| Definition | Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 chromosome, complete genome. |
|---|---|
| Accession | NC_003197 |
| Length | 4,857,432 |
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The map label for this gene is ytbE [H]
Identifier: 16765019
GI number: 16765019
Start: 1768804
End: 1769673
Strand: Reverse
Name: ytbE [H]
Synonym: STM1676
Alternate gene names: 16765019
Gene position: 1769673-1768804 (Counterclockwise)
Preceding gene: 16765020
Following gene: 16765017
Centisome position: 36.43
GC content: 46.67
Gene sequence:
>870_bases GTGGAATATTCAATATTAAGTAACAACCTTAAAATGCCTATGGTTGGTTTTGGCGTTTTTAAGGTAACCGACAAAGAAGA ATGTCAGCAGTCAGTGTTAAGCGCTATTCGCAGCGGTTATCGTCTTATCGATACCGCTGCGGTATACGGCAATGAAGATG CCGTTGGTGACGCTGTTCGTGAAGCCATCGCGACAGGTCTGTGTACCCGTGAGGAGTTATTTATTACTTCTAAACTGTGG GTGCAAGATATGGCTAACTACGATCTGGCCAAAGCAGGTATTGAAGCGTCGCTGAAAAAATCCGGGTTAGATTATTTTGA TCTCTATTTATTGCATCAGGCAATGGGTGATTATTTTAGCGCGTGGCGCGCGCTGGAGGACGCTTATGAAGCCGGTAAAC TAAAAGCCATTGGCGTGTCCAACTTCTATGCGCATGTGTTAGCCAACTTCTGTGAAACCGTCAGAATTACGCCAATGGTA AACCAGGTCGAATTGCATCCATACTTTGCACAACCCGCCGCGCTGGAAACCATGAAGCATTATAACGTTCAGCCTGAAGC GTGGGCGCCGTTAGGCGGCGGGAGACATAAACCGTATGAAAATGTCATGCTTCAAGGGATTGCCGATGCCCATCAAAAAA CCATCGCGCAGGTTGTCCTGCGTTGGAACGTGCAGCGTGGCGTCACGGTTATTCCTAAATCCACTCGACAGGAACGTATT GAAGAGAACTTTGCTATCTGGGATTTCTCACTAACGGATAACGAAATGGCTCAAATCAACGCCCTTGATTTAGGCTACGT TGGCGAAGCGGTGAAGCATTTTAATCCTGAATTTGTTCGCGGTTGTCTTGGCGTTAAAATCCACGATTGA
Upstream 100 bases:
>100_bases TAATGAACTTTTTGTATAAATATAATCGTATTTAACAATACTCATTGTACCTGTATTTTGCTCTTATCATGGCGTCTTTA CGACGAAAGGGTGCTTTAGC
Downstream 100 bases:
>100_bases TCCCGGCGCTTGCGGATGTTTTCTCGCATGAACAGCTTCTAACACGGTTGCCGGAGCGTAGACGGCAACCGTGTGATATT CGCCTGGCCGTCAGGCGCCG
Product: aldo/keto reductase
Products: 2-keto-L-gulonate; NADP [C]
Alternate protein names: NA
Number of amino acids: Translated: 289; Mature: 289
Protein sequence:
>289_residues MEYSILSNNLKMPMVGFGVFKVTDKEECQQSVLSAIRSGYRLIDTAAVYGNEDAVGDAVREAIATGLCTREELFITSKLW VQDMANYDLAKAGIEASLKKSGLDYFDLYLLHQAMGDYFSAWRALEDAYEAGKLKAIGVSNFYAHVLANFCETVRITPMV NQVELHPYFAQPAALETMKHYNVQPEAWAPLGGGRHKPYENVMLQGIADAHQKTIAQVVLRWNVQRGVTVIPKSTRQERI EENFAIWDFSLTDNEMAQINALDLGYVGEAVKHFNPEFVRGCLGVKIHD
Sequences:
>Translated_289_residues MEYSILSNNLKMPMVGFGVFKVTDKEECQQSVLSAIRSGYRLIDTAAVYGNEDAVGDAVREAIATGLCTREELFITSKLW VQDMANYDLAKAGIEASLKKSGLDYFDLYLLHQAMGDYFSAWRALEDAYEAGKLKAIGVSNFYAHVLANFCETVRITPMV NQVELHPYFAQPAALETMKHYNVQPEAWAPLGGGRHKPYENVMLQGIADAHQKTIAQVVLRWNVQRGVTVIPKSTRQERI EENFAIWDFSLTDNEMAQINALDLGYVGEAVKHFNPEFVRGCLGVKIHD >Mature_289_residues MEYSILSNNLKMPMVGFGVFKVTDKEECQQSVLSAIRSGYRLIDTAAVYGNEDAVGDAVREAIATGLCTREELFITSKLW VQDMANYDLAKAGIEASLKKSGLDYFDLYLLHQAMGDYFSAWRALEDAYEAGKLKAIGVSNFYAHVLANFCETVRITPMV NQVELHPYFAQPAALETMKHYNVQPEAWAPLGGGRHKPYENVMLQGIADAHQKTIAQVVLRWNVQRGVTVIPKSTRQERI EENFAIWDFSLTDNEMAQINALDLGYVGEAVKHFNPEFVRGCLGVKIHD
Specific function: Reduction [C]
COG id: COG0656
COG function: function code R; Aldo/keto reductases, related to diketogulonate reductase
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the aldo/keto reductase family [H]
Homologues:
Organism=Homo sapiens, GI5174695, Length=293, Percent_Identity=38.5665529010239, Blast_Score=189, Evalue=2e-48, Organism=Homo sapiens, GI310109922, Length=265, Percent_Identity=36.9811320754717, Blast_Score=171, Evalue=7e-43, Organism=Homo sapiens, GI300116271, Length=270, Percent_Identity=38.1481481481481, Blast_Score=169, Evalue=2e-42, Organism=Homo sapiens, GI310109920, Length=286, Percent_Identity=34.965034965035, Blast_Score=169, Evalue=2e-42, Organism=Homo sapiens, GI300116273, Length=276, Percent_Identity=36.9565217391304, Blast_Score=169, Evalue=2e-42, Organism=Homo sapiens, GI45446745, Length=286, Percent_Identity=35.3146853146853, Blast_Score=169, Evalue=2e-42, Organism=Homo sapiens, GI4503285, Length=286, Percent_Identity=35.3146853146853, Blast_Score=169, Evalue=2e-42, Organism=Homo sapiens, GI223468663, Length=292, Percent_Identity=35.6164383561644, Blast_Score=169, Evalue=3e-42, Organism=Homo sapiens, GI24497583, Length=286, Percent_Identity=34.965034965035, Blast_Score=169, Evalue=3e-42, Organism=Homo sapiens, GI5453543, Length=286, Percent_Identity=34.965034965035, Blast_Score=168, Evalue=6e-42, Organism=Homo sapiens, GI24497577, Length=289, Percent_Identity=34.6020761245675, Blast_Score=166, Evalue=3e-41, Organism=Homo sapiens, GI5174391, Length=289, Percent_Identity=34.6020761245675, Blast_Score=166, Evalue=3e-41, Organism=Homo sapiens, GI24497585, Length=289, Percent_Identity=34.9480968858132, Blast_Score=164, Evalue=7e-41, Organism=Homo sapiens, GI291291012, Length=280, Percent_Identity=33.9285714285714, Blast_Score=151, Evalue=7e-37, Organism=Homo sapiens, GI93277124, Length=296, Percent_Identity=32.0945945945946, Blast_Score=148, Evalue=7e-36, Organism=Homo sapiens, GI4502049, Length=287, Percent_Identity=35.191637630662, Blast_Score=143, Evalue=2e-34, Organism=Homo sapiens, GI310109924, Length=150, Percent_Identity=35.3333333333333, Blast_Score=96, Evalue=4e-20, Organism=Homo sapiens, GI207028673, Length=103, Percent_Identity=43.6893203883495, Blast_Score=86, Evalue=5e-17, Organism=Homo sapiens, GI310109926, Length=103, Percent_Identity=42.7184466019417, Blast_Score=85, Evalue=7e-17, Organism=Escherichia coli, GI87082198, Length=257, Percent_Identity=40.0778210116732, Blast_Score=196, Evalue=1e-51, Organism=Escherichia coli, GI1786400, Length=259, Percent_Identity=32.8185328185328, Blast_Score=126, Evalue=1e-30, Organism=Escherichia coli, GI1788081, Length=276, Percent_Identity=30.0724637681159, Blast_Score=89, Evalue=5e-19, Organism=Escherichia coli, GI48994888, Length=282, Percent_Identity=25.886524822695, Blast_Score=67, Evalue=2e-12, Organism=Caenorhabditis elegans, GI17550248, Length=283, Percent_Identity=36.7491166077738, Blast_Score=176, Evalue=1e-44, Organism=Caenorhabditis elegans, GI17564128, Length=306, Percent_Identity=33.6601307189542, Blast_Score=167, Evalue=4e-42, Organism=Caenorhabditis elegans, GI17566692, Length=288, Percent_Identity=36.1111111111111, Blast_Score=163, Evalue=8e-41, Organism=Caenorhabditis elegans, GI17537077, Length=288, Percent_Identity=34.7222222222222, Blast_Score=162, Evalue=1e-40, Organism=Caenorhabditis elegans, GI17537075, Length=291, Percent_Identity=34.020618556701, Blast_Score=157, Evalue=4e-39, Organism=Caenorhabditis elegans, GI71998625, Length=269, Percent_Identity=34.5724907063197, Blast_Score=157, Evalue=5e-39, Organism=Caenorhabditis elegans, GI17561298, Length=274, Percent_Identity=31.7518248175182, Blast_Score=149, Evalue=1e-36, Organism=Caenorhabditis elegans, GI17552492, Length=268, Percent_Identity=28.7313432835821, Blast_Score=130, Evalue=7e-31, Organism=Caenorhabditis elegans, GI17537079, Length=296, Percent_Identity=27.7027027027027, Blast_Score=128, Evalue=3e-30, Organism=Caenorhabditis elegans, GI17538386, Length=272, Percent_Identity=28.3088235294118, Blast_Score=123, Evalue=1e-28, Organism=Caenorhabditis elegans, GI17562292, Length=275, Percent_Identity=26.9090909090909, Blast_Score=123, Evalue=1e-28, Organism=Caenorhabditis elegans, GI17561300, Length=265, Percent_Identity=28.3018867924528, Blast_Score=112, Evalue=3e-25, Organism=Caenorhabditis elegans, GI17550246, Length=74, Percent_Identity=45.945945945946, Blast_Score=72, Evalue=4e-13, Organism=Saccharomyces cerevisiae, GI6321896, Length=303, Percent_Identity=34.6534653465347, Blast_Score=181, Evalue=1e-46, Organism=Saccharomyces cerevisiae, GI6324694, Length=301, Percent_Identity=30.8970099667774, Blast_Score=149, Evalue=6e-37, Organism=Saccharomyces cerevisiae, GI6320576, Length=288, Percent_Identity=30.5555555555556, Blast_Score=148, Evalue=1e-36, Organism=Saccharomyces cerevisiae, GI6322556, Length=267, Percent_Identity=33.7078651685393, Blast_Score=142, Evalue=7e-35, Organism=Saccharomyces cerevisiae, GI6319625, Length=317, Percent_Identity=29.6529968454259, Blast_Score=134, Evalue=1e-32, Organism=Saccharomyces cerevisiae, GI6320079, Length=289, Percent_Identity=28.3737024221453, Blast_Score=111, Evalue=1e-25, Organism=Drosophila melanogaster, GI24662789, Length=292, Percent_Identity=36.6438356164384, Blast_Score=181, Evalue=7e-46, Organism=Drosophila melanogaster, GI24657054, Length=290, Percent_Identity=37.2413793103448, Blast_Score=172, Evalue=2e-43, Organism=Drosophila melanogaster, GI24663317, Length=302, Percent_Identity=35.7615894039735, Blast_Score=164, Evalue=8e-41, Organism=Drosophila melanogaster, GI24644950, Length=299, Percent_Identity=33.4448160535117, Blast_Score=164, Evalue=8e-41, Organism=Drosophila melanogaster, GI20129731, Length=287, Percent_Identity=36.2369337979094, Blast_Score=163, Evalue=1e-40, Organism=Drosophila melanogaster, GI21356425, Length=289, Percent_Identity=34.2560553633218, Blast_Score=161, Evalue=5e-40, Organism=Drosophila melanogaster, GI24662785, Length=272, Percent_Identity=38.2352941176471, Blast_Score=156, Evalue=1e-38, Organism=Drosophila melanogaster, GI221378297, Length=319, Percent_Identity=31.3479623824451, Blast_Score=156, Evalue=1e-38, Organism=Drosophila melanogaster, GI24662781, Length=277, Percent_Identity=37.5451263537906, Blast_Score=155, Evalue=3e-38, Organism=Drosophila melanogaster, GI45553081, Length=288, Percent_Identity=31.5972222222222, Blast_Score=155, Evalue=4e-38, Organism=Drosophila melanogaster, GI281366140, Length=255, Percent_Identity=31.7647058823529, Blast_Score=134, Evalue=5e-32,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR001395 - InterPro: IPR018170 - InterPro: IPR020471 - InterPro: IPR023210 [H]
Pfam domain/function: PF00248 Aldo_ket_red [H]
EC number: NA
Molecular weight: Translated: 32407; Mature: 32407
Theoretical pI: Translated: 5.38; Mature: 5.38
Prosite motif: PS00798 ALDOKETO_REDUCTASE_1 ; PS00063 ALDOKETO_REDUCTASE_3
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.4 %Cys (Translated Protein) 3.1 %Met (Translated Protein) 4.5 %Cys+Met (Translated Protein) 1.4 %Cys (Mature Protein) 3.1 %Met (Mature Protein) 4.5 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MEYSILSNNLKMPMVGFGVFKVTDKEECQQSVLSAIRSGYRLIDTAAVYGNEDAVGDAVR CCCCEECCCCCCCEEECEEEEECCHHHHHHHHHHHHHCCCEEEEHHHHCCCCHHHHHHHH EAIATGLCTREELFITSKLWVQDMANYDLAKAGIEASLKKSGLDYFDLYLLHQAMGDYFS HHHHHCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH AWRALEDAYEAGKLKAIGVSNFYAHVLANFCETVRITPMVNQVELHPYFAQPAALETMKH HHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHEEECCCCCEEEECCCCCCHHHHHHHHH YNVQPEAWAPLGGGRHKPYENVMLQGIADAHQKTIAQVVLRWNVQRGVTVIPKSTRQERI CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCHHHHHH EENFAIWDFSLTDNEMAQINALDLGYVGEAVKHFNPEFVRGCLGVKIHD HCCCEEEEEECCCCCHHEEECCCHHHHHHHHHHCCHHHHHHHHCCEECC >Mature Secondary Structure MEYSILSNNLKMPMVGFGVFKVTDKEECQQSVLSAIRSGYRLIDTAAVYGNEDAVGDAVR CCCCEECCCCCCCEEECEEEEECCHHHHHHHHHHHHHCCCEEEEHHHHCCCCHHHHHHHH EAIATGLCTREELFITSKLWVQDMANYDLAKAGIEASLKKSGLDYFDLYLLHQAMGDYFS HHHHHCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH AWRALEDAYEAGKLKAIGVSNFYAHVLANFCETVRITPMVNQVELHPYFAQPAALETMKH HHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHEEECCCCCEEEECCCCCCHHHHHHHHH YNVQPEAWAPLGGGRHKPYENVMLQGIADAHQKTIAQVVLRWNVQRGVTVIPKSTRQERI CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCHHHHHH EENFAIWDFSLTDNEMAQINALDLGYVGEAVKHFNPEFVRGCLGVKIHD HCCCEEEEEECCCCCHHEEECCCHHHHHHHHHHCCHHHHHHHHCCEECC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: 2,5-diketo-D-gluconate; NADPH [C]
Specific reaction: 2,5-diketo-D-gluconate + NADPH = 2-keto-L-gulonate + NADP [C]
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 9387221; 9384377 [H]