Click here to switch to the map view.

The map label for this gene is cysM [H]

Identifier: 218930058

GI number: 218930058

Start: 3364982

End: 3365860

Strand: Reverse

Name: cysM [H]

Synonym: YPO3011

Alternate gene names: 218930058

Gene position: 3365860-3364982 (Counterclockwise)

Preceding gene: 218930059

Following gene: 218930057

Centisome position: 72.33

GC content: 54.38

Gene sequence:

>879_bases
GTGACAACCCTGGAACACTGCATCGGCCATACACCATTGGTGAAACTACAACGCTTAAGCCAAGGGCTAAATGCGGAGAT
TTGGGTCAAACTGGAAGGGAACAATCCGGCCGGTTCGGTTAAAGATAGAGCCGCGCTGGCGATGATCCAGCAGGCAGAGT
TACGTGGTGATATTGCCCCCGGTGATGTCCTGATTGAAGCGACCAGTGGAAATACCGGGATTGCCTTGGCGATGATTGCC
GCCATGAAAGGCTATCACTTGAAGTTACTGATGCCAGAAAACATGAGTCAGGAGCGTCAGGCGGCGATGCGGGCTTACGG
CGCGGAACTGATTCTGGTTAGCCGTGAACAGGGCATGGAAGGGGCGCGTGATCTGGCGTTAACCATGCAGGAGAACGGCG
AAGGTAACGTGCTGGATCAATTTAATAATGCGGATAATCCCTATGCGCATTTTACGGGGACCGGGCCGGAAATTTGGCAG
CAAACGGCGGGTAAAGTGAGCCACTTTGTCTCCAGTATGGGGACCACCGGTACGATCACCGGTGTCAGCCAGTATCTAAA
AAGCCAAAATCCGCAGGTGAAGGTTATCGGCCTGCAACCAGCAGAAGGCAGCAGTATTCCGGGGATCCGCCGGTGGTCAG
CGGAATATATACCGGGTATTTTCCGCCCCGAGCTGGTGGATCAGGTGTTGGATATCACGCAGAGTGTTGCAGAGCAAACC
ATGCGGCGGCTGGCGAAAGAAGAGGGGATATTCTGTGGCGTCAGTTCTGGTGGTGCGGTGGCTGGGGCGCTGCGGATCGC
GGCAGATAACCCTGATGCGGTGATTGTGGCGATTATCTGTGACCGTGGTGACCGCTATTTATCAACTGGGGTTTTTTAA

Upstream 100 bases:

>100_bases
GCAAACCCCGATGAGCTGACAGGCGTCAGTCATTCGGGTTCATGAGAGCGGTGAACACCGTTGCAACGTCAAGGGCCAAG
GGTATTCAAAGGTAATCAAT

Downstream 100 bases:

>100_bases
GTAAGGGGGATAAATTTTTCCTCCACTTAAGTCTGGTGAGGGCTGTTTATGACAGCCCGAATATTCAATCAAGATATAGC
ATTTTTATTGAAAACCTATT

Product: cysteine synthase B

Products: NA

Alternate protein names: CSase B; O-acetylserine (thiol)-lyase B; OAS-TL B; O-acetylserine sulfhydrylase B [H]

Number of amino acids: Translated: 292; Mature: 291

Protein sequence:

>292_residues
MTTLEHCIGHTPLVKLQRLSQGLNAEIWVKLEGNNPAGSVKDRAALAMIQQAELRGDIAPGDVLIEATSGNTGIALAMIA
AMKGYHLKLLMPENMSQERQAAMRAYGAELILVSREQGMEGARDLALTMQENGEGNVLDQFNNADNPYAHFTGTGPEIWQ
QTAGKVSHFVSSMGTTGTITGVSQYLKSQNPQVKVIGLQPAEGSSIPGIRRWSAEYIPGIFRPELVDQVLDITQSVAEQT
MRRLAKEEGIFCGVSSGGAVAGALRIAADNPDAVIVAIICDRGDRYLSTGVF

Sequences:

>Translated_292_residues
MTTLEHCIGHTPLVKLQRLSQGLNAEIWVKLEGNNPAGSVKDRAALAMIQQAELRGDIAPGDVLIEATSGNTGIALAMIA
AMKGYHLKLLMPENMSQERQAAMRAYGAELILVSREQGMEGARDLALTMQENGEGNVLDQFNNADNPYAHFTGTGPEIWQ
QTAGKVSHFVSSMGTTGTITGVSQYLKSQNPQVKVIGLQPAEGSSIPGIRRWSAEYIPGIFRPELVDQVLDITQSVAEQT
MRRLAKEEGIFCGVSSGGAVAGALRIAADNPDAVIVAIICDRGDRYLSTGVF
>Mature_291_residues
TTLEHCIGHTPLVKLQRLSQGLNAEIWVKLEGNNPAGSVKDRAALAMIQQAELRGDIAPGDVLIEATSGNTGIALAMIAA
MKGYHLKLLMPENMSQERQAAMRAYGAELILVSREQGMEGARDLALTMQENGEGNVLDQFNNADNPYAHFTGTGPEIWQQ
TAGKVSHFVSSMGTTGTITGVSQYLKSQNPQVKVIGLQPAEGSSIPGIRRWSAEYIPGIFRPELVDQVLDITQSVAEQTM
RRLAKEEGIFCGVSSGGAVAGALRIAADNPDAVIVAIICDRGDRYLSTGVF

Specific function: Two cysteine synthase enzymes are found. Both catalyze the same reaction. Cysteine synthase B can also use thiosulfate in place of sulfide to give cysteine thiosulfonate as a product [H]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=284, Percent_Identity=38.3802816901408, Blast_Score=178, Evalue=5e-45,
Organism=Homo sapiens, GI295821200, Length=284, Percent_Identity=38.3802816901408, Blast_Score=178, Evalue=5e-45,
Organism=Homo sapiens, GI4557415, Length=284, Percent_Identity=38.3802816901408, Blast_Score=178, Evalue=5e-45,
Organism=Escherichia coli, GI2367138, Length=292, Percent_Identity=76.3698630136986, Blast_Score=471, Evalue=1e-134,
Organism=Escherichia coli, GI1788754, Length=305, Percent_Identity=44.2622950819672, Blast_Score=200, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI17562970, Length=296, Percent_Identity=42.9054054054054, Blast_Score=228, Evalue=2e-60,
Organism=Caenorhabditis elegans, GI32566674, Length=291, Percent_Identity=43.6426116838488, Blast_Score=226, Evalue=1e-59,
Organism=Caenorhabditis elegans, GI115535073, Length=296, Percent_Identity=43.2432432432432, Blast_Score=213, Evalue=9e-56,
Organism=Caenorhabditis elegans, GI17535051, Length=296, Percent_Identity=42.5675675675676, Blast_Score=212, Evalue=2e-55,
Organism=Caenorhabditis elegans, GI17561720, Length=296, Percent_Identity=41.554054054054, Blast_Score=196, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI32566672, Length=212, Percent_Identity=38.2075471698113, Blast_Score=146, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI25147552, Length=285, Percent_Identity=36.140350877193, Blast_Score=135, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17534315, Length=306, Percent_Identity=35.9477124183007, Blast_Score=134, Evalue=6e-32,
Organism=Caenorhabditis elegans, GI17539800, Length=331, Percent_Identity=24.4712990936556, Blast_Score=70, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6321594, Length=313, Percent_Identity=35.7827476038339, Blast_Score=176, Evalue=3e-45,
Organism=Saccharomyces cerevisiae, GI6321449, Length=324, Percent_Identity=30.8641975308642, Blast_Score=127, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24643623, Length=279, Percent_Identity=40.8602150537634, Blast_Score=164, Evalue=8e-41,
Organism=Drosophila melanogaster, GI20129101, Length=279, Percent_Identity=40.8602150537634, Blast_Score=164, Evalue=8e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005858
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 31279; Mature: 31148

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTLEHCIGHTPLVKLQRLSQGLNAEIWVKLEGNNPAGSVKDRAALAMIQQAELRGDIAP
CCCHHHHHCCCHHHHHHHHHCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCC
GDVLIEATSGNTGIALAMIAAMKGYHLKLLMPENMSQERQAAMRAYGAELILVSREQGME
CCEEEEECCCCCCHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHCCCEEEEEECCCCCC
GARDLALTMQENGEGNVLDQFNNADNPYAHFTGTGPEIWQQTAGKVSHFVSSMGTTGTIT
CHHHEEEEEECCCCCCCHHCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCHH
GVSQYLKSQNPQVKVIGLQPAEGSSIPGIRRWSAEYIPGIFRPELVDQVLDITQSVAEQT
HHHHHHHCCCCCEEEEEECCCCCCCCCCHHHCCHHHCCCCCCHHHHHHHHHHHHHHHHHH
MRRLAKEEGIFCGVSSGGAVAGALRIAADNPDAVIVAIICDRGDRYLSTGVF
HHHHHHHCCCEEEECCCCCEEEEEEEEECCCCEEEEEEEECCCCCCHHCCCC
>Mature Secondary Structure 
TTLEHCIGHTPLVKLQRLSQGLNAEIWVKLEGNNPAGSVKDRAALAMIQQAELRGDIAP
CCHHHHHCCCHHHHHHHHHCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCC
GDVLIEATSGNTGIALAMIAAMKGYHLKLLMPENMSQERQAAMRAYGAELILVSREQGME
CCEEEEECCCCCCHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHCCCEEEEEECCCCCC
GARDLALTMQENGEGNVLDQFNNADNPYAHFTGTGPEIWQQTAGKVSHFVSSMGTTGTIT
CHHHEEEEEECCCCCCCHHCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCHH
GVSQYLKSQNPQVKVIGLQPAEGSSIPGIRRWSAEYIPGIFRPELVDQVLDITQSVAEQT
HHHHHHHCCCCCEEEEEECCCCCCCCCCHHHCCHHHCCCCCCHHHHHHHHHHHHHHHHHH
MRRLAKEEGIFCGVSSGGAVAGALRIAADNPDAVIVAIICDRGDRYLSTGVF
HHHHHHHCCCEEEECCCCCEEEEEEEEECCCCEEEEEEEECCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2188958; 9205837; 9278503 [H]