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The map label for this gene is rspB [C]

Identifier: 16764887

GI number: 16764887

Start: 1617320

End: 1618345

Strand: Reverse

Name: rspB [C]

Synonym: STM1542

Alternate gene names: 16764887

Gene position: 1618345-1617320 (Counterclockwise)

Preceding gene: 16764888

Following gene: 16764884

Centisome position: 33.32

GC content: 47.66

Gene sequence:

>1026_bases
ATGAAAGTCAAAGCTGTGTTCATTAATAAGCCTGGTGAAGTTGAAACCCGCTGGGTGGATTATCCCCATAAGAAAGAAAA
TGAAGTATTAATTAAGGTTGATGCTGCAGGCATTTGCGGATCGGATATCGGGGCTTTTCGTGGAACGAACCCACTGGTTA
CTTACCCAAGAATTATTGGGCATGAAGTGACCGGAATTGTTCTTCAGGAAGGCGCCGGAATGCCGGACAATATTAAAGAA
GGTGACCGCGTAATTGTTGACCCCTATATTTATTGTGGTCACTGCTACCCTTGCTCTGTCGGCAGAACTAATTGTTGTGA
AAATTTAAACGTCATTGGCGTGCATGTCGATGGCGCAATGCAGGAGGTGGTTACTCATCCCGCACATTTAATTCATAAAA
TACCAGATAATGTGCCTTCTGAAATGGCGCCGCTGGCAGAACCGCTGACCATCGCTCTGCACGCGTTGCATCGGGCAAAC
GTTAAGGCCGGGGAATATGTTGCCATCATCGGCGCGGGGGCCATTGGTCTTATGGCGGCATTAAGCGCGCGTCATTACAA
GGCAACGCCTATTCTGATCGATATTGTGGAAGAAAGGCTACGCTATGCGCAAAAGCTTGGCGTTCCTTATGTGCTGAACG
CCGCTGACGATCAGGTTATCGACGCTATTAAAAATATCACCCACGGCACCATGGCGCAGGTCGTGATAGAAGCTTCCGGC
GCAAATAGCGCTATTCGAAATACGCTTGATTTAGCATCGTTTGCTGGTCGTATTTCGTTTACCGGATGGCCAAAACAGGA
AACGTCGCTGCCGACGAACCTGATCACCTATAAAGAACTGGATTTACGCGGTTCCCGCACCAGTGCCGGTGAATTTGATG
AGGCATTACGTATGCTGTCTACGCTGGAGATTAATCCGCAAGATGTCGTCAGTAAGGTCGTCAATCTTGATGAGATCCCT
GATGCAGTTAAAGAACTTGATCGCTATCCGGAGCGCTACTTAAAGATTAATGCTGTTTTCCATTGA

Upstream 100 bases:

>100_bases
AGCGGTAAATATGACTATGCGTTCTATCTGGCTGGTGCTATCGCTATCGTTTCAAGCCTGTTGGTCTTCGTGTTTGTAAA
AAGTAAAGGATTCAAAGCCA

Downstream 100 bases:

>100_bases
TTTACGGCAAGCTCCACCGCATGGCATGACCGCCATGCGGTGTTATTCATCGACAAAATTAGCCGCCGACAATCTTTCTC
ACATAGCGTAAATGTTCCAG

Product: zinc-binding dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 341; Mature: 341

Protein sequence:

>341_residues
MKVKAVFINKPGEVETRWVDYPHKKENEVLIKVDAAGICGSDIGAFRGTNPLVTYPRIIGHEVTGIVLQEGAGMPDNIKE
GDRVIVDPYIYCGHCYPCSVGRTNCCENLNVIGVHVDGAMQEVVTHPAHLIHKIPDNVPSEMAPLAEPLTIALHALHRAN
VKAGEYVAIIGAGAIGLMAALSARHYKATPILIDIVEERLRYAQKLGVPYVLNAADDQVIDAIKNITHGTMAQVVIEASG
ANSAIRNTLDLASFAGRISFTGWPKQETSLPTNLITYKELDLRGSRTSAGEFDEALRMLSTLEINPQDVVSKVVNLDEIP
DAVKELDRYPERYLKINAVFH

Sequences:

>Translated_341_residues
MKVKAVFINKPGEVETRWVDYPHKKENEVLIKVDAAGICGSDIGAFRGTNPLVTYPRIIGHEVTGIVLQEGAGMPDNIKE
GDRVIVDPYIYCGHCYPCSVGRTNCCENLNVIGVHVDGAMQEVVTHPAHLIHKIPDNVPSEMAPLAEPLTIALHALHRAN
VKAGEYVAIIGAGAIGLMAALSARHYKATPILIDIVEERLRYAQKLGVPYVLNAADDQVIDAIKNITHGTMAQVVIEASG
ANSAIRNTLDLASFAGRISFTGWPKQETSLPTNLITYKELDLRGSRTSAGEFDEALRMLSTLEINPQDVVSKVVNLDEIP
DAVKELDRYPERYLKINAVFH
>Mature_341_residues
MKVKAVFINKPGEVETRWVDYPHKKENEVLIKVDAAGICGSDIGAFRGTNPLVTYPRIIGHEVTGIVLQEGAGMPDNIKE
GDRVIVDPYIYCGHCYPCSVGRTNCCENLNVIGVHVDGAMQEVVTHPAHLIHKIPDNVPSEMAPLAEPLTIALHALHRAN
VKAGEYVAIIGAGAIGLMAALSARHYKATPILIDIVEERLRYAQKLGVPYVLNAADDQVIDAIKNITHGTMAQVVIEASG
ANSAIRNTLDLASFAGRISFTGWPKQETSLPTNLITYKELDLRGSRTSAGEFDEALRMLSTLEINPQDVVSKVVNLDEIP
DAVKELDRYPERYLKINAVFH

Specific function: Not Known; Probable Catabolic Enzyme. [C]

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=331, Percent_Identity=26.8882175226586, Blast_Score=133, Evalue=2e-31,
Organism=Homo sapiens, GI71565154, Length=233, Percent_Identity=27.0386266094421, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI1787863, Length=340, Percent_Identity=32.6470588235294, Blast_Score=192, Evalue=4e-50,
Organism=Escherichia coli, GI226510992, Length=304, Percent_Identity=36.1842105263158, Blast_Score=176, Evalue=3e-45,
Organism=Escherichia coli, GI1788073, Length=334, Percent_Identity=29.0419161676647, Blast_Score=155, Evalue=5e-39,
Organism=Escherichia coli, GI1790045, Length=270, Percent_Identity=33.7037037037037, Blast_Score=147, Evalue=1e-36,
Organism=Escherichia coli, GI1788407, Length=319, Percent_Identity=27.2727272727273, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI1790718, Length=307, Percent_Identity=26.7100977198697, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1788075, Length=335, Percent_Identity=25.9701492537313, Blast_Score=95, Evalue=6e-21,
Organism=Escherichia coli, GI87082125, Length=334, Percent_Identity=29.0419161676647, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI87081918, Length=328, Percent_Identity=25.609756097561, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1786825, Length=299, Percent_Identity=28.0936454849498, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1786552, Length=368, Percent_Identity=27.445652173913, Blast_Score=77, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17562876, Length=330, Percent_Identity=31.2121212121212, Blast_Score=148, Evalue=4e-36,
Organism=Caenorhabditis elegans, GI17562878, Length=310, Percent_Identity=29.6774193548387, Blast_Score=138, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI17562584, Length=330, Percent_Identity=26.3636363636364, Blast_Score=78, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI71988145, Length=326, Percent_Identity=25.7668711656442, Blast_Score=75, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6323099, Length=343, Percent_Identity=29.4460641399417, Blast_Score=149, Evalue=4e-37,
Organism=Saccharomyces cerevisiae, GI6322619, Length=336, Percent_Identity=27.3809523809524, Blast_Score=133, Evalue=5e-32,
Organism=Saccharomyces cerevisiae, GI6319955, Length=336, Percent_Identity=27.0833333333333, Blast_Score=130, Evalue=3e-31,
Organism=Saccharomyces cerevisiae, GI6319258, Length=351, Percent_Identity=27.0655270655271, Blast_Score=104, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6319257, Length=351, Percent_Identity=27.0655270655271, Blast_Score=97, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6319621, Length=264, Percent_Identity=31.0606060606061, Blast_Score=93, Evalue=6e-20,
Organism=Saccharomyces cerevisiae, GI6323729, Length=335, Percent_Identity=26.865671641791, Blast_Score=91, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6320033, Length=272, Percent_Identity=27.2058823529412, Blast_Score=88, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6323961, Length=336, Percent_Identity=26.7857142857143, Blast_Score=84, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6324486, Length=267, Percent_Identity=28.4644194756554, Blast_Score=83, Evalue=8e-17,
Organism=Drosophila melanogaster, GI17737897, Length=321, Percent_Identity=33.6448598130841, Blast_Score=157, Evalue=7e-39,
Organism=Drosophila melanogaster, GI17137530, Length=315, Percent_Identity=32.3809523809524, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI17737895, Length=316, Percent_Identity=27.5316455696203, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI221457811, Length=224, Percent_Identity=27.6785714285714, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI45550770, Length=224, Percent_Identity=27.6785714285714, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI45551930, Length=224, Percent_Identity=27.6785714285714, Blast_Score=82, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.1.1.- [C]

Molecular weight: Translated: 37247; Mature: 37247

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVKAVFINKPGEVETRWVDYPHKKENEVLIKVDAAGICGSDIGAFRGTNPLVTYPRIIG
CCEEEEEECCCCCCEEEECCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCEECHHHHC
HEVTGIVLQEGAGMPDNIKEGDRVIVDPYIYCGHCYPCSVGRTNCCENLNVIGVHVDGAM
CCCEEEEEECCCCCCCCCCCCCEEEECCEEEECCEEECCCCCCHHHCCCCEEEEEECHHH
QEVVTHPAHLIHKIPDNVPSEMAPLAEPLTIALHALHRANVKAGEYVAIIGAGAIGLMAA
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCHHHHHHH
LSARHYKATPILIDIVEERLRYAQKLGVPYVLNAADDQVIDAIKNITHGTMAQVVIEASG
HHHCCCCCCCHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHCCCCCEEEEEEEECC
ANSAIRNTLDLASFAGRISFTGWPKQETSLPTNLITYKELDLRGSRTSAGEFDEALRMLS
CCHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHH
TLEINPQDVVSKVVNLDEIPDAVKELDRYPERYLKINAVFH
HCCCCHHHHHHHHHCHHHHHHHHHHHHHCCHHHEEEEEEEC
>Mature Secondary Structure
MKVKAVFINKPGEVETRWVDYPHKKENEVLIKVDAAGICGSDIGAFRGTNPLVTYPRIIG
CCEEEEEECCCCCCEEEECCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCEECHHHHC
HEVTGIVLQEGAGMPDNIKEGDRVIVDPYIYCGHCYPCSVGRTNCCENLNVIGVHVDGAM
CCCEEEEEECCCCCCCCCCCCCEEEECCEEEECCEEECCCCCCHHHCCCCEEEEEECHHH
QEVVTHPAHLIHKIPDNVPSEMAPLAEPLTIALHALHRANVKAGEYVAIIGAGAIGLMAA
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCHHHHHHH
LSARHYKATPILIDIVEERLRYAQKLGVPYVLNAADDQVIDAIKNITHGTMAQVVIEASG
HHHCCCCCCCHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHCCCCCEEEEEEEECC
ANSAIRNTLDLASFAGRISFTGWPKQETSLPTNLITYKELDLRGSRTSAGEFDEALRMLS
CCHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHH
TLEINPQDVVSKVVNLDEIPDAVKELDRYPERYLKINAVFH
HCCCCHHHHHHHHHCHHHHHHHHHHHHHCCHHHEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]