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The map label for this gene is dctA [H]

Identifier: 218930987

GI number: 218930987

Start: 4498350

End: 4499639

Strand: Reverse

Name: dctA [H]

Synonym: YPO3992

Alternate gene names: 218930987

Gene position: 4499639-4498350 (Counterclockwise)

Preceding gene: 218930988

Following gene: 218930986

Centisome position: 96.69

GC content: 46.74

Gene sequence:

>1290_bases
ATGAAAGTCTCTATTTTTAAAACGCTTTATTTTCAAGTGCTAACGGCGATAACTATTGGTGTGTTGCTTGGCCATTTCTA
CCCGGAAATCGGCGCTCAGATGAAACCACTGGGTGATGGATTTGTTAAATTAATTAAAATGATTATCGCGCCCGTCATTT
TTTGTACCGTTGTTACTGGTATCGCGGGCATGGAGAGCATGAAGGCCGTTGGCCGTACTGGTGCGATTGCACTGCTCTAT
TTTGAAATTGTCAGTACTCTGGCGCTGCTGATTGGTTTAGTGGTGGTTAACGTGGCGCAACCCGGTGTTGGGATGAACAT
CGATCCTGCGACACTGGATGCTAAAGCGGTTGCACTTTATGCTGAGCAAGCCTCACAACAGGGGATTATTCCATTCTTGC
TGGATATTATTCCCGGTAGCGTAGTTGGCGCATTTGCCAGCGGCAACATTCTGCAGGTCTTACTGTTTGCGGTCTTGTTT
GGTTTTGCTTTACACCGTTTGGGTGAAAAGGGGCAGTTGATTTTCAATGTTATTGAAAGCTTCTCCCGTGTTATTTTTGG
TGTCATCAATATGATCATGCGCTTGGCACCGCTCGGGGCTTTCGGTGCGATGGCCTTTACTATCGGTAAATATGGTGTAG
GAAGTCTGGTGCAATTGGGGCAATTAATCCTCTGCTTCTATTTGACCTGTATTCTGTTTGTCGTTTTGGTACTTGGTACG
ATTGCGAAATTCAATGGTTTTAATATCTTCAAATTTATCCGTTATATCAAAGAAGAGCTGTTGATCGTGTTAGGCACCTC
CTCTTCTGAGTCAGTGCTCCCTCGCATGTTGGATAAAATGGAGAACGCCGGGTGTAAAAAATCGGTAGTGGGTCTGGTTA
TCCCAACGGGCTACTCATTTAACCTGGATGGCACCTCTATTTACCTGACGATGGCCGCGGTATTTATCGCTCAGGCAACT
AACACCCATATGGATATTATGCATCAGGTGACATTGCTGGTGGTGCTGCTGCTCTCCTCAAAAGGTGCGGCAGGTGTCAC
AGGCAGTGGCTTTATCGTGTTGGCCGCCACCATTTCTGCGGTTGGACATTTACCTTTGGCTGGGCTGGCATTGATTCTGG
GGATTGACCGCTTTATGTCCGAGGCTCGCGCCCTGACTAATCTGGTAGGTAACGGTGTTGCCACCATTGTGGTCGCTAAA
TGGTGTAAGCAACTGGACAATGACCAACTGCAAGCGGTGCTATCCAATAAAGTGCTGCCTAATGTAAAAAGCAGTGTTTC
TGTGTCCTGA

Upstream 100 bases:

>100_bases
TGTTATTTTTCGCGCAATCACGGTTAAACGAAAGTGTTGCTTATTCATCACTGAAAGTAAAACGACATGCCGCCGTGTCA
CTCTTCAAAAGGACATTGTT

Downstream 100 bases:

>100_bases
TATCGTTCAATAGTAAAAAATCAGATATTTCTCCCTTCAATTCGCTACCAGTGGCTTGCTGTCACTGGTAGCGTCTCTGC
ATAATGTCACCATTCATTTC

Product: C4-dicarboxylate transporter DctA

Products: orotate [Cytoplasm]; fumarate [Cytoplasm]; malate [Cytoplasm]; Na (I) [Cytoplasm]; succinate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 429; Mature: 429

Protein sequence:

>429_residues
MKVSIFKTLYFQVLTAITIGVLLGHFYPEIGAQMKPLGDGFVKLIKMIIAPVIFCTVVTGIAGMESMKAVGRTGAIALLY
FEIVSTLALLIGLVVVNVAQPGVGMNIDPATLDAKAVALYAEQASQQGIIPFLLDIIPGSVVGAFASGNILQVLLFAVLF
GFALHRLGEKGQLIFNVIESFSRVIFGVINMIMRLAPLGAFGAMAFTIGKYGVGSLVQLGQLILCFYLTCILFVVLVLGT
IAKFNGFNIFKFIRYIKEELLIVLGTSSSESVLPRMLDKMENAGCKKSVVGLVIPTGYSFNLDGTSIYLTMAAVFIAQAT
NTHMDIMHQVTLLVVLLLSSKGAAGVTGSGFIVLAATISAVGHLPLAGLALILGIDRFMSEARALTNLVGNGVATIVVAK
WCKQLDNDQLQAVLSNKVLPNVKSSVSVS

Sequences:

>Translated_429_residues
MKVSIFKTLYFQVLTAITIGVLLGHFYPEIGAQMKPLGDGFVKLIKMIIAPVIFCTVVTGIAGMESMKAVGRTGAIALLY
FEIVSTLALLIGLVVVNVAQPGVGMNIDPATLDAKAVALYAEQASQQGIIPFLLDIIPGSVVGAFASGNILQVLLFAVLF
GFALHRLGEKGQLIFNVIESFSRVIFGVINMIMRLAPLGAFGAMAFTIGKYGVGSLVQLGQLILCFYLTCILFVVLVLGT
IAKFNGFNIFKFIRYIKEELLIVLGTSSSESVLPRMLDKMENAGCKKSVVGLVIPTGYSFNLDGTSIYLTMAAVFIAQAT
NTHMDIMHQVTLLVVLLLSSKGAAGVTGSGFIVLAATISAVGHLPLAGLALILGIDRFMSEARALTNLVGNGVATIVVAK
WCKQLDNDQLQAVLSNKVLPNVKSSVSVS
>Mature_429_residues
MKVSIFKTLYFQVLTAITIGVLLGHFYPEIGAQMKPLGDGFVKLIKMIIAPVIFCTVVTGIAGMESMKAVGRTGAIALLY
FEIVSTLALLIGLVVVNVAQPGVGMNIDPATLDAKAVALYAEQASQQGIIPFLLDIIPGSVVGAFASGNILQVLLFAVLF
GFALHRLGEKGQLIFNVIESFSRVIFGVINMIMRLAPLGAFGAMAFTIGKYGVGSLVQLGQLILCFYLTCILFVVLVLGT
IAKFNGFNIFKFIRYIKEELLIVLGTSSSESVLPRMLDKMENAGCKKSVVGLVIPTGYSFNLDGTSIYLTMAAVFIAQAT
NTHMDIMHQVTLLVVLLLSSKGAAGVTGSGFIVLAATISAVGHLPLAGLALILGIDRFMSEARALTNLVGNGVATIVVAK
WCKQLDNDQLQAVLSNKVLPNVKSSVSVS

Specific function: Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate from the periplasm across the membrane [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI5032093, Length=401, Percent_Identity=30.4239401496259, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI223468564, Length=270, Percent_Identity=32.5925925925926, Blast_Score=125, Evalue=8e-29,
Organism=Homo sapiens, GI21314632, Length=440, Percent_Identity=27.0454545454545, Blast_Score=125, Evalue=9e-29,
Organism=Homo sapiens, GI223468566, Length=270, Percent_Identity=32.5925925925926, Blast_Score=125, Evalue=9e-29,
Organism=Homo sapiens, GI194239697, Length=483, Percent_Identity=23.6024844720497, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI4827012, Length=404, Percent_Identity=25.7425742574257, Blast_Score=116, Evalue=3e-26,
Organism=Homo sapiens, GI40254478, Length=435, Percent_Identity=25.2873563218391, Blast_Score=116, Evalue=5e-26,
Organism=Homo sapiens, GI66773030, Length=397, Percent_Identity=26.448362720403, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI169790839, Length=282, Percent_Identity=29.4326241134752, Blast_Score=113, Evalue=4e-25,
Organism=Homo sapiens, GI301601644, Length=205, Percent_Identity=30.2439024390244, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI262359914, Length=230, Percent_Identity=28.2608695652174, Blast_Score=80, Evalue=5e-15,
Organism=Escherichia coli, GI1789947, Length=424, Percent_Identity=85.377358490566, Blast_Score=741, Evalue=0.0,
Organism=Escherichia coli, GI1790514, Length=414, Percent_Identity=39.6135265700483, Blast_Score=315, Evalue=3e-87,
Organism=Escherichia coli, GI1788024, Length=389, Percent_Identity=22.3650385604113, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1789473, Length=324, Percent_Identity=22.5308641975309, Blast_Score=65, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17537407, Length=423, Percent_Identity=25.7683215130024, Blast_Score=134, Evalue=7e-32,
Organism=Caenorhabditis elegans, GI71996953, Length=451, Percent_Identity=26.3858093126386, Blast_Score=124, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI71983099, Length=428, Percent_Identity=24.7663551401869, Blast_Score=122, Evalue=5e-28,
Organism=Caenorhabditis elegans, GI71983106, Length=428, Percent_Identity=24.7663551401869, Blast_Score=121, Evalue=6e-28,
Organism=Caenorhabditis elegans, GI193206505, Length=449, Percent_Identity=24.2761692650334, Blast_Score=105, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI17541374, Length=424, Percent_Identity=23.5849056603774, Blast_Score=100, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI193206654, Length=458, Percent_Identity=22.4890829694323, Blast_Score=98, Evalue=8e-21,
Organism=Drosophila melanogaster, GI24583025, Length=402, Percent_Identity=24.1293532338308, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI17137668, Length=402, Percent_Identity=24.1293532338308, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24583023, Length=402, Percent_Identity=24.1293532338308, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI281360481, Length=451, Percent_Identity=23.2815964523282, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI281360483, Length=451, Percent_Identity=23.2815964523282, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI17137666, Length=451, Percent_Identity=23.2815964523282, Blast_Score=78, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 45499; Mature: 45499

Theoretical pI: Translated: 9.30; Mature: 9.30

Prosite motif: PS00713 NA_DICARBOXYL_SYMP_1 ; PS00714 NA_DICARBOXYL_SYMP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVSIFKTLYFQVLTAITIGVLLGHFYPEIGAQMKPLGDGFVKLIKMIIAPVIFCTVVTG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
IAGMESMKAVGRTGAIALLYFEIVSTLALLIGLVVVNVAQPGVGMNIDPATLDAKAVALY
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHH
AEQASQQGIIPFLLDIIPGSVVGAFASGNILQVLLFAVLFGFALHRLGEKGQLIFNVIES
HHHHCCCCHHHHHHHHCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
FSRVIFGVINMIMRLAPLGAFGAMAFTIGKYGVGSLVQLGQLILCFYLTCILFVVLVLGT
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IAKFNGFNIFKFIRYIKEELLIVLGTSSSESVLPRMLDKMENAGCKKSVVGLVIPTGYSF
HHHCCCCHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHCCCCCHHHEEEEEECCEEE
NLDGTSIYLTMAAVFIAQATNTHMDIMHQVTLLVVLLLSSKGAAGVTGSGFIVLAATISA
CCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHH
VGHLPLAGLALILGIDRFMSEARALTNLVGNGVATIVVAKWCKQLDNDQLQAVLSNKVLP
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHCCCC
NVKSSVSVS
CCCCCCCCC
>Mature Secondary Structure
MKVSIFKTLYFQVLTAITIGVLLGHFYPEIGAQMKPLGDGFVKLIKMIIAPVIFCTVVTG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
IAGMESMKAVGRTGAIALLYFEIVSTLALLIGLVVVNVAQPGVGMNIDPATLDAKAVALY
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHH
AEQASQQGIIPFLLDIIPGSVVGAFASGNILQVLLFAVLFGFALHRLGEKGQLIFNVIES
HHHHCCCCHHHHHHHHCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
FSRVIFGVINMIMRLAPLGAFGAMAFTIGKYGVGSLVQLGQLILCFYLTCILFVVLVLGT
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IAKFNGFNIFKFIRYIKEELLIVLGTSSSESVLPRMLDKMENAGCKKSVVGLVIPTGYSF
HHHCCCCHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHCCCCCHHHEEEEEECCEEE
NLDGTSIYLTMAAVFIAQATNTHMDIMHQVTLLVVLLLSSKGAAGVTGSGFIVLAATISA
CCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHH
VGHLPLAGLALILGIDRFMSEARALTNLVGNGVATIVVAKWCKQLDNDQLQAVLSNKVLP
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHCCCC
NVKSSVSVS
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: orotate [Periplasm]; fumarate [Periplasm]; malate [Periplasm]; Na (I) [Periplasm]; succinate [Periplasm] [C]

Specific reaction: Na (I) [Periplasm] + orotate [Periplasm] = Na (I) [Cytoplasm] + orotate [Cytoplasm] Na (I) [Periplasm] + fumarate [Periplasm] = Na (I) [Cytoplasm] + fumarate [Cytoplasm] Na (I) [Periplasm] + malate [Periplasm] = Na (I) [Cytoplasm] + malate [Cytoplasm] Na

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA