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The map label for this gene is yiaY [H]

Identifier: 218927532

GI number: 218927532

Start: 335861

End: 337009

Strand: Reverse

Name: yiaY [H]

Synonym: YPO0327

Alternate gene names: 218927532

Gene position: 337009-335861 (Counterclockwise)

Preceding gene: 218927533

Following gene: 218927531

Centisome position: 7.24

GC content: 51.09

Gene sequence:

>1149_bases
ATGAGTTTCATGTTGGCACTACCGAAAATCAGCTTGCACGGCACGGGTGCAATCGGCGATATGGTTAAATTACTCAGTGA
CAAACAGTGGGGGAAAGCACTGATTGTTACTGACGGGCAACTGGTTGAACTCGGCTTATTGGACAGTTTATTCGCGGCGA
TGGCGCAGTATCAGTTACCTTACGGGCTGTTTGGGGAGGTATTCCCTAATCCAACAGAAGAGTTGGTCCAGGCCGGTTTT
GCCGCCTTTACCCAGCATCAATGTGACTATTTGATTGCCTTCGGTGGCGGCAGCCCCATTGATACCGCCAAAGCCATCAA
AATACTGACTGCCAATCCGGGGCCATCCACCGCTTATTCCGGTGTAGGTAAAGTCAAACAAACGGGTGTTCCGTTGATAG
CCATCAATACCACGGCAGGAACGGCAGCGGAATTGACCAGTAATGCGGTGATTATTGATAGCCAGCGGCAAGTTAAGGAG
GTGATTATCGATACCAATCTCATCCCTGATATTGCGGTTGACGATCCCTCAGTAATGCTCAATATTCCCGCCAGTGTCAC
GGCGGCGACGGGGATGGATGCCCTTACCCACGCTGTCGAAGCGTATGTCTCGTTAGGTGCACATACGTTAACGGACCATT
CAGCGCTCGAATCAATCCGTCTTATCAGCCAATGGTTGCCATTAGCGGTCGCTGACGGCAAAAACCTACAAGCGCGCGAA
ATGATGGCATGTGGGCAATATTTGGCGGGTATGGCGTTTAACAGTGCTGGGCTAGGTTTGGTTCACGCACTGGCCCACCA
ACCGGGTGCCACACATAATCTTCCTCATGGCGTCTGCAATGCTATCTTGCTGCCGGTAATTGAAGAATATAATCGCCCGC
AGGCTACCCGCCGTTTTGCCCGAATTGCACAGGCAATGGGGGTAGACACTCAGGACATGAGTGATGAGCAAGCAAGTCAT
CAGGCGATAGCGGCCATTCGTCAGTTATCGCTGCAAGTTGGTATTCCTGCCGGGTTCTCCGCCTTAGGTATTGAGGAAAG
TGATATTGAAGGTTGGTTAGATAAAGCGCTGGCTGACCCTTGTGCTCCTTGTAACCCACGTTCTGCAGATCGGGAACAAA
TTCGCACACTGTACTTACAGGCACTTTAA

Upstream 100 bases:

>100_bases
TGTTACGCCGATGGCAGCGGCGCTGGACGCCTAATCCCCTCGATTAAAGCCCTGGCTAACGTCGGGGCGAATCATTTATG
CGTTATTTGAGGAGTACAGT

Downstream 100 bases:

>100_bases
GCGAGGGAATATGATGATACGTAAAGCGTTTGTTATGGCAGTAAATCCGGATGCCCATGCTGAATATCAGCGACGGCACA
CGCCAATCTGGCCAGAGCTG

Product: putative alcohol dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 382; Mature: 381

Protein sequence:

>382_residues
MSFMLALPKISLHGTGAIGDMVKLLSDKQWGKALIVTDGQLVELGLLDSLFAAMAQYQLPYGLFGEVFPNPTEELVQAGF
AAFTQHQCDYLIAFGGGSPIDTAKAIKILTANPGPSTAYSGVGKVKQTGVPLIAINTTAGTAAELTSNAVIIDSQRQVKE
VIIDTNLIPDIAVDDPSVMLNIPASVTAATGMDALTHAVEAYVSLGAHTLTDHSALESIRLISQWLPLAVADGKNLQARE
MMACGQYLAGMAFNSAGLGLVHALAHQPGATHNLPHGVCNAILLPVIEEYNRPQATRRFARIAQAMGVDTQDMSDEQASH
QAIAAIRQLSLQVGIPAGFSALGIEESDIEGWLDKALADPCAPCNPRSADREQIRTLYLQAL

Sequences:

>Translated_382_residues
MSFMLALPKISLHGTGAIGDMVKLLSDKQWGKALIVTDGQLVELGLLDSLFAAMAQYQLPYGLFGEVFPNPTEELVQAGF
AAFTQHQCDYLIAFGGGSPIDTAKAIKILTANPGPSTAYSGVGKVKQTGVPLIAINTTAGTAAELTSNAVIIDSQRQVKE
VIIDTNLIPDIAVDDPSVMLNIPASVTAATGMDALTHAVEAYVSLGAHTLTDHSALESIRLISQWLPLAVADGKNLQARE
MMACGQYLAGMAFNSAGLGLVHALAHQPGATHNLPHGVCNAILLPVIEEYNRPQATRRFARIAQAMGVDTQDMSDEQASH
QAIAAIRQLSLQVGIPAGFSALGIEESDIEGWLDKALADPCAPCNPRSADREQIRTLYLQAL
>Mature_381_residues
SFMLALPKISLHGTGAIGDMVKLLSDKQWGKALIVTDGQLVELGLLDSLFAAMAQYQLPYGLFGEVFPNPTEELVQAGFA
AFTQHQCDYLIAFGGGSPIDTAKAIKILTANPGPSTAYSGVGKVKQTGVPLIAINTTAGTAAELTSNAVIIDSQRQVKEV
IIDTNLIPDIAVDDPSVMLNIPASVTAATGMDALTHAVEAYVSLGAHTLTDHSALESIRLISQWLPLAVADGKNLQAREM
MACGQYLAGMAFNSAGLGLVHALAHQPGATHNLPHGVCNAILLPVIEEYNRPQATRRFARIAQAMGVDTQDMSDEQASHQ
AIAAIRQLSLQVGIPAGFSALGIEESDIEGWLDKALADPCAPCNPRSADREQIRTLYLQAL

Specific function: Unknown

COG id: COG1454

COG function: function code C; Alcohol dehydrogenase, class IV

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI133922590, Length=378, Percent_Identity=25.1322751322751, Blast_Score=108, Evalue=1e-23,
Organism=Escherichia coli, GI48994951, Length=376, Percent_Identity=43.6170212765958, Blast_Score=326, Evalue=2e-90,
Organism=Escherichia coli, GI1789163, Length=383, Percent_Identity=42.0365535248042, Blast_Score=278, Evalue=5e-76,
Organism=Escherichia coli, GI87082107, Length=377, Percent_Identity=38.7267904509284, Blast_Score=244, Evalue=5e-66,
Organism=Escherichia coli, GI1787493, Length=369, Percent_Identity=32.7913279132791, Blast_Score=192, Evalue=2e-50,
Organism=Escherichia coli, GI1789386, Length=367, Percent_Identity=28.0653950953678, Blast_Score=97, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17537053, Length=407, Percent_Identity=28.5012285012285, Blast_Score=142, Evalue=3e-34,
Organism=Saccharomyces cerevisiae, GI6321181, Length=370, Percent_Identity=40.8108108108108, Blast_Score=287, Evalue=2e-78,
Organism=Drosophila melanogaster, GI24657991, Length=390, Percent_Identity=25.8974358974359, Blast_Score=104, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001670
- InterPro:   IPR018211 [H]

Pfam domain/function: PF00465 Fe-ADH [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 40403; Mature: 40272

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: PS00913 ADH_IRON_1 ; PS00060 ADH_IRON_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFMLALPKISLHGTGAIGDMVKLLSDKQWGKALIVTDGQLVELGLLDSLFAAMAQYQLP
CCCEEECCCEEECCCCHHHHHHHHHCCCCCCCEEEEECCCEEEHHHHHHHHHHHHHHCCC
YGLFGEVFPNPTEELVQAGFAAFTQHQCDYLIAFGGGSPIDTAKAIKILTANPGPSTAYS
CCHHHCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCEEEEEECCCCCCHHHH
GVGKVKQTGVPLIAINTTAGTAAELTSNAVIIDSQRQVKEVIIDTNLIPDIAVDDPSVML
CCCCHHHCCCCEEEEECCCCCHHHHCCCEEEEECHHHHHHHHHCCCCCCCCCCCCCCEEE
NIPASVTAATGMDALTHAVEAYVSLGAHTLTDHSALESIRLISQWLPLAVADGKNLQARE
ECCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCEEEECCCCCHHHH
MMACGQYLAGMAFNSAGLGLVHALAHQPGATHNLPHGVCNAILLPVIEEYNRPQATRRFA
HHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHH
RIAQAMGVDTQDMSDEQASHQAIAAIRQLSLQVGIPAGFSALGIEESDIEGWLDKALADP
HHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHCCCCHHHHHHHHHHHHCCC
CAPCNPRSADREQIRTLYLQAL
CCCCCCCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
SFMLALPKISLHGTGAIGDMVKLLSDKQWGKALIVTDGQLVELGLLDSLFAAMAQYQLP
CCEEECCCEEECCCCHHHHHHHHHCCCCCCCEEEEECCCEEEHHHHHHHHHHHHHHCCC
YGLFGEVFPNPTEELVQAGFAAFTQHQCDYLIAFGGGSPIDTAKAIKILTANPGPSTAYS
CCHHHCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCEEEEEECCCCCCHHHH
GVGKVKQTGVPLIAINTTAGTAAELTSNAVIIDSQRQVKEVIIDTNLIPDIAVDDPSVML
CCCCHHHCCCCEEEEECCCCCHHHHCCCEEEEECHHHHHHHHHCCCCCCCCCCCCCCEEE
NIPASVTAATGMDALTHAVEAYVSLGAHTLTDHSALESIRLISQWLPLAVADGKNLQARE
ECCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCEEEECCCCCHHHH
MMACGQYLAGMAFNSAGLGLVHALAHQPGATHNLPHGVCNAILLPVIEEYNRPQATRRFA
HHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHH
RIAQAMGVDTQDMSDEQASHQAIAAIRQLSLQVGIPAGFSALGIEESDIEGWLDKALADP
HHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHCCCCHHHHHHHHHHHHCCC
CAPCNPRSADREQIRTLYLQAL
CCCCCCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8041620; 9278503; 7768815 [H]