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The map label for this gene is xapA [H]

Identifier: 218928335

GI number: 218928335

Start: 1319480

End: 1320343

Strand: Direct

Name: xapA [H]

Synonym: YPO1171

Alternate gene names: 218928335

Gene position: 1319480-1320343 (Clockwise)

Preceding gene: 218928333

Following gene: 218928336

Centisome position: 28.35

GC content: 45.02

Gene sequence:

>864_bases
ATGACAACAGTAAATTCAAATATAAACGTTGATGCTGATTTCAATGAATTACCATTTCAAGCCGTTAAATATATTCAGAA
AATAAAACCCGGATTTAAGCCTCAAATCGCGTTTATTTTAGGTTCTGGATTGGGTGATTTAGTTGATCAAATTACGAATG
ACACCACAATTAGCTACGCTGATATCCCTGGCTTCCCTGTAAGCTCGGTTCACGGCCATGCTGGCGAACTGGTGCTGGGC
GATCTGTGTGGTGTTCCTGTGATGTGCATGAAAGGCCGTGGCCACTTTTACGAAGGCAAAGGCATGAGCATCATGACCAA
TCCGGTGCGCACATTTAAATTGATGGGCTGCGAATTCTTATTCTGTACTAATGCCGCCGGTTCATTGCGCCCAGAAGTTT
TGCCAGGTTCGGTGGTGATGCTAAAAGATCACATTAATACCATGCCGGGCACGCCGTTAGTTGGCCCTAATGATGATCGC
TTTGGCCCACGTTTCTTTAGCCTAGCGAATGCCTATGATAAAGATCTGCGTGCTGATATGGCTAAAATTGCTCAACAGCT
TGATATCCCGCTGACCGAAGGTGTATTTGTCTCTTACCTAGGGCCTTGCTTTGAAACACCGGCTGAGATTCGCATGATGC
AGATCATCGGCGGTGATGTTGTGGGTATGTCTGTCGTGCCGGAAGTTCTCTCCGCAGCCCATTGTGGTTTAAAAGTTATT
GCTCTGACCGCGATTACTAACCTGGCTGAAGGCCTTTCTGATGTCGTTCTGTCCCATGAACAAACCTTAAAATTTGCTAA
AGTGGCATCCGTCAATTTCACTAAATTGATTGAAGCATTCTTAAAAAGCAAAGCGCTCCGTTAA

Upstream 100 bases:

>100_bases
AGCTCATCACTTTGCGCTCAGGTGTAGTAACGCCAATTACTCGAGGTACATATTTAGCCGGTTTATTTGAGCGTTATTAA
AATAATCAAGGGGTTTTATT

Downstream 100 bases:

>100_bases
TCGATAAAGACGTCATAAATATTTTATGCCCCCTATTATGCCAGCCGCAAATAGGGGCACCGTAAATGAGGGATATACCC
TATAGGCTCAATGCGAAAAA

Product: purine nucleoside phosphorylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 287; Mature: 286

Protein sequence:

>287_residues
MTTVNSNINVDADFNELPFQAVKYIQKIKPGFKPQIAFILGSGLGDLVDQITNDTTISYADIPGFPVSSVHGHAGELVLG
DLCGVPVMCMKGRGHFYEGKGMSIMTNPVRTFKLMGCEFLFCTNAAGSLRPEVLPGSVVMLKDHINTMPGTPLVGPNDDR
FGPRFFSLANAYDKDLRADMAKIAQQLDIPLTEGVFVSYLGPCFETPAEIRMMQIIGGDVVGMSVVPEVLSAAHCGLKVI
ALTAITNLAEGLSDVVLSHEQTLKFAKVASVNFTKLIEAFLKSKALR

Sequences:

>Translated_287_residues
MTTVNSNINVDADFNELPFQAVKYIQKIKPGFKPQIAFILGSGLGDLVDQITNDTTISYADIPGFPVSSVHGHAGELVLG
DLCGVPVMCMKGRGHFYEGKGMSIMTNPVRTFKLMGCEFLFCTNAAGSLRPEVLPGSVVMLKDHINTMPGTPLVGPNDDR
FGPRFFSLANAYDKDLRADMAKIAQQLDIPLTEGVFVSYLGPCFETPAEIRMMQIIGGDVVGMSVVPEVLSAAHCGLKVI
ALTAITNLAEGLSDVVLSHEQTLKFAKVASVNFTKLIEAFLKSKALR
>Mature_286_residues
TTVNSNINVDADFNELPFQAVKYIQKIKPGFKPQIAFILGSGLGDLVDQITNDTTISYADIPGFPVSSVHGHAGELVLGD
LCGVPVMCMKGRGHFYEGKGMSIMTNPVRTFKLMGCEFLFCTNAAGSLRPEVLPGSVVMLKDHINTMPGTPLVGPNDDRF
GPRFFSLANAYDKDLRADMAKIAQQLDIPLTEGVFVSYLGPCFETPAEIRMMQIIGGDVVGMSVVPEVLSAAHCGLKVIA
LTAITNLAEGLSDVVLSHEQTLKFAKVASVNFTKLIEAFLKSKALR

Specific function: The nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the nucleoside molecule, with the formation of the corresponding free bases and pentose-1-phosphate. This protein can degrade all purine nucleosides except ade

COG id: COG0005

COG function: function code F; Purine nucleoside phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PNP/MTAP phosphorylase family [H]

Homologues:

Organism=Homo sapiens, GI157168362, Length=259, Percent_Identity=43.2432432432432, Blast_Score=209, Evalue=3e-54,
Organism=Homo sapiens, GI47132622, Length=259, Percent_Identity=27.027027027027, Blast_Score=72, Evalue=5e-13,
Organism=Escherichia coli, GI1788746, Length=273, Percent_Identity=69.96336996337, Blast_Score=393, Evalue=1e-111,
Organism=Caenorhabditis elegans, GI17541190, Length=299, Percent_Identity=34.7826086956522, Blast_Score=181, Evalue=3e-46,
Organism=Saccharomyces cerevisiae, GI6323238, Length=294, Percent_Identity=39.7959183673469, Blast_Score=184, Evalue=1e-47,
Organism=Drosophila melanogaster, GI24656090, Length=299, Percent_Identity=40.4682274247492, Blast_Score=209, Evalue=2e-54,
Organism=Drosophila melanogaster, GI24656093, Length=278, Percent_Identity=41.0071942446043, Blast_Score=207, Evalue=7e-54,
Organism=Drosophila melanogaster, GI45552887, Length=278, Percent_Identity=41.0071942446043, Blast_Score=206, Evalue=1e-53,
Organism=Drosophila melanogaster, GI45552885, Length=278, Percent_Identity=41.0071942446043, Blast_Score=206, Evalue=2e-53,
Organism=Drosophila melanogaster, GI24762376, Length=241, Percent_Identity=36.5145228215768, Blast_Score=136, Evalue=2e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011268
- InterPro:   IPR000845
- InterPro:   IPR010943
- InterPro:   IPR001369
- InterPro:   IPR018099 [H]

Pfam domain/function: PF01048 PNP_UDP_1 [H]

EC number: 2.4.2.-

Molecular weight: Translated: 30929; Mature: 30798

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: PS00134 TRYPSIN_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTVNSNINVDADFNELPFQAVKYIQKIKPGFKPQIAFILGSGLGDLVDQITNDTTISYA
CCEECCCEEECCCCCCCCHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHCCCCEEEEE
DIPGFPVSSVHGHAGELVLGDLCGVPVMCMKGRGHFYEGKGMSIMTNPVRTFKLMGCEFL
CCCCCCCCCCCCCCCCEEEHHHCCCCEEEECCCCCEECCCCCEEEECCHHHHHHHCCEEE
FCTNAAGSLRPEVLPGSVVMLKDHINTMPGTPLVGPNDDRFGPRFFSLANAYDKDLRADM
EEECCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
AKIAQQLDIPLTEGVFVSYLGPCFETPAEIRMMQIIGGDVVGMSVVPEVLSAAHCGLKVI
HHHHHHHCCCCCCCHHHHHHHHHHCCHHHHEEHHHHCCCHHHHHHHHHHHHHHHCCHHHH
ALTAITNLAEGLSDVVLSHEQTLKFAKVASVNFTKLIEAFLKSKALR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TTVNSNINVDADFNELPFQAVKYIQKIKPGFKPQIAFILGSGLGDLVDQITNDTTISYA
CEECCCEEECCCCCCCCHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHCCCCEEEEE
DIPGFPVSSVHGHAGELVLGDLCGVPVMCMKGRGHFYEGKGMSIMTNPVRTFKLMGCEFL
CCCCCCCCCCCCCCCCEEEHHHCCCCEEEECCCCCEECCCCCEEEECCHHHHHHHCCEEE
FCTNAAGSLRPEVLPGSVVMLKDHINTMPGTPLVGPNDDRFGPRFFSLANAYDKDLRADM
EEECCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
AKIAQQLDIPLTEGVFVSYLGPCFETPAEIRMMQIIGGDVVGMSVVPEVLSAAHCGLKVI
HHHHHHHCCCCCCCHHHHHHHHHHCCHHHHEEHHHHCCCHHHHHHHHHHHHHHHCCHHHH
ALTAITNLAEGLSDVVLSHEQTLKFAKVASVNFTKLIEAFLKSKALR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7559336; 9205837; 9278503 [H]