Click here to switch to the map view.

The map label for this gene is lpxC [H]

Identifier: 16763524

GI number: 16763524

Start: 156935

End: 157852

Strand: Direct

Name: lpxC [H]

Synonym: STM0134

Alternate gene names: 16763524

Gene position: 156935-157852 (Clockwise)

Preceding gene: 16763523

Following gene: 161353611

Centisome position: 3.23

GC content: 50.44

Gene sequence:

>918_bases
ATGATCAAACAAAGGACACTTAAACGTATCGTTCAGGCGACTGGCGTCGGTTTACACACCGGCAAAAAAGTCACCCTGAC
ATTACGCCCTGCGCCGGCCAATACCGGGGTCATCTATCGTCGCACCGACTTGAATCCACCGGTAGATTTCCCGGCCGATG
CCAAATCTGTGCGTGATACCATGCTCTGTACGTGTCTGGTGAATGAGCATGATGTACGGATTTCAACCGTTGAGCACCTG
AATGCTGCTCTGGCGGGCTTAGGTATCGATAACATCGTTATTGAGGTTAATGCCCCGGAAATCCCGATCATGGATGGCAG
TGCCGCTCCGTTTGTCTACCTGCTGCTTGATGCCGGTATTGATGAACTGAACTGCGCCAAAAAATTCGTACGCATCAAAG
AGACTGTTCGGGTTGAAGATGGCGATAAATGGGCTGAATTCAGACCGTACAATGGTTTTACGTTGGATTTCACCATCGAC
TTTAACCATCCGGCGATCGATTCCAGCAGCCAGCGCTACGCGATGAACTTCTCTGCGGATGCGTTCATGCGCCAGATCAG
CCGTGCGCGTACCTTCGGTTTTATGCGTGATATCGAATATCTGCAGTCCCGCGGCCTGTGCCTGGGCGGCAGCTTCGATT
GTGCCATCGTTGTTGACGATTATCGCGTATTGAACGAAGACGGCCTGCGTTTTGAAGATGAATTCGTTCGTCACAAAATG
CTTGACGCGATCGGTGACTTGTTCATGTGTGGTCACAATATTATTGGTGCGTTTACCGCGTATAAATCCGGTCACGCATT
GAATAATAAATTGTTACAGGCAGTCCTGGCAAAACAGGAAGCCTGGGAATTTGTGACCTTCCAGGACGACGCAGAACTGC
CGTTGGCTTTCAAAGCGCCTTCGACGGTACTGGCATAA

Upstream 100 bases:

>100_bases
GAATTAGCTGGAATTTGGGATTCTGGGCTCTTTGTGCTAAACTGGCCCGCCGAATGTATAGTACACTTCGGTTGGATAGG
TAATTTGGCGAGATTATACG

Downstream 100 bases:

>100_bases
CGACATACGCTGTCGTATAAAATTCGACTGGTTAACCTGGCACTCTCTCCGGCCAGGCGAGCCAGTCGTTTTTTTACTAT
CCTTTATCTGCGCTTTCCTT

Product: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase

Products: NA

Alternate protein names: UDP-3-O-acyl-GlcNAc deacetylase [H]

Number of amino acids: Translated: 305; Mature: 305

Protein sequence:

>305_residues
MIKQRTLKRIVQATGVGLHTGKKVTLTLRPAPANTGVIYRRTDLNPPVDFPADAKSVRDTMLCTCLVNEHDVRISTVEHL
NAALAGLGIDNIVIEVNAPEIPIMDGSAAPFVYLLLDAGIDELNCAKKFVRIKETVRVEDGDKWAEFRPYNGFTLDFTID
FNHPAIDSSSQRYAMNFSADAFMRQISRARTFGFMRDIEYLQSRGLCLGGSFDCAIVVDDYRVLNEDGLRFEDEFVRHKM
LDAIGDLFMCGHNIIGAFTAYKSGHALNNKLLQAVLAKQEAWEFVTFQDDAELPLAFKAPSTVLA

Sequences:

>Translated_305_residues
MIKQRTLKRIVQATGVGLHTGKKVTLTLRPAPANTGVIYRRTDLNPPVDFPADAKSVRDTMLCTCLVNEHDVRISTVEHL
NAALAGLGIDNIVIEVNAPEIPIMDGSAAPFVYLLLDAGIDELNCAKKFVRIKETVRVEDGDKWAEFRPYNGFTLDFTID
FNHPAIDSSSQRYAMNFSADAFMRQISRARTFGFMRDIEYLQSRGLCLGGSFDCAIVVDDYRVLNEDGLRFEDEFVRHKM
LDAIGDLFMCGHNIIGAFTAYKSGHALNNKLLQAVLAKQEAWEFVTFQDDAELPLAFKAPSTVLA
>Mature_305_residues
MIKQRTLKRIVQATGVGLHTGKKVTLTLRPAPANTGVIYRRTDLNPPVDFPADAKSVRDTMLCTCLVNEHDVRISTVEHL
NAALAGLGIDNIVIEVNAPEIPIMDGSAAPFVYLLLDAGIDELNCAKKFVRIKETVRVEDGDKWAEFRPYNGFTLDFTID
FNHPAIDSSSQRYAMNFSADAFMRQISRARTFGFMRDIEYLQSRGLCLGGSFDCAIVVDDYRVLNEDGLRFEDEFVRHKM
LDAIGDLFMCGHNIIGAFTAYKSGHALNNKLLQAVLAKQEAWEFVTFQDDAELPLAFKAPSTVLA

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0774

COG function: function code M; UDP-3-O-acyl-N-acetylglucosamine deacetylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxC family [H]

Homologues:

Organism=Escherichia coli, GI1786285, Length=305, Percent_Identity=98.3606557377049, Blast_Score=626, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020568
- InterPro:   IPR004463
- InterPro:   IPR011334
- InterPro:   IPR015870 [H]

Pfam domain/function: PF03331 LpxC [H]

EC number: 3.5.1.-

Molecular weight: Translated: 33985; Mature: 33985

Theoretical pI: Translated: 5.64; Mature: 5.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKQRTLKRIVQATGVGLHTGKKVTLTLRPAPANTGVIYRRTDLNPPVDFPADAKSVRDT
CCCHHHHHHHHHHCCCCEECCCEEEEEEECCCCCCCEEEEECCCCCCCCCCCCHHHHHHH
MLCTCLVNEHDVRISTVEHLNAALAGLGIDNIVIEVNAPEIPIMDGSAAPFVYLLLDAGI
EEEEEEECCCCEEEEHHHHHHHHHHCCCCCEEEEEECCCCCEEECCCCCCEEEEEECCCC
DELNCAKKFVRIKETVRVEDGDKWAEFRPYNGFTLDFTIDFNHPAIDSSSQRYAMNFSAD
CHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCEEEEECCHH
AFMRQISRARTFGFMRDIEYLQSRGLCLGGSFDCAIVVDDYRVLNEDGLRFEDEFVRHKM
HHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCEEEEEECEEEECCCCCCCHHHHHHHHH
LDAIGDLFMCGHNIIGAFTAYKSGHALNNKLLQAVLAKQEAWEFVTFQDDAELPLAFKAP
HHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCEEEEECCCCCCCEEEECC
STVLA
CCCCC
>Mature Secondary Structure
MIKQRTLKRIVQATGVGLHTGKKVTLTLRPAPANTGVIYRRTDLNPPVDFPADAKSVRDT
CCCHHHHHHHHHHCCCCEECCCEEEEEEECCCCCCCEEEEECCCCCCCCCCCCHHHHHHH
MLCTCLVNEHDVRISTVEHLNAALAGLGIDNIVIEVNAPEIPIMDGSAAPFVYLLLDAGI
EEEEEEECCCCEEEEHHHHHHHHHHCCCCCEEEEEECCCCCEEECCCCCCEEEEEECCCC
DELNCAKKFVRIKETVRVEDGDKWAEFRPYNGFTLDFTIDFNHPAIDSSSQRYAMNFSAD
CHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCEEEEECCHH
AFMRQISRARTFGFMRDIEYLQSRGLCLGGSFDCAIVVDDYRVLNEDGLRFEDEFVRHKM
HHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCEEEEEECEEEECCCCCCCHHHHHHHHH
LDAIGDLFMCGHNIIGAFTAYKSGHALNNKLLQAVLAKQEAWEFVTFQDDAELPLAFKAP
HHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCEEEEECCCCCCCEEEECC
STVLA
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on carbon-nitrogen bonds, other than peptide bonds; In linear amides [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA