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The map label for this gene is copS [H]

Identifier: 16764453

GI number: 16764453

Start: 1182280

End: 1183644

Strand: Reverse

Name: copS [H]

Synonym: STM1095

Alternate gene names: 16764453

Gene position: 1183644-1182280 (Counterclockwise)

Preceding gene: 161353605

Following gene: 16764452

Centisome position: 24.37

GC content: 51.5

Gene sequence:

>1365_bases
ATGGTTAAGTTATCAATGACGCTGCGCCTGACAATTTCTTTTATCGCCATCCTTATCCTCGCCTGTACCGGCATTAGCTG
GACGCTCTATAACGCGCTGAGCAAAGAATTAACGTATCGGGATGATATGACGCTAATAAATCGGGCGGCGCAAATGCAGC
AACTGTTACTGGATGGCGCCAGGCCGGAAAATCTGCCGCTCTATTTCAATCGGATGGTGGATACGAAGCAGGACATCTTA
TTGATCCATTCAGCAACAGGCCACAATGTTGCGATTAATCATAGCGGCATCCCCGACCAACGCTTTAACGAGATTCCGCT
GACTAAAAACATCACCCGCGAAACCTTATTTCGCCAGGCGGTACAAGGCACGGAACTGACCGCGGTACGCGTAAGCGCCA
GAAGCGGCGATGACCCGCTGACCCTTACTATTGCCAGGCTGGCGACGGAAAGGCGGCAAATGCTGGCGCAATATCGCCGC
AACAGTTTGCTGATGAGCCTTATCGCGATCCTCGTCTGTTCGGCGCTCAGTCCATTAGTCATCAGAAACGGGCTGCGGGC
CATTACGTCGCTCAGCCGACTCACCGCGGCGACAGATAGCGGCACACTTCGCCAGCCGTTGGCGGAACAGGCGTTACCCG
TTGAGCTCAGGCCGCTTGGACAAGCGCTAAATACCATGCGCCAGAAGCTTTCCGACGATTTTGAACGCCTGAACCAATTT
GCCGACGATCTGGCGCATGAGCTGCGCACGCCGGTTAATATTTTACTGGGGAAGAATCAGGTGATGCTGAGTCAGGAACG
CAGCGCCGAAGAGTATCAACAAGCCCTTGTCGATAATATTGAAGAGCTGGAGGGACTGTCGCGACTGACAGAAAATATTC
TCTTTCTGGCACGCGCGGAGCACCAGAATATAGCGGTAAAAAAACAGCCTGTTTCGCTCAATGCGCTGGTCGAAAATATG
CTGGATTATCTTAGCCCCCTTGCCGAGGAGAAGCGCATCTGTTTTATAAATCAATGTCAGGGAACGGTATGGGCTGACGA
AATATTATTACAAAGAGTGCTCTCAAACCTGCTGACGAATGCCATCCGTTATTCTGATGAAAACGCCGTGATACGTATTG
AAAGCGCTTATGATGATAACGTTGCAGAAATTCGGGTCGCTAATCCAGGCAGCCACCCCGCCGATGCGGATAAGCTTTTC
CGGCGTTTTTGGCGAGGAGATAATGCCCGCCACACTGCCGGTTTCGGCCTGGGGTTATCGTTAGTTAACGCGATTGCTCT
ATTACACGGTGGCTCGGCATCTTACCGCTATGCCGATGAACATAATATCTTTTCGGTTCGTCTGCCTGATAGTGGTGATA
GCTAA

Upstream 100 bases:

>100_bases
ATTCGTCGGCTGCGCGCCAAAGTAGACGATCCATTTGAAAAGAAGCTCATTATGACCGTCCGGGGGATGGGTTATCGATT
ACAGGCGGAAACGTCGCAGA

Downstream 100 bases:

>100_bases
GGTCAGGACAGGTTCTGTTCCCCTTCCCTGCCACAGGGCTGTGGTTATCAATACAACCTCAATAAAGAGAAAATAAAGGA
TGCCGGCAAAGAATATTGCT

Product: copper resistance protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 454; Mature: 454

Protein sequence:

>454_residues
MVKLSMTLRLTISFIAILILACTGISWTLYNALSKELTYRDDMTLINRAAQMQQLLLDGARPENLPLYFNRMVDTKQDIL
LIHSATGHNVAINHSGIPDQRFNEIPLTKNITRETLFRQAVQGTELTAVRVSARSGDDPLTLTIARLATERRQMLAQYRR
NSLLMSLIAILVCSALSPLVIRNGLRAITSLSRLTAATDSGTLRQPLAEQALPVELRPLGQALNTMRQKLSDDFERLNQF
ADDLAHELRTPVNILLGKNQVMLSQERSAEEYQQALVDNIEELEGLSRLTENILFLARAEHQNIAVKKQPVSLNALVENM
LDYLSPLAEEKRICFINQCQGTVWADEILLQRVLSNLLTNAIRYSDENAVIRIESAYDDNVAEIRVANPGSHPADADKLF
RRFWRGDNARHTAGFGLGLSLVNAIALLHGGSASYRYADEHNIFSVRLPDSGDS

Sequences:

>Translated_454_residues
MVKLSMTLRLTISFIAILILACTGISWTLYNALSKELTYRDDMTLINRAAQMQQLLLDGARPENLPLYFNRMVDTKQDIL
LIHSATGHNVAINHSGIPDQRFNEIPLTKNITRETLFRQAVQGTELTAVRVSARSGDDPLTLTIARLATERRQMLAQYRR
NSLLMSLIAILVCSALSPLVIRNGLRAITSLSRLTAATDSGTLRQPLAEQALPVELRPLGQALNTMRQKLSDDFERLNQF
ADDLAHELRTPVNILLGKNQVMLSQERSAEEYQQALVDNIEELEGLSRLTENILFLARAEHQNIAVKKQPVSLNALVENM
LDYLSPLAEEKRICFINQCQGTVWADEILLQRVLSNLLTNAIRYSDENAVIRIESAYDDNVAEIRVANPGSHPADADKLF
RRFWRGDNARHTAGFGLGLSLVNAIALLHGGSASYRYADEHNIFSVRLPDSGDS
>Mature_454_residues
MVKLSMTLRLTISFIAILILACTGISWTLYNALSKELTYRDDMTLINRAAQMQQLLLDGARPENLPLYFNRMVDTKQDIL
LIHSATGHNVAINHSGIPDQRFNEIPLTKNITRETLFRQAVQGTELTAVRVSARSGDDPLTLTIARLATERRQMLAQYRR
NSLLMSLIAILVCSALSPLVIRNGLRAITSLSRLTAATDSGTLRQPLAEQALPVELRPLGQALNTMRQKLSDDFERLNQF
ADDLAHELRTPVNILLGKNQVMLSQERSAEEYQQALVDNIEELEGLSRLTENILFLARAEHQNIAVKKQPVSLNALVENM
LDYLSPLAEEKRICFINQCQGTVWADEILLQRVLSNLLTNAIRYSDENAVIRIESAYDDNVAEIRVANPGSHPADADKLF
RRFWRGDNARHTAGFGLGLSLVNAIALLHGGSASYRYADEHNIFSVRLPDSGDS

Specific function: Probable member of a two-component regulatory system yedW/yedV. May activate yedW by phosphorylation [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788279, Length=450, Percent_Identity=54.4444444444444, Blast_Score=487, Evalue=1e-139,
Organism=Escherichia coli, GI1786783, Length=298, Percent_Identity=33.2214765100671, Blast_Score=157, Evalue=1e-39,
Organism=Escherichia coli, GI1786912, Length=217, Percent_Identity=29.0322580645161, Blast_Score=89, Evalue=8e-19,
Organism=Escherichia coli, GI1790861, Length=265, Percent_Identity=30.5660377358491, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI1788393, Length=243, Percent_Identity=27.5720164609054, Blast_Score=79, Evalue=9e-16,
Organism=Escherichia coli, GI1790346, Length=312, Percent_Identity=28.525641025641, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1787894, Length=221, Percent_Identity=32.1266968325792, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1790551, Length=287, Percent_Identity=27.5261324041812, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1789403, Length=239, Percent_Identity=27.1966527196653, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1788713, Length=218, Percent_Identity=28.4403669724771, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI1788549, Length=211, Percent_Identity=28.436018957346, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI87082128, Length=319, Percent_Identity=26.0188087774295, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI87081816, Length=289, Percent_Identity=25.9515570934256, Blast_Score=66, Evalue=5e-12,
Organism=Escherichia coli, GI1789808, Length=298, Percent_Identity=25.8389261744966, Blast_Score=64, Evalue=3e-11,
Organism=Escherichia coli, GI1786600, Length=193, Percent_Identity=28.4974093264249, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR006290
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 50766; Mature: 50766

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVKLSMTLRLTISFIAILILACTGISWTLYNALSKELTYRDDMTLINRAAQMQQLLLDGA
CEEEEEHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCC
RPENLPLYFNRMVDTKQDILLIHSATGHNVAINHSGIPDQRFNEIPLTKNITRETLFRQA
CCCCCCHHHHHHHCCCCCEEEEEECCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHH
VQGTELTAVRVSARSGDDPLTLTIARLATERRQMLAQYRRNSLLMSLIAILVCSALSPLV
HCCCCEEEEEEECCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
IRNGLRAITSLSRLTAATDSGTLRQPLAEQALPVELRPLGQALNTMRQKLSDDFERLNQF
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
ADDLAHELRTPVNILLGKNQVMLSQERSAEEYQQALVDNIEELEGLSRLTENILFLARAE
HHHHHHHHCCCCEEEECCCCEEECHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECC
HQNIAVKKQPVSLNALVENMLDYLSPLAEEKRICFINQCQGTVWADEILLQRVLSNLLTN
CCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHH
AIRYSDENAVIRIESAYDDNVAEIRVANPGSHPADADKLFRRFWRGDNARHTAGFGLGLS
HHHCCCCCCEEEEECCCCCCCEEEEEECCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHH
LVNAIALLHGGSASYRYADEHNIFSVRLPDSGDS
HHHHHHHHCCCCCCCEECCCCCEEEEECCCCCCC
>Mature Secondary Structure
MVKLSMTLRLTISFIAILILACTGISWTLYNALSKELTYRDDMTLINRAAQMQQLLLDGA
CEEEEEHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCC
RPENLPLYFNRMVDTKQDILLIHSATGHNVAINHSGIPDQRFNEIPLTKNITRETLFRQA
CCCCCCHHHHHHHCCCCCEEEEEECCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHH
VQGTELTAVRVSARSGDDPLTLTIARLATERRQMLAQYRRNSLLMSLIAILVCSALSPLV
HCCCCEEEEEEECCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
IRNGLRAITSLSRLTAATDSGTLRQPLAEQALPVELRPLGQALNTMRQKLSDDFERLNQF
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
ADDLAHELRTPVNILLGKNQVMLSQERSAEEYQQALVDNIEELEGLSRLTENILFLARAE
HHHHHHHHCCCCEEEECCCCEEECHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECC
HQNIAVKKQPVSLNALVENMLDYLSPLAEEKRICFINQCQGTVWADEILLQRVLSNLLTN
CCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHH
AIRYSDENAVIRIESAYDDNVAEIRVANPGSHPADADKLFRRFWRGDNARHTAGFGLGLS
HHHCCCCCCEEEEECCCCCCCEEEEEECCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHH
LVNAIALLHGGSASYRYADEHNIFSVRLPDSGDS
HHHHHHHHCCCCCCCEECCCCCEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503 [H]