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The map label for this gene is ddhA [H]

Identifier: 218930148

GI number: 218930148

Start: 3471573

End: 3472358

Strand: Reverse

Name: ddhA [H]

Synonym: YPO3115

Alternate gene names: 218930148

Gene position: 3472358-3471573 (Counterclockwise)

Preceding gene: 218930149

Following gene: 218930147

Centisome position: 74.61

GC content: 43.77

Gene sequence:

>786_bases
ATGGAGATTCAAGTGAAAGCAGTCATTTTGGCCGGAGGCCTTGGAACCCGTCTTAGTGAAGAGACCGTAGTAAAACCAAA
ACCAATGGTAGAGATTGGTGGGAAGCCTATTCTCTGGCATATTATGAAACTTTACTCTTCTTATGGCATCAATGATTTCG
TTATTTGCTGTGGTTATAAAGGCTATGTCATTAAAGAATATTTTGCGAATTACTTTATGCACATGTCGGATATTACCTTC
TGCATGCGTGATAATGAAATGATAGTACACCAAAAGCGAGTCGAACCCTGGAATGTCACGTTAGTAGACACCGGCGAAGA
TTCTATGACCGGTGGCCGACTGAGGCGTGTAAAAGATTACGTCAAAGACGATGAGGCTTTCTGTTTCACCTATGGTGATG
GTGTGAGTGACGTCAATATTGCTGAATTAATTGAATTCCATAAGAGCCACGGCAAGCAAGCCACATTAACGGCAACCTAT
CCCCCAGGCCGTTTTGGTGCGCTGGATATTAAAGATAAACAAGTACGTAGTTTTAAAGAAAAACCAAAAGGCGATGGCGC
ATTGATCAACGGCGGTTATTTTGTTTTGTCGCCTAAAGTTATCGATCTGATCGATGGTGATAAGTCTACTTGGGAGCAGG
AACCTTTAATGACATTAGCTGCGCAGGGGGAGTTGATGGCGTTTGAACATGCCGGGTTCTGGCAGCCAATGGATACGTTG
CGTGACAAGATCTATCTGCATGAACTATGGGAAGAAGGCAGGGCACCTTGGAAGGTATGGGAATAA

Upstream 100 bases:

>100_bases
GCTCGTAATGATTTCATCAATCATGGATTAGCTGAAAATAAATTTTTCTCTGATGCCTTTGTGCCATCAAAATAACTTTG
AGAGATCAAAGTAATACGTA

Downstream 100 bases:

>100_bases
CAAAATGATTAATAATAGTTTCTGGCAAGGTAAACGGGTTTTTGTAACAGGCCATACTGGGTTTAAAGGTGGCTGGTTGA
GTTTATGGTTGCAAACCATG

Product: glucose-1-phosphate cytidylyltransferase

Products: NA

Alternate protein names: CDP-glucose pyrophosphorylase [H]

Number of amino acids: Translated: 261; Mature: 261

Protein sequence:

>261_residues
MEIQVKAVILAGGLGTRLSEETVVKPKPMVEIGGKPILWHIMKLYSSYGINDFVICCGYKGYVIKEYFANYFMHMSDITF
CMRDNEMIVHQKRVEPWNVTLVDTGEDSMTGGRLRRVKDYVKDDEAFCFTYGDGVSDVNIAELIEFHKSHGKQATLTATY
PPGRFGALDIKDKQVRSFKEKPKGDGALINGGYFVLSPKVIDLIDGDKSTWEQEPLMTLAAQGELMAFEHAGFWQPMDTL
RDKIYLHELWEEGRAPWKVWE

Sequences:

>Translated_261_residues
MEIQVKAVILAGGLGTRLSEETVVKPKPMVEIGGKPILWHIMKLYSSYGINDFVICCGYKGYVIKEYFANYFMHMSDITF
CMRDNEMIVHQKRVEPWNVTLVDTGEDSMTGGRLRRVKDYVKDDEAFCFTYGDGVSDVNIAELIEFHKSHGKQATLTATY
PPGRFGALDIKDKQVRSFKEKPKGDGALINGGYFVLSPKVIDLIDGDKSTWEQEPLMTLAAQGELMAFEHAGFWQPMDTL
RDKIYLHELWEEGRAPWKVWE
>Mature_261_residues
MEIQVKAVILAGGLGTRLSEETVVKPKPMVEIGGKPILWHIMKLYSSYGINDFVICCGYKGYVIKEYFANYFMHMSDITF
CMRDNEMIVHQKRVEPWNVTLVDTGEDSMTGGRLRRVKDYVKDDEAFCFTYGDGVSDVNIAELIEFHKSHGKQATLTATY
PPGRFGALDIKDKQVRSFKEKPKGDGALINGGYFVLSPKVIDLIDGDKSTWEQEPLMTLAAQGELMAFEHAGFWQPMDTL
RDKIYLHELWEEGRAPWKVWE

Specific function: Involved in the biosynthesis of the tyvelose, a 3,6- dideoxyhexose found in the O-antigen of the surface lipopolysaccharides. It catalyzes the transfer of a CMP moiety from CTP to glucose 1-phosphate. This enzyme can utilize either CTP or UTP as the nucle

COG id: COG1208

COG function: function code MJ; Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate cytidylyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=246, Percent_Identity=27.2357723577236, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI11761619, Length=246, Percent_Identity=27.2357723577236, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI133931050, Length=248, Percent_Identity=30.6451612903226, Blast_Score=112, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6320148, Length=268, Percent_Identity=32.089552238806, Blast_Score=117, Evalue=2e-27,
Organism=Drosophila melanogaster, GI21355443, Length=259, Percent_Identity=28.5714285714286, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24644084, Length=259, Percent_Identity=28.5714285714286, Blast_Score=93, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013446
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.33 [H]

Molecular weight: Translated: 29763; Mature: 29763

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIQVKAVILAGGLGTRLSEETVVKPKPMVEIGGKPILWHIMKLYSSYGINDFVICCGYK
CEEEEEEEEEECCCCCCCCCCCCCCCCCCEEECCCHHHHHHHHHHHHCCCCEEEEEECCC
GYVIKEYFANYFMHMSDITFCMRDNEMIVHQKRVEPWNVTLVDTGEDSMTGGRLRRVKDY
CHHHHHHHHHHHHHHHHEEEEEECCEEEEEECCCCCEEEEEEECCCCCCCCHHHHHHHHH
VKDDEAFCFTYGDGVSDVNIAELIEFHKSHGKQATLTATYPPGRFGALDIKDKQVRSFKE
HCCCCEEEEEECCCCCCCCHHHHHHHHHHCCCEEEEEEECCCCCCCEECCCHHHHHHHHH
KPKGDGALINGGYFVLSPKVIDLIDGDKSTWEQEPLMTLAAQGELMAFEHAGFWQPMDTL
CCCCCCEEEECCEEEECCEEEEEECCCCCCCCCCCCEEEECCCCEEEEECCCCCCHHHHH
RDKIYLHELWEEGRAPWKVWE
HHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MEIQVKAVILAGGLGTRLSEETVVKPKPMVEIGGKPILWHIMKLYSSYGINDFVICCGYK
CEEEEEEEEEECCCCCCCCCCCCCCCCCCEEECCCHHHHHHHHHHHHCCCCEEEEEECCC
GYVIKEYFANYFMHMSDITFCMRDNEMIVHQKRVEPWNVTLVDTGEDSMTGGRLRRVKDY
CHHHHHHHHHHHHHHHHEEEEEECCEEEEEECCCCCEEEEEEECCCCCCCCHHHHHHHHH
VKDDEAFCFTYGDGVSDVNIAELIEFHKSHGKQATLTATYPPGRFGALDIKDKQVRSFKE
HCCCCEEEEEECCCCCCCCHHHHHHHHHHCCCEEEEEEECCCCCCCEECCCHHHHHHHHH
KPKGDGALINGGYFVLSPKVIDLIDGDKSTWEQEPLMTLAAQGELMAFEHAGFWQPMDTL
CCCCCCEEEECCEEEECCEEEEEECCCCCCCCCCCCEEEECCCCEEEEECCCCCCHHHHH
RDKIYLHELWEEGRAPWKVWE
HHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]