLKDAPASISVITQQDLQ
CCCCCCHHHHHHHHHHHHHHHEEEEECCCCCEEEEEHHHHHHHHHCCCCEEEEEEHHHHH
RRPVQNLKDVLKEVPGVQLTNEGDNRKGVSIRGLDSSYTLILIDGKRVNSRNAVFRHNDF
HCCHHHHHHHHHHCCCEEEECCCCCCCCCEEEECCCCEEEEEEECCEECCCCCEEEECCC
DLNWIPVDAIERIEVVRGPMSSLYGSDALGGVVNIITKKIGQKWHGSVTVDSTIQEHRDR
CCEEEEHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHHHHHCHHHCCCEEEHHHHHHHHHC
GDTYNGQFFTSGPLIDGVLGMKAYGSLAKREKDEQQSSATTATGETPRIEGFTSRDGNVE
CCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEECCCCCEE
FAWTPNENHDVTAGYGFDRQDRDSDSLDKNRLERQNYALSHNGRWDLGNSELKFYGEKVE
EEECCCCCCCEEECCCCCCCCCCCCCHHHHHHHHHCEEECCCCEECCCCCCEEEEEHHHC
NKNPGNSSPITSESNSIDGKYVLPLASVNQFLTFGGEWRHDKLSDAVNLTGGSSTKTSAS
CCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHCCCCCCCCHHCCEEEECCCCCCCCCCC
QYALFLEDEWRIFEPLALTTGIRMDDHETYGDHWSPRAYLVYNATDTLTVKGGWATAFKA
EEEEEEECCCEEECCEEHHCCCEECCCCCCCCCCCCCEEEEEECCEEEEEECCEEEEECC
PSLLQLSPDWATNSCRGGCRIVGSPDLKPETSESWELGLYYRGEEGILEGVEASVTTFRN
CCEEEECCCCCCCCCCCCEEEECCCCCCCCCCCCEEEEEEEECCCCHHHCCHHHHHHHHC
DVDNRISISRTPDVNAAPGYSNFVGFETNSRGQRVPVFRYYNVNKARIQGVETELKVPFN
CCCCEEEEECCCCCCCCCCCCCEEEEECCCCCCCCCEEEEECCCHHHEECCCEEEECCCC
EAWKLSLNYTYNDGRDVSNGGNKPLSDLPFHTANGTLDWKPVQLEDWSFYVSGNYTGRKR
CEEEEEEEEEECCCCCCCCCCCCCCCCCCEECCCCEECCEEEEEECEEEEEECCCCCCCC
ADSATAKTPGGYVVWDTGAAWQATKNVKLRAGVLNVGDKDLKRDDYGYTEDGRRYFMAVD
CCCCCCCCCCCEEEECCCCCEEECCCEEEEEEEECCCCHHCCCCCCCCCCCCCEEEEEEE
YRF
ECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2644220; 9278503; 3316180; 1315732; 2160948 [H]