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The map label for this gene is slrP [H]

Identifier: 16764163

GI number: 16764163

Start: 866944

End: 869241

Strand: Direct

Name: slrP [H]

Synonym: STM0800

Alternate gene names: 16764163

Gene position: 866944-869241 (Clockwise)

Preceding gene: 16764161

Following gene: 16764165

Centisome position: 17.85

GC content: 46.0

Gene sequence:

>2298_bases
ATGTTTAATATTACTAATATACAATCTACGGCAAGGCATCAAAGTATTAGCAATGAGGCCTCAACAGAGGTGCCTTTAAA
AGAAGAGATATGGAATAAAATAAGTGCCTTTTTCTCTTCAGAACATCAGGTTGAAGCACAAAACTGCATCGCTTATCTTT
GTCATCCACCTGAAACCGCCTCGCCAGAAGAGATCAAAAGCAAGTTTGAATGTTTAAGGATGTTAGCTTTCCCGGCGTAT
GCGGATAATATTCAGTATAGTAGAGGAGGGGCAGACCAATACTGTATTTTGAGTGAAAATAGTCAGGAAATTCTGTCTAT
AGTTTTTAATACAGAGGGCTATACCGTTGAGGGAGGGGGAAAGTCAGTCACCTATACCCGTGTGACAGAAAGCGAGCAGG
CGAGTAGCGCTTCCGGCTCCAAAGATGCTGTGAATTATGAGTTAATCTGGTCTGAGTGGGTAAAAGAGGCGCCAGCGAAA
GAGGCAGCAAATCGTGAAGAAGCCGTACAACGGATGCGTGACTGCCTGAAAAATAATAAGACGGAACTTCGTCTGAAAAT
ATTAGGACTTACCACTATACCTGCCTATATTCCTGAGCAGATAACTACTCTGATACTCGATAACAATGAACTGAAAAGTT
TGCCGGAAAATTTACAGGGAAATATAAAGACCCTGTATGCCAACAGTAATCAGCTAACCAGTATCCCTGCCACGTTACCG
GATACCATACAGGAAATGGAGCTGAGCATTAACCGTATTACTGAATTGCCGGAACGTTTGCCTTCAGCGCTTCAATCGCT
GGATCTTTTCCATAATAAAATTAGTTGCTTACCTGAAAATCTACCTGAGGAACTTCGGTACCTGAGCGTTTATGATAACA
GCATAAGGACACTGCCAGCACATCTTCCGTCAGGGATTACCCATTTGAATGTGCAGAGTAATTCGTTAACCGCTTTGCCT
GAAACATTGCCGCCGGGCCTGAAGACTCTGGAGGCCGGCGAAAATGCCTTAACCAGTCTGCCCGCATCGTTACCACCAGA
ATTACAGGTCCTGGATGTAAGTAAAAATCAGATTACGGTTCTGCCTGAAACACTTCCTCCCACGATAACAACGCTGGATG
TTTCCCGTAACGCATTGACTAATCTACCGGAAAACCTCCCGGCGGCATTACAAATAATGCAGGCCTCTCGCAATAACCTG
GTCCGTCTCCCGGAGTCGTTACCCCATTTTCGTGGTGAAGGACCTCAACCTACAAGAATAATCGTAGAATATAATCCTTT
TTCAGAACGAACAATACAGAATATGCAGCGGCTAATGTCCTCTGTAGATTATCAGGGACCCCGGGTATTGTTTGCCATGG
GCGACTTTTCAATTGTTCGGGTAACTCGACCACTGCATCAAGCTGTCCAGGGGTGGCTAACCAGTCTCGAGGAGGAAGAC
GTCAACCAATGGCGGGCGTTTGAGGCAGAGGCAAACGCGGCGGCTTTCAGCGGATTCCTGGACTATCTTGGTGATACGCA
GAATACCCGACACCCGGATTTTAAGGAACAAGTCTCCGCCTGGCTAATGCGCCTGGCTGAAGATAGCGCACTAAGAGAAA
CCGTATTTATTATAGCGATGAATGCAACGATAAGCTGTGAAGATCGGGTCACACTGGCATACCACCAAATGCAGGAAGCG
ACGTTGGTTCATGATGCTGAAAGAGGCGCCTTTGATAGCCACTTAGCGGAACTGATTATGGCGGGGCGTGAAATCTTTCG
GCTGGAGCAAATAGAATCGCTCGCCAGAGAAAAGGTAAAACGGCTGTTTTTTATTGACGAAGTCGAAGTATTTCTGGGGT
TTCAGAATCAGTTACGAGAGTCGCTGTCGCTGACAACAATGACCCGGGATATGCGATTTTATAACGTTTCGGGTATCACT
GAGTCTGACCTGGACGAGGCGGAAATAAGGATAAAAATGGCTGAAAATAGGGATTTTCACAAATGGTTTGCGCTGTGGGG
GCCGTGGCATAAAGTGCTGGAGCGCATAGCGCCAGAAGAGTGGCGTGAAATGATGGCTAAAAGGGATGAGTGTATTGAAA
CGGATGAGTATCAGAGCCGGGTCAATGCTGAACTGGAAGATTTAAGAATAGCAGACGACTCTGACGCAGAGCGTACTACT
GAGGTACAGATGGATGCAGAGCGTGCTATTGGGATAAAAATAATGGAAGAGATCAATCAGACCCTCTTTACTGAGATCAT
GGAGAATATATTGCTGAAAAAAGAGGTGAGCTCGCTCATGAGCGCCTACTGGCGATAG

Upstream 100 bases:

>100_bases
AATGATTTGTCCGAAATAATGACGACTGTGACCTCTTATTTAAAGTTGAGAATATCCTTATCTGTTACTTTAGGTTACGT
TCAGATCAGGTAGGGAAAAT

Downstream 100 bases:

>100_bases
CTGAACGCAGTTTATCAGAAGAGGGAGAGAGCCTGTTTACCCTTCGGTGTAAACAGGCTTCTGATAAGCGCAGCGTCGTC
GGTAAACGGGCTTAACCCAA

Product: leucine-rich repeat-containing protein

Products: NA

Alternate protein names: Secreted effector protein slrP [H]

Number of amino acids: Translated: 765; Mature: 765

Protein sequence:

>765_residues
MFNITNIQSTARHQSISNEASTEVPLKEEIWNKISAFFSSEHQVEAQNCIAYLCHPPETASPEEIKSKFECLRMLAFPAY
ADNIQYSRGGADQYCILSENSQEILSIVFNTEGYTVEGGGKSVTYTRVTESEQASSASGSKDAVNYELIWSEWVKEAPAK
EAANREEAVQRMRDCLKNNKTELRLKILGLTTIPAYIPEQITTLILDNNELKSLPENLQGNIKTLYANSNQLTSIPATLP
DTIQEMELSINRITELPERLPSALQSLDLFHNKISCLPENLPEELRYLSVYDNSIRTLPAHLPSGITHLNVQSNSLTALP
ETLPPGLKTLEAGENALTSLPASLPPELQVLDVSKNQITVLPETLPPTITTLDVSRNALTNLPENLPAALQIMQASRNNL
VRLPESLPHFRGEGPQPTRIIVEYNPFSERTIQNMQRLMSSVDYQGPRVLFAMGDFSIVRVTRPLHQAVQGWLTSLEEED
VNQWRAFEAEANAAAFSGFLDYLGDTQNTRHPDFKEQVSAWLMRLAEDSALRETVFIIAMNATISCEDRVTLAYHQMQEA
TLVHDAERGAFDSHLAELIMAGREIFRLEQIESLAREKVKRLFFIDEVEVFLGFQNQLRESLSLTTMTRDMRFYNVSGIT
ESDLDEAEIRIKMAENRDFHKWFALWGPWHKVLERIAPEEWREMMAKRDECIETDEYQSRVNAELEDLRIADDSDAERTT
EVQMDAERAIGIKIMEEINQTLFTEIMENILLKKEVSSLMSAYWR

Sequences:

>Translated_765_residues
MFNITNIQSTARHQSISNEASTEVPLKEEIWNKISAFFSSEHQVEAQNCIAYLCHPPETASPEEIKSKFECLRMLAFPAY
ADNIQYSRGGADQYCILSENSQEILSIVFNTEGYTVEGGGKSVTYTRVTESEQASSASGSKDAVNYELIWSEWVKEAPAK
EAANREEAVQRMRDCLKNNKTELRLKILGLTTIPAYIPEQITTLILDNNELKSLPENLQGNIKTLYANSNQLTSIPATLP
DTIQEMELSINRITELPERLPSALQSLDLFHNKISCLPENLPEELRYLSVYDNSIRTLPAHLPSGITHLNVQSNSLTALP
ETLPPGLKTLEAGENALTSLPASLPPELQVLDVSKNQITVLPETLPPTITTLDVSRNALTNLPENLPAALQIMQASRNNL
VRLPESLPHFRGEGPQPTRIIVEYNPFSERTIQNMQRLMSSVDYQGPRVLFAMGDFSIVRVTRPLHQAVQGWLTSLEEED
VNQWRAFEAEANAAAFSGFLDYLGDTQNTRHPDFKEQVSAWLMRLAEDSALRETVFIIAMNATISCEDRVTLAYHQMQEA
TLVHDAERGAFDSHLAELIMAGREIFRLEQIESLAREKVKRLFFIDEVEVFLGFQNQLRESLSLTTMTRDMRFYNVSGIT
ESDLDEAEIRIKMAENRDFHKWFALWGPWHKVLERIAPEEWREMMAKRDECIETDEYQSRVNAELEDLRIADDSDAERTT
EVQMDAERAIGIKIMEEINQTLFTEIMENILLKKEVSSLMSAYWR
>Mature_765_residues
MFNITNIQSTARHQSISNEASTEVPLKEEIWNKISAFFSSEHQVEAQNCIAYLCHPPETASPEEIKSKFECLRMLAFPAY
ADNIQYSRGGADQYCILSENSQEILSIVFNTEGYTVEGGGKSVTYTRVTESEQASSASGSKDAVNYELIWSEWVKEAPAK
EAANREEAVQRMRDCLKNNKTELRLKILGLTTIPAYIPEQITTLILDNNELKSLPENLQGNIKTLYANSNQLTSIPATLP
DTIQEMELSINRITELPERLPSALQSLDLFHNKISCLPENLPEELRYLSVYDNSIRTLPAHLPSGITHLNVQSNSLTALP
ETLPPGLKTLEAGENALTSLPASLPPELQVLDVSKNQITVLPETLPPTITTLDVSRNALTNLPENLPAALQIMQASRNNL
VRLPESLPHFRGEGPQPTRIIVEYNPFSERTIQNMQRLMSSVDYQGPRVLFAMGDFSIVRVTRPLHQAVQGWLTSLEEED
VNQWRAFEAEANAAAFSGFLDYLGDTQNTRHPDFKEQVSAWLMRLAEDSALRETVFIIAMNATISCEDRVTLAYHQMQEA
TLVHDAERGAFDSHLAELIMAGREIFRLEQIESLAREKVKRLFFIDEVEVFLGFQNQLRESLSLTTMTRDMRFYNVSGIT
ESDLDEAEIRIKMAENRDFHKWFALWGPWHKVLERIAPEEWREMMAKRDECIETDEYQSRVNAELEDLRIADDSDAERTT
EVQMDAERAIGIKIMEEINQTLFTEIMENILLKKEVSSLMSAYWR

Specific function: Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is an E3 ubiquitin ligase that interferes with host's ubiquitination pathway. Can ubiquitinate both ubiquitin and host TXN (Thioredoxin).

COG id: COG4886

COG function: function code S; Leucine-rich repeat (LRR) protein

Gene ontology:

Cell location: Secreted. Host cytoplasm. Note=Secreted via type III secretion systems 1 and 2 (SPI-1 and SPI-2 TTSS), and delivered into the host cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 10 LRR (leucine-rich) repeats [H]

Homologues:

Organism=Homo sapiens, GI95113664, Length=279, Percent_Identity=30.4659498207885, Blast_Score=81, Evalue=4e-15,
Organism=Homo sapiens, GI21361633, Length=295, Percent_Identity=30.1694915254237, Blast_Score=73, Evalue=1e-12,
Organism=Homo sapiens, GI226342933, Length=255, Percent_Identity=30.9803921568627, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI226342931, Length=255, Percent_Identity=30.9803921568627, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI45827731, Length=215, Percent_Identity=33.4883720930233, Blast_Score=67, Evalue=7e-11,
Organism=Homo sapiens, GI45827729, Length=215, Percent_Identity=33.4883720930233, Blast_Score=67, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI71981152, Length=265, Percent_Identity=27.9245283018868, Blast_Score=70, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI71991525, Length=279, Percent_Identity=29.7491039426523, Blast_Score=69, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI71991531, Length=279, Percent_Identity=29.7491039426523, Blast_Score=69, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI71981160, Length=264, Percent_Identity=27.6515151515151, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI17933612, Length=259, Percent_Identity=31.2741312741313, Blast_Score=71, Evalue=3e-12,
Organism=Drosophila melanogaster, GI281362653, Length=245, Percent_Identity=28.9795918367347, Blast_Score=69, Evalue=1e-11,
Organism=Drosophila melanogaster, GI281362651, Length=245, Percent_Identity=28.9795918367347, Blast_Score=68, Evalue=2e-11,
Organism=Drosophila melanogaster, GI281362655, Length=245, Percent_Identity=28.9795918367347, Blast_Score=68, Evalue=2e-11,
Organism=Drosophila melanogaster, GI281362657, Length=245, Percent_Identity=28.9795918367347, Blast_Score=68, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24650334, Length=245, Percent_Identity=28.9795918367347, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24650332, Length=245, Percent_Identity=28.9795918367347, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI116007092, Length=245, Percent_Identity=28.9795918367347, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24650330, Length=245, Percent_Identity=28.9795918367347, Blast_Score=67, Evalue=4e-11,
Organism=Drosophila melanogaster, GI62472958, Length=245, Percent_Identity=28.9795918367347, Blast_Score=66, Evalue=8e-11,
Organism=Drosophila melanogaster, GI24650336, Length=245, Percent_Identity=28.9795918367347, Blast_Score=66, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001611 [H]

Pfam domain/function: PF00560 LRR_1 [H]

EC number: NA

Molecular weight: Translated: 86873; Mature: 86873

Theoretical pI: Translated: 4.50; Mature: 4.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFNITNIQSTARHQSISNEASTEVPLKEEIWNKISAFFSSEHQVEAQNCIAYLCHPPETA
CCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHCEEEEECCCCCC
SPEEIKSKFECLRMLAFPAYADNIQYSRGGADQYCILSENSQEILSIVFNTEGYTVEGGG
CHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCHHHEEEEEECCCCEEEECCC
KSVTYTRVTESEQASSASGSKDAVNYELIWSEWVKEAPAKEAANREEAVQRMRDCLKNNK
CEEEEEEECCCHHHCCCCCCCCCEEHHHHHHHHHHHCCHHHHCCHHHHHHHHHHHHHCCC
TELRLKILGLTTIPAYIPEQITTLILDNNELKSLPENLQGNIKTLYANSNQLTSIPATLP
CEEEEEEEEEHHHHHHHHHHHEEEEECCCHHHHCCHHHCCCEEEEEECCCCCEECCCCCH
DTIQEMELSINRITELPERLPSALQSLDLFHNKISCLPENLPEELRYLSVYDNSIRTLPA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHH
HLPSGITHLNVQSNSLTALPETLPPGLKTLEAGENALTSLPASLPPELQVLDVSKNQITV
HCCCCCEEEEECCCCCCCCCCCCCCCCHHHHCCCHHHHHCCCCCCCCEEEEECCCCEEEE
LPETLPPTITTLDVSRNALTNLPENLPAALQIMQASRNNLVRLPESLPHFRGEGPQPTRI
ECCCCCCCEEEEECCHHHHHCCCCCCHHHHHHHHHHCCCEEECCHHCCHHCCCCCCCCEE
IVEYNPFSERTIQNMQRLMSSVDYQGPRVLFAMGDFSIVRVTRPLHQAVQGWLTSLEEED
EEEECCCHHHHHHHHHHHHHHCCCCCCEEEEEECCEEEEEHHHHHHHHHHHHHHHCCHHH
VNQWRAFEAEANAAAFSGFLDYLGDTQNTRHPDFKEQVSAWLMRLAEDSALRETVFIIAM
HHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHEEEEEEEE
NATISCEDRVTLAYHQMQEATLVHDAERGAFDSHLAELIMAGREIFRLEQIESLAREKVK
CCEEECCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLFFIDEVEVFLGFQNQLRESLSLTTMTRDMRFYNVSGITESDLDEAEIRIKMAENRDFH
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCEEEEEECCCCCHH
KWFALWGPWHKVLERIAPEEWREMMAKRDECIETDEYQSRVNAELEDLRIADDSDAERTT
HHHHHHCHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHCCCHHHCEECCCCCCCHHH
EVQMDAERAIGIKIMEEINQTLFTEIMENILLKKEVSSLMSAYWR
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MFNITNIQSTARHQSISNEASTEVPLKEEIWNKISAFFSSEHQVEAQNCIAYLCHPPETA
CCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHCEEEEECCCCCC
SPEEIKSKFECLRMLAFPAYADNIQYSRGGADQYCILSENSQEILSIVFNTEGYTVEGGG
CHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCHHHEEEEEECCCCEEEECCC
KSVTYTRVTESEQASSASGSKDAVNYELIWSEWVKEAPAKEAANREEAVQRMRDCLKNNK
CEEEEEEECCCHHHCCCCCCCCCEEHHHHHHHHHHHCCHHHHCCHHHHHHHHHHHHHCCC
TELRLKILGLTTIPAYIPEQITTLILDNNELKSLPENLQGNIKTLYANSNQLTSIPATLP
CEEEEEEEEEHHHHHHHHHHHEEEEECCCHHHHCCHHHCCCEEEEEECCCCCEECCCCCH
DTIQEMELSINRITELPERLPSALQSLDLFHNKISCLPENLPEELRYLSVYDNSIRTLPA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHH
HLPSGITHLNVQSNSLTALPETLPPGLKTLEAGENALTSLPASLPPELQVLDVSKNQITV
HCCCCCEEEEECCCCCCCCCCCCCCCCHHHHCCCHHHHHCCCCCCCCEEEEECCCCEEEE
LPETLPPTITTLDVSRNALTNLPENLPAALQIMQASRNNLVRLPESLPHFRGEGPQPTRI
ECCCCCCCEEEEECCHHHHHCCCCCCHHHHHHHHHHCCCEEECCHHCCHHCCCCCCCCEE
IVEYNPFSERTIQNMQRLMSSVDYQGPRVLFAMGDFSIVRVTRPLHQAVQGWLTSLEEED
EEEECCCHHHHHHHHHHHHHHCCCCCCEEEEEECCEEEEEHHHHHHHHHHHHHHHCCHHH
VNQWRAFEAEANAAAFSGFLDYLGDTQNTRHPDFKEQVSAWLMRLAEDSALRETVFIIAM
HHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHEEEEEEEE
NATISCEDRVTLAYHQMQEATLVHDAERGAFDSHLAELIMAGREIFRLEQIESLAREKVK
CCEEECCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLFFIDEVEVFLGFQNQLRESLSLTTMTRDMRFYNVSGITESDLDEAEIRIKMAENRDFH
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCEEEEEECCCCCHH
KWFALWGPWHKVLERIAPEEWREMMAKRDECIETDEYQSRVNAELEDLRIADDSDAERTT
HHHHHHCHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHCCCHHHCEECCCCCCCHHH
EVQMDAERAIGIKIMEEINQTLFTEIMENILLKKEVSSLMSAYWR
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10861017 [H]