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The map label for this gene is ltaA [H]

Identifier: 218928505

GI number: 218928505

Start: 1520589

End: 1521608

Strand: Reverse

Name: ltaA [H]

Synonym: YPO1357

Alternate gene names: 218928505

Gene position: 1521608-1520589 (Counterclockwise)

Preceding gene: 218928506

Following gene: 218928504

Centisome position: 32.7

GC content: 52.55

Gene sequence:

>1020_bases
ATGCTGATCGATTTACGCAGTGACACAGTAACGCAACCCTGTGCCGCCATGCGCGCCGCGATGGCGAATGCCGAGGTCGG
TGATGATGTGTATGGCGATGACCCAACCGTCAATGCGCTTGAAGCCAAAGCCGCCAGTTTATCCGGTAAAGAAGCCGCGC
TGTTTCTGCCAACAGGCACTCAGGCAAATTTGGTGGCGCTATTGACCCATTGTCAGCGTGGTGAAGAGTATATTGTCGGC
CAAAAAGCCCATAACTATTTGTATGAAGCCGGGGGTGCCGCCGTTTTGGGCAGTATCCAACCACAACCTATTGATGCCAA
CGATGACGGCACACTACCACTGGATAACGTTCTGGCCGCCATCAAACCCGATGACATTCACTTTGCCCCCACCCGGCTGT
TAAGTTTGGAAAATACTCACAATGGCAAAGTCTTGCCTTTGCGTTATTTACAGCAAGCCTGGGCGTTGACCCGCGAAAAA
AAACTGGCGTTACATATTGATGGCGCACGTGTTTTTAATGCTGCGGTGGCGCTGAATGTGCCACTGAACGATATTAGCCA
GTATTGCGATACCCTGACAATTTGTCTGTCAAAAGGATTAGGGACGCCTGTTGGTTCCCTGCTCTGTGGCAGCGCAGAAT
TCATTCATCGCGCCCGGCGCTGGCGAAAAATGACCGGTGGTGGTATGCGTCAGGCCGGTATTTTAGCGGCAGCCGGGTTG
TATGCGCTGCAACATAATGTGGCGAGACTCAAAGATGATCACGATAACGCCCAGTGGTTGGAACAGCAATTACGTGACTT
AGGCATTGAGATAGCCGCCCCCGGCGCGCAAACAAACGTGCTGTACATTACGCAATCTGCCGAATCAGCGTTGAAACTTG
GCCCCTGGATGCGTGAACGTGGTGTGCTGATCAGTGCCGGGCCGCTCACCCGCCTGATTACTCACCTTAACGTGAGCCGA
AAAGATCTGGAAAAAGTCGTCGCGCTGTGGCGTGAATTTATTGCCGAGCAACATTCATGA

Upstream 100 bases:

>100_bases
TCCGTCGCGGGCACTTTGTCAATAACCTCGAGCCAGTAGGCTTTTTTGTTTCGATATTCTCGCTATGATGAAATCTATTT
TTCTAGCCAATGAGAAGACG

Downstream 100 bases:

>100_bases
CACCACAACGGATATTAGTATTAGGTGCCAGTGGCTATATTGGCCAACATTTGGTCCCCTTGCTAAGCCAGCAAGGCCAT
CAAGTCACGGCTGCTGGCCG

Product: L-threonine aldolase

Products: NA

Alternate protein names: Low-specificity L-TA [H]

Number of amino acids: Translated: 339; Mature: 339

Protein sequence:

>339_residues
MLIDLRSDTVTQPCAAMRAAMANAEVGDDVYGDDPTVNALEAKAASLSGKEAALFLPTGTQANLVALLTHCQRGEEYIVG
QKAHNYLYEAGGAAVLGSIQPQPIDANDDGTLPLDNVLAAIKPDDIHFAPTRLLSLENTHNGKVLPLRYLQQAWALTREK
KLALHIDGARVFNAAVALNVPLNDISQYCDTLTICLSKGLGTPVGSLLCGSAEFIHRARRWRKMTGGGMRQAGILAAAGL
YALQHNVARLKDDHDNAQWLEQQLRDLGIEIAAPGAQTNVLYITQSAESALKLGPWMRERGVLISAGPLTRLITHLNVSR
KDLEKVVALWREFIAEQHS

Sequences:

>Translated_339_residues
MLIDLRSDTVTQPCAAMRAAMANAEVGDDVYGDDPTVNALEAKAASLSGKEAALFLPTGTQANLVALLTHCQRGEEYIVG
QKAHNYLYEAGGAAVLGSIQPQPIDANDDGTLPLDNVLAAIKPDDIHFAPTRLLSLENTHNGKVLPLRYLQQAWALTREK
KLALHIDGARVFNAAVALNVPLNDISQYCDTLTICLSKGLGTPVGSLLCGSAEFIHRARRWRKMTGGGMRQAGILAAAGL
YALQHNVARLKDDHDNAQWLEQQLRDLGIEIAAPGAQTNVLYITQSAESALKLGPWMRERGVLISAGPLTRLITHLNVSR
KDLEKVVALWREFIAEQHS
>Mature_339_residues
MLIDLRSDTVTQPCAAMRAAMANAEVGDDVYGDDPTVNALEAKAASLSGKEAALFLPTGTQANLVALLTHCQRGEEYIVG
QKAHNYLYEAGGAAVLGSIQPQPIDANDDGTLPLDNVLAAIKPDDIHFAPTRLLSLENTHNGKVLPLRYLQQAWALTREK
KLALHIDGARVFNAAVALNVPLNDISQYCDTLTICLSKGLGTPVGSLLCGSAEFIHRARRWRKMTGGGMRQAGILAAAGL
YALQHNVARLKDDHDNAQWLEQQLRDLGIEIAAPGAQTNVLYITQSAESALKLGPWMRERGVLISAGPLTRLITHLNVSR
KDLEKVVALWREFIAEQHS

Specific function: Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde. L-threo-phenylserine and L- erythro-phenylserine are also good substrates [H]

COG id: COG2008

COG function: function code E; Threonine aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine aldolase family [H]

Homologues:

Organism=Escherichia coli, GI1787095, Length=334, Percent_Identity=69.1616766467066, Blast_Score=482, Evalue=1e-137,
Organism=Caenorhabditis elegans, GI193206522, Length=346, Percent_Identity=42.1965317919075, Blast_Score=256, Evalue=9e-69,
Organism=Caenorhabditis elegans, GI193206524, Length=346, Percent_Identity=42.1965317919075, Blast_Score=256, Evalue=1e-68,
Organism=Caenorhabditis elegans, GI193206520, Length=346, Percent_Identity=42.1965317919075, Blast_Score=256, Evalue=1e-68,
Organism=Saccharomyces cerevisiae, GI6320789, Length=329, Percent_Identity=38.2978723404255, Blast_Score=201, Evalue=1e-52,
Organism=Drosophila melanogaster, GI21355439, Length=296, Percent_Identity=47.972972972973, Blast_Score=266, Evalue=1e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001597
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01212 Beta_elim_lyase [H]

EC number: =4.1.2.5 [H]

Molecular weight: Translated: 36720; Mature: 36720

Theoretical pI: Translated: 6.67; Mature: 6.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLIDLRSDTVTQPCAAMRAAMANAEVGDDVYGDDPTVNALEAKAASLSGKEAALFLPTGT
CEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCCEEEEECCCC
QANLVALLTHCQRGEEYIVGQKAHNYLYEAGGAAVLGSIQPQPIDANDDGTLPLDNVLAA
CHHHHHHHHHHHCCCCEEECHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCCCHHHHHHH
IKPDDIHFAPTRLLSLENTHNGKVLPLRYLQQAWALTREKKLALHIDGARVFNAAVALNV
CCCCCCEECCHHEEEECCCCCCCEEHHHHHHHHHHHHHCCEEEEEECCHHHEEEEEEEEC
PLNDISQYCDTLTICLSKGLGTPVGSLLCGSAEFIHRARRWRKMTGGGMRQAGILAAAGL
CHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
YALQHNVARLKDDHDNAQWLEQQLRDLGIEIAAPGAQTNVLYITQSAESALKLGPWMRER
HHHHHHHHHHCCCCCHHHHHHHHHHHCCEEEECCCCCCEEEEEECCCHHHHHHCCCHHHC
GVLISAGPLTRLITHLNVSRKDLEKVVALWREFIAEQHS
CEEEECCHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MLIDLRSDTVTQPCAAMRAAMANAEVGDDVYGDDPTVNALEAKAASLSGKEAALFLPTGT
CEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCCEEEEECCCC
QANLVALLTHCQRGEEYIVGQKAHNYLYEAGGAAVLGSIQPQPIDANDDGTLPLDNVLAA
CHHHHHHHHHHHCCCCEEECHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCCCHHHHHHH
IKPDDIHFAPTRLLSLENTHNGKVLPLRYLQQAWALTREKKLALHIDGARVFNAAVALNV
CCCCCCEECCHHEEEECCCCCCCEEHHHHHHHHHHHHHCCEEEEEECCHHHEEEEEEEEC
PLNDISQYCDTLTICLSKGLGTPVGSLLCGSAEFIHRARRWRKMTGGGMRQAGILAAAGL
CHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
YALQHNVARLKDDHDNAQWLEQQLRDLGIEIAAPGAQTNVLYITQSAESALKLGPWMRER
HHHHHHHHHHCCCCCHHHHHHHHHHHCCEEEECCCCCCEEEEEECCCHHHHHHCCCHHHC
GVLISAGPLTRLITHLNVSRKDLEKVVALWREFIAEQHS
CEEEECCHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]