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The map label for this gene is zwf [H]

Identifier: 218929173

GI number: 218929173

Start: 2345994

End: 2347469

Strand: Direct

Name: zwf [H]

Synonym: YPO2066

Alternate gene names: 218929173

Gene position: 2345994-2347469 (Clockwise)

Preceding gene: 218929170

Following gene: 218929174

Centisome position: 50.41

GC content: 48.51

Gene sequence:

>1476_bases
ATGAATACAGTCCAGGTAGCCCAGGCGTGTGACCTGGTGATTTTCGGCGCTAAAGGTGATTTGGCTCGCCGGAAACTGCT
GCCTTCTCTTTACCAATTAGAAAAAGCGGGTCATATCCACCCAGATACTCGGATAATCGGTGTTGGCCGTGCTGAGTGGG
ATAAAGATGCGTACACCGCTGTGGTAAAGGAAGCCCTCGATACCTTTATGAAAGAGCCGCTGGATGACGAGCTATGGCAA
AAACTCAGCTCGCGCCTCGACTTCTGCAATCTGGATGTGAATGACAGTAAGCATTTCACCAAATTAGGTAAAATGCTCGA
TCAAAAACATCGCACCACGATTAACTACTTTGCTATGCCGCCGAGTACATTTGGTGCGATTTGTAAAGGCCTGGGAGAAG
CCGGGTTAAACAAAGAGCCTAGCCGAGTGGTAATGGAAAAACCATTGGGAACCGATTTAGCGCCCTCAAGGGTAATTAAC
GATCAGGTAGCCGAGTATTTCAACGAATGTCAGGTTTACCGTATTGACCACTATTTAGGGAAAGAAACGGTATTAAACCT
GTTGGCGCTTCGCTTCGCTAACTCGTTGTTCGCCTCAAACTGGGACAACCGCACTATCGATCATGTGCAAATTACCGTCG
CAGAAGAGGTCGGAATTGAAGGGCGTTGGGGCTATTTTGATCAGGCCGGTCAGATGCGTGACATGATCCAAAACCATCTG
TTGCAAATCCTGACGATGATCGCCATGTCACCCCCCGCAGATCTCAGTACGGATCGCATCCGTGATGAAAAAGTAAAAGT
ACTGCGTTCGCTGCGCCGTATTGATCACACCAATGTGCGCGAAACTACAGTTCGTGGGCAATATACTGCCGGCTTTGTAC
AGGGCAATAAAGTGCCGGGTTATCTGGAAGAGGAAGGCGCGAATAAGAATAGCAATACCGAAACATTTGTGTCTATTCGG
GTGGATATCGATGACTGGCGTTGGGCTGGGGTACCTTTCTACCTGAGAACCGGTAAGCGCCTACCCAGCAAATGCTCTGA
AGTTGTGGTTTACTTTAAGAACCCCGCACTGAATCTCTTCCGCGAATCTTATCAACAACTGCCACAAAACAAACTGACAA
TTCGTTTGCAACCGGACGAAGGGATCGAAATTGAAGTGCTGAATAAAGTCCCCGGATTGGAACATAAGCATCGTTTACAA
ACCACTAAGCTTGATCTCAGTTTCTCCAAAACCTTCAATGAGCAGCATATTGCTGATGCCTATGAACGTCTGCTACTGGA
GACCATGCGGGGTATTCAAGCGCTGTTTGTGCGCCGTGATGAGGTCGAAGAGGCGTGGAAATGGGTCGATTCTATTATGA
ATGCGTGGGCGGCAGATAATGAAGCACCAAAACCATACCAGTCCGGTACATGGGGGCCTGTGGCATCCGTTGCTATGATC
ACCCGTGATGGCCGGTCATGGAATGAGTTCGAGTAA

Upstream 100 bases:

>100_bases
CGCATTTTTATCTGGGTTTACTGGCTATAGTCAAAGAGAGTACATTAGTAATGTAAGAAAATTACAAATATCCTGCAACG
AGGAGAATAGCATGGCAGTA

Downstream 100 bases:

>100_bases
TCGCTAACCGCACGATAATAGCGCGCCACCAGAGGCGAATCTGATGGCGCGTGACTGCCAGGGAGAGCAGGGGGCAGCCT
GCGTAATAATAAAGAGCGAG

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD [H]

Number of amino acids: Translated: 491; Mature: 491

Protein sequence:

>491_residues
MNTVQVAQACDLVIFGAKGDLARRKLLPSLYQLEKAGHIHPDTRIIGVGRAEWDKDAYTAVVKEALDTFMKEPLDDELWQ
KLSSRLDFCNLDVNDSKHFTKLGKMLDQKHRTTINYFAMPPSTFGAICKGLGEAGLNKEPSRVVMEKPLGTDLAPSRVIN
DQVAEYFNECQVYRIDHYLGKETVLNLLALRFANSLFASNWDNRTIDHVQITVAEEVGIEGRWGYFDQAGQMRDMIQNHL
LQILTMIAMSPPADLSTDRIRDEKVKVLRSLRRIDHTNVRETTVRGQYTAGFVQGNKVPGYLEEEGANKNSNTETFVSIR
VDIDDWRWAGVPFYLRTGKRLPSKCSEVVVYFKNPALNLFRESYQQLPQNKLTIRLQPDEGIEIEVLNKVPGLEHKHRLQ
TTKLDLSFSKTFNEQHIADAYERLLLETMRGIQALFVRRDEVEEAWKWVDSIMNAWAADNEAPKPYQSGTWGPVASVAMI
TRDGRSWNEFE

Sequences:

>Translated_491_residues
MNTVQVAQACDLVIFGAKGDLARRKLLPSLYQLEKAGHIHPDTRIIGVGRAEWDKDAYTAVVKEALDTFMKEPLDDELWQ
KLSSRLDFCNLDVNDSKHFTKLGKMLDQKHRTTINYFAMPPSTFGAICKGLGEAGLNKEPSRVVMEKPLGTDLAPSRVIN
DQVAEYFNECQVYRIDHYLGKETVLNLLALRFANSLFASNWDNRTIDHVQITVAEEVGIEGRWGYFDQAGQMRDMIQNHL
LQILTMIAMSPPADLSTDRIRDEKVKVLRSLRRIDHTNVRETTVRGQYTAGFVQGNKVPGYLEEEGANKNSNTETFVSIR
VDIDDWRWAGVPFYLRTGKRLPSKCSEVVVYFKNPALNLFRESYQQLPQNKLTIRLQPDEGIEIEVLNKVPGLEHKHRLQ
TTKLDLSFSKTFNEQHIADAYERLLLETMRGIQALFVRRDEVEEAWKWVDSIMNAWAADNEAPKPYQSGTWGPVASVAMI
TRDGRSWNEFE
>Mature_491_residues
MNTVQVAQACDLVIFGAKGDLARRKLLPSLYQLEKAGHIHPDTRIIGVGRAEWDKDAYTAVVKEALDTFMKEPLDDELWQ
KLSSRLDFCNLDVNDSKHFTKLGKMLDQKHRTTINYFAMPPSTFGAICKGLGEAGLNKEPSRVVMEKPLGTDLAPSRVIN
DQVAEYFNECQVYRIDHYLGKETVLNLLALRFANSLFASNWDNRTIDHVQITVAEEVGIEGRWGYFDQAGQMRDMIQNHL
LQILTMIAMSPPADLSTDRIRDEKVKVLRSLRRIDHTNVRETTVRGQYTAGFVQGNKVPGYLEEEGANKNSNTETFVSIR
VDIDDWRWAGVPFYLRTGKRLPSKCSEVVVYFKNPALNLFRESYQQLPQNKLTIRLQPDEGIEIEVLNKVPGLEHKHRLQ
TTKLDLSFSKTFNEQHIADAYERLLLETMRGIQALFVRRDEVEEAWKWVDSIMNAWAADNEAPKPYQSGTWGPVASVAMI
TRDGRSWNEFE

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI109389365, Length=480, Percent_Identity=34.5833333333333, Blast_Score=303, Evalue=3e-82,
Organism=Homo sapiens, GI108773793, Length=483, Percent_Identity=34.3685300207039, Blast_Score=302, Evalue=4e-82,
Organism=Homo sapiens, GI52145310, Length=498, Percent_Identity=26.1044176706827, Blast_Score=147, Evalue=2e-35,
Organism=Escherichia coli, GI1788158, Length=491, Percent_Identity=84.5213849287169, Blast_Score=886, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17538218, Length=485, Percent_Identity=34.8453608247423, Blast_Score=292, Evalue=2e-79,
Organism=Saccharomyces cerevisiae, GI6324088, Length=486, Percent_Identity=33.3333333333333, Blast_Score=278, Evalue=1e-75,
Organism=Drosophila melanogaster, GI24643350, Length=471, Percent_Identity=35.6687898089172, Blast_Score=288, Evalue=8e-78,
Organism=Drosophila melanogaster, GI24643352, Length=471, Percent_Identity=35.6687898089172, Blast_Score=287, Evalue=1e-77,
Organism=Drosophila melanogaster, GI221513548, Length=491, Percent_Identity=26.6802443991853, Blast_Score=176, Evalue=4e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 56142; Mature: 56142

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: PS00069 G6P_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTVQVAQACDLVIFGAKGDLARRKLLPSLYQLEKAGHIHPDTRIIGVGRAEWDKDAYTA
CCCHHHHHHCCEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCHHHHHH
VVKEALDTFMKEPLDDELWQKLSSRLDFCNLDVNDSKHFTKLGKMLDQKHRTTINYFAMP
HHHHHHHHHHHCCCCHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHHHCCEEEEEECC
PSTFGAICKGLGEAGLNKEPSRVVMEKPLGTDLAPSRVINDQVAEYFNECQVYRIDHYLG
CHHHHHHHHHHHHCCCCCCCCHHHEECCCCCCCCHHHHHHHHHHHHHHHCEEEEHHHHHC
KETVLNLLALRFANSLFASNWDNRTIDHVQITVAEEVGIEGRWGYFDQAGQMRDMIQNHL
HHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEHHHCCCCCCCCCHHHHHHHHHHHHHHH
LQILTMIAMSPPADLSTDRIRDEKVKVLRSLRRIDHTNVRETTVRGQYTAGFVQGNKVPG
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHEECCCEEEEEEECCCCCC
YLEEEGANKNSNTETFVSIRVDIDDWRWAGVPFYLRTGKRLPSKCSEVVVYFKNPALNLF
CHHHCCCCCCCCCEEEEEEEEEECCCEECCCCCEECCCCCCCCCHHHEEEEECCCHHHHH
RESYQQLPQNKLTIRLQPDEGIEIEVLNKVPGLEHKHRLQTTKLDLSFSKTFNEQHIADA
HHHHHHCCCCCEEEEECCCCCCEEEEECCCCCCCHHHHHHHHEEEEEHHHHCCHHHHHHH
YERLLLETMRGIQALFVRRDEVEEAWKWVDSIMNAWAADNEAPKPYQSGTWGPVASVAMI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHEE
TRDGRSWNEFE
ECCCCCCCCCC
>Mature Secondary Structure
MNTVQVAQACDLVIFGAKGDLARRKLLPSLYQLEKAGHIHPDTRIIGVGRAEWDKDAYTA
CCCHHHHHHCCEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCHHHHHH
VVKEALDTFMKEPLDDELWQKLSSRLDFCNLDVNDSKHFTKLGKMLDQKHRTTINYFAMP
HHHHHHHHHHHCCCCHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHHHCCEEEEEECC
PSTFGAICKGLGEAGLNKEPSRVVMEKPLGTDLAPSRVINDQVAEYFNECQVYRIDHYLG
CHHHHHHHHHHHHCCCCCCCCHHHEECCCCCCCCHHHHHHHHHHHHHHHCEEEEHHHHHC
KETVLNLLALRFANSLFASNWDNRTIDHVQITVAEEVGIEGRWGYFDQAGQMRDMIQNHL
HHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEHHHCCCCCCCCCHHHHHHHHHHHHHHH
LQILTMIAMSPPADLSTDRIRDEKVKVLRSLRRIDHTNVRETTVRGQYTAGFVQGNKVPG
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHEECCCEEEEEEECCCCCC
YLEEEGANKNSNTETFVSIRVDIDDWRWAGVPFYLRTGKRLPSKCSEVVVYFKNPALNLF
CHHHCCCCCCCCCEEEEEEEEEECCCEECCCCCEECCCCCCCCCHHHEEEEECCCHHHHH
RESYQQLPQNKLTIRLQPDEGIEIEVLNKVPGLEHKHRLQTTKLDLSFSKTFNEQHIADA
HHHHHHCCCCCEEEEECCCCCCEEEEECCCCCCCHHHHHHHHEEEEEHHHHCCHHHHHHH
YERLLLETMRGIQALFVRRDEVEEAWKWVDSIMNAWAADNEAPKPYQSGTWGPVASVAMI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHEE
TRDGRSWNEFE
ECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8145647 [H]