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The map label for this gene is clpP3 [H]

Identifier: 16764274

GI number: 16764274

Start: 983263

End: 985449

Strand: Direct

Name: clpP3 [H]

Synonym: STM0912

Alternate gene names: 16764274

Gene position: 983263-985449 (Clockwise)

Preceding gene: 16764273

Following gene: 16764276

Centisome position: 20.24

GC content: 57.66

Gene sequence:

>2187_bases
ATGAAAACCGTAAGCTGGGGCTGGTGTTTGACACCGATCCGGCGCATGAAACCGGAGAGCAATCCGATGTTAAAGAGGAA
AAAAAGGACCCTGAAAAGTCCACCCAGGGCGATGGCAGCCGCGCGCGGGAAGAACGAAAGCGGCGCTGAATCCTGGTACA
CCATCCGCGCGGCGGCGGATAACGCGGCCGATATCAGTATTTACGATGAAATTGGTGGCTGGGGAATTTCGGCGCACTGG
TTTGCCGAAGAGCTGGTGGCCCTGGGGAGTATCACGCAGATCAACCTGCATATTCATTCCCCGGGTGGCAGTATTTTCGA
CGGGCTGGCCATTTACAATCTGCTGAAAAATCACCCGGCGAGAAAAGTGGTGTATGTGGACGGTGTGGCCTGTTCGATGG
CGTCGGTCATCGCGATGGTGGGCGACCCCGTCATCATGCCGGAAAACGCGATGATGATGATCCACCGCCCACGCGGTATT
GCCGGCGGTGAGTCCTCTGATATTCGCGACTATGCCGATCTGCTCGACAAGATGGAAAGCGTCATCATCCCGATTTACGC
CGAAAAAACGGGGAAGTCACCGGACGATATTGCCGCGCTGCTCGCCAGTGAGACCTGGATGAGCGGGGCCGAGTGTGTCC
GGGAAGGCTTTGCCGACAAAGTTATTCAGCCCGTCCGGGCAATGGCTCATCTGCATTCAAAACGACTTGAGGAATTTGAA
CATATGCCACAGAACGTCAAAAACATGATTATTGCCCCCCAGGGTAACGCCGGGACACTGACGCAGCCGGAGCCGGAGCC
GCAGGCCATCATGACCACGCCGCCGGTGGCGGTCACCACACCGTCGCCACAACCTGCTACCACTGCTCCGGGGACGGATG
AAATCACCCTGCGCGCCCGTTTTCAGGAAGAGCAGCGACAGCGTATCAGCGGGATCCAGAATGTGTTTGGTATGTTCGGT
AACCGCCACGGCGAGCTGATGGCGCAGTGCATTGCGGATGTGGACTGCAATGTGGACGCGGCAAAAGACAAACTGCTGGA
GGCGCTGGGCCGGGGGGTGACCCCCACCAACACGCTGGGCGGGACGCAGAACACACAAAATCCGATGCTCTCCCATATCT
ATGCGGGGAACGGTAACTTTGCCGGGGATGGCATCCGGGCTTCCCTGATGGCGCGGGCGGGGTTTGAAAGCAGCCAGGCG
GATAACCCGTATAACGCCATGACCATGCGGGAACTGGCGCGCATGTCACTGACCGAACGTGGCGTGGGTGTCTCGACGCT
GAACCCGATGCAGATGGTCGGGATGGCGTTCACGCACAGCACCTCAGATTTTGGCAACATTCTGCTGGATGTGGCGAACA
AGGCCATTCTGCAGGGATGGGAGGAAGCCCCGGAAACCTACGAACTGTGGACGCGCAAAGGCCAGCTTTCTGACTTCAAA
ACCGCACACCGTGTGGGGATGGGGGGCTTTAATTCCCTGCGTCAGGTGCGCGAGGGGGCAGAATATAAGTACGTCACCAC
CGGGGACAAACAGGCCACCATTGCGCTGGCAACCTACGGGGAACTGTTCAGCATCACCCGTCAGGCCATCATTAACGACG
ACCTGAACATGCTGACCGATGTCCCGATGAAGCTGGGGCGGGCAGCGAAGTCCACCATTGCCGATCTGGTTTATGCCATC
CTGACCTCCAACCCGAAAATGTCCACGGACAACGTGAACCTGTTCGATAAGGCGAAACACGCGAATGTGCTGGAAGGGGC
GCTGATGGATGTGGCATCGCTGGATAAAGCCCGCCAGCTGATGCGTACCCAGAAAGAAGGTGAGCGTCACCTGAATATTC
GCCCGGCATTCGTGCTGGTGCCGACAGCACTGGAGTCCGTCACTAACCAGGTGATCAAATCCACGAGCGTGAAAGGCGCG
GATATTAATGCCGGCATTATTAACCCGGTGAAAGATTTTGCGACCGTCATCGCCGAGCCACGCCTTGATGATAACAGCCA
GTCCACTTTTTATCTGGCTGCCGCCAAAGGCACTGACACCATTGAGGTGGCCTATCTCAACGGCGTGGATACGCCGTATA
TCGATCAGCAGGACGGTTTCAGCGTCGACGGCGTGACTACCAAAGTACGTATCGATGCCGGGGTGGCCCCGGTCGATCAC
CGCGGCCTGGTGAAATGTTCCGCATAA

Upstream 100 bases:

>100_bases
CGGGTGCTGATACGTGGCGGGGCCGCAACAGAAGGTGACTGGGTGAGGGCCAGAGGGGGCGCGCCTGCCGACGTGAAACG
CCGCCGCAAGGCGGAAACTG

Downstream 100 bases:

>100_bases
ATGTCACAGACAACTATCCGAATGGCCCGTCAGGGCTTTTTTTACGTCTGAAATCCGGCCATTCGTGACCGGAACGGAGA
AAATCATTATGGCAAAGAAT

Product: ATP-dependent protease

Products: NA

Alternate protein names: Endopeptidase Clp 3 [H]

Number of amino acids: Translated: 728; Mature: 728

Protein sequence:

>728_residues
MKTVSWGWCLTPIRRMKPESNPMLKRKKRTLKSPPRAMAAARGKNESGAESWYTIRAAADNAADISIYDEIGGWGISAHW
FAEELVALGSITQINLHIHSPGGSIFDGLAIYNLLKNHPARKVVYVDGVACSMASVIAMVGDPVIMPENAMMMIHRPRGI
AGGESSDIRDYADLLDKMESVIIPIYAEKTGKSPDDIAALLASETWMSGAECVREGFADKVIQPVRAMAHLHSKRLEEFE
HMPQNVKNMIIAPQGNAGTLTQPEPEPQAIMTTPPVAVTTPSPQPATTAPGTDEITLRARFQEEQRQRISGIQNVFGMFG
NRHGELMAQCIADVDCNVDAAKDKLLEALGRGVTPTNTLGGTQNTQNPMLSHIYAGNGNFAGDGIRASLMARAGFESSQA
DNPYNAMTMRELARMSLTERGVGVSTLNPMQMVGMAFTHSTSDFGNILLDVANKAILQGWEEAPETYELWTRKGQLSDFK
TAHRVGMGGFNSLRQVREGAEYKYVTTGDKQATIALATYGELFSITRQAIINDDLNMLTDVPMKLGRAAKSTIADLVYAI
LTSNPKMSTDNVNLFDKAKHANVLEGALMDVASLDKARQLMRTQKEGERHLNIRPAFVLVPTALESVTNQVIKSTSVKGA
DINAGIINPVKDFATVIAEPRLDDNSQSTFYLAAAKGTDTIEVAYLNGVDTPYIDQQDGFSVDGVTTKVRIDAGVAPVDH
RGLVKCSA

Sequences:

>Translated_728_residues
MKTVSWGWCLTPIRRMKPESNPMLKRKKRTLKSPPRAMAAARGKNESGAESWYTIRAAADNAADISIYDEIGGWGISAHW
FAEELVALGSITQINLHIHSPGGSIFDGLAIYNLLKNHPARKVVYVDGVACSMASVIAMVGDPVIMPENAMMMIHRPRGI
AGGESSDIRDYADLLDKMESVIIPIYAEKTGKSPDDIAALLASETWMSGAECVREGFADKVIQPVRAMAHLHSKRLEEFE
HMPQNVKNMIIAPQGNAGTLTQPEPEPQAIMTTPPVAVTTPSPQPATTAPGTDEITLRARFQEEQRQRISGIQNVFGMFG
NRHGELMAQCIADVDCNVDAAKDKLLEALGRGVTPTNTLGGTQNTQNPMLSHIYAGNGNFAGDGIRASLMARAGFESSQA
DNPYNAMTMRELARMSLTERGVGVSTLNPMQMVGMAFTHSTSDFGNILLDVANKAILQGWEEAPETYELWTRKGQLSDFK
TAHRVGMGGFNSLRQVREGAEYKYVTTGDKQATIALATYGELFSITRQAIINDDLNMLTDVPMKLGRAAKSTIADLVYAI
LTSNPKMSTDNVNLFDKAKHANVLEGALMDVASLDKARQLMRTQKEGERHLNIRPAFVLVPTALESVTNQVIKSTSVKGA
DINAGIINPVKDFATVIAEPRLDDNSQSTFYLAAAKGTDTIEVAYLNGVDTPYIDQQDGFSVDGVTTKVRIDAGVAPVDH
RGLVKCSA
>Mature_728_residues
MKTVSWGWCLTPIRRMKPESNPMLKRKKRTLKSPPRAMAAARGKNESGAESWYTIRAAADNAADISIYDEIGGWGISAHW
FAEELVALGSITQINLHIHSPGGSIFDGLAIYNLLKNHPARKVVYVDGVACSMASVIAMVGDPVIMPENAMMMIHRPRGI
AGGESSDIRDYADLLDKMESVIIPIYAEKTGKSPDDIAALLASETWMSGAECVREGFADKVIQPVRAMAHLHSKRLEEFE
HMPQNVKNMIIAPQGNAGTLTQPEPEPQAIMTTPPVAVTTPSPQPATTAPGTDEITLRARFQEEQRQRISGIQNVFGMFG
NRHGELMAQCIADVDCNVDAAKDKLLEALGRGVTPTNTLGGTQNTQNPMLSHIYAGNGNFAGDGIRASLMARAGFESSQA
DNPYNAMTMRELARMSLTERGVGVSTLNPMQMVGMAFTHSTSDFGNILLDVANKAILQGWEEAPETYELWTRKGQLSDFK
TAHRVGMGGFNSLRQVREGAEYKYVTTGDKQATIALATYGELFSITRQAIINDDLNMLTDVPMKLGRAAKSTIADLVYAI
LTSNPKMSTDNVNLFDKAKHANVLEGALMDVASLDKARQLMRTQKEGERHLNIRPAFVLVPTALESVTNQVIKSTSVKGA
DINAGIINPVKDFATVIAEPRLDDNSQSTFYLAAAKGTDTIEVAYLNGVDTPYIDQQDGFSVDGVTTKVRIDAGVAPVDH
RGLVKCSA

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family [H]

Homologues:

Organism=Homo sapiens, GI5174419, Length=132, Percent_Identity=33.3333333333333, Blast_Score=68, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17538017, Length=131, Percent_Identity=34.3511450381679, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI20129427, Length=133, Percent_Identity=30.8270676691729, Blast_Score=69, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001907
- InterPro:   IPR018215 [H]

Pfam domain/function: PF00574 CLP_protease [H]

EC number: =3.4.21.92 [H]

Molecular weight: Translated: 79027; Mature: 79027

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTVSWGWCLTPIRRMKPESNPMLKRKKRTLKSPPRAMAAARGKNESGAESWYTIRAAAD
CCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCEEEEEEECC
NAADISIYDEIGGWGISAHWFAEELVALGSITQINLHIHSPGGSIFDGLAIYNLLKNHPA
CCCEEEEEECCCCCCCCHHHHHHHHHHHCCEEEEEEEEECCCCHHHHHHHHHHHHHCCCC
RKVVYVDGVACSMASVIAMVGDPVIMPENAMMMIHRPRGIAGGESSDIRDYADLLDKMES
CEEEEECCHHHHHHHHHHHHCCCEECCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHH
VIIPIYAEKTGKSPDDIAALLASETWMSGAECVREGFADKVIQPVRAMAHLHSKRLEEFE
EEEEEEECCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HMPQNVKNMIIAPQGNAGTLTQPEPEPQAIMTTPPVAVTTPSPQPATTAPGTDEITLRAR
HCCHHHHCEEEECCCCCCCCCCCCCCCCEEEECCCEEEECCCCCCCCCCCCCCCEEEEHH
FQEEQRQRISGIQNVFGMFGNRHGELMAQCIADVDCNVDAAKDKLLEALGRGVTPTNTLG
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCC
GTQNTQNPMLSHIYAGNGNFAGDGIRASLMARAGFESSQADNPYNAMTMRELARMSLTER
CCCCCCCCHHHEEECCCCCCCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHC
GVGVSTLNPMQMVGMAFTHSTSDFGNILLDVANKAILQGWEEAPETYELWTRKGQLSDFK
CCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCHHHH
TAHRVGMGGFNSLRQVREGAEYKYVTTGDKQATIALATYGELFSITRQAIINDDLNMLTD
HHHHHCCCCHHHHHHHHCCCCEEEEECCCCCEEEEEEHHHHHHHHHHHHHHCCCHHHHHH
VPMKLGRAAKSTIADLVYAILTSNPKMSTDNVNLFDKAKHANVLEGALMDVASLDKARQL
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
MRTQKEGERHLNIRPAFVLVPTALESVTNQVIKSTSVKGADINAGIINPVKDFATVIAEP
HHHHHCCCCCCCCCCEEEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCC
RLDDNSQSTFYLAAAKGTDTIEVAYLNGVDTPYIDQQDGFSVDGVTTKVRIDAGVAPVDH
CCCCCCCCEEEEEEECCCCEEEEEEECCCCCCCCCCCCCCEECCEEEEEEECCCCCCCCC
RGLVKCSA
CCCEEECC
>Mature Secondary Structure
MKTVSWGWCLTPIRRMKPESNPMLKRKKRTLKSPPRAMAAARGKNESGAESWYTIRAAAD
CCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCEEEEEEECC
NAADISIYDEIGGWGISAHWFAEELVALGSITQINLHIHSPGGSIFDGLAIYNLLKNHPA
CCCEEEEEECCCCCCCCHHHHHHHHHHHCCEEEEEEEEECCCCHHHHHHHHHHHHHCCCC
RKVVYVDGVACSMASVIAMVGDPVIMPENAMMMIHRPRGIAGGESSDIRDYADLLDKMES
CEEEEECCHHHHHHHHHHHHCCCEECCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHH
VIIPIYAEKTGKSPDDIAALLASETWMSGAECVREGFADKVIQPVRAMAHLHSKRLEEFE
EEEEEEECCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HMPQNVKNMIIAPQGNAGTLTQPEPEPQAIMTTPPVAVTTPSPQPATTAPGTDEITLRAR
HCCHHHHCEEEECCCCCCCCCCCCCCCCEEEECCCEEEECCCCCCCCCCCCCCCEEEEHH
FQEEQRQRISGIQNVFGMFGNRHGELMAQCIADVDCNVDAAKDKLLEALGRGVTPTNTLG
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCC
GTQNTQNPMLSHIYAGNGNFAGDGIRASLMARAGFESSQADNPYNAMTMRELARMSLTER
CCCCCCCCHHHEEECCCCCCCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHC
GVGVSTLNPMQMVGMAFTHSTSDFGNILLDVANKAILQGWEEAPETYELWTRKGQLSDFK
CCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCHHHH
TAHRVGMGGFNSLRQVREGAEYKYVTTGDKQATIALATYGELFSITRQAIINDDLNMLTD
HHHHHCCCCHHHHHHHHCCCCEEEEECCCCCEEEEEEHHHHHHHHHHHHHHCCCHHHHHH
VPMKLGRAAKSTIADLVYAILTSNPKMSTDNVNLFDKAKHANVLEGALMDVASLDKARQL
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
MRTQKEGERHLNIRPAFVLVPTALESVTNQVIKSTSVKGADINAGIINPVKDFATVIAEP
HHHHHCCCCCCCCCCEEEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCC
RLDDNSQSTFYLAAAKGTDTIEVAYLNGVDTPYIDQQDGFSVDGVTTKVRIDAGVAPVDH
CCCCCCCCEEEEEEECCCCEEEEEEECCCCCCCCCCCCCCEECCEEEEEEECCCCCCCCC
RGLVKCSA
CCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12000953 [H]