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The map label for this gene is sirC

Identifier: 16765115

GI number: 16765115

Start: 1872112

End: 1872501

Strand: Reverse

Name: sirC

Synonym: STM1774

Alternate gene names: 16765115

Gene position: 1872501-1872112 (Counterclockwise)

Preceding gene: 16765116

Following gene: 16765114

Centisome position: 38.55

GC content: 51.28

Gene sequence:

>390_bases
ATGACAATTGCAATGTTGCTCACGCTTCATCTTATCTGTGTTGCGCTCTCCGTCAGTTTGTTTGTCGCTCGTTACTGGTG
GCGCTATTGCGGCCATGCGTTGGCCGCCGCGCGCTGGACACGAATCGTGCCTCCCGTCATAGATACCCTGTTACTGCTTA
GCGGTATTGGGTTAATCGTTAAAACGCACATCCTGCCATTCACGGAGTCGGGCTCATGGCTGACTGAAAAACTGTTTGGC
GTTATCATCTACATCGTTTTGGGTTTTATTGCGCTTGATTATCGTCAGGCGCGCAGCCAGCAGGCGCGTTTTATCGCTTT
CCCGCTGGCGCTGGTGGTGCTGTACATCATCATTAAACTCGCCACCACAAAAATACCGTTACTGGGGTAA

Upstream 100 bases:

>100_bases
AAGCGGTAAGAGCGGTTTTCAGGCGGTCTGGTTACTCGGATGTAGAAACGTGTCGTGATTATGGTGGTAATGAACGCGTG
ACCTGCGGACGTTTTACGCC

Downstream 100 bases:

>100_bases
GTCATGAGGTCGTTAGCTGATTTCGAATTTAACAATGCGCCGCTGTGTGATGGCATGATCCTGGCATCAGAGATGATTCG
CCTGGATTTTCCCACGCAGT

Product: transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 129; Mature: 128

Protein sequence:

>129_residues
MTIAMLLTLHLICVALSVSLFVARYWWRYCGHALAAARWTRIVPPVIDTLLLLSGIGLIVKTHILPFTESGSWLTEKLFG
VIIYIVLGFIALDYRQARSQQARFIAFPLALVVLYIIIKLATTKIPLLG

Sequences:

>Translated_129_residues
MTIAMLLTLHLICVALSVSLFVARYWWRYCGHALAAARWTRIVPPVIDTLLLLSGIGLIVKTHILPFTESGSWLTEKLFG
VIIYIVLGFIALDYRQARSQQARFIAFPLALVVLYIIIKLATTKIPLLG
>Mature_128_residues
TIAMLLTLHLICVALSVSLFVARYWWRYCGHALAAARWTRIVPPVIDTLLLLSGIGLIVKTHILPFTESGSWLTEKLFGV
IIYIVLGFIALDYRQARSQQARFIAFPLALVVLYIIIKLATTKIPLLG

Specific function: Not essential for the expression of the invasive phenotype. Required for maximal expression of sirC

COG id: COG3094

COG function: function code S; Uncharacterized protein conserved in bacteria

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1787464, Length=128, Percent_Identity=73.4375, Blast_Score=186, Evalue=3e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SIRB2_SALTI (P0A238)

Other databases:

- EMBL:   AL627271
- EMBL:   AE014613
- RefSeq:   NP_456284.1
- RefSeq:   NP_804916.1
- GeneID:   1070464
- GeneID:   1248258
- GenomeReviews:   AE014613_GR
- GenomeReviews:   AL513382_GR
- KEGG:   stt:t1102
- KEGG:   sty:STY1899
- HOGENOM:   HBG644082
- OMA:   GAWLTEK
- ProtClustDB:   PRK10278
- BioCyc:   SENT209261:T1102-MONOMER
- BioCyc:   SENT220341:STY1899-MONOMER
- InterPro:   IPR007360
- PIRSF:   PIRSF005610

Pfam domain/function: PF04247 SirB

EC number: NA

Molecular weight: Translated: 14467; Mature: 14336

Theoretical pI: Translated: 10.30; Mature: 10.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xb806850)-; HASH(0xb91cb64)-; HASH(0xc956f68)-; HASH(0xe784b2c)-;

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIAMLLTLHLICVALSVSLFVARYWWRYCGHALAAARWTRIVPPVIDTLLLLSGIGLIV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
KTHILPFTESGSWLTEKLFGVIIYIVLGFIALDYRQARSQQARFIAFPLALVVLYIIIKL
HHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ATTKIPLLG
HHHCCCCCH
>Mature Secondary Structure 
TIAMLLTLHLICVALSVSLFVARYWWRYCGHALAAARWTRIVPPVIDTLLLLSGIGLIV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
KTHILPFTESGSWLTEKLFGVIIYIVLGFIALDYRQARSQQARFIAFPLALVVLYIIIKL
HHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ATTKIPLLG
HHHCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504