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The map label for this gene is pagC

Identifier: 16764600

GI number: 16764600

Start: 1332251

End: 1332808

Strand: Direct

Name: pagC

Synonym: STM1246

Alternate gene names: 16764600

Gene position: 1332251-1332808 (Clockwise)

Preceding gene: 16764594

Following gene: 16764602

Centisome position: 27.43

GC content: 43.19

Gene sequence:

>558_bases
ATGAAAAATATTATTTTATCCACTTTAGTTATTACTACAAGCGTTTTGGTTGTAAATGTTGCACAGGCCGATACTAACGC
CTTTTCCGTGGGGTATGCACAAAGTAAAGTTCAGGATTTCAAAAATATCCGAGGGGTAAATGTGAAATACCGTTATGAGG
ATGACTCTCCGGTAAGTTTTATTTCCTCGCTAAGTTACTTATATGGAGACAGACAGGCTTCCGGGTCTGTTGAGCCTGAA
GGTATTCATTACCATGACAAGTTTGAGGTGAAGTACGGTTCTTTAATGGTTGGGCCAGCCTATCGATTGTCTGACAATTT
TTCGTTATACGCGCTGGCGGGTGTCGGCACGGTAAAGGCGACATTTAAAGAACATTCCACTCAGGATGGCGATTCTTTTT
CTAACAAAATTTCCTCAAGGAAAACGGGATTTGCCTGGGGCGCGGGTGTACAGATGAATCCGCTGGAGAATATCGTCGTC
GATGTTGGGTATGAAGGAAGCAACATCTCCTCTACAAAAATAAACGGCTTCAACGTCGGGGTTGGATACCGTTTCTGA

Upstream 100 bases:

>100_bases
TGGTTTTGTCGATTCGGCATAGTGGCGATAACTGAATGCCGGATCGGTACTGCAGGTGTTTAAACACACCGTAAATAATA
AGTAGTATTAAGGAGTTGTT

Downstream 100 bases:

>100_bases
AAAGCATAAGCTATGCGGAAGGTTCGCCTTCCGCACCGCCAGTCAATAAAACAGGGCTTCTTTACCAGTGACACGTACCT
GCCTGTCTTTTCTCTCTTCG

Product: virulence membrane protein PAGC precursor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 185; Mature: 185

Protein sequence:

>185_residues
MKNIILSTLVITTSVLVVNVAQADTNAFSVGYAQSKVQDFKNIRGVNVKYRYEDDSPVSFISSLSYLYGDRQASGSVEPE
GIHYHDKFEVKYGSLMVGPAYRLSDNFSLYALAGVGTVKATFKEHSTQDGDSFSNKISSRKTGFAWGAGVQMNPLENIVV
DVGYEGSNISSTKINGFNVGVGYRF

Sequences:

>Translated_185_residues
MKNIILSTLVITTSVLVVNVAQADTNAFSVGYAQSKVQDFKNIRGVNVKYRYEDDSPVSFISSLSYLYGDRQASGSVEPE
GIHYHDKFEVKYGSLMVGPAYRLSDNFSLYALAGVGTVKATFKEHSTQDGDSFSNKISSRKTGFAWGAGVQMNPLENIVV
DVGYEGSNISSTKINGFNVGVGYRF
>Mature_185_residues
MKNIILSTLVITTSVLVVNVAQADTNAFSVGYAQSKVQDFKNIRGVNVKYRYEDDSPVSFISSLSYLYGDRQASGSVEPE
GIHYHDKFEVKYGSLMVGPAYRLSDNFSLYALAGVGTVKATFKEHSTQDGDSFSNKISSRKTGFAWGAGVQMNPLENIVV
DVGYEGSNISSTKINGFNVGVGYRF

Specific function: Essential for full virulence and survival within macrophages

COG id: COG3637

COG function: function code M; Opacity protein and related surface antigens

Gene ontology:

Cell location: Cell outer membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ail/ompX/pagC/lom family

Homologues:

Organism=Escherichia coli, GI1787034, Length=187, Percent_Identity=35.8288770053476, Blast_Score=101, Evalue=4e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PAGC_SALTY (P23988)

Other databases:

- EMBL:   M55546
- EMBL:   AE006468
- PIR:   A39185
- RefSeq:   NP_460215.1
- ProteinModelPortal:   P23988
- SMR:   P23988
- PRIDE:   P23988
- GeneID:   1252764
- GenomeReviews:   AE006468_GR
- KEGG:   stm:STM1246
- HOGENOM:   HBG685626
- OMA:   SYLYGDS
- ProtClustDB:   CLSK894199
- BioCyc:   STYP99287:STM1246-MONOMER
- GO:   GO:0009405
- InterPro:   IPR000758
- InterPro:   IPR011250
- Gene3D:   G3DSA:2.40.160.20
- PRINTS:   PR00316

Pfam domain/function: PF06316 Ail_Lom

EC number: NA

Molecular weight: Translated: 20184; Mature: 20184

Theoretical pI: Translated: 7.72; Mature: 7.72

Prosite motif: PS00694 ENT_VIR_OMP_1; PS00695 ENT_VIR_OMP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNIILSTLVITTSVLVVNVAQADTNAFSVGYAQSKVQDFKNIRGVNVKYRYEDDSPVSF
CCCHHHHHHHHHHHEEEEEEECCCCCEEEECHHHHHHHHHHHCCCCEEEEEECCCCHHHH
ISSLSYLYGDRQASGSVEPEGIHYHDKFEVKYGSLMVGPAYRLSDNFSLYALAGVGTVKA
HHHHHHHHCCCCCCCCCCCCCCEECCEEEEEECCEEECCCEEECCCCEEEEEECCCEEEE
TFKEHSTQDGDSFSNKISSRKTGFAWGAGVQMNPLENIVVDVGYEGSNISSTKINGFNVG
HHHHCCCCCCCHHHHHHHCCCCCEEECCCCEECCCCEEEEEECCCCCCCCCEEECCEEEC
VGYRF
CEECC
>Mature Secondary Structure
MKNIILSTLVITTSVLVVNVAQADTNAFSVGYAQSKVQDFKNIRGVNVKYRYEDDSPVSF
CCCHHHHHHHHHHHEEEEEEECCCCCEEEECHHHHHHHHHHHCCCCEEEEEECCCCHHHH
ISSLSYLYGDRQASGSVEPEGIHYHDKFEVKYGSLMVGPAYRLSDNFSLYALAGVGTVKA
HHHHHHHHCCCCCCCCCCCCCCEECCEEEEEECCEEECCCEEECCCCEEEEEECCCEEEE
TFKEHSTQDGDSFSNKISSRKTGFAWGAGVQMNPLENIVVDVGYEGSNISSTKINGFNVG
HHHHCCCCCCCHHHHHHHCCCCCEEECCCCEECCCCEEEEEECCCCCCCCCEEECCEEEC
VGYRF
CEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 1846140; 11677609