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The map label for this gene is udg

Identifier: 16765410

GI number: 16765410

Start: 2157958

End: 2159124

Strand: Reverse

Name: udg

Synonym: STM2080

Alternate gene names: 16765410

Gene position: 2159124-2157958 (Counterclockwise)

Preceding gene: 16765411

Following gene: 16765409

Centisome position: 44.45

GC content: 44.04

Gene sequence:

>1167_bases
ATGAAAATCACGATATCCGGGACGGGTTATGTTGGCTTGTCTAATGGTTTGCTTATTGCACAACATCATGATGTGGTGGC
GTTAGACATTGTTCCTTCCCGTGTTGAACTGTTAAATGATCGGATATCTCCGATTGTTGATAAAGAAATTCAGCAATTTT
TAAAGGAAGATAACATCAGATTCAGGGCAACGCTGGATAAGTTTGATGCGTACCAGAATGCAGATTACGTCATCATTGCT
ACGCCTACGGATTACGATCCCAAAACTAACTATTTTAATACGTCCAGTGTGGAATCGGTCATGCAGGATGTGATCAGCAT
CAACCCCGCAGCAGTGATGATTATTAAGTCTACGGTGCCGGTTGGCTTCACGGCGGCAATGCGTCAGAAGTTTGCGACAG
AAAATATCATTTTCTCTCCGGAGTTTTTACGTGAAGGTAAAGCCCTTTACGATAACCTTTATCCCTCCCGTATCGTGATT
GGGGAACAGTCTGAGCGCGCCAGAGAATTTGCCGCATTACTCCAGGAAGGCGCTATTAAACAGGAGATTCCAACGCTGTT
TACGGACTCCACTGAGGCGGAAGCCATTAAACTTTTCGCCAATACTTATCTCGCTATGCGAGTCGCTTATTTTAATGAAT
TAGACAGCTATGCTGAAACGTTAGGATTAAATACCCGACAAATTATTGAAGGGGTGTGCCTCGACCCGCGTATTGGCAAT
CATTATAATAATCCCTCTTTTGGTTATGGCGGATATTGTTTGCCAAAAGATACCAAACAGTTGCTGGCCAATTATCAGTC
GGTGCCTAATAATATTATCTCCGCTATCGTTGAAGCAAACCGTACGCGTAAAGATTTTATTGCCGACGCTATCCTCGCCA
GAAAGCCTAAAGTGGTGGGCATTTATCGCCTGATTATGAAGAGTGGCTCCGATAACTTCCGCGCCTCATCGATTCAGGGG
ATTATGAAGCGCATTAAAGCGAAAGGCGTAGAGGTCATCATCTATGAGCCGGTAATGGAAGAAGATACTTTCTTTAACTC
ACGTCTTGAACGTGATTTGCACTGCTTTAAACAGCAGGCGGATGTCATTATTTCCAACAGGATGGCGGCAGAGCTTTTGG
ATGTCGCTGAAAAAGTGTATACCCGCGATCTTTTCGGTAGTGATTAA

Upstream 100 bases:

>100_bases
CTGCGTTGCACTTTATATACTCAGGCGTTAAAACTTTAATATCTTATCAGGATGCGAAATACATCATGATTCATAATTAA
GTTAATTCTGAGAGCGAATA

Downstream 100 bases:

>100_bases
TAAGGCAATCGGGGCTGATGAGTCCCGATGATTTATTGACCAAATGGAAATAATGTCTGATTTTTATCATTAATCCTATG
GCATATATTTGCTTTATGGC

Product: UDP-glucose/GDP-mannose dehydrogenase

Products: NA

Alternate protein names: UDP-Glc dehydrogenase; UDP-GlcDH; UDPGDH

Number of amino acids: Translated: 388; Mature: 388

Protein sequence:

>388_residues
MKITISGTGYVGLSNGLLIAQHHDVVALDIVPSRVELLNDRISPIVDKEIQQFLKEDNIRFRATLDKFDAYQNADYVIIA
TPTDYDPKTNYFNTSSVESVMQDVISINPAAVMIIKSTVPVGFTAAMRQKFATENIIFSPEFLREGKALYDNLYPSRIVI
GEQSERAREFAALLQEGAIKQEIPTLFTDSTEAEAIKLFANTYLAMRVAYFNELDSYAETLGLNTRQIIEGVCLDPRIGN
HYNNPSFGYGGYCLPKDTKQLLANYQSVPNNIISAIVEANRTRKDFIADAILARKPKVVGIYRLIMKSGSDNFRASSIQG
IMKRIKAKGVEVIIYEPVMEEDTFFNSRLERDLHCFKQQADVIISNRMAAELLDVAEKVYTRDLFGSD

Sequences:

>Translated_388_residues
MKITISGTGYVGLSNGLLIAQHHDVVALDIVPSRVELLNDRISPIVDKEIQQFLKEDNIRFRATLDKFDAYQNADYVIIA
TPTDYDPKTNYFNTSSVESVMQDVISINPAAVMIIKSTVPVGFTAAMRQKFATENIIFSPEFLREGKALYDNLYPSRIVI
GEQSERAREFAALLQEGAIKQEIPTLFTDSTEAEAIKLFANTYLAMRVAYFNELDSYAETLGLNTRQIIEGVCLDPRIGN
HYNNPSFGYGGYCLPKDTKQLLANYQSVPNNIISAIVEANRTRKDFIADAILARKPKVVGIYRLIMKSGSDNFRASSIQG
IMKRIKAKGVEVIIYEPVMEEDTFFNSRLERDLHCFKQQADVIISNRMAAELLDVAEKVYTRDLFGSD
>Mature_388_residues
MKITISGTGYVGLSNGLLIAQHHDVVALDIVPSRVELLNDRISPIVDKEIQQFLKEDNIRFRATLDKFDAYQNADYVIIA
TPTDYDPKTNYFNTSSVESVMQDVISINPAAVMIIKSTVPVGFTAAMRQKFATENIIFSPEFLREGKALYDNLYPSRIVI
GEQSERAREFAALLQEGAIKQEIPTLFTDSTEAEAIKLFANTYLAMRVAYFNELDSYAETLGLNTRQIIEGVCLDPRIGN
HYNNPSFGYGGYCLPKDTKQLLANYQSVPNNIISAIVEANRTRKDFIADAILARKPKVVGIYRLIMKSGSDNFRASSIQG
IMKRIKAKGVEVIIYEPVMEEDTFFNSRLERDLHCFKQQADVIISNRMAAELLDVAEKVYTRDLFGSD

Specific function: Unknown

COG id: COG1004

COG function: function code M; Predicted UDP-glucose 6-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family

Homologues:

Organism=Homo sapiens, GI4507813, Length=367, Percent_Identity=27.5204359673025, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI296040438, Length=242, Percent_Identity=27.6859504132231, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI296040443, Length=216, Percent_Identity=27.3148148148148, Blast_Score=81, Evalue=2e-15,
Organism=Escherichia coli, GI1788340, Length=388, Percent_Identity=88.9175257731959, Blast_Score=715, Evalue=0.0,
Organism=Escherichia coli, GI48994968, Length=376, Percent_Identity=25, Blast_Score=79, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17560350, Length=383, Percent_Identity=25.3263707571802, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI17136908, Length=376, Percent_Identity=25.531914893617, Blast_Score=97, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UDG_SALTY (Q04873)

Other databases:

- EMBL:   Z17278
- EMBL:   AE006468
- RefSeq:   NP_461025.1
- ProteinModelPortal:   Q04873
- SMR:   Q04873
- PRIDE:   Q04873
- GeneID:   1253601
- GenomeReviews:   AE006468_GR
- KEGG:   stm:STM2080
- NMPDR:   fig|99287.1.peg.2005
- HOGENOM:   HBG400967
- OMA:   LNFRATT
- ProtClustDB:   PRK15057
- BioCyc:   STYP99287:STM2080-MONOMER
- BRENDA:   1.1.1.22
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732
- Gene3D:   G3DSA:3.40.50.720
- Gene3D:   G3DSA:1.10.1040.10
- Gene3D:   G3DSA:3.40.50.1870
- PANTHER:   PTHR11374
- PIRSF:   PIRSF000124
- TIGRFAMs:   TIGR03026

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N; SSF48179 6DGDH_C_like; SSF52413 UDP-Glc/GDP-Man_DH_C

EC number: =1.1.1.22

Molecular weight: Translated: 43634; Mature: 43634

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: NA

Important sites: ACT_SITE 253-253

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKITISGTGYVGLSNGLLIAQHHDVVALDIVPSRVELLNDRISPIVDKEIQQFLKEDNIR
CEEEEECCCEEECCCCEEEEECCCEEEEEECHHHHHHHHHHCCHHHHHHHHHHHHHCCCE
FRATLDKFDAYQNADYVIIATPTDYDPKTNYFNTSSVESVMQDVISINPAAVMIIKSTVP
EEEEHHHHHHHCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEECCCC
VGFTAAMRQKFATENIIFSPEFLREGKALYDNLYPSRIVIGEQSERAREFAALLQEGAIK
CCHHHHHHHHHHHCCEEECHHHHHCCHHHHHCCCCCEEEECCCHHHHHHHHHHHHHCCHH
QEIPTLFTDSTEAEAIKLFANTYLAMRVAYFNELDSYAETLGLNTRQIIEGVCLDPRIGN
HHCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCC
HYNNPSFGYGGYCLPKDTKQLLANYQSVPNNIISAIVEANRTRKDFIADAILARKPKVVG
CCCCCCCCCCCEECCHHHHHHHHHHHHCHHHHHHHHHHHCCHHHHHHHHHHHHCCCCHHH
IYRLIMKSGSDNFRASSIQGIMKRIKAKGVEVIIYEPVMEEDTFFNSRLERDLHCFKQQA
HHHHHHHCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHH
DVIISNRMAAELLDVAEKVYTRDLFGSD
HHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKITISGTGYVGLSNGLLIAQHHDVVALDIVPSRVELLNDRISPIVDKEIQQFLKEDNIR
CEEEEECCCEEECCCCEEEEECCCEEEEEECHHHHHHHHHHCCHHHHHHHHHHHHHCCCE
FRATLDKFDAYQNADYVIIATPTDYDPKTNYFNTSSVESVMQDVISINPAAVMIIKSTVP
EEEEHHHHHHHCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEECCCC
VGFTAAMRQKFATENIIFSPEFLREGKALYDNLYPSRIVIGEQSERAREFAALLQEGAIK
CCHHHHHHHHHHHCCEEECHHHHHCCHHHHHCCCCCEEEECCCHHHHHHHHHHHHHCCHH
QEIPTLFTDSTEAEAIKLFANTYLAMRVAYFNELDSYAETLGLNTRQIIEGVCLDPRIGN
HHCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCC
HYNNPSFGYGGYCLPKDTKQLLANYQSVPNNIISAIVEANRTRKDFIADAILARKPKVVG
CCCCCCCCCCCEECCHHHHHHHHHHHHCHHHHHHHHHHHCCHHHHHHHHHHHHCCCCHHH
IYRLIMKSGSDNFRASSIQGIMKRIKAKGVEVIIYEPVMEEDTFFNSRLERDLHCFKQQA
HHHHHHHCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHH
DVIISNRMAAELLDVAEKVYTRDLFGSD
HHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7682279; 11677609