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The map label for this gene is trpC [H]

Identifier: 16765069

GI number: 16765069

Start: 1821711

End: 1823069

Strand: Direct

Name: trpC [H]

Synonym: STM1725

Alternate gene names: 16765069

Gene position: 1821711-1823069 (Clockwise)

Preceding gene: 16765068

Following gene: 16765070

Centisome position: 37.5

GC content: 55.19

Gene sequence:

>1359_bases
ATGCAAACCGTTTTAGCGAAAATCGTCGCAGACAAGGCGATTTGGGTAGAAGCCCGCAAACAGCAACAGCCGCTGGCCAG
TTTTCAAAATGAGATCCAGCCAAGTACACGCCATTTTTATGATGCGCTCCAGGGCGCGCGTACCGCCTTTATTCTGGAGT
GTAAGAAAGCATCGCCATCAAAAGGCGTGATTCGCGACGATTTCGATCCGGCGCGTATTGCCAGTATTTATCAACATTAC
GCCTCGGCGATCTCGGTGCTCACCGACGAAAAATATTTTCAGGGGAGCTTCGATTTTCTGCCGGTCGTTAGCCAAAGCGC
GCCGCAGCCGATTCTGTGTAAGGATTTTATTATCGATCCCTATCAGATCTACCTTGCCCGTTACTATCAGGCCGATGCCT
GTTTACTGATGCTCTCGGTTCTGGATGACGAACAGTATCGCCAACTCTCCGCCGTCGCGCACAGTCTGAAAATGGGCGTG
CTCACGGAGGTCAGTAATGACGAAGAACGGGAGCGCGCGATAGCGTTAGGCGCAAAAGTGGTAGGTATCAACAATCGCGA
TCTGCGCGATCTGTCGATTGATTTGAATCGCACCCGCCAGCTGGCGCCAAAACTGGGCCACGGCGTGACTGTCATCAGCG
AGTCCGGGATTAACACCTATGGTCAGGTACGCGAACTGAGCCACTTCGCCAACGGTTTTTTAATTGGCTCCGCGTTAATG
GCGCATGACGATCTTAACGCCGCCGTCCGTCGCGTGCTGCTTGGCGAAAATAAAGTCTGCGGCCTGACCCGCGCCCAGGA
CGCTAAAGCGGCCTGTGACGCTGGCGCAATATATGGCGGGTTGATTTTTGTGCCCTCATCTCCGCGCGCGGTTAGCGTTG
AGCAGGCGCGAGAAGTGATAAGCGGCGCGCCATTGCAGTATGTCGGCGTTTTCAAGAACGCTGATATCGCCGATGTTTGC
CAGAAAGCCGCCGTCCTGTCGCTTTCTGCCGTACAGCTACATGGCAGCGAAGACCAGGCGTATGTCAACGCGCTGCGCGA
GGCGTTGCCGAAACAGGTGCAAATCTGGAAGGCGCTGAGCGTTAGCGATGCCCTTCCCGCACGCGATTATCACCATGTCG
ATAAATACATTTTCGACAATGGGCAAGGCGGCAGCGGGCAGCGCTTCGACTGGTCACTGCTACAGGGGCAACCGCTGGAT
AATGTGTTACTGGCGGGCGGGCTGGCGGCCGATAACTGCGTCCAGGCGGCGCAAGTCGGCTGTGCCGGTCTCGATTTTAA
TTCAGGTGTGGAGTCACAGCCGGGCATCAAAGATGCTCGTCTTCTGGCCTCAGTTTTTCAGACACTGCGCGCATATTAA

Upstream 100 bases:

>100_bases
TCAGGAAGATCTCAAGGCCAACGCGCAAACCGTGCTTGATGTTCTGCGCAACGGCACCGCATATGACAGAGTCACCGCAC
TGGCGGCAAGAGGGTAAATA

Downstream 100 bases:

>100_bases
GGAAAAAACATGACAACACTTCTCAACCCCTACTTTGGTGAATTCGGCGGCATGTATGTGCCGCAGATCCTGATGCCTGC
GCTGAACCAGCTTGAAGAGG

Product: bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase

Products: NA

Alternate protein names: Indole-3-glycerol phosphate synthase; IGPS; N-(5'-phospho-ribosyl)anthranilate isomerase; PRAI [H]

Number of amino acids: Translated: 452; Mature: 452

Protein sequence:

>452_residues
MQTVLAKIVADKAIWVEARKQQQPLASFQNEIQPSTRHFYDALQGARTAFILECKKASPSKGVIRDDFDPARIASIYQHY
ASAISVLTDEKYFQGSFDFLPVVSQSAPQPILCKDFIIDPYQIYLARYYQADACLLMLSVLDDEQYRQLSAVAHSLKMGV
LTEVSNDEERERAIALGAKVVGINNRDLRDLSIDLNRTRQLAPKLGHGVTVISESGINTYGQVRELSHFANGFLIGSALM
AHDDLNAAVRRVLLGENKVCGLTRAQDAKAACDAGAIYGGLIFVPSSPRAVSVEQAREVISGAPLQYVGVFKNADIADVC
QKAAVLSLSAVQLHGSEDQAYVNALREALPKQVQIWKALSVSDALPARDYHHVDKYIFDNGQGGSGQRFDWSLLQGQPLD
NVLLAGGLAADNCVQAAQVGCAGLDFNSGVESQPGIKDARLLASVFQTLRAY

Sequences:

>Translated_452_residues
MQTVLAKIVADKAIWVEARKQQQPLASFQNEIQPSTRHFYDALQGARTAFILECKKASPSKGVIRDDFDPARIASIYQHY
ASAISVLTDEKYFQGSFDFLPVVSQSAPQPILCKDFIIDPYQIYLARYYQADACLLMLSVLDDEQYRQLSAVAHSLKMGV
LTEVSNDEERERAIALGAKVVGINNRDLRDLSIDLNRTRQLAPKLGHGVTVISESGINTYGQVRELSHFANGFLIGSALM
AHDDLNAAVRRVLLGENKVCGLTRAQDAKAACDAGAIYGGLIFVPSSPRAVSVEQAREVISGAPLQYVGVFKNADIADVC
QKAAVLSLSAVQLHGSEDQAYVNALREALPKQVQIWKALSVSDALPARDYHHVDKYIFDNGQGGSGQRFDWSLLQGQPLD
NVLLAGGLAADNCVQAAQVGCAGLDFNSGVESQPGIKDARLLASVFQTLRAY
>Mature_452_residues
MQTVLAKIVADKAIWVEARKQQQPLASFQNEIQPSTRHFYDALQGARTAFILECKKASPSKGVIRDDFDPARIASIYQHY
ASAISVLTDEKYFQGSFDFLPVVSQSAPQPILCKDFIIDPYQIYLARYYQADACLLMLSVLDDEQYRQLSAVAHSLKMGV
LTEVSNDEERERAIALGAKVVGINNRDLRDLSIDLNRTRQLAPKLGHGVTVISESGINTYGQVRELSHFANGFLIGSALM
AHDDLNAAVRRVLLGENKVCGLTRAQDAKAACDAGAIYGGLIFVPSSPRAVSVEQAREVISGAPLQYVGVFKNADIADVC
QKAAVLSLSAVQLHGSEDQAYVNALREALPKQVQIWKALSVSDALPARDYHHVDKYIFDNGQGGSGQRFDWSLLQGQPLD
NVLLAGGLAADNCVQAAQVGCAGLDFNSGVESQPGIKDARLLASVFQTLRAY

Specific function: Bifunctional enzyme that catalyzes two sequential steps of tryptophan biosynthetic pathway. The first reaction is catalyzed by the isomerase, coded by the trpF domain; the second reaction is catalyzed by the synthase, coded by the trpC domain [H]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the trpF family [H]

Homologues:

Organism=Escherichia coli, GI87081863, Length=452, Percent_Identity=87.8318584070797, Blast_Score=825, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6322638, Length=270, Percent_Identity=34.4444444444444, Blast_Score=121, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6320210, Length=217, Percent_Identity=31.7972350230415, Blast_Score=76, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR001240
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00218 IGPS; PF00697 PRAI [H]

EC number: =4.1.1.48; =5.3.1.24 [H]

Molecular weight: Translated: 49202; Mature: 49202

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTVLAKIVADKAIWVEARKQQQPLASFQNEIQPSTRHFYDALQGARTAFILECKKASPS
CHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHCCCEEEEEEECCCCCC
KGVIRDDFDPARIASIYQHYASAISVLTDEKYFQGSFDFLPVVSQSAPQPILCKDFIIDP
CCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHCCCCCHHHHHCCCCCCCEEHHHHCCCH
YQIYLARYYQADACLLMLSVLDDEQYRQLSAVAHSLKMGVLTEVSNDEERERAIALGAKV
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCEEE
VGINNRDLRDLSIDLNRTRQLAPKLGHGVTVISESGINTYGQVRELSHFANGFLIGSALM
EECCCCCCCEEEECHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHCCHHHHHHHH
AHDDLNAAVRRVLLGENKVCGLTRAQDAKAACDAGAIYGGLIFVPSSPRAVSVEQAREVI
HHHHHHHHHHHHHHCCCCEECCCCCCCHHHHHCCCCEECCEEEECCCCCEECHHHHHHHH
SGAPLQYVGVFKNADIADVCQKAAVLSLSAVQLHGSEDQAYVNALREALPKQVQIWKALS
CCCCEEEEEEECCCCHHHHHHHHHHHHHEEEEEECCCHHHHHHHHHHHCHHHHHHHHHHH
VSDALPARDYHHVDKYIFDNGQGGSGQRFDWSLLQGQPLDNVLLAGGLAADNCVQAAQVG
HCCCCCCCHHHHHHHHHEECCCCCCCCCEEEHHHCCCCCCHHHHCCCCCHHHHHHHHHHC
CAGLDFNSGVESQPGIKDARLLASVFQTLRAY
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQTVLAKIVADKAIWVEARKQQQPLASFQNEIQPSTRHFYDALQGARTAFILECKKASPS
CHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHCCCEEEEEEECCCCCC
KGVIRDDFDPARIASIYQHYASAISVLTDEKYFQGSFDFLPVVSQSAPQPILCKDFIIDP
CCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHCCCCCHHHHHCCCCCCCEEHHHHCCCH
YQIYLARYYQADACLLMLSVLDDEQYRQLSAVAHSLKMGVLTEVSNDEERERAIALGAKV
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCEEE
VGINNRDLRDLSIDLNRTRQLAPKLGHGVTVISESGINTYGQVRELSHFANGFLIGSALM
EECCCCCCCEEEECHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHCCHHHHHHHH
AHDDLNAAVRRVLLGENKVCGLTRAQDAKAACDAGAIYGGLIFVPSSPRAVSVEQAREVI
HHHHHHHHHHHHHHCCCCEECCCCCCCHHHHHCCCCEECCEEEECCCCCEECHHHHHHHH
SGAPLQYVGVFKNADIADVCQKAAVLSLSAVQLHGSEDQAYVNALREALPKQVQIWKALS
CCCCEEEEEEECCCCHHHHHHHHHHHHHEEEEEECCCHHHHHHHHHHHCHHHHHHHHHHH
VSDALPARDYHHVDKYIFDNGQGGSGQRFDWSLLQGQPLDNVLLAGGLAADNCVQAAQVG
HCCCCCCCHHHHHHHHHEECCCCCCCCCEEEHHHCCCCCCHHHHCCCCCHHHHHHHHHHC
CAGLDFNSGVESQPGIKDARLLASVFQTLRAY
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]