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The map label for this gene is fhuB

Identifier: 16763584

GI number: 16763584

Start: 227660

End: 229717

Strand: Direct

Name: fhuB

Synonym: STM0194

Alternate gene names: 16763584

Gene position: 227660-229717 (Clockwise)

Preceding gene: 16763583

Following gene: 16763585

Centisome position: 4.69

GC content: 61.08

Gene sequence:

>2058_bases
GTGAGCAGAAAACGTGAAATGCCGGATGGCGGCGCGAAAAGCGTCTTATCCGACCTACGGTTCGGGCGCTTTGTAGGCCG
GATAAGGCGAAGCCGCCATCCGGCGTTGCTGTTATTGGCGCTGTTTGTTGCCGCCTGCTGGCTGACATGGGTTAACTTCT
CCGTTGCGCTACCGCGCAGCCAGTGGCAACAGGCTATCTGGTCACCGGATATCGACATCATTGAGCAGATGATTTTTCAT
TACAGCCAGCTGCCAAGACTGGCGATTTCGCTGCTGGTGGGCGCGGGGCTTGGGCTGGTAGGCGTCCTGTTCCAGCAAGT
ATTACGTAACCCGCTGGCGGAACCGACCACGCTGGGCGTGGCGACCGGCGCGCAATTGGGGATCACGGTGACTACGCTTT
GGGCGATTCCCGGCGCGCTGACCACGCAGTTTGCCGCCCTGACGGGAGCCTGTATCGTCGGCGCGCTGGTGTTCGGCGTG
GCGTGGGGCAAACGTCTGTCGCCAGTGACCCTGATCCTCGCCGGGCTGGTGGTTAGCCTCTATTGTGGCGCAATCAACCA
GTTACTGGTGATTTTCCACCACGATCAGTTGCAAAGCATGTTTTTATGGAGCACCGGAACGCTAACGCAAACCGACTGGA
GCGGCGTGCAGCGTCTGTGGCCGCAGTTGCTGGGCGGTGTGATGCTCACGTTATTGTTGTTACGCCCGATGACGCTGATG
GGGCTGGATGACGGCGTTGCGCGTAATCTGGGTCTGGCGCTGTCGTTAGCGCGTCTGGCGGCGCTGTCGCTGGCGATTGT
GTTGAGCGCTCTGCTGGTCAACGCGGTGGGCATTATCGGTTTTATCGGCCTGTTTGCGCCGCTGCTGGCGAAAATGCTTG
GCGCAAGACGTCTGCTGGCGCGCCTGATGCTGGCGCCGCTCATTGGGGCGCTTATTTTGTGGCTATCCGATCAGATTATC
CTTTGGCTAACCCGCGTATGGATGGAGGTTTCCACCGGGTCAGTGACGGCGTTAATCGGCGCGCCGCTGCTCCTGTGGCT
GCTGCCGCGGCTTAAAAGCATGAGCGCGCCGGATATGAACGCCAGCGATCGTGTGGCAGCGGAACGTCGGCACGTTCTTG
CTTTTGCCGTTGCCGGTGGCGCGCTCCTGCTGCTGGCAACATGGGTCGCCCTCTCTTTTGGTCGCGACGCGCACGGCTGG
ACGTGGGCGAGCGGAACGCTGCTTGAAGAACTGATGCCGTGGCGCTGGCCGCGGATACTGGCGGCGTTAATGGCGGGCGT
CATGCTGGCGGTGGCGGGCTGCATTATTCAGCGTCTGACCGGTAATCCAATGGCCAGCCCGGAAGTGCTGGGGATCAGTT
CCGGAGCCGCGTTTGGCGTGGTGTTGATGCTGTTTTTGGTGCCGGGGAATGCCTTCGGTTGGCTACTGCCTGCCGGAAGC
CTGGGCGCGGCGGCGACACTGCTGATTATTATGATAGCCGCCGGGCGCGGCGGTTTCTCGCCGCAACGGATGTTGCTGGC
GGGGATGGCGCTCAGCACCGCGTTTACCATGCTGCTAATGATGCTCCAGGCGAGCGGCGACCCGCGGATGGCGGAAGTAT
TGACCTGGCTCTCAGGATCTACCTATAACGCCACTGGCGGGCAGGTTACGCGAACCGCGATCGTGATGGTGATTTTGCTG
GCCATTGTGCCGTTGTGTCGCCGCTGGTTAACGATTTTGCCCCTGGGCGGCGATGCCGCGCGTGCGGTGGGCATGGCGCT
TACGCCGTCGCGTATCGCGCTGCTGGCGCTGGCGGCTTGTTTGACGGCAACCGCGACGATGACCATTGGGCCGCTGAGTT
TCGTTGGACTGATGGCGCCGCATATTGCGCGGATGCTCGGTTTTCGCCGGACGATGCCGCATATGGTCATCTCGGCGCTG
GCAGGGGGCGTTTTACTGGTCTTTGCCGACTGGTGCGGCAGGATGGCGCTATTTCCGTATCAGATCCCGGCGGGACTGCT
TTCAAGCTTTATTGGCGCGCCGTACTTTATCTATTTGCTACGTAAACAGAGTCGGTAA

Upstream 100 bases:

>100_bases
CCGGGCGCTTTCACCGGGTGCCCGCCGTTTGGTTCTATGGCGCGACCCTCTCCACGATGCACTTTGTCCGCATCCTGAAT
AACGTGTTGGGAGGCAAAGC

Downstream 100 bases:

>100_bases
AAAAAAGCTGTGCCACATTTATGTCGGGTGGCAGCCATGCTCAACCCGACCTACAAATTACACAATATCAATATGTTGTG
GCAATATTTTGTAGGCCTAA

Product: iron-hydroxamate transporter permease subunit

Products: ADP; phosphate; iron (III) hydroxamate [Cytoplasm] [C]

Alternate protein names: Ferric hydroxamate uptake protein B; Ferrichrome transport system permease protein fhuB; Ferrichrome uptake protein fhuB; Iron(III)-hydroxamate import system permease protein fhuB

Number of amino acids: Translated: 685; Mature: 684

Protein sequence:

>685_residues
MSRKREMPDGGAKSVLSDLRFGRFVGRIRRSRHPALLLLALFVAACWLTWVNFSVALPRSQWQQAIWSPDIDIIEQMIFH
YSQLPRLAISLLVGAGLGLVGVLFQQVLRNPLAEPTTLGVATGAQLGITVTTLWAIPGALTTQFAALTGACIVGALVFGV
AWGKRLSPVTLILAGLVVSLYCGAINQLLVIFHHDQLQSMFLWSTGTLTQTDWSGVQRLWPQLLGGVMLTLLLLRPMTLM
GLDDGVARNLGLALSLARLAALSLAIVLSALLVNAVGIIGFIGLFAPLLAKMLGARRLLARLMLAPLIGALILWLSDQII
LWLTRVWMEVSTGSVTALIGAPLLLWLLPRLKSMSAPDMNASDRVAAERRHVLAFAVAGGALLLLATWVALSFGRDAHGW
TWASGTLLEELMPWRWPRILAALMAGVMLAVAGCIIQRLTGNPMASPEVLGISSGAAFGVVLMLFLVPGNAFGWLLPAGS
LGAAATLLIIMIAAGRGGFSPQRMLLAGMALSTAFTMLLMMLQASGDPRMAEVLTWLSGSTYNATGGQVTRTAIVMVILL
AIVPLCRRWLTILPLGGDAARAVGMALTPSRIALLALAACLTATATMTIGPLSFVGLMAPHIARMLGFRRTMPHMVISAL
AGGVLLVFADWCGRMALFPYQIPAGLLSSFIGAPYFIYLLRKQSR

Sequences:

>Translated_685_residues
MSRKREMPDGGAKSVLSDLRFGRFVGRIRRSRHPALLLLALFVAACWLTWVNFSVALPRSQWQQAIWSPDIDIIEQMIFH
YSQLPRLAISLLVGAGLGLVGVLFQQVLRNPLAEPTTLGVATGAQLGITVTTLWAIPGALTTQFAALTGACIVGALVFGV
AWGKRLSPVTLILAGLVVSLYCGAINQLLVIFHHDQLQSMFLWSTGTLTQTDWSGVQRLWPQLLGGVMLTLLLLRPMTLM
GLDDGVARNLGLALSLARLAALSLAIVLSALLVNAVGIIGFIGLFAPLLAKMLGARRLLARLMLAPLIGALILWLSDQII
LWLTRVWMEVSTGSVTALIGAPLLLWLLPRLKSMSAPDMNASDRVAAERRHVLAFAVAGGALLLLATWVALSFGRDAHGW
TWASGTLLEELMPWRWPRILAALMAGVMLAVAGCIIQRLTGNPMASPEVLGISSGAAFGVVLMLFLVPGNAFGWLLPAGS
LGAAATLLIIMIAAGRGGFSPQRMLLAGMALSTAFTMLLMMLQASGDPRMAEVLTWLSGSTYNATGGQVTRTAIVMVILL
AIVPLCRRWLTILPLGGDAARAVGMALTPSRIALLALAACLTATATMTIGPLSFVGLMAPHIARMLGFRRTMPHMVISAL
AGGVLLVFADWCGRMALFPYQIPAGLLSSFIGAPYFIYLLRKQSR
>Mature_684_residues
SRKREMPDGGAKSVLSDLRFGRFVGRIRRSRHPALLLLALFVAACWLTWVNFSVALPRSQWQQAIWSPDIDIIEQMIFHY
SQLPRLAISLLVGAGLGLVGVLFQQVLRNPLAEPTTLGVATGAQLGITVTTLWAIPGALTTQFAALTGACIVGALVFGVA
WGKRLSPVTLILAGLVVSLYCGAINQLLVIFHHDQLQSMFLWSTGTLTQTDWSGVQRLWPQLLGGVMLTLLLLRPMTLMG
LDDGVARNLGLALSLARLAALSLAIVLSALLVNAVGIIGFIGLFAPLLAKMLGARRLLARLMLAPLIGALILWLSDQIIL
WLTRVWMEVSTGSVTALIGAPLLLWLLPRLKSMSAPDMNASDRVAAERRHVLAFAVAGGALLLLATWVALSFGRDAHGWT
WASGTLLEELMPWRWPRILAALMAGVMLAVAGCIIQRLTGNPMASPEVLGISSGAAFGVVLMLFLVPGNAFGWLLPAGSL
GAAATLLIIMIAAGRGGFSPQRMLLAGMALSTAFTMLLMMLQASGDPRMAEVLTWLSGSTYNATGGQVTRTAIVMVILLA
IVPLCRRWLTILPLGGDAARAVGMALTPSRIALLALAACLTATATMTIGPLSFVGLMAPHIARMLGFRRTMPHMVISALA
GGVLLVFADWCGRMALFPYQIPAGLLSSFIGAPYFIYLLRKQSR

Specific function: Part of the ABC transporter complex fhuCDB involved in iron(3+)-hydroxamate import. Responsible for the translocation of the substrate across the membrane

COG id: COG0609

COG function: function code P; ABC-type Fe3+-siderophore transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily

Homologues:

Organism=Escherichia coli, GI1786347, Length=643, Percent_Identity=90.9797822706065, Blast_Score=1035, Evalue=0.0,
Organism=Escherichia coli, GI1790740, Length=277, Percent_Identity=36.101083032491, Blast_Score=119, Evalue=5e-28,
Organism=Escherichia coli, GI1790741, Length=281, Percent_Identity=35.2313167259786, Blast_Score=111, Evalue=2e-25,
Organism=Escherichia coli, GI1786804, Length=278, Percent_Identity=31.6546762589928, Blast_Score=104, Evalue=2e-23,
Organism=Escherichia coli, GI1788004, Length=287, Percent_Identity=33.1010452961672, Blast_Score=95, Evalue=2e-20,
Organism=Escherichia coli, GI1786805, Length=277, Percent_Identity=35.3790613718412, Blast_Score=95, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FHUB_SALTY (O87656)

Other databases:

- EMBL:   AE006468
- EMBL:   AF093503
- RefSeq:   NP_459199.1
- ProteinModelPortal:   O87656
- GeneID:   1251712
- GenomeReviews:   AE006468_GR
- KEGG:   stm:STM0194
- NMPDR:   fig|99287.1.peg.192
- HOGENOM:   HBG700016
- OMA:   WMSGSTY
- ProtClustDB:   PRK10577
- BioCyc:   STYP99287:STM0194-MONOMER
- InterPro:   IPR000522
- InterPro:   IPR006311
- TIGRFAMs:   TIGR01409

Pfam domain/function: PF01032 FecCD

EC number: NA

Molecular weight: Translated: 73205; Mature: 73074

Theoretical pI: Translated: 11.63; Mature: 11.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x4216b8c4)-; HASH(0x421631b8)-; HASH(0xba01ca8)-; HASH(0x421371d8)-; HASH(0xbe2b49c)-; HASH(0xb997498)-; HASH(0xb68a5a4)-; HASH(0xbca9ec8)-; HASH(0x42144d2c)-; HASH(0xc81c240)-; HASH(0x42161700)-; HASH(0x42161304)-; HASH(0xb559604)-; HASH(0xc9e25e0)-; HASH(0x42144cc0)-; HASH(0xb6e5508)-; HASH(0xc2c4668)-;

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRKREMPDGGAKSVLSDLRFGRFVGRIRRSRHPALLLLALFVAACWLTWVNFSVALPRS
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHEECCHH
QWQQAIWSPDIDIIEQMIFHYSQLPRLAISLLVGAGLGLVGVLFQQVLRNPLAEPTTLGV
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCE
ATGAQLGITVTTLWAIPGALTTQFAALTGACIVGALVFGVAWGKRLSPVTLILAGLVVSL
ECCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
YCGAINQLLVIFHHDQLQSMFLWSTGTLTQTDWSGVQRLWPQLLGGVMLTLLLLRPMTLM
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHH
GLDDGVARNLGLALSLARLAALSLAIVLSALLVNAVGIIGFIGLFAPLLAKMLGARRLLA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLMLAPLIGALILWLSDQIILWLTRVWMEVSTGSVTALIGAPLLLWLLPRLKSMSAPDMN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCC
ASDRVAAERRHVLAFAVAGGALLLLATWVALSFGRDAHGWTWASGTLLEELMPWRWPRIL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCCHHHHH
AALMAGVMLAVAGCIIQRLTGNPMASPEVLGISSGAAFGVVLMLFLVPGNAFGWLLPAGS
HHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCHHHHHHHHHHHHCCCCCCHHCCCCC
LGAAATLLIIMIAAGRGGFSPQRMLLAGMALSTAFTMLLMMLQASGDPRMAEVLTWLSGS
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCC
TYNATGGQVTRTAIVMVILLAIVPLCRRWLTILPLGGDAARAVGMALTPSRIALLALAAC
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEECCCCHHHHHHCCCCCHHHHHHHHHHHH
LTATATMTIGPLSFVGLMAPHIARMLGFRRTMPHMVISALAGGVLLVFADWCGRMALFPY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCH
QIPAGLLSSFIGAPYFIYLLRKQSR
HCCHHHHHHHHCCHHHHHHHHHCCH
>Mature Secondary Structure 
SRKREMPDGGAKSVLSDLRFGRFVGRIRRSRHPALLLLALFVAACWLTWVNFSVALPRS
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHEECCHH
QWQQAIWSPDIDIIEQMIFHYSQLPRLAISLLVGAGLGLVGVLFQQVLRNPLAEPTTLGV
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCE
ATGAQLGITVTTLWAIPGALTTQFAALTGACIVGALVFGVAWGKRLSPVTLILAGLVVSL
ECCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
YCGAINQLLVIFHHDQLQSMFLWSTGTLTQTDWSGVQRLWPQLLGGVMLTLLLLRPMTLM
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHH
GLDDGVARNLGLALSLARLAALSLAIVLSALLVNAVGIIGFIGLFAPLLAKMLGARRLLA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLMLAPLIGALILWLSDQIILWLTRVWMEVSTGSVTALIGAPLLLWLLPRLKSMSAPDMN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCC
ASDRVAAERRHVLAFAVAGGALLLLATWVALSFGRDAHGWTWASGTLLEELMPWRWPRIL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCCHHHHH
AALMAGVMLAVAGCIIQRLTGNPMASPEVLGISSGAAFGVVLMLFLVPGNAFGWLLPAGS
HHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCHHHHHHHHHHHHCCCCCCHHCCCCC
LGAAATLLIIMIAAGRGGFSPQRMLLAGMALSTAFTMLLMMLQASGDPRMAEVLTWLSGS
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCC
TYNATGGQVTRTAIVMVILLAIVPLCRRWLTILPLGGDAARAVGMALTPSRIALLALAAC
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEECCCCHHHHHHCCCCCHHHHHHHHHHHH
LTATATMTIGPLSFVGLMAPHIARMLGFRRTMPHMVISALAGGVLLVFADWCGRMALFPY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCH
QIPAGLLSSFIGAPYFIYLLRKQSR
HCCHHHHHHHHCCHHHHHHHHHCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; iron (III) hydroxamate [Periplasm]; H2O [C]

Specific reaction: ATP + iron (III) hydroxamate [Periplasm] + H2O = ADP + phosphate + iron (III) hydroxamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11677609; 10103258