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The map label for this gene is kdsA [H]

Identifier: 218929132

GI number: 218929132

Start: 2292514

End: 2293368

Strand: Direct

Name: kdsA [H]

Synonym: YPO2021

Alternate gene names: 218929132

Gene position: 2292514-2293368 (Clockwise)

Preceding gene: 218929131

Following gene: 218929133

Centisome position: 49.26

GC content: 50.18

Gene sequence:

>855_bases
ATGAAACAGAAAGTGGTTAGCATTGGCGATATCAACGTAGCGAACGACCTGCCTTTCGTGCTGTTTGGTGGTATGAATGT
GCTTGAGTCACGCGATCTGGCGATGCGCATCTGCGAGCATTACGTGACGGTGACTCAAAAGCTCGGCATCCCTTACGTAT
TTAAAGCCTCGTTCGACAAAGCCAACCGTTCTTCAATTCATTCTTACCGCGGCCCAGGCCTGGAAGAAGGGATGAAAATC
TTTCAAGAGCTGAAGCAACAGTTTGGCGTTAAAGTGATCACCGATGTGCATGAAGCCAGCCAGGCACAGCCAGTATCTGA
AGTGGTTGATGTTATCCAGTTGCCTGCATTCTTGGCGCGTCAAACAGATTTGGTCGAGGCGATGGCCCGTACCGGTGCTG
TCATCAACGTGAAAAAACCTCAGTTCGTTAGCCCCGGTCAGATGGGCAATATCGTTGAGAAATTTAAAGAAGCGGGTAAC
GACCAGGTGATCCTCTGTGATCGCGGCAGTAACTTTGGTTATGACAATCTGGTGGTTGATATGTTGGGTATCAATGTAAT
GGTACAAGCAACAGGCGGTCACCCGGTTATTTTCGATGTGACTCATGCGTTACAATGCCGTGACCCGTTTGGCGCGGCAT
CTGGTGGCCGTCGTGCTCAGGTCGCTGAACTGGCCCGCGCAGGTATGGCGGTTGGTTTGGCAGGGCTATTTATCGAAGCA
CATCCAGAGCCGAATAGCGCGAAATGTGATGGTCCATCAGCACTACCACTGGATAAGTTGGAGCCATTCTTAGTGCAGAT
GAAGGCTATCGATGATTTGGTGAAGAGTTTCCCTGCGCTGGATACCAGTAAGTAA

Upstream 100 bases:

>100_bases
ACTGATCTTTTTTATGCGCAGCGGTTTTATAGGGCAATAGCCCTCGTATACCATAATGCGCTGTAATTAATCTCGATTTA
CCCTTTATAAAGGTATAAGT

Downstream 100 bases:

>100_bases
CCCCCCCCTGCGTCCTTGGCGCTACAGCGTTGTTAGCGGCACTCGCTCACCCGAATCACTGACCTGACGTTCTTGTAACC
ACCGAATGGTTTTTCAGTTG

Product: 2-dehydro-3-deoxyphosphooctonate aldolase

Products: NA

Alternate protein names: 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase; KDO-8-phosphate synthase; KDO 8-P synthase; KDOPS; Phospho-2-dehydro-3-deoxyoctonate aldolase [H]

Number of amino acids: Translated: 284; Mature: 284

Protein sequence:

>284_residues
MKQKVVSIGDINVANDLPFVLFGGMNVLESRDLAMRICEHYVTVTQKLGIPYVFKASFDKANRSSIHSYRGPGLEEGMKI
FQELKQQFGVKVITDVHEASQAQPVSEVVDVIQLPAFLARQTDLVEAMARTGAVINVKKPQFVSPGQMGNIVEKFKEAGN
DQVILCDRGSNFGYDNLVVDMLGINVMVQATGGHPVIFDVTHALQCRDPFGAASGGRRAQVAELARAGMAVGLAGLFIEA
HPEPNSAKCDGPSALPLDKLEPFLVQMKAIDDLVKSFPALDTSK

Sequences:

>Translated_284_residues
MKQKVVSIGDINVANDLPFVLFGGMNVLESRDLAMRICEHYVTVTQKLGIPYVFKASFDKANRSSIHSYRGPGLEEGMKI
FQELKQQFGVKVITDVHEASQAQPVSEVVDVIQLPAFLARQTDLVEAMARTGAVINVKKPQFVSPGQMGNIVEKFKEAGN
DQVILCDRGSNFGYDNLVVDMLGINVMVQATGGHPVIFDVTHALQCRDPFGAASGGRRAQVAELARAGMAVGLAGLFIEA
HPEPNSAKCDGPSALPLDKLEPFLVQMKAIDDLVKSFPALDTSK
>Mature_284_residues
MKQKVVSIGDINVANDLPFVLFGGMNVLESRDLAMRICEHYVTVTQKLGIPYVFKASFDKANRSSIHSYRGPGLEEGMKI
FQELKQQFGVKVITDVHEASQAQPVSEVVDVIQLPAFLARQTDLVEAMARTGAVINVKKPQFVSPGQMGNIVEKFKEAGN
DQVILCDRGSNFGYDNLVVDMLGINVMVQATGGHPVIFDVTHALQCRDPFGAASGGRRAQVAELARAGMAVGLAGLFIEA
HPEPNSAKCDGPSALPLDKLEPFLVQMKAIDDLVKSFPALDTSK

Specific function: Synthesis Of Kdo 8-P Which Is Required For Lipid A Maturation And Cellular Growth. [C]

COG id: COG2877

COG function: function code M; 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the kdsA family [H]

Homologues:

Organism=Escherichia coli, GI1787466, Length=284, Percent_Identity=90.1408450704225, Blast_Score=529, Evalue=1e-152,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006218
- InterPro:   IPR006269 [H]

Pfam domain/function: PF00793 DAHP_synth_1 [H]

EC number: =2.5.1.55 [H]

Molecular weight: Translated: 30741; Mature: 30741

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQKVVSIGDINVANDLPFVLFGGMNVLESRDLAMRICEHYVTVTQKLGIPYVFKASFDK
CCCCEEEECCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCC
ANRSSIHSYRGPGLEEGMKIFQELKQQFGVKVITDVHEASQAQPVSEVVDVIQLPAFLAR
CCHHHHHHCCCCCHHHHHHHHHHHHHHCCCEEEHHHHHHHCCCCHHHHHHHHHHHHHHHH
QTDLVEAMARTGAVINVKKPQFVSPGQMGNIVEKFKEAGNDQVILCDRGSNFGYDNLVVD
HHHHHHHHHHCCCEEEECCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHH
MLGINVMVQATGGHPVIFDVTHALQCRDPFGAASGGRRAQVAELARAGMAVGLAGLFIEA
HHCCEEEEEECCCCEEEEEHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHEEEEEE
HPEPNSAKCDGPSALPLDKLEPFLVQMKAIDDLVKSFPALDTSK
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MKQKVVSIGDINVANDLPFVLFGGMNVLESRDLAMRICEHYVTVTQKLGIPYVFKASFDK
CCCCEEEECCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCC
ANRSSIHSYRGPGLEEGMKIFQELKQQFGVKVITDVHEASQAQPVSEVVDVIQLPAFLAR
CCHHHHHHCCCCCHHHHHHHHHHHHHHCCCEEEHHHHHHHCCCCHHHHHHHHHHHHHHHH
QTDLVEAMARTGAVINVKKPQFVSPGQMGNIVEKFKEAGNDQVILCDRGSNFGYDNLVVD
HHHHHHHHHHCCCEEEECCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHH
MLGINVMVQATGGHPVIFDVTHALQCRDPFGAASGGRRAQVAELARAGMAVGLAGLFIEA
HHCCEEEEEECCCCEEEEEHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHEEEEEE
HPEPNSAKCDGPSALPLDKLEPFLVQMKAIDDLVKSFPALDTSK
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14528314 [H]