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The map label for this gene is clpA [H]

Identifier: 218928516

GI number: 218928516

Start: 1535361

End: 1537637

Strand: Direct

Name: clpA [H]

Synonym: YPO1368

Alternate gene names: 218928516

Gene position: 1535361-1537637 (Clockwise)

Preceding gene: 218928515

Following gene: 218928517

Centisome position: 32.99

GC content: 49.45

Gene sequence:

>2277_bases
ATGCTCAATCAAGAACTTGAACTCAGTCTTAATATGGCTTTCGCCAGAGCGCGTGAGCACAGACACGAGTTTATGACCGT
GGAGCACCTGTTGCTGGCATTGCTGAGCAATCCAGCCGCGCGGGAAGCGTTGGAGGCCTGTACGGTTGACCTGGTGGCGT
TACGCCAGGAATTAGAAGCGTTTATCGAACAAACTACACCGACACTACCTGTCAGTGAGGAAGAGCGTGATACCCAGCCA
ACGCTCAGTTTTCAGCGCGTACTACAACGTGCGGTCTTTCATGTGCAGTCATCGGGCCGTAATGAGGTTTCCGGCGCGAA
CGTGTTGGTCGCCATCTTCAGTGAACAAGAGTCTCAGGCGGCCTACCTGTTGCGTAAGCATGATGTCAGCCGCTTGGATG
TCGTGAACTTTATTTCCCATGGTGCCCGTAAGGACGAGCCTAGCCAGACGCCGAATGTCGATAACTCGCCAAGTGAAGAG
CAGGCCAGCGGGGAAGACCGTATGGAAAACTTCACCACAAACCTAAATCAACTGGCCCGTGTTGGCGGCATTGATCCGCT
TATTGGGCGCGATAAAGAGCTGGAGCGGACCATTCAGGTACTGTGCCGTCGGCGTAAAAACAACCCGCTGCTGGTGGGGG
AATCCGGTGTTGGTAAAACTGCCATTGCTGAGGGGCTGGCTTGGCGTATTGTGCAAGGTGATGTTCCTGACGTCATATCC
GAATGCACGCTGTACTCATTGGATATCGGTTCATTGCTGGCGGGTACCAAATACCGTGGTGACTTTGAAAAACGGTTTAA
GGCACTGCTAAAGCAGTTGGAAAACGACAAAGACAGCATCCTGTTTATCGATGAAATCCACACAATCATTGGCGCTGGTG
CGGCTTCTGGTGGTCAGGTGGATGCCGCGAATCTGATTAAACCTCTGCTTTCCAGTGGCAAGATCCGGGTTATTGGTTCC
ACGACGTATCAGGAATTCAGTAATATCTTTGAGAAAGATCGCGCGCTGGCACGTCGTTTCCAGAAAATTGATATCATTGA
ACCAACACCAGAAGAGACGGTTCAAATTATTAATGGTCTGAAACCCAAATATGAAGCGCACCACGATGTGCGTTACACCG
CGAAAGCGATACGTGCTGCGGTTGAATTGTCGGTTAAATATATTAATGACCGCCATTTGCCAGACAAAGCCATTGATGTC
ATTGATGAAGCAGGTGCGCGTAGCCGCCTGATGCCAGTGAATAAACGCAAGAAAACGGTCAATGTCTCGGATATCGAATC
GGTGGTAGCCCGTATTGCCCGTATCCCGGAGAAAACGGTTTCTGCCAGTGACCGCGATGTCCTACGAAATCTGAGTGATC
GCCTAAACATGTTGGTATTCGGTCAAGATAAGGCGATTGAGGCGTTATCTGAAGCGATCAAAATGAGCCGTGCGGGGTTA
GGGCATGAGCGTCAACCTGTCGGGTCCTTCTTGTTTGCTGGCCCTACGGGGGTAGGTAAAACAGAAGTGACGGTGCAGTT
GGCCAAAGCGCTCGATATCGAATTGCTCCGCTTTGATATGTCTGAGTATATGGAGCGCCATACTGTCAGCCGCCTGATTG
GTGCGCCCCCAGGGTATGTTGGTTACGATCAGGGCGGGTTATTGACTGATTCAGTGATCAAACATCCTCATGCTGTGTTG
TTATTGGACGAAATTGAAAAAGCGCATCCTGATGTGTTTAATCTGTTATTGCAGGTGATGGATAACGGAACACTGACTGA
TAACAATGGGCGTAAGGCCGATTTCCGTAACGTCATTTTGGTGATGACCACCAACGCCGGTGTACGGGAAACGCAGCGCA
CTTCCATTGGTTTTAAACAGCAGGATAGCAGCACTGATGCGCTGGAAGAGATCAAAAAAATATTCACACCGGAGTTCCGT
AACCGGTTAGATAATATTATTTGGTTCAACCATTTGTCTCCTGCGGTTATCCAGCAGGTGGTCGATAAATTTATCGTTGA
GTTGCAGGCACAATTAGATGCGAAAGGCGTGTCATTGGAGGTCAGTGATGAAGCGCGCGATTGGTTATCTGAGAAGGGCT
ATGACAAAGCGATGGGTGCTCGACCAATGACCCGGGTGATTCAGGAGAATCTGAAGAAACCACTGGCGAATGAATTGTTA
TTTGGTTCTCTGGTTGATGGTGGTTCGGTTACGGTTAATCTGGATAAAGAGAAACAACAACTGGCCTATGAATTCCAGAG
CGCGCAAAAACGTAAAACTGAAGGGGCAGTTCATTAA

Upstream 100 bases:

>100_bases
ACAAAAGTCGCCCATGTAAATCAATACGCCAGGGAGAACGAGCATCCACTGCTTTGTACGCTGGAAAAAGCCTGATTAAG
GCAATTATTGGGAGGTGCCT

Downstream 100 bases:

>100_bases
GTCAACGGGCTAGAAAGCGGCAGCCAACGACATTGGCGTGGTAATCAGGCTGAAACCACGCCTGCAACGTCCATGTCTGC
AACATCCATGTCTGCAATAT

Product: ATP-dependent Clp protease ATP-binding subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 758; Mature: 758

Protein sequence:

>758_residues
MLNQELELSLNMAFARAREHRHEFMTVEHLLLALLSNPAAREALEACTVDLVALRQELEAFIEQTTPTLPVSEEERDTQP
TLSFQRVLQRAVFHVQSSGRNEVSGANVLVAIFSEQESQAAYLLRKHDVSRLDVVNFISHGARKDEPSQTPNVDNSPSEE
QASGEDRMENFTTNLNQLARVGGIDPLIGRDKELERTIQVLCRRRKNNPLLVGESGVGKTAIAEGLAWRIVQGDVPDVIS
ECTLYSLDIGSLLAGTKYRGDFEKRFKALLKQLENDKDSILFIDEIHTIIGAGAASGGQVDAANLIKPLLSSGKIRVIGS
TTYQEFSNIFEKDRALARRFQKIDIIEPTPEETVQIINGLKPKYEAHHDVRYTAKAIRAAVELSVKYINDRHLPDKAIDV
IDEAGARSRLMPVNKRKKTVNVSDIESVVARIARIPEKTVSASDRDVLRNLSDRLNMLVFGQDKAIEALSEAIKMSRAGL
GHERQPVGSFLFAGPTGVGKTEVTVQLAKALDIELLRFDMSEYMERHTVSRLIGAPPGYVGYDQGGLLTDSVIKHPHAVL
LLDEIEKAHPDVFNLLLQVMDNGTLTDNNGRKADFRNVILVMTTNAGVRETQRTSIGFKQQDSSTDALEEIKKIFTPEFR
NRLDNIIWFNHLSPAVIQQVVDKFIVELQAQLDAKGVSLEVSDEARDWLSEKGYDKAMGARPMTRVIQENLKKPLANELL
FGSLVDGGSVTVNLDKEKQQLAYEFQSAQKRKTEGAVH

Sequences:

>Translated_758_residues
MLNQELELSLNMAFARAREHRHEFMTVEHLLLALLSNPAAREALEACTVDLVALRQELEAFIEQTTPTLPVSEEERDTQP
TLSFQRVLQRAVFHVQSSGRNEVSGANVLVAIFSEQESQAAYLLRKHDVSRLDVVNFISHGARKDEPSQTPNVDNSPSEE
QASGEDRMENFTTNLNQLARVGGIDPLIGRDKELERTIQVLCRRRKNNPLLVGESGVGKTAIAEGLAWRIVQGDVPDVIS
ECTLYSLDIGSLLAGTKYRGDFEKRFKALLKQLENDKDSILFIDEIHTIIGAGAASGGQVDAANLIKPLLSSGKIRVIGS
TTYQEFSNIFEKDRALARRFQKIDIIEPTPEETVQIINGLKPKYEAHHDVRYTAKAIRAAVELSVKYINDRHLPDKAIDV
IDEAGARSRLMPVNKRKKTVNVSDIESVVARIARIPEKTVSASDRDVLRNLSDRLNMLVFGQDKAIEALSEAIKMSRAGL
GHERQPVGSFLFAGPTGVGKTEVTVQLAKALDIELLRFDMSEYMERHTVSRLIGAPPGYVGYDQGGLLTDSVIKHPHAVL
LLDEIEKAHPDVFNLLLQVMDNGTLTDNNGRKADFRNVILVMTTNAGVRETQRTSIGFKQQDSSTDALEEIKKIFTPEFR
NRLDNIIWFNHLSPAVIQQVVDKFIVELQAQLDAKGVSLEVSDEARDWLSEKGYDKAMGARPMTRVIQENLKKPLANELL
FGSLVDGGSVTVNLDKEKQQLAYEFQSAQKRKTEGAVH
>Mature_758_residues
MLNQELELSLNMAFARAREHRHEFMTVEHLLLALLSNPAAREALEACTVDLVALRQELEAFIEQTTPTLPVSEEERDTQP
TLSFQRVLQRAVFHVQSSGRNEVSGANVLVAIFSEQESQAAYLLRKHDVSRLDVVNFISHGARKDEPSQTPNVDNSPSEE
QASGEDRMENFTTNLNQLARVGGIDPLIGRDKELERTIQVLCRRRKNNPLLVGESGVGKTAIAEGLAWRIVQGDVPDVIS
ECTLYSLDIGSLLAGTKYRGDFEKRFKALLKQLENDKDSILFIDEIHTIIGAGAASGGQVDAANLIKPLLSSGKIRVIGS
TTYQEFSNIFEKDRALARRFQKIDIIEPTPEETVQIINGLKPKYEAHHDVRYTAKAIRAAVELSVKYINDRHLPDKAIDV
IDEAGARSRLMPVNKRKKTVNVSDIESVVARIARIPEKTVSASDRDVLRNLSDRLNMLVFGQDKAIEALSEAIKMSRAGL
GHERQPVGSFLFAGPTGVGKTEVTVQLAKALDIELLRFDMSEYMERHTVSRLIGAPPGYVGYDQGGLLTDSVIKHPHAVL
LLDEIEKAHPDVFNLLLQVMDNGTLTDNNGRKADFRNVILVMTTNAGVRETQRTSIGFKQQDSSTDALEEIKKIFTPEFR
NRLDNIIWFNHLSPAVIQQVVDKFIVELQAQLDAKGVSLEVSDEARDWLSEKGYDKAMGARPMTRVIQENLKKPLANELL
FGSLVDGGSVTVNLDKEKQQLAYEFQSAQKRKTEGAVH

Specific function: ATP-dependent specificity component of the ClpP protease. It directs the protease to specific substrates. The primary function of the ClpA-ClpP complex appears to be the degradation of unfolded or abnormal proteins [H]

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the clpA/clpB family [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=339, Percent_Identity=30.9734513274336, Blast_Score=152, Evalue=9e-37,
Organism=Escherichia coli, GI1787109, Length=757, Percent_Identity=89.4319682959049, Blast_Score=1400, Evalue=0.0,
Organism=Escherichia coli, GI1788943, Length=325, Percent_Identity=43.6923076923077, Blast_Score=283, Evalue=3e-77,
Organism=Saccharomyces cerevisiae, GI6320464, Length=327, Percent_Identity=46.4831804281346, Blast_Score=296, Evalue=6e-81,
Organism=Saccharomyces cerevisiae, GI6323002, Length=404, Percent_Identity=36.1386138613861, Blast_Score=248, Evalue=2e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR013461
- InterPro:   IPR023150 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 84405; Mature: 84405

Theoretical pI: Translated: 6.00; Mature: 6.00

Prosite motif: PS00870 CLPAB_1 ; PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNQELELSLNMAFARAREHRHEFMTVEHLLLALLSNPAAREALEACTVDLVALRQELEA
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
FIEQTTPTLPVSEEERDTQPTLSFQRVLQRAVFHVQSSGRNEVSGANVLVAIFSEQESQA
HHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCHHH
AYLLRKHDVSRLDVVNFISHGARKDEPSQTPNVDNSPSEEQASGEDRMENFTTNLNQLAR
HHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHH
VGGIDPLIGRDKELERTIQVLCRRRKNNPLLVGESGVGKTAIAEGLAWRIVQGDVPDVIS
HCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHCCEEEEECCCHHHHHH
ECTLYSLDIGSLLAGTKYRGDFEKRFKALLKQLENDKDSILFIDEIHTIIGAGAASGGQV
HCEEEEECHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHCCCCCCCCC
DAANLIKPLLSSGKIRVIGSTTYQEFSNIFEKDRALARRFQKIDIIEPTPEETVQIINGL
CHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCC
KPKYEAHHDVRYTAKAIRAAVELSVKYINDRHLPDKAIDVIDEAGARSRLMPVNKRKKTV
CCCHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCC
NVSDIESVVARIARIPEKTVSASDRDVLRNLSDRLNMLVFGQDKAIEALSEAIKMSRAGL
CHHHHHHHHHHHHHCCHHHCCCCHHHHHHHHHHHCCEEEECCHHHHHHHHHHHHHHHHCC
GHERQPVGSFLFAGPTGVGKTEVTVQLAKALDIELLRFDMSEYMERHTVSRLIGAPPGYV
CCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
GYDQGGLLTDSVIKHPHAVLLLDEIEKAHPDVFNLLLQVMDNGTLTDNNGRKADFRNVIL
CCCCCCCCCHHHHCCCCCEEEHHHHHHHCCHHHHHHHHHHCCCCEECCCCCCCCCCCEEE
VMTTNAGVRETQRTSIGFKQQDSSTDALEEIKKIFTPEFRNRLDNIIWFNHLSPAVIQQV
EEECCCCCCHHHHHCCCCCCCCCCHHHHHHHHHHHCHHHHHHHHHEEEECCCCHHHHHHH
VDKFIVELQAQLDAKGVSLEVSDEARDWLSEKGYDKAMGARPMTRVIQENLKKPLANELL
HHHHHHHHHHHHCCCCCEEEECHHHHHHHHHCCCCHHCCCCHHHHHHHHHHHHHHHHHHH
FGSLVDGGSVTVNLDKEKQQLAYEFQSAQKRKTEGAVH
HHHEECCCEEEEEECHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MLNQELELSLNMAFARAREHRHEFMTVEHLLLALLSNPAAREALEACTVDLVALRQELEA
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
FIEQTTPTLPVSEEERDTQPTLSFQRVLQRAVFHVQSSGRNEVSGANVLVAIFSEQESQA
HHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCHHH
AYLLRKHDVSRLDVVNFISHGARKDEPSQTPNVDNSPSEEQASGEDRMENFTTNLNQLAR
HHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHH
VGGIDPLIGRDKELERTIQVLCRRRKNNPLLVGESGVGKTAIAEGLAWRIVQGDVPDVIS
HCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHCCEEEEECCCHHHHHH
ECTLYSLDIGSLLAGTKYRGDFEKRFKALLKQLENDKDSILFIDEIHTIIGAGAASGGQV
HCEEEEECHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHCCCCCCCCC
DAANLIKPLLSSGKIRVIGSTTYQEFSNIFEKDRALARRFQKIDIIEPTPEETVQIINGL
CHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCC
KPKYEAHHDVRYTAKAIRAAVELSVKYINDRHLPDKAIDVIDEAGARSRLMPVNKRKKTV
CCCHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCC
NVSDIESVVARIARIPEKTVSASDRDVLRNLSDRLNMLVFGQDKAIEALSEAIKMSRAGL
CHHHHHHHHHHHHHCCHHHCCCCHHHHHHHHHHHCCEEEECCHHHHHHHHHHHHHHHHCC
GHERQPVGSFLFAGPTGVGKTEVTVQLAKALDIELLRFDMSEYMERHTVSRLIGAPPGYV
CCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
GYDQGGLLTDSVIKHPHAVLLLDEIEKAHPDVFNLLLQVMDNGTLTDNNGRKADFRNVIL
CCCCCCCCCHHHHCCCCCEEEHHHHHHHCCHHHHHHHHHHCCCCEECCCCCCCCCCCEEE
VMTTNAGVRETQRTSIGFKQQDSSTDALEEIKKIFTPEFRNRLDNIIWFNHLSPAVIQQV
EEECCCCCCHHHHHCCCCCCCCCCHHHHHHHHHHHCHHHHHHHHHEEEECCCCHHHHHHH
VDKFIVELQAQLDAKGVSLEVSDEARDWLSEKGYDKAMGARPMTRVIQENLKKPLANELL
HHHHHHHHHHHHCCCCCEEEECHHHHHHHHHCCCCHHCCCCHHHHHHHHHHHHHHHHHHH
FGSLVDGGSVTVNLDKEKQQLAYEFQSAQKRKTEGAVH
HHHEECCCEEEEEECHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]